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Gut Flora & Probiotic 11    Saira Salmon   DipNN, MFNTP
Your gut….• Is teeming with microbes – up to 70% of the  body’s total number• It is an extremely complex ecosystem  harbou...
Many of these have a symbiotic relationship with us –    and help to keep less beneficial strains at bay.A healthy gut in ...
They play a vital role in the body – without them              we would not survive. Sterilise your gut and you die, have ...
Hippocrates The Father of Modern Medicine“All disease begins in the gut”
What Role Do They Play? Beneficial bacteria take part in our digestion and                absorption of foodThey produce a...
What Role Do They Play?They can actively synthesize nutrients such as K2, many of the B vitamins and some amino           ...
What Role Do They PlayThey play a crucial role in our immune system,    keeping the body’s immunity active.Around 83% of o...
How it Starts We inherit our gut flora from our mother at birth.     As the baby comes through the birth canal itswallows ...
DysbiosisWhen gut flora is damaged or in imbalance it iscalled dysbiosis.Opportunistic gut microbes including yeast, harmf...
When Good Guts Turn Bad…….
What Can Damage Gut FloraAntibiotics      Steroids, The PillOther drugs      StressPoor diet        InfectionsBottle feedi...
When gut flora is damaged…• Microbes ie. ‘bad’ bacteria, multiply.• They can perforate and damage the thin layer  of epith...
Leaky gut• Causes include:   – poorly digested foods      alcohol   – antibiotics or infection   painkillers   – heavy met...
Leaky gutConsequences  Body has to use whatever routes it can to eliminate toxins.  They initially get taken to liver.  Th...
all this – and more – from damaged gut flora          These guys are important!
Bowel Bacteria & Health                    IBSA variety of studies have found evidence of the benefit of using probiotics ...
Bowel Bacteria & Health                   Cholesterol       Some strains of bowel bacteria, includingL. Acidophilus and Bi...
Bowel Bacteria & Health                  Colon Cancer        Bowel bacteria have also been linked to                  colo...
Bowel Bacteria & HealthAutism     People with autistic spectrum disordershave been shown to have imbalances in gutbacteria...
Bowel Bacteria & HealthAutism     People with autistic spectrum disordershave been shown to have imbalances in gutbacteria...
Bowel Bacteria & HealthTherapeutically     A probiotic is used within a wide range of     therapeutic regimes by practitio...
How to Maintain Probiotic HealthAvoid things which damage gut floraEat prebiotic foods       Raw chicory root, Jerusalem a...
How to Maintain Probiotic HealthEat probiotic (fermented) foods     Live yoghurt, Miso, tempeh, sauerkraut, nattoSupplemen...
Introducing Probiotic 11! A high potency, broad spectrum probiotic. 11 different strains of friendly bacteria. Contains...
The Bacteria in Probiotic 117 strains of Lactobacillus:• Lactobacillus acidophilus (acid loving milk  bacteria).      Grow...
The Bacteria in Probiotic 11• L rhamnosus      - may help reduce the incidence of developing      childhood allergies and ...
The Bacteria in Probiotic 113 strains of Bifidobacterium:• Bifidobacterium longum   – creates B vitamins.• B.bifidum   – s...
The Bacteria in Probiotic 11          Streptococcus thermophilus         Used to start fermentation process of            ...
The Bacteria in Probiotic 11  FOS (Fructo Oligo Saccharides )Prebiotic - food for healthy bacteria Help to nourish and spr...
When to Use Probiotic 11•   Following a course of antibiotics, or a cleanse.•   Before and after hospital treatment•   Dur...
When to Use Probiotic 11• During and after a stomach upset• With those prone to low mood / behavioural  disturbance• With ...
How to Use Probiotic 11Take 1-2 capsules daily     with a mealEach pot last 6 weeks     - 2 months.
What Makes Probiotic 11 Special? One of the most potent probiotics available on  the market Also unusual to get so many ...
The End
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  • Main source of K2 and many B vitamins. Why? These are water soluble and will not stay in body long so will be periods in day when we are deficient. Gut flora provides our own factory of these to release these into our bloodstream all the time.
  • Naturopaths believe that nearly all disease can be traced back to damaged or abnormal gut flora.
  • Caesarean births, lack of breast feeding etc all impact on gut flora and immune system. Bottle fed babies acquire a completely different balance of gut flora to those breast fed. Medication, antibiotics etc all affect this as well.
  • V vulnerable to antibiotics – die first and take weeks to recover giving time for less vulnerable microbes like candida and clostridia to take over.Other drugs – all prescription medications taken on a repeat basis will change the makeup of the gut floraBottle feeding – much higher chance of allergies, eczema, asthma, glue ear etcDental work – most of what he puts into your mouth is toxic to gut flora and will be for weeks afterwards
  • Behavioural changes in children, failure to thrive
  • Botschinsky B et al (2011) A review of the evidence available for the use and effectiveness of probiotic drinks and supplements for the treatment of IBS> Int J ProbitoicsPrebitoics 6:21-33, 2011Moayyedi P et al (2008) The efficacy of probitoics in the therapy of irritable bowel syndrome: a systematic review. E Gut 17Wu (2010) Complementary and Alternataive Medicine Modalities for the Treatment of IBS: Fact or Myths? Gastr Hep 6: 705-711
  • Grill, J.P. et al (1995) Purification and characterisation of conjugated bile salt hydrolase from Bifidobacteriumlongum BB536. Appl Environ Microbiol 61:2577–2582Lye, H. et al (2009) The improvement of hypertension by probiotics: Effects on cholesterol, diabetes, rennin and phytoestrogens. Int J MolSci 10:3755-3775Oh, C.Y., Lee, W.K. (2000) Cholesterol lowering effect of lactic acid bacteria isolated from the human intestine. Korean J Vet Public Health 24:181-188Ooi, L-G., Liong, M-T. (2010) Cholesterol lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int J MolSci 11:2499-2522
  • Iannitti, T., Palmeieri, B., (2010) Therapeutical use of probiotic formulations in clinical practice. ClinNutr 1-25Kulkarni, N., Reddy, B.S. (1994) Inhibitory effect of Bifidobacteriumlongum cultures on the azoxymethane induced aberrant crypt foci formation and faecal bacterial ß-glucuronidase. ProcSocExptBiol Med 207: 278-283Rowland, I. (2008) Probiotics and cancer – from in vitro to human studies. Int J Probiotics Prebiotics 3:165-168Tang, Y. et al (2011) The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer. Autophagy 7:235-7
  • Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  • Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  • Adams, J. et al (2011) Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity Gastroenterology 11:22Finegold, et al (2010) Pyrosequencing study of fecalmicroflora of autistic and control children. Anaerobe 16:444-53Garvey, J. (2002) Diet in autism and associated disorders. J Fam Health Care 12:34-38Melmed, R. et al (2000) Metabolic markers and GI symptoms in children with autism and related disorders. J PediatrGasteroenterolNutr 31:31-32
  • T cells – Boirivant 2007UTI – Zuccotti 2008
  • Allergies tooth decay – Nase 2001, Wickens 2008Chrons – Hessle 1999
  • IBS – William 2008Diarrhea – Plummer 2004Whorwell PJ, Altringer L, Morel J et al (July 2006). "Efficacy of an encapsulated probiotic Bifidobacteriuminfantis 35624 in women with irritable bowel syndrome". Am. J. Gastroenterol.101 (7): 1581–90. doi:10.1111/j.1572-0241.2006.00734.x. PMID 16863564.
  • IBS – William 2008Diarrhea – Plummer 2004Whorwell PJ, Altringer L, Morel J et al (July 2006). "Efficacy of an encapsulated probiotic Bifidobacteriuminfantis 35624 in women with irritable bowel syndrome". Am. J. Gastroenterol.101 (7): 1581–90. doi:10.1111/j.1572-0241.2006.00734.x. PMID 16863564.
  • Transcript of "Gut flora & probiotic 11"

    1. 1. Gut Flora & Probiotic 11 Saira Salmon DipNN, MFNTP
    2. 2. Your gut….• Is teeming with microbes – up to 70% of the body’s total number• It is an extremely complex ecosystem harbouring more than 100 trillion micro-organisms• There are thought to be around 30 – 40 different species of bacteria.
    3. 3. Many of these have a symbiotic relationship with us – and help to keep less beneficial strains at bay.A healthy gut in an adult human has somewhere in the region of 2 kg of these bacteria in the gut.
    4. 4. They play a vital role in the body – without them we would not survive. Sterilise your gut and you die, have good levels of probiotic bacteria and you thrive!
    5. 5. Hippocrates The Father of Modern Medicine“All disease begins in the gut”
    6. 6. What Role Do They Play? Beneficial bacteria take part in our digestion and absorption of foodThey produce a number of enzymes to break down proteins, carbohydrates, fibre and fats They produce various substances to transportvitamins, minerals and other nutrients through the gut wall
    7. 7. What Role Do They Play?They can actively synthesize nutrients such as K2, many of the B vitamins and some amino acids They help chelate heavy metals from our system. Help control parasites
    8. 8. What Role Do They PlayThey play a crucial role in our immune system, keeping the body’s immunity active.Around 83% of our immunity is located in the gut wall. Beneficial flora imbalance will have an immediate impact on immune system.
    9. 9. How it Starts We inherit our gut flora from our mother at birth. As the baby comes through the birth canal itswallows its first mouthfuls of bacteria, which begin to inhabit baby’s sterile gut. Breast feeding continues the process. It takes about 2 years for a baby’s immune system to fully develop
    10. 10. DysbiosisWhen gut flora is damaged or in imbalance it iscalled dysbiosis.Opportunistic gut microbes including yeast, harmfulbacteria, viruses and parasitesstart to take hold.They can be very difficult toeradicate once they have movedin.
    11. 11. When Good Guts Turn Bad…….
    12. 12. What Can Damage Gut FloraAntibiotics Steroids, The PillOther drugs StressPoor diet InfectionsBottle feeding Old AgePollution RadiationAlcohol Toxic chemicalsDental work
    13. 13. When gut flora is damaged…• Microbes ie. ‘bad’ bacteria, multiply.• They can perforate and damage the thin layer of epithelial cells lining the gut, which then allows unwanted microbes and toxins to inter into our bloodstream.• This is termed ‘leaky gut’ syndrome.
    14. 14. Leaky gut• Causes include: – poorly digested foods alcohol – antibiotics or infection painkillers – heavy metal toxicity smoking – birth control pills antacids – chlorinated water food additives – high homocysteine levels parasites, yeasts food allergies• Underactive & constipated bowel will also cause problems
    15. 15. Leaky gutConsequences Body has to use whatever routes it can to eliminate toxins. They initially get taken to liver. The increased flow leads to blocked detox pathways All liver functions suffer Toxins bypass the filtering and go into blood stream. Get taken: To lungs -asthma, and other chronic lung conditions To skin – eczema, rashes and other skin problems Urine – cystitis, thrush, bedwetting Through mucous membranes – sinusitis, post nasal drip, rhinitis, gingivitis, vaginitis, diarrhea/constipation
    16. 16. all this – and more – from damaged gut flora These guys are important!
    17. 17. Bowel Bacteria & Health IBSA variety of studies have found evidence of the benefit of using probiotics in themanagement of irritable bowel syndrome.
    18. 18. Bowel Bacteria & Health Cholesterol Some strains of bowel bacteria, includingL. Acidophilus and Bifidobacteria seem to have a direct action on lowering cholesterol levels.
    19. 19. Bowel Bacteria & Health Colon Cancer Bowel bacteria have also been linked to colon cancer. Many enzyme pathways are influenced eg.Bifido longum inhibits B-glucuronidase, elevated levels of which are associated with increased colon cancer
    20. 20. Bowel Bacteria & HealthAutism People with autistic spectrum disordershave been shown to have imbalances in gutbacteria. Research in this field suggestsimproving bowel flora levels is an important partof managing this disorder.
    21. 21. Bowel Bacteria & HealthAutism People with autistic spectrum disordershave been shown to have imbalances in gutbacteria. Research in this field suggestsimproving bowel flora levels is an important partof managing this disorder.
    22. 22. Bowel Bacteria & HealthTherapeutically A probiotic is used within a wide range of therapeutic regimes by practitioners
    23. 23. How to Maintain Probiotic HealthAvoid things which damage gut floraEat prebiotic foods Raw chicory root, Jerusalem artichoke, garlic and leek,asparagus, banana, raw and cooked onion.
    24. 24. How to Maintain Probiotic HealthEat probiotic (fermented) foods Live yoghurt, Miso, tempeh, sauerkraut, nattoSupplement with a good probiotic
    25. 25. Introducing Probiotic 11! A high potency, broad spectrum probiotic. 11 different strains of friendly bacteria. Contains almost 12 billion bacteria per serving. Enteric coated to disperse in the intestines. In a prebiotic blend to spread and nourish.
    26. 26. The Bacteria in Probiotic 117 strains of Lactobacillus:• Lactobacillus acidophilus (acid loving milk bacteria). Grown on milk but doesn’t contain it, and helps break down lactose. Supports immune system by stimulating production of regulation T cells Inhibits patogenic growth in urinary tract infections by adhering to uro-epithelial cells
    27. 27. The Bacteria in Probiotic 11• L rhamnosus - may help reduce the incidence of developing childhood allergies and tooth decay in children - Increases cell mediated immunity in Chron’s disease• L brevis• L bulgaricus• L plantarum• L casei• L salvarius
    28. 28. The Bacteria in Probiotic 113 strains of Bifidobacterium:• Bifidobacterium longum – creates B vitamins.• B.bifidum – significantly improves pain and bowel habits in irritable bowel syndrome – Prevents diarrhea that occurs with post-antibiotic overgrowths of C difficile and Candida albicans• B.infantis – Helped improve abdominal pain and discomfort in IBS– see table on Wikipedia for more information.
    29. 29. The Bacteria in Probiotic 11 Streptococcus thermophilus Used to start fermentation process of making yoghurt.Also some interesting research conducted on this – see Wikipedia for more info.
    30. 30. The Bacteria in Probiotic 11 FOS (Fructo Oligo Saccharides )Prebiotic - food for healthy bacteria Help to nourish and spread the bacteria throughout the gut.
    31. 31. When to Use Probiotic 11• Following a course of antibiotics, or a cleanse.• Before and after hospital treatment• During preconception & pregnancy• With confirmed dairy intolerance• During treatment for candidiasis
    32. 32. When to Use Probiotic 11• During and after a stomach upset• With those prone to low mood / behavioural disturbance• With someone who has regular colonic irrigation• Combined with Caprylic Acid for a week before going on holiday, until returning home.
    33. 33. How to Use Probiotic 11Take 1-2 capsules daily with a mealEach pot last 6 weeks - 2 months.
    34. 34. What Makes Probiotic 11 Special? One of the most potent probiotics available on the market Also unusual to get so many strains in one supplement – would appeal to many clinical therapists. Built in prebiotic Enteric coated
    35. 35. The End
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