Preventive pharmacology
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Preventive pharmacology

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Angelo Tremblay

Angelo Tremblay

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Preventive pharmacology Preventive pharmacology Presentation Transcript

  • How do wepreventobesityin 2011?
    Angelo Tremblay
    Division of Kinesiology
  • How do wepreventobesityin 2011?
    • By counteracting the impact of obesogenicenvironmentalfactors
    • By promotingadequatesleep
    • By increasing the physicalwork/cognitive effort ratio
    • By investing in nutrition competence and healthyfoodavailability
    • By promotinghealthyfood-relatedbehaviours
    • By investing in preventivepharmacology!!
  • Is methylphenidate (Ritalin) the solution?
  • Wholebrainmetabolismwhen the cognitive taskwasgivenwith:
    Placebo increased 21%
    Methylphenidateincreased 11% (50% less)
    FromVolkow N.D. et al, PLoS ONE 2008
  • Methylphenidatereducesenergyintake and dietary fat intakeduring a buffet-style meal in adults
    Variable Mean change (%)
    Energyintake -11*
    Fat intake -17*
    Values are means
    * Significantdifference versus a placebo condition: p < 0.05
    Adaptedfrom Goldfield GS. AJCN 86: 308-315, 2007
  • Treatment:
    Medications used include mixed salts amphetamine (Adderall XR), mythylphenidate sustained-release capsule (Concerta), and sustained release destroamphetamine sulfate (Dexedrine Spansules).
    All participants, including control subjects, were offered individual assessment and diet instruction by the clinic’s registered dietitian.
    All participants were counselled regarding the need to be physically more activie.
    Duration of ADHD management: 466 days
  • Body weight changes with ADHD management
    ADHD-treated subjects Untreated controls
    (n = 65) (n = 13)
    body weight (kg) -15.05 +3.26*
    (%) -12.36 +2.78*
    *Significant difference between groups, p < 0.001
    Adapted from Levy LD et al, Int J Obes
    33: 326-334, 2009
  • How do wepreventobesityin 2011?
    • By counteracting the impact of obesogenicenvironmentalfactors
    • By promotingadequatesleep
    • By increasing the physicalwork/cognitive effort ratio
    • By investing in nutrition competence and healthyfoodavailability
    • By promotinghealthyfood-relatedbehaviours
    • By investing in preventivepharmacology !!!