Trana discovery staph aureus 201 hts assay

Trana Discovery, Inc.Developing tools to find new treatments for serious infectious diseases
Staphylococcusaureus HTS Assay
July 2011

Introducing Trana Discovery
An anti-infective drug discovery
technology company
Who we are:
Enable organizations to find novel classes of drugs for the treatment of serious viral, bacterial and fungal infectious diseases
What we do:
Technology identifies compounds that work through a unique mechanism of action: the target pathogen’s ability to use organism-specific transfer RNA (tRNA) in protein synthesis
How it works:
Applies to human, animal and plant pathogens
Where it works:
2

Management Team
Over 300 combined years of research, discovery, clinical, financial, accounting, sales, product development, and marketing experience
Steve Peterson, CEO
Winnell Newman, Co-founder
Dick Guenther, CTO
Mike Gallucci, Sr. VP, Finance & CFO
Michael Ossi, MD, CSO
Sam Yenne, PhD, VP, Chief Development Officer
Chris Ellis, Director, Bioinformatics tRNA Database
Dan Mitchell, PharmD, VP
Dan Sternbach, PhD, Director, Medicinal Chemistry
Ed Gallagher, VP, Intellectual Prop.
Karl von Gunten, VP, Communications
Leigh Ann Gallucci, VP, Fin. Reporting & Acct.
Frank Johnson, VP, Sales & Marketing
AndrzejMalkiewicz, Scientific Research Consultant
3

Intellectual Property
16 patents issued, licensed and pending
Extensive patent surveys confirm freedom to operate
Licensed production of probes from Technical University
Filed US and International patents for discovery and diagnostic applications
4

Market Needs
Desperate Need for New Classes of Anti-infectives
Staphylococcus aureus
A major health concern
MRSA resistant to most antibiotics
5% of all hospital and nursing home patients are infected with MRSA
New Drug Pipeline
1988 - 1992: average of three new antibiotic approvals each year
Since 2003: average one new approval a year
5

Trana S. aureus Assay Components
Ribosome complex programmed with a short oligomer representing mRNA
Codon for fMet at the P site
Codon for a S. aureus specific tRNA at the A site
Full length fMet tRNA used to stabilize the complex prior to the addition of an RNA mimic for tRNAArgASL
Cartoon of protein synthesis.
(Source: Wikimedia Commons)
6
ASL Arg

Trana S.aureus HTS Assay
Uses a fluorescein-labeled oligonucleotide mimic of the ASL loop of tRNAArg with a programmed ribosome
Identifies compounds that inhibit the use of tRNAArg that is specific to S. aureus and which is required for protein synthesis
Assay optimized for high-throughput screening
Development funded through small business research loan from NCBC
7

Assay Validation
8
60,000 compound library screening identified 283 compounds
89 confirmed as biochemically active in dose response curve study
38 selected based on an acceptable IC50 concentration
8 demonstrated activity against 2 or more strains of S. aureus in a bacterial assay

Value Proposition
Low risk, low cost means for identification of drug candidates
High certainty of effectiveness
Licensing opportunities for exclusive rights to new drug classes
9

Licensing Models
1. Individual Company License
Use rights of assay with milestone and royalty payments based on development and commercial success
2. Exclusive Option License
Exclusivity offered to one company - currently available
Milestone and royalty payments scheduled downstream as drugs progress to market
Applies to discovery product areas (both options include rights to patented identified compounds, additionally first refusal option available)
10

Please Feel Free to Contact
Steve Peterson, CEO
stevepeterson@tranadiscovery.com
Sam Yenne, PhD, VP, Chief Development Officer
samyenne@tranadiscovery.com
Frank Johnson, VP, Sales & Marketing frankjohnson@tranadiscovery.com
919-303-4948
www.tranadiscovery.com
11

Trana discovery staph aureus 201 hts assay

by TranaDiscovery on Jun 21, 2011

Accessibility

Categories

Tags

Upload Details

Usage Rights

2 Embeds 166

Statistics

Trana discovery staph aureus 201 hts assay — Presentation Transcript

http://www.tranadiscovery.com	162
http://tranadiscovery.lemonstripe.com	4