SYRCLE_Leenaars mini symposium sr animal studies 30082012

342 views
262 views

Published on

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
342
On SlideShare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
3
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

SYRCLE_Leenaars mini symposium sr animal studies 30082012

  1. 1. How to facilitate SRs:moving towards evidence-based translational research Dr Marlies Leenaars SYRCLE, Nijmegen
  2. 2. Added value of systematic reviews of animal studiesGet an overview of existing knowledgeHelp design a clinical trial (patient safety)Collaboration between disciplinesTransparency in (quality of) all primary studiesFacilitate translational researchGet an idea of missing „inconclusive‟ dataPrevent unnecessary animals studiesNew results without using animals
  3. 3. Pound et al BMJ 2004,Where is the evidence that animal research benefits humans?Conclusion: The contribution of animal studies to clinical medicinerequires urgent formal evaluation. Systematic reviews and meta-analysesof the existing animal experiments would represent an important stepforward in this process’
  4. 4. Performing SR of animal studies results in:A valuable publication in a peer reviewed journal (Hooijmans, J of Alz Dis; van Drongelen, Am J Phys; Wever, PlosOne) (Impact factor: 3.7 - 4.1)Costs: Systematic review: Animal experiment: -Computer -Computer -Time -Time -Animals, housing, materials, etc. -Analyses of samples etc Rough estimate: Rough estimate: € 20.000 € 100.000
  5. 5. SYRCLESince 2008 our research group facilitates: implementation of SR of animal studiesEducation on SRsDeveloping methodology for SRs (tools)Executing SRs(Inter)national collaboration
  6. 6. Implementation of SRs:Education: Increase awareness of potential of concept of SRs Improve skills in performing SRsDeveloping tools and guidelines: Facilitate performing SRs Ease the process
  7. 7. “If you take a closer look, you see more”
  8. 8. Increase awarenessEducation for future animal researchersSince 2009: education on SRs in course on Laboratory Animal Science (obligatory 2 weeks course) o Lecture on SRs o Workshop on: „comprehensive search strategies‟ Quote of student: “This is so logical. Why is this not common practice in animal research?”
  9. 9. Increase awareness Helsinki, Finland Do like us!Prof. Rob Scholten, The Dutch CochraneCentre, Amsterdam, The Netherlands
  10. 10. Increase awareness www.ccac.wc8.ca
  11. 11. Increase awareness Talks are available on YouTube via link on: www.umcn.nl/SYRCLE
  12. 12. Implementation of SRs:Education: Increase awareness of potential of concept of SRsImprove skills in performing SRsDeveloping tools and guidelines: Facilitate performing SRs Ease the process
  13. 13. Education to improve (skills in) performing SRs• Since 2010; 1 EC = 1 week• In curriculum of Biomedical Sciences MSc. studentsMain objectives:- Improve skills in performing SRs- Critical appraisal of animal data- Increase knowledge: move towardsevidence-based translational research * internal validity * external validity
  14. 14. Student evaluationsScore January 2012: 8.3Question: Was this topic relevant for you? “Zeer leerzaam en state-of-the-art” “It gave me a completely different view on animal studies and published papers” “Never done this in another course. Very relevant not only for animal studies but also for clinical studies” “SRs could be very helpful in all majors”
  15. 15. Training to improve skills in performing SRsOne day hands-on training for PhD students, researchersTopics: 1. Comprehensive search strategies 2. Risk of bias assessment 3. Data extraction and meta analysis February 10th 2012
  16. 16. Implementation of SRs:Education: Increase awareness of potential of concept of SRs Improve skills in performing SRsDeveloping tools and guidelines: Facilitate performing SRs Ease the process
  17. 17. Identify all relevant animal studies Tools to ease the process Tools used educational programs
  18. 18. Tools to ease the process: identify all animal studies - Step-by-step guide to identify relevant animal studies (Leenaars et al., 2012, Laboratory Animals, 46(1), 24-31) - EMBASE filter to find all animal studies (De Vries et al., 2011, Laboratory Animals, 45(4), 268-270) - PubMed filter to find all animal studies (Hooijmans et al., 2010, Laboratory Animals, 44(3), 170-175) Open Access available!
  19. 19. Quote about tools and guidelinesSent: Friday 6 July 2012 20:09Topic: Thank you and I‟m using the articles and guides and support materials from SYRCLE“.. It reaffirmed my faith that it is possible to do much more, now that your group has provided the Why and Hows, validated by researchers who use animals.”Ann Viera: Associate Professor; Veterinary LibrarianPendergrass AG-VET MED LibraryUniversity of Tennessee Knoxville
  20. 20. Implementation of SRs of animal studies in the futureFurther development education: Translational research Curriculum of BSc students Molecular Mechanisms of disease (MMD) MSc. students (Inter)national workshops (clinical PhD council)Further development tools and guidelines (i.e. risk of bias tool, protocol SR, handbook)New EU directive 2010/63 on animal experimentation: o Course on laboratory animal science o Continuing education
  21. 21. SYRCLESYstematic Review Centre for Laboratory animal Experimentation- Prof. Merel Ritskes-Hoitinga- Dr Marlies Leenaars- Dr Carlijn Hooijmans- Dr Rob de Vries- MSc Judith van Luijk (PhD student)Collaboration in Nijmegen: • o Prof. Maroeska Rovers • • Department of Obstetrics and Gynecology Department of Pharmacology and Toxicology o Alice Tillema (Information specialist) • Department of Operating Rooms Department of Epidemiology, Biostatistics and HTA • Department of Surgery • Department of Urology www.umcn.nl/SYRCLE • Department of Paediatric Physical Therapy M.Leenaars@cdl.umcn.nl • IQ Health care • Department of Orthodontics and Craniofacial Biology • Department of Oral and Maxillofacial Surgery • QM Diagnostics
  22. 22. NKCAMarcel Gyger
  23. 23. Thanks foryour attention!

×