SYRCLE_Oort mini symposium sr animal studies 30082012

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SYRCLE_Oort mini symposium sr animal studies 30082012

  1. 1. Replacement, Reduction and Refinement in animal experimentation
  2. 2. More Knowledge with Fewer Animals2011: Kick-off ZonMw grantprogram MKMDProgram goals: • Development of innovative 3R methods • Implementation of new and existing 3R methods
  3. 3. More Knowledge with Fewer AnimalsGeneral program conditions: • Multi-disciplinary research • Collaboration between relevant stakeholders • Chain involvement • Publication of all project results, open access, synthesis of evidence (SR) • Implementation of results
  4. 4. More Knowledge with Fewer AnimalsProgram structure: • Flexible, set up in modules • Modules to be commissioned by different parties • First three modules have been commissioned:  Animal-Free Research Techniques  Amendement 21  New Module: in development
  5. 5. Module Animal-Free Research TechniquesFocus on Replacement • Research projects (3.3 M€)  Cancer and other human diseases  Public-private partnerships  Multi-disciplinary collaborations • Follow-up ASAT2010 projects (0.8M€) • Implementation projects
  6. 6. Module Amendment 21 (2012-2014)Focus on 3R knowledge infrastructure • Publication of negative results and stimulating the use of the ‘Gold Standard Publication checklist’ (or ‘ARRIVE guidelines’) • Synthesis of Evidence in animal experimentation (Systematic Reviews)
  7. 7. Module Amendment 21Publication of negative results involving animal studiesTarget group: ZonMw project leaders • Additional financial support to publish negative results • Open access • ‘Gold Standard Publication Checklist’/ARRIVEAim: more awareness of the importance of publishingmeaningful negative results (bias in literature, repetition ofexperiments) Call open September!
  8. 8. Module Amendment 21Synthesis of evidence of animal experimentation(Systematic Reviews)Target group: researchers considering animal studies(mandatory for MKMD project leaders) • Synthesis of evidence (SR) workshops (about six) • Continued support for workshop participants • Additional training for a few workshop participants Call open on invitation March 2012
  9. 9. Systematic Reviews obligatory within ZonMwprogram:Health Care Efficiency Research (HCER)
  10. 10. Health Care Efficiency Research (HCER)Actively promotes research on recognition, assessmentand implementation of cost-effective interventions andfosters generalisation of knowledge• Clinical research in patients• Structural programme (1999)
  11. 11. Why a systematic review?To identify knowledge gap / added value ofproposed researchSystematic overview:• what’s already known on (cost-)effectiveness ofintervention / implementationstrategy under study• currently ongoing studies on similar subjectOptional: input for powercalculation (effectsize)
  12. 12. Quality item for reviewersHow do you judge the systematic review?Consider: • selection of search terms; • all relevant databases included; • selection of papers; • do you miss any references relevant to this specific proposal? • are the conclusions of the systematic review justified?

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