TLR ligand functionalized nanocarriers to enhance immunogenicity of vaccines
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VHIR Seminar led by Gerrit Borchard, Section of Pharmaceutical Sciences University of Geneva, University of Lausanne Biopharmaceutical Sciences Geneva Switzerland. ...
VHIR Seminar led by Gerrit Borchard, Section of Pharmaceutical Sciences University of Geneva, University of Lausanne Biopharmaceutical Sciences Geneva Switzerland.
Abstract: In order to enhance the efficacy of vaccines, antigen and adjuvants are combined in particulate carrier systems resembling pathogens in size, shape and surface properties. These novelnano- and microcarriervaccines strategies, using DNA or subunit vaccines as antigens and specific ligands of receptors of the innate immune system,offer several advantages, such as enhanced immune recognition, direction of immune response bias, and enhancement of vaccine stability. We are focusing on eliciting protective immune responses against M. tuberculosis, a pathogen transmitted through inhalation, bydeveloping vaccine delivery systems composed of different materialsand administered by the mucosal route.
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