Systematic reviewsin research usinganimals; a policyperspective.Henk ReinenIngrid Hartgers
Animal tests in the Netherlands                     1.800.000                                                             ...
Overview output Three R research                        vaccine quality control RIVM/NVITest                          Anim...
Trend?                     1.800.000                     1.600.000                     1.400.000                     1.200...
Action Plan                              Sharing    Science     Education                             knowlegdeCollaborati...
Pagina met twee tekstblokken          Directive                               Action Plan       Alternatives    Protection...
Synthesis of evidenceBetter science with less animalsMotion; standard in medical science,should be common practice in scie...
Upcoming SlideShare
Loading in …5
×

SYRCLE_Reinen mini symposium sr animal studies 30082012

262 views
219 views

Published on

Published in: Health & Medicine, Lifestyle
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
262
On SlideShare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
2
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

SYRCLE_Reinen mini symposium sr animal studies 30082012

  1. 1. Systematic reviewsin research usinganimals; a policyperspective.Henk ReinenIngrid Hartgers
  2. 2. Animal tests in the Netherlands 1.800.000 Bron: Zo doende (NVWA) 1.600.000 1.400.000 1.200.000Aantal dierproeven 1.000.000 800.000 600.000 400.000 200.000 0 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 Jaar2
  3. 3. Overview output Three R research vaccine quality control RIVM/NVITest Animal model Three R method StatusPotency testing lethal challenge humane endpoints accepted Eur.Ph./WHO/FDA(general) 100 Animal use in BilthovenPotency testing 90 lethal challenge serology accepted Eur.Ph./WHOtetanus vaccine 80 mouse 70Potency testing 60 lethal challenge serology accepted EurPh./WHOdiphteria vaccine guinea-pig 50Potency testing 40 lethal challenge serology international validationwhole cell pertussis 30 study 20Potency testing 10 multi-dose test one dose test accepted Eur.Ph./WHO 0Safety diphtheria 1989 1991 1993 1995 1997 Vero cell test 2003 2005 2007 accepted Ph.Eur./WHO dermal study in 1999 2001vaccine guinea-pigs 3V-Platfom RIVM, 08-09-2011
  4. 4. Trend? 1.800.000 1.600.000 1.400.000 1.200.000Aantal dierproeven 1.000.000 800.000 600.000 Refine 400.000 Reduce 200.000 Replace € 0 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 Jaar Action4 Plan
  5. 5. Action Plan Sharing Science Education knowlegdeCollaboration EU, global Society6
  6. 6. Pagina met twee tekstblokken Directive Action Plan Alternatives Protection of animals Transparancy Registrations Initiatives Level playing field Monitoring “Stimulate” Knowledge Project evaluation Registrations Facilitate Networks => Publications Regulate EU authorisation Research Funds (ZonMW Global7
  7. 7. Synthesis of evidenceBetter science with less animalsMotion; standard in medical science,should be common practice in scienceusing animalsQuality of publicationsZonMW , research Thank you!Raise support; awareness;change of cultureDevelop instruments, methodology,guidelines, education8

×