• Like
  • Save
Ulcerative conditions
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

Ulcerative conditions

  • 237 views
Published

Oral Pathology I …

Oral Pathology I
Third Year

Published in Health & Medicine , Technology
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads

Views

Total Views
237
On SlideShare
0
From Embeds
0
Number of Embeds
0

Actions

Shares
Downloads
0
Comments
0
Likes
0

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide

Transcript

  • 1. ULCERATIVE CONDITIONS By: Yousef Alothman Abdulrahman Alsulaiman Faheed Alzoabi
  • 2. Immunological disease :Aphthous ulcer-1 .It’s the most common non-traumatic ulceration :Prevalence tend to be higher in .Professionals.Upper socioeconomic group- . Non smoker-
  • 3. .Cont :Etiology :The main cause is unknown, however        focal immune dysfunction . endogenous or exogenous antigen . non specific factor, such as trauma . neuropeptide could mediate lymphocytes infiltration and epithelial necrosis . Focal release of cytokines . B12 , folic acid and iron deficiency . Hormonal alteration , stress and allergy .
  • 4. Clinical features : Minor aphthae Major aphthae Herpetiform aphthae Size <0.5 cm >0.5 cm <0.5 cm Pain painful Sever pain Considerable pain location Nonkeratinized Nonkeratinized mucosa mucosa Any intraoral site treatment Topical corticosteroids , tetracycline mouth rinse Topical/systimic corticosteroids , tetracycline mouth rinse Topical / systemic corticosteroids, immunosuppresive
  • 5. Histopathology :  biopsy is usually unnecessary .  Non specific microscopic findings . Differential diagnosis :  Other painful ulcerative conditions .
  • 6. 2- behcet`s syndrome : Etiology : unknown , yet: immunodysfunction. Clinical features : it affect : -nonkeratenized oral mucosa. -eyes. -joints. -CNS , as headache . Histopathology : - T lymphocytes are prominent . - neutrophilic within the vessel wall ( vasiculitis). Treatment : systemic steroids and immunosuppressive drugs .
  • 7. 3- reiter`s syndrome : Etiology :An abnormal immune response to microbial antigen(s) is likely to be the mechanism for this syndrom Clinical features : painless aphthous ulcer , its occurrence predominantly in white men in their third decayed . Treatment: NSAID .
  • 8. 4- erythema multiform : it’s a hypersensitivity reaction that target skin lesion and/or ulcerative oral lesion . Etiology : minor form – HSV trigger. major form – triggered by certain drugs. hypersensitivity reaction. antigen antibody complex. Clinical features : most common in young adult . sites: buccal, tongue, lips, and palat.
  • 9. .Cont Histopathology : Epithelial hyperplasia. Basal and parabasal apoptotic keratinocytes. Vesicle at epithelium-connective tissue interface. Infiltration of lymphocytes and macrophages. Differential diagnosis: for the oral expression of the disease: HSV infection , aphthous ulcers and pemphigus valgaris. Treatment : minor- symptomatic treatment. major- topical corticosteroids with antifungal.
  • 10. 5- drug reaction: Etiology: 1-immunologic response (allergy), related to drug immunogenicity, frequency, rout of adminstration. 2-nonimmunologic response , realated to over dose, toxicity, side effect. Clinical features: urticaria, maculopopular rash,erythema,vesicle ulcers. angioedema appears as soft diffuse painless with swelling. Histopathology: nonspecific ulcer. Treatment: antihistamine and occasionally corticosteroids.
  • 11. 6-Contact allergy: It occurs directly adjacent to the causative agent (erythematous,vesicular, ulcerative lesion). Clinical features :mainly skin but when its in the oral cavity its due to mouth paste, mouth wash and chewing gum . Histopathology: nonspecific ulcer. Treatment : eleminate the causative agent. topical steroids may hasten the healing.
  • 12. 7-Wegner`s granuloma: A systemic inflammatory condition of unknown etiology. Clinical features: upper respiratory tract,lung and kidney involvement Intraoral lesion consists of red, hyperplastic, granular lesion the attached gingiva. Histopathology: granulomatous lesion , necrosis and multinucleated giant cells. Treatment: cytotoxic agent cyclophsphamide combined with corticosteroids.
  • 13. 8- midline granuloma : Etiology: occult T-cell lymphomas. Clinical features: a unifocal destructive process, generally in the midline of the oronasal region. Aggressive necrotic ulcer that is nonhealing. Perforation can be seen. Histopathology: acute and chronic inflammatory in partially necrotic tissue. Treatment: local radiation.
  • 14. 9- chronic granulmatous: It’s a rare systemic disease caused by defect of (NADPH) oxidate complex that result in altered neutrophil and macrophages function . Manifistation appear during childhood, it affect the lymph nodes, lung, liver, spleen, bone and skin.
  • 15. 10-Cyclic neutropenia: Its presented as sever cyclic depletions of neutrophils from the blood and marrow with periodicity of 21 days. Fever , malaise, oral ulcer and cervical lymphadenopathy can be seen.
  • 16. Thank you 