Saini NK et al
Source Journal: Inventi Rapid: Pharmacy Practice
Vol.2011, Issue 2
Introduction
 C-reactive protein plays a role in the expression of
different adhesion molecules on endothelial cells
and ...
C-Reactive protein
 C-reactive protein is an acute phase protein,
the levels of which rise in response to
inflammation, m...
Normal CRP levels
 C-Reactive protein normal: 0-1.0mg/dl (or) 10mg/L (SI Units)
 The hs-CRP test measures the risk for c...
Atorvastatin
 Atorvastatin is a synthetic HMG-CoA reductase
inhibitor with a great potency to lower both cholesterol
and ...
Mechanism of action of
Atorvastatin
Pleiotropy of statins
 Statins have been shown to decrease ROS production
and VSMC proliferation, enhances eNOS levels
ex...
Role of Atorvastatin on CRP level
 Atorvastatin improves endothelium dependent
vasodilatation and a lowering of plasma CR...
Artherosclerotic plaque attenuatuion
through CRP level reduction
 Increased levels of C-reactive protein have associated ...
Suppression of
expression of
inflammatory
parameters by
Atorvastatin
Reduction in
C-reactive
protein level.
Reduction of
e...
Vasodilation
Increase in perfusion
Sufficient blood
supply to the cardiac
tissue in need
Prevention of
myocardial ischemia
Clinical trials
Name of the study Type Drug % Reduction in
CRP level
MIRACL Randomized
controlled trial
Atorvastatin 83%
C...
Inference
 The use of statins may prevent ischemia by
both inhibiting deposition of lipids and
decreasing inflammation.
...
Doses of commonly used statins
Statin Dose Brand name Manufacturer
Lovastatin 10mg, 20mg ROVACOR,
AZTATIN,
LOVAMEG
Ranbaxy...
Thank you!!!
Upcoming SlideShare
Loading in...5
×

Role of atorvastatin

1,276
-1

Published on

Role of atorvastatin,Role of atorvastatin, atrovastatin, statin, journal, pharmd, vels, Facebook, Diabetes mellitus, Diabetes mellitus type 2,

Published in: Education, Business, Technology
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
1,276
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
58
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Role of atorvastatin

  1. 1. Saini NK et al Source Journal: Inventi Rapid: Pharmacy Practice Vol.2011, Issue 2
  2. 2. Introduction  C-reactive protein plays a role in the expression of different adhesion molecules on endothelial cells and the protein is able to activate human complement within the plaque.  It has been proven that an elevated CRP level is associated with an increased risk of occlusive arterial disease.
  3. 3. C-Reactive protein  C-reactive protein is an acute phase protein, the levels of which rise in response to inflammation, microbial infection.  CRP serves as a critical component of the innate immune system by enhancing the uptake of microbes by phagocytic cells of the immune system.
  4. 4. Normal CRP levels  C-Reactive protein normal: 0-1.0mg/dl (or) 10mg/L (SI Units)  The hs-CRP test measures the risk for cardiovascular problems. It may be done to find out an increased chance of having a sudden heart problem, such as a heart attack. High-sensitivity C-reactive protein (hs-CRP) levels Less than 1.0mg/L Lowest risk 1.0-3.0mg/L Average risk More than 3.0mg/L Highest risk
  5. 5. Atorvastatin  Atorvastatin is a synthetic HMG-CoA reductase inhibitor with a great potency to lower both cholesterol and triglyceride concentrations.  Controlled studies with various groups of hyperlipidemic patients showed reduction of LDL cholesterol by up to 60% and triglyceride by up to 50%.  Mechanism of action:  Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate limiting enzyme in cholesterol synthesis.
  6. 6. Mechanism of action of Atorvastatin
  7. 7. Pleiotropy of statins  Statins have been shown to decrease ROS production and VSMC proliferation, enhances eNOS levels exhibit anti-thrombotic and anti-inflammatory effects thereby, attenuate artherosclerotic plaques.  Trials using different statins, including pravastatin, simvastatin and atorvastatin have all demonstrated favourable reductions in C-reactive protein level. VSMC-Vascular Smooth Muscle Cell
  8. 8. Role of Atorvastatin on CRP level  Atorvastatin improves endothelium dependent vasodilatation and a lowering of plasma CRP concentrations.  It has been demonstrated that statins have an effect on markers of inflammation, particularly C-reactive protein, independent of their lipid lowering effect.  Novel route of plaque attenuation: Artherosclerotic plaque growth may be attenuated with therapy aimed at minimizing inflammation.
  9. 9. Artherosclerotic plaque attenuatuion through CRP level reduction  Increased levels of C-reactive protein have associated with arterial wall inflammation.  Thus reduction in CRP levels may reduce the extent of endothelial-cell opsonisation, macrophage recruitment and blunting of nitric oxide release.  Prevention of vasoconstriction by attenuating the pro- inflammatory process and preserving vasodilatation may allow sufficient perfusion to prevent myocardial ischemia.
  10. 10. Suppression of expression of inflammatory parameters by Atorvastatin Reduction in C-reactive protein level. Reduction of endothelial cell opsonisation. Increase in nitric oxide release Vasodilation
  11. 11. Vasodilation Increase in perfusion Sufficient blood supply to the cardiac tissue in need Prevention of myocardial ischemia
  12. 12. Clinical trials Name of the study Type Drug % Reduction in CRP level MIRACL Randomized controlled trial Atorvastatin 83% CURVES Comparative dose efficacy study Pravastatin, Simvastatin, Atorvastatin Significant TexCAPS Randomized placebo controlled trial Lovastatin 14.8% PRINCE trial Antiinflammatory effects Pravastatin 16.9% REVERSAL Atorvastatin Pravastatin 36.4% 5.2%
  13. 13. Inference  The use of statins may prevent ischemia by both inhibiting deposition of lipids and decreasing inflammation.  Atorvastatin also lowers plasma LDL cholesterol and C-reactive protein in type-2 diabetic patients, therefore could be a useful medication for the prevention of cardiovascular diseases in diabetic patients.
  14. 14. Doses of commonly used statins Statin Dose Brand name Manufacturer Lovastatin 10mg, 20mg ROVACOR, AZTATIN, LOVAMEG Ranbaxy, Sun Pharma Simvastatin 5mg, 10mg, 20mg SIMVOTIN, SIMCARD Ranbaxy (Stancare) Pravastatin 10mg, 20mg PRAVATOR Ranbaxy(Solus) Atorvastatin 5mg, 10mg, 20mg AZTOR, ATORVA, ATORLIP, LIPITOR Zydus Cadilla, Pfizer. Rosuvastatin 5mg, 10mg, 20mg ROSUVAS, ROSYN Ranbaxy
  15. 15. Thank you!!!
  1. Gostou de algum slide específico?

    Recortar slides é uma maneira fácil de colecionar informações para acessar mais tarde.

×