Current and Future Treatments for Azoospermia

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The 2nd Gulf Andrology Conference
Riyadh Military Hospital, Ministry of Defense
Riyadh, Saudi Arabia, March 3-4, 2012

Lectures: Current and Future Treatments for Azoospermia

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Current and Future Treatments for Azoospermia

  1. 1. Sperm!Detection! Rate! FNA Sites/Testicle!
  2. 2. Finding Sperm in Nonobstructive Azoospermia Microdissection FNA Mapping
  3. 3. “Directed” TESE Sperm Present <2 sites >2 FNA All FNA sperm/map sites/map sites/map TESE TESA (n=29) (n=38)
  4. 4. What Exactly is Metabolomics? !!
  5. 5. In the testis, somatic cellsare metabolically“quiet” compared torapidly dividing germcells!Analogy: A pile of bricksalong a desert road-indicates something isbeing built.!
  6. 6. The Metabolomic Signature of a Testicle Phosphocholine (PC)! Glycerophosphocholine (GPC)! Total Choline! Choline!Normal/Fertile ! Aaronson et al. ! Creatine! Hum Reprod. 2010! Alanine! Lactate!Azoospermic Menwith Sertoli CellOnly !
  7. 7. Aaronson et al. Hum Reprod.2010
  8. 8. Leydig cells!Stromal cells!Sertoli cells!Fibronectin!

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