15.20 mevr Luizink


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  • An ultrasensitive sensor for rapid detection of micro-organisms such as viruses and bacteria, and biomarkers has been developed at the MESA+ Institute based on a Lab-on-a-Chip Interferometric Nanotechnology. This sensor has been quoted by Forbes.com as one of the “ 13 Amazing New Nanotechnologies ” worldwide! The essential innovation in this technique is the combination of an integrated optics interferometric sensor with antibody-antigen recognition approaches. The sensor basically consists of a laser, which is shone through an optical chip on which several measuring and reference channels are located . To spot a particular virus (or any other analyte), the appropriate antibodies are immobilized onto one of the measuring channels and then a sample containing the virus is flowed through that channel. If the virus particles bind to the antibodies, the interference pattern of the light, which is recorded on a CCD camera, changes, allowing estimation of the concentration. The sensor is able to spot the Herpes virus at concentrations of just 850 particles per milliliter under physiological conditions in a few minutes. The sensitivity of the sensor approaches detection of a single virus particle, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics. Detection of other types of viruses, bacteria, cells and biomarkers in complex mediums has been performed as well. The technology is amenable to miniaturization and mass-production, and thus has significant potential to be developed into a handheld, point-of-care device.
  • Based on this nanotechnology, Ostendum - a new spin-off of the MESA+, has developed a prototype, consisting of a Lab-on-a-Chip system and a portable Detector. Working principle of such a prototype is schematically shown in this slide: First, a sample such as blood, serum, saliva, etc., is delivered to the pre-coated chip; Next, the chip is inserted into the portable detector and an automated analysis will be started; In a few minutes, via an easy-to-handle user interface, the type of analyte such as virus, bacteria, biomarker, etc., and respective concentration will be provided. This Lab-on-a-Chip sensor device has potential applications in medical diagnostics, food and water safety, security applications, environmental monitoring, animal and plant health monitoring, etc.
  • Indirect costs: bijvoorbeeld opnames van patienten in ziekenhuis met alle gevolgen van dien.
  • 15.20 mevr Luizink

    1. 1. From scientific excellence towards high-volume production in nanotechnology ir. Miriam Luizink technical-commercial director MESA+ Instituut voor Nanotechnologie Universiteit Twente
    2. 2. Thin film displays and lightings Scratchproof windows with Lotus-effect Hip Joint Fuel cells for mobility, hydrogen storage Intelligent clothing Lightweight and robust frame LEDs save energy Notebook-Displays Data storage Nanotechnology: large opportunities Drug delivery Medical imaging Mobile phones Energy savings of houses Clear water Food & nutrition
    3. 3. MESA+ Institute for Nanotechnology <ul><li>Combines nanotechnology, microsystems and materials science research at the University of Twente </li></ul><ul><li>Yearly turnover: 45 M€ with 60% from external sources </li></ul><ul><li>Staff: ~500 people, 28 research groups </li></ul><ul><li>Facilities: </li></ul><ul><ul><li>1250 m2 cleanroom </li></ul></ul><ul><ul><li>Materials analysis laboratory </li></ul></ul><ul><ul><li>Specialized group laboratories </li></ul></ul>
    4. 4. September 2009
    5. 5. <ul><li>Cooperative environment </li></ul><ul><ul><li>> 40 spin-off companies </li></ul></ul><ul><ul><li>joint projects </li></ul></ul><ul><li>MESA+ Technology Accelerator </li></ul><ul><li>MESA+ Tech Park </li></ul><ul><ul><li>co-location (offices) </li></ul></ul><ul><ul><li>facility sharing (cleanroom & lab) </li></ul></ul><ul><ul><li>High Tech Factory (production) </li></ul></ul>Commercialisation
    6. 6. <ul><li>MESA+ </li></ul><ul><li>Business </li></ul><ul><li>Cases </li></ul><ul><li>Till now: > 40 spin off companies </li></ul>
    7. 7. <ul><li>Detection of one micro-organism </li></ul><ul><li>such as 1 virus particle </li></ul><ul><li>Results in 5 minutes </li></ul><ul><li>Small sample volume (  l) </li></ul><ul><li>Potential for a handheld device </li></ul>Lab-on-a-Chip Interferometric Nanotechnology “ 13 Amazing New Nanotechnologies” FORBES.com Lab-on-a-chip prof. Vinod Subramaniam group
    8. 8. Portable Detector <ul><li>Medical Diagnostics </li></ul><ul><li>Food and Water Safety </li></ul><ul><li>Security Applications </li></ul><ul><li>Environmental Monitoring </li></ul><ul><li>Animal and Plant Health Monitoring </li></ul>Virus: H1N1 Conc: 1 p/ml Biosensor device prototype LOC system Sample
    9. 9. Microsieve enabled uniform microspheres
    10. 10. Drug loaded biodegradable microspheres Size control enables smaller needle diameters = less painful injections and better patient compliance
    11. 11. Traditional MEDIMATE Analyze: > 1 hour < 2 minutes Where: Hospital Home Hardware: Complex KISS User: Highly educated Patient Indirect costs: High Low Sample: Tube of blood (Serum) 1 droplet of blood Maintenance: Required None Patient Empowerment: No Yes Improve quality of life
    12. 12. MD-Patients Kidney patients Dehydration PKU Rheumatism Lithium Potassium Phosphate Sodium & Potassium Phenylalanine Market size MD = > 300 M€ I.M. Kolthoff award Leverhulme Technology Transfer Award TIME Outcome Innovation chain ? ? Jan 08 Research Experimental platform Integrated platform Application area Proof of principle Research- and demonstration- model Prototypes Charged species analysis products
    13. 15. High Tech Factory <ul><li>shared production facility </li></ul><ul><li>micro- and nanotechnology based products </li></ul><ul><li>applications in food and health sector </li></ul><ul><li>testing, packaging & assembly </li></ul>
    14. 16. <ul><li>Phase 4: realization production facility (2010/11) </li></ul><ul><li>Phase 3: redevelopment (2010) </li></ul><ul><li>Phase 2: tech infrastructure fund (2010) </li></ul><ul><li>Phase 1: development of production (2008…) processes and equipment </li></ul>Steps to take….
    15. 17. PARTNERS U-Needle UT International Ventures
    16. 18. Medspray inhalers <ul><li>Partners develop and produce devices </li></ul><ul><li>Medspray develops and produces spray nozzle units </li></ul><ul><li>5 to 10 x less medicine needed & less side effects </li></ul>Medspray © 2009
    17. 19. Nozzle chips Medspray © 2009
    18. 20. Spray Nozzle Unit: 2 plastic parts and 1 nozzle chip Medspray © 2009
    19. 21. Spray Nozzle Unit: laser welding the nozzle chip Medspray © 2009
    20. 22. Context <ul><li>Science: MESA+ Institute for Nanotechnology University of Twente </li></ul><ul><li>Innovation: > 40 spin-off companies </li></ul><ul><li>Talent: ~ 1200 people </li></ul><ul><li>Partnership: intensive & practical network </li></ul><ul><li>Technical: nanotechnology – mechatronics testing, packaging & assembly </li></ul>