Patrick Balthrop of Luminex on the Convergence of Health Care Technology and Public Policy

Innovation and the Convergence of Technologies in the 21 st Century: The Century of Life Science

November 24, 1859

Charles Darwin
HMS Beagle and Captain Fitzroy
Natural selection
Immutability of species
Church of England and Darwin’s mentors
“ Tree of Life”
Adaptation: “Species theory”

1700’s: Biology
Science through the Centuries

1700’s: Biology
1800’s: Chemistry

1700’s: Biology
1800’s: Chemistry
1900’s: Physics

1700’s: Biology
1800’s: Chemistry
1900’s: Physics
2000’s: Life Science

1700 Science through the Centuries 2009 1700 - Van Leeuwenhoek Microscope Biology 1859 – Darwin Natural Selection Biology 1866 – Mendel Genetics Biology 1880 - Pasteur Bacteriology Biology 1802 - Dalton Atomic Theory Chemistry 1869 – Mendeleev Periodic Table Chemistry 1950 - Pauling Chemical Bonds Chemistry 1983 - Mullis PCR Chemistry 2003 - Collins Human Genome Life Science 1937 - Turing Artificial Intelligence Physics 1900 - Curie Radioactivity Physics 1850 – Kelvin Thermodynamics Physics 1700 - Newton Gravity Physics 1953 – Watson & Crick DNA Biology

Human Genome and Human Proteome

Human Genome Project

Forbes’ 2009 Fastest Growing Technology Companies in America

Healthcare Reform BILL SIMILAR TO SENATE'S Months of talks yield $894 billion package HOW AN INSURANCE MANDATE COULD LEAVE MANY WORSE OFF Costs Keep Rising BUOYANT DEMOCRATS UNVEIL HEALTHCARE LEGISLATION

Personalized Medicine

Personalized Medicine - Tamoxifen

Personalized Medicine

Tamoxifen Efficacy by Genetic Profile Personalized Medicine Percentage of Patients Relapse-free survival Overall survival

The US Healthcare System is Procedure-Based

Help is on the Way
Medco's New Idea: PGx Program for Generics to Dispense 'Smarter' Treatments and Increase Savings
Breast Cancer: Genetics may hold key to prevention, treatment
SAEC Conducting Feasibility Gene-Association Study with HMO Network's E-Records
Medco Study to Gauge Whether PGx-Based Plavix Dosing is as Effective as Higher-Priced Effient
Generation Health Emulates the PBM Model to Optimize Genetic Testing for Payors
National Survey Shows Physicians See Value in Genetic Testing

Predicate device model
Not innovation-friendly
Critical Path Initiative
User fees
“ Rearview Mirror Navigation”
Review and reform underway
Regulation: Strategic Considerations

1700 Science through the Centuries 2000 1700 - Van Leeuwenhoek Microscope Biology 1859 – Darwin Natural Selection Biology 1866 – Mendel Genetics Biology 1880 - Pasteur Bacteriology Biology 1802 - Dalton Atomic Theory Chemistry 1869 – Mendeleev Periodic Table Chemistry 1950 - Pauling Chemical Bonds Chemistry 1983 - Mullis PCR Chemistry 2003 - Collins Human Genome Life Science 1937 - Turing Artificial Intelligence Physics 1900 - Curie Radioactivity Physics 1850 – Kelvin Thermodynamics Physics 1700 - Newton Gravity Physics 1953 – Watson & Crick DNA Biology 2009

Science through the Centuries 1700 - Van Leeuwenhoek Microscope 1859 – Darwin Natural Selection 1866 – Mendel Genetics 1880 - Pasteur Bacteriology 1953 – Watson & Crick DNA Physics 1802 - Dalton Atomic Theory 1869 – Mendeleev Periodic Table 1950 - Pauling Chemical Bonds 1983 - Mullis PCR Chemistry Century of Life Science Biology 1937 - Turing Artificial Intelligence 1900 - Curie Radioactivity 1850 – Kelvin Thermodynamics 1700 - Newton Gravity

R&D is Our Future NIH Budget 1990-2008 0 10 15 20 30 5 25 $ Billion

Progress Over the Last 100 Years *per Merck Manual 1899 1900 Present Death Rate per 100K Population, US 1,500 <800 Leading Causes of Death Heart disease, infectious disease Heart disease, cancer Treatment, Diabetes* Arsenic Insulin, BGM Treatment, Asthma* Tobacco Corticosteriods Treatment, Cardiac Disease* Cocaine Statins, stents, CABG Treatment, Insomnia* Cannabis Zolpidem, eszopiclone

Innovation and the Convergence of Technologies in the 21 st Century: The Century of Life Science

Patrick Balthrop of Luminex on the Convergence of Health Care Technology and Public Policy

by UT Austin McCombs School of Business on Nov 19, 2009

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Patrick Balthrop of Luminex on the Convergence of Health Care Technology and Public Policy Presentation Transcript