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From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi
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From Discovery to Delivery: Benchwork to Global Health: Jerry Cangelosi

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Explores relationships and discrepancies between important research-based medical advancements and subsequent real world implementation. Advancements in the management and potential elimination of …

Explores relationships and discrepancies between important research-based medical advancements and subsequent real world implementation. Advancements in the management and potential elimination of infectious diseases such as HIV and TB will be addressed, as related to development and implementation of effective diagnostics, vaccines, or treatments.

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  • 1. Global Health Education Consortium From Discovery to Delivery: Benchwork to Global Health Jerry Cangelosi BioAffinity Consulting Seattle Biomedical Research Institute Departments of Global Health and Epidemiology University of Washington [email_address] 256-7313 Research interests: Molecular diagnosis of infectious disease Molecular epidemiology of infectious disease
  • 2. American Red Cross <ul><li>Tuberculosis (TB) </li></ul><ul><li>Airborne transmission </li></ul><ul><li>7+ million cases, 2+ million deaths per year </li></ul><ul><li>Many people latently infected </li></ul><ul><li>Limited vaccine (BCG) </li></ul><ul><li>Treatment long and difficult </li></ul><ul><li>Poorest countries have highest incidence </li></ul>
  • 3. TB and homelessness: Tough all over National incidence (cases per 100,000 population; 2004) 1 U.S.A. 4.9 Hungary 24.5 Extrapolated incidence among the homeless (cases per 100,000; 2004) Seattle ~400 2 Budapest ~700 3 1 WHO 2 Public Health – Seattle & King County 3 National Korányi Institute for Tuberculosis and Respiratory Medicine, Budapest
  • 4. TB risk factors associated with homelessness <ul><li>___ </li></ul><ul><li>___ </li></ul><ul><li>___ </li></ul><ul><li>___ </li></ul><ul><li>___ </li></ul>
  • 5. <ul><ul><li>Public Health – Seattle & King County </li></ul></ul>Global Fund to Fight AIDS, Tuberculosis, and Malaria <ul><li>Timely diagnosis is critical to : </li></ul><ul><li>Patient care </li></ul><ul><ul><li>Case detection </li></ul></ul><ul><ul><li>Correct and timely treatment decisions </li></ul></ul><ul><ul><li>Confirmation of treatment (test of cure) </li></ul></ul><ul><li>Control of disease transmission </li></ul><ul><li>Surveillance </li></ul><ul><li>Research and development </li></ul>
  • 6. Diagnostic technology development 1. Diagnostic technologies are modular MicroProbe Affirm VPIII test for vaginosis pathogens MBARI “ESP” for detecting harmful algae blooms
  • 7. Diagnostic technology development 2. Needed for global health: low cost and “point of care” Response Biomedical RAMP test for anthrax spores
  • 8. Diagnostic technology development 3. Biomarkers needed <ul><li>“ Accelerated Molecular Probe Pipeline” </li></ul><ul><li>Entamoeba histolytica (ameobic diarrhea) </li></ul><ul><li>Biomarkers  diagnostic test </li></ul><ul><li>Collaborators in US, Australia, Bangladesh </li></ul>

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