The nature of consciousness, its occurrence in the brain, and its ultimate place in the universe are
unknown. We proposed in the mid 1990's that consciousness depends on biologically
'orchestrated' quantum computations in collections of microtubules within brain neurons, that
these quantum computations correlate with and regulate neuronal activity, and that the continuous
Schrödinger evolution of each quantum computation terminates in accordance with the specific
Diósi–Penrose (DP) scheme of 'objective reduction' of the quantum state (OR). This orchestrated
OR activity (Orch OR) is taken to result in a moment of conscious awareness and/or choice.
This particular (DP) form of OR is taken to be a quantum-gravity process related to the
fundamentals of spacetime geometry, so Orch OR suggests a connection between brain
biomolecular processes and fine-scale structure of the universe. Here we review and update Orch
OR in light of criticisms and developments in quantum biology, neuroscience, physics and
cosmology. We conclude that consciousness plays an intrinsic role in the universe.