0
WHAT IS OBESITY
• It is second only to smoking as a preventable
cause of death.
• Defination - obesity can be defined as a...
WHEN DOES OBESITY DEVELOPE
• When the calorie intake exceeds the energy
expenditure over a long period of time.
• Factors ...
HOW TO MEASURE OBESITY
• BMI= Wt(kgs)/ Ht 2 (m)
• Waist circumference.
BMI
classification

BMI( Kg/m2)

risk

UNDERWEIGHT

< 18.5

INCREASED

NORMAL WEIGHT

18.9- 24.9

LEAST

OVERWEIGHT

25- 2...
WAIST CIRCUMFERENCE
WAIST
CIRCUMFERENCE

NORMAL WT

OVERWT

OBESE CLASS 1

< 102 CM
< 88 CM

LEAST RISK

INCREASED

HIGH

...
INCIDENCE OF HEALTH RISK
METABOLIC SYNDROME

MIDDLE AGED(>30%)

TYPE 2 DIABETES

BMI> 23

HTN

BMI> 25, 5X OBESITY

CAD AN...
METABOLIC SYNDROME
FEATURES
ABDOMINAL OBESITY
ATHEROGENIC DYSLIPIDEMIA (TG, HDL, APO B)
ELEVATED BLOOD PRESSURE
INSULIN RE...
CRITERIA
CRITERIA

VALUES

ABDOMINAL OBESITY

W.C> 102(M) & > 88(F)

TRIGLYCERIDES

> 150 MG/DL

HDLP

<40(M) AND <50MG/DL...
• Inflammatory response plays an important role in
metabolic syndrome.
• Visceral adipose tissue is a major source of
proi...
EFFECTS ON RESPIRATORY SYSTEM

• Fat accumulation on the thorax and abdomen decreases chest wall and
lung compliance.
• In...
OSA/ OSH SYNDROME
• Characterized by recurrent episodes of upper
respiratory obstruction occurring during sleep.
• OSA- co...
DIAGNOSIS
• Polysomnography.
• Sleep studyEEG, ECG, EOG, Capnography, nasal/oral
airflow, esophagial pressure,BP, pulse
ox...
RESULTS
MILD DISEASE -

AHI 5-15 EVENTS/ HOUR

MODERATE DISEASE- AHI 15-30 EVENTS/ HOUR
SEVERE DISEASE- AHI . 30 EVNTS/ HO...
Anesthetic considerations
• Adipose tissue in oral and pharnygeal tissues.
• Increased fat deposition in the lateral walls...
• It is necessary to diagnose and treat OSA
before surgery.
• T/T- CPAP, conservatively- weight reduction ,
avoidance of a...
MANAGEMENT OF OBESITY
• NON – SURGICAL
• SURGICAL
NON- SURGICAL
1. Daily exercise for 30min
2. Statins- to reduce LDL
3. Statins and ezetimide ( inhibits interstinal
absorp...
Behavioral modifications.
Drugs- BMI> 30
APPETITE SUPRESSANTS
• PHENTERMINE- adrenergic
reuptake inhibitor,
decreases appe...
SURGICAL MANAGEMENT
• BARIATRIC SURGERIES- surgical alterations of
the small intestine or stomach with a view
towards prod...
contraindications
•
•
•
•
•

Unstable CAD
Uncontrolled severe OSA
Psychiatric disorder
Mental retardation(IQ<60)
Drug abus...
ANESTHETIC MANAGEMENT
• PRE-OP EVALUATION
• INTRA-OP- patient positioning
- airway management
- drugs/ induction
- extubat...
PREOPERATIVE EVALUATIONo Assessment of HTN, DM, heart failure, OSA
o Examination of history of previous surgery,
their ane...
Lab investigations
• FBS, lipid profile, CBC, ferritin, vit B12,
thyrotroin and 1,25-dihydroxyvitamin D
• Screening for OS...
Intraoperative care
• Patient positioning- rhabdomyolysis from
pressure on the gluteal muscles  RF & Death
• Cushioning g...
Airway management
• Difficulty in ventilation and laryngoscopy short thick
neck, large tongue, redundant pharyngeal soft ...
TROOP ELEVATION PILLOW/HELP
INFLATABLE PILLOW(HELP)
• Low VC, inspiratory capacity, ERV, FRC, CC may
fall in supine or recumbent position rapid
desaturation.
• Application o...
Maneuvers to maintain lung vol and
ventilation
• Increasing TV- 13-22ml/kg
• PEEP- 10 cm
• Lap surg- sustained lung inflat...
Drugs
• Sedatives, opioids, benzodiazepine decrease the
pharyngeal musculature tone
• Volatile agents- diminish the ventil...
• Thiopental. Prolonged somnolence with thiopental is expected
because it is highly lipophilic and has a larger VD in the ...
• The choice of volatile agents is based on tissue
solubility, blood gas partition coeff, fat- blood
pat coeff
• Desfluran...
Induction
• Obese patients have a risk of aspiration due to
delayed gastric emptying.
• Prophylaxis for acid aspiration is...
• Monitoring- no invasive monitoring is required
unless the patient is suffering from any comorbid
condition.
• In conditi...
Other considerations
• Appropriate sized table availability.
• Strapping the patient during sedation and sleep
• Placing a...
EXTUBATION & TRANSPORT
• The patient should be preferably extubated in the
semirecumbent position, which has less adverse ...
Post-op pain management
• IV- analgesia via PCA
• Thoracic epidural
• Local anesthetic infilteration in the wound
with adj...
Post operative management
• Bariatric patients should stay at the same location
after surgery.
• They are maintained on CP...
Post-op complications
• Bariatric surgeries are considered to be safe
• Mortality is associated with intestinal leakage,
I...
ALL SURGERIES

GASTRIC BANDING

ROUX-EN-Y

EARLY

•Bleeding
•Infection
•Dehydration
•Peritonitis
•Bowel obstruction
•Perfo...
REFERENCES
• MILLER’S ANESTHESIA
• BARASH
THANKYOU……
Obesity and anesthesia
Obesity and anesthesia
Obesity and anesthesia
Obesity and anesthesia
Obesity and anesthesia
Obesity and anesthesia
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Obesity and anesthesia

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Transcript of "Obesity and anesthesia"

  1. 1. WHAT IS OBESITY • It is second only to smoking as a preventable cause of death. • Defination - obesity can be defined as a disease because it a physiological dysfunction of the human organism with genetic, environmental, and endocrinological cause.
  2. 2. WHEN DOES OBESITY DEVELOPE • When the calorie intake exceeds the energy expenditure over a long period of time. • Factors influencing- genetic, behavioral, cultural, socioeconomic and metabolic. • Ex- leptin deficiency, Prader Willi syndrome etc.
  3. 3. HOW TO MEASURE OBESITY • BMI= Wt(kgs)/ Ht 2 (m) • Waist circumference.
  4. 4. BMI classification BMI( Kg/m2) risk UNDERWEIGHT < 18.5 INCREASED NORMAL WEIGHT 18.9- 24.9 LEAST OVERWEIGHT 25- 29.9 INCREASED CLASS 1 30- 34.9 HIGH CLASS 2 35- 39.9 VERY HIGH CLASS 3 40-49.9 EXTREMELY HIGH SUPEROBESE > 50 EXTREMELY HIGH OBESE
  5. 5. WAIST CIRCUMFERENCE WAIST CIRCUMFERENCE NORMAL WT OVERWT OBESE CLASS 1 < 102 CM < 88 CM LEAST RISK INCREASED HIGH >120CM > 88 CM INCREASED HIGH VERY HIGH
  6. 6. INCIDENCE OF HEALTH RISK METABOLIC SYNDROME MIDDLE AGED(>30%) TYPE 2 DIABETES BMI> 23 HTN BMI> 25, 5X OBESITY CAD AND STROKE 3.6X OBESITY, 70% LVH, 10% CCF, RESPIRATORY EFFECTS NECK CIRCUMFERENCE >43(m), > 40.5(F)OSA, DAYTIME SOMNOLENCE, PUL HTN CANCER ENDOMETRICAL Ca, 10% CANCER DEATHS REPRODUCTIVE FUNCTION 6% INFERTILY(F), IMPOTENCY (M) OSTEOARTHRITIS ELDERLY LIVER AND GALL BLADDER DISEASE NAFLD & NASH, 20% DYSLIPEDEMIA
  7. 7. METABOLIC SYNDROME FEATURES ABDOMINAL OBESITY ATHEROGENIC DYSLIPIDEMIA (TG, HDL, APO B) ELEVATED BLOOD PRESSURE INSULIN RESISTENCE WITH OR WITHOUT GLUCOSE INTOLERENCE PROINFLAMATORY STATES OTHERS ( endocrinological dysf, microalbuminuria, pcod, hypoandrogenism, hyperurecemia) Comman in men, > 60, south asians, drugs- corticosteroids, SSRI, antidepressants
  8. 8. CRITERIA CRITERIA VALUES ABDOMINAL OBESITY W.C> 102(M) & > 88(F) TRIGLYCERIDES > 150 MG/DL HDLP <40(M) AND <50MG/DL( F) BLOOD PRESSURE > 130/90 mmHg FASTING GLUCOSE >110 mg/dl
  9. 9. • Inflammatory response plays an important role in metabolic syndrome. • Visceral adipose tissue is a major source of proinflammatory cytokines- TNF-a, IL-6, adiponectin. • raised levels of proinflammatory cytokines contribute to insulin resistance. • Adipokines- leptin is reduced which results in increased appetite , slow metabolism and susceptibility to proinflammatory stimuli. They also contribute to progession of heart disease and DM in obese patients.
  10. 10. EFFECTS ON RESPIRATORY SYSTEM • Fat accumulation on the thorax and abdomen decreases chest wall and lung compliance. • Increase in blood volume as more volume is required to perfuse the additional body fat. Polycythemia of chronic hypoxemia contributes to increased total blood volume. • Increased elastic resistance and decreased compliance of the chest wall further reduces total respiratory compliance while supine, leading to shallow and rapid breathing, increased work of breathing, • Respiratory muscle efficiency is below normal in obese individuals. • Decreased pulmonary compliance leads to decreased functional residual capacity (FRC), vital capacity, and total lung capacity. Residual volume and closing capacity are unchanged. • Reduced FRC Leads to small airway closure, ventilation-perfusion mismatch, right-to-left shunting, and arterial hypoxemia. • Anesthesia worsens this situation such that up to a 50% reduction in FRC occurs in the obese anesthetized patient compared with 20% in the nonobese individual • ERV is the most sensitive indicator of the effect of obesity on pulmonary function.
  11. 11. OSA/ OSH SYNDROME • Characterized by recurrent episodes of upper respiratory obstruction occurring during sleep. • OSA- complete cessation of airflow during breathing lasting 10sec or longer despite of maintenance of neuromuscular ventilatory efforts and occurring 5times or > during sleep, decrease of Sao2 of atleast 4%. • OSH- partial reduction of airflow of > 50% lasting for 10sec, occurring 15 times or more/ hour of sleep and associated with decrease Sao2 of atleast 4%.
  12. 12. DIAGNOSIS • Polysomnography. • Sleep studyEEG, ECG, EOG, Capnography, nasal/oral airflow, esophagial pressure,BP, pulse oximetry & room noise are monitered and recorded.
  13. 13. RESULTS MILD DISEASE - AHI 5-15 EVENTS/ HOUR MODERATE DISEASE- AHI 15-30 EVENTS/ HOUR SEVERE DISEASE- AHI . 30 EVNTS/ HOUR RISK ASSOCIATED WITH MODERATE AND SEVERE DISEASE systemic and pulmonary HTN, LVH, cardiac arrhythmias, cognitive impairment, presence of daytime somnolence.
  14. 14. Anesthetic considerations • Adipose tissue in oral and pharnygeal tissues. • Increased fat deposition in the lateral walls decreases the size of the airway and changes the shape of the oropharynx – ellipitical, short transverse and long AP diameter. • Makes mask ventilation and laryngoscopy difficult • Contributes to increased severity of airway obstruction during GA • airway obstruction after Extubation increases with the use of opiates and sedative drugs .
  15. 15. • It is necessary to diagnose and treat OSA before surgery. • T/T- CPAP, conservatively- weight reduction , avoidance of alcohol intake before bedtime ,and sleeping on one side.
  16. 16. MANAGEMENT OF OBESITY • NON – SURGICAL • SURGICAL
  17. 17. NON- SURGICAL 1. Daily exercise for 30min 2. Statins- to reduce LDL 3. Statins and ezetimide ( inhibits interstinal absorption of cholesterol) 4. Fibrates- decrease triglycerides and increase HDL-C 5. Omega-3 fatty acids- decrease TG & insulin resistance 6. Salt restriction- HTN+ Obesity+ metabolic syndrome
  18. 18. Behavioral modifications. Drugs- BMI> 30 APPETITE SUPRESSANTS • PHENTERMINE- adrenergic reuptake inhibitor, decreases appetite and food intake , increases RMR. S/Etaccy, HTN • SIBUTRAMINE- adrenergic and serotninergic agent which supresses appetite & increases thermogenesis. S.E- htn, taccy, dry mouth, insomnia LIPASE INHIBITOR • ORLISTAT- binds to lipase and prevents both absorption and digestion of dietary fats. S/E- prevents absorption of fat sol vitamins, diarrhea, steatorrhea, flautulence, incontinence, oily recal discharge.
  19. 19. SURGICAL MANAGEMENT • BARIATRIC SURGERIES- surgical alterations of the small intestine or stomach with a view towards producing weight loss • RESTRICTIVE- decreases the capacity of food intake by creating a small pouch in proximal part of stomach. Vertical band gastroplasty and laparoscopic gastric band • MALABSORPTIVE – gastric bypass and pancreatic diversion.
  20. 20. contraindications • • • • • Unstable CAD Uncontrolled severe OSA Psychiatric disorder Mental retardation(IQ<60) Drug abuse and malignancy
  21. 21. ANESTHETIC MANAGEMENT • PRE-OP EVALUATION • INTRA-OP- patient positioning - airway management - drugs/ induction - extubation/ transport • POST-OP MANAGEMENT
  22. 22. PREOPERATIVE EVALUATIONo Assessment of HTN, DM, heart failure, OSA o Examination of history of previous surgery, their anesthetic challenges, need for ICU admission, surgical outcome and weight of the pt at that time.
  23. 23. Lab investigations • FBS, lipid profile, CBC, ferritin, vit B12, thyrotroin and 1,25-dihydroxyvitamin D • Screening for OSA • LFT- NAFLD, NASH,( portal HTN & Cirrhosis is considered as C.I)
  24. 24. Intraoperative care • Patient positioning- rhabdomyolysis from pressure on the gluteal muscles  RF & Death • Cushioning gel pads, wt bearing rolls • Pressure points should be adequately padded • Axillary roll – pts with excessive axillary tissue • Minimize compression injury or development of compartment syndrome.
  25. 25. Airway management • Difficulty in ventilation and laryngoscopy short thick neck, large tongue, redundant pharyngeal soft tissue. • Assessing –MP, TMD, Neck circumference, MO, neck mobility, USG-pretracheal soft tissue. • Placing the patient in semirecumbent position (30D) elevation with the head in sniffing position, ramped positioning & head elevation. • Minimized- awake intubation, topicalized direct laryngoscopy with modest sedation, sedated fiberoptic, ( LMA, Fiberoptic shd be available in case of emergency)
  26. 26. TROOP ELEVATION PILLOW/HELP
  27. 27. INFLATABLE PILLOW(HELP)
  28. 28. • Low VC, inspiratory capacity, ERV, FRC, CC may fall in supine or recumbent position rapid desaturation. • Application of CPAP (8-10cms H2O)during preoxygenation & PEEP & mechanical ventilation after induction is advised. • To avoid desaturation & atelecatsis/ increase airway pressure- 30 D reverse trendelenburg position.
  29. 29. Maneuvers to maintain lung vol and ventilation • Increasing TV- 13-22ml/kg • PEEP- 10 cm • Lap surg- sustained lung inflation to 50cms H2O & PEEP 12cms  increase Pao2 • Extubation- adequate muscle strength, sustained tetanus NS, 5sec head lift, awake following commands can be extubated. CPAP/Pressure support can be applied.
  30. 30. Drugs • Sedatives, opioids, benzodiazepine decrease the pharyngeal musculature tone • Volatile agents- diminish the ventilatory response to CO2 . • there is increased volume of distribution of lipophilic drugs( benzodizepines, barbiturates) • Dosing of the commonly used drugs like propofol, vec, rocuronium,remifentanyl- IBW & thipopental, midaz, scholine,atra, cisarta, fentanyl, sufentanyl- TBW
  31. 31. • Thiopental. Prolonged somnolence with thiopental is expected because it is highly lipophilic and has a larger VD in the obese patient. • Propofol. There is no difference in initial VD between obese and nonobese patients with propofol.Propofol has high affinity for excess fat and other well-perfused organs. • Benzodiazepines. Benzodiazepines persist long after discontinuation because they are highly lipophilic drugs with a larger VD in obese patients. Midazolam, although considered short acting, has the potential for prolonged sedation in obese patients because larger initial doses are required to achieve adequate serum concentrations. • Neuromuscular Blocking and Reversal Agents. Pseudocholinesterase activity increases linearly with increasing weight and larger extracellular fluid compartment; therefore, the dose of succinylcholine should be increased somewhat. Nondepolarizing muscle relaxants should be administered according to LBW to prevent delayed recovery because of increased VD and impaired hepatic clearance. Prompt early reversal but slow full recovery has been documented in overweight and obese patients during neostigmine-induced reversal of vecuronium.
  32. 32. • The choice of volatile agents is based on tissue solubility, blood gas partition coeff, fat- blood pat coeff • Desflurane is the agent of choice or sevoflurane. • Nitrous oxide is avoided as these patients have more o2 demand, in lap surgery can increase bowel gas volume & make the procedure more challenging.
  33. 33. Induction • Obese patients have a risk of aspiration due to delayed gastric emptying. • Prophylaxis for acid aspiration is required. • Regional anesthesia is a safe option in such patients but it is technically more difficultlarger needles or USG guidance. • Care should be taken regarding the dose as there can be cephalad spread of the drug and block( smaller epidural space).
  34. 34. • Monitoring- no invasive monitoring is required unless the patient is suffering from any comorbid condition. • In conditions like obesity-hypoventilation syndrome with PHT- PA catheter or TEE. • For ease of peripheral access – USG guidance or CVC can be used. • For NIBP-adequate sized cuff shd be available/ arterial catheter can be placed. • Intra-op ABG analysis- guidance for I/O ventilation and extubation.
  35. 35. Other considerations • Appropriate sized table availability. • Strapping the patient during sedation and sleep • Placing a bean bag under the patient to keep the patient from sliding. • Armboards should have extra padding. • Thermal management- warmers. • Fluids- greater requirement, 4-5L of crystalloids may be needed to prevent ATN.
  36. 36. EXTUBATION & TRANSPORT • The patient should be preferably extubated in the semirecumbent position, which has less adverse effect on respiration. • Supplemental oxygen should be administrated after extubation. • Lifting devices such as the HoverMatt (Patient Handling Technologies, Allentown, PA), the Patient Transfer Device (PTD; Alimed, Dedham, MA), and gantry-style mechanical lifting devices that use a sling are useful for transporting morbidly obese patients onto or off the operating table. • The PTD can be combined with the Walter Henderson Maneuver to safely and gently transfer obese patients onto their postoperative beds.
  37. 37. Post-op pain management • IV- analgesia via PCA • Thoracic epidural • Local anesthetic infilteration in the wound with adjuctive non- narcotic medication.
  38. 38. Post operative management • Bariatric patients should stay at the same location after surgery. • They are maintained on CPAP/ biphasic positive airway pressure machines as much as possible with monitoring of SpO2. • Patients with difficult intubation should have a labeled armband , a note by the attending anesthesiologist explaining the difficulty in intubation and equipements to tackle difficult airway should be kept ready.
  39. 39. Post-op complications • Bariatric surgeries are considered to be safe • Mortality is associated with intestinal leakage, Intra abdominal bleeding, suture line dehiscence, small bowel obstruction & deep wound infection. • Categorized- wound, GIT, pulmonary and CVS • Complications are considerably lesser in laparoscopic than open surgeries. • Pul embolism and DVT
  40. 40. ALL SURGERIES GASTRIC BANDING ROUX-EN-Y EARLY •Bleeding •Infection •Dehydration •Peritonitis •Bowel obstruction •Perforation •Pneumonia •DVT/PE •Death •Band slippage •Band malfunction •infection Leak from site LATE Cholelithiasis Cholecystitis GERD/dysphagia Fat soluble & vit B12 deficiency Anorexia ,band slippage Band malfunction infection Small bowel obstruction Marginal ulcers Pancreatitis Strictures.
  41. 41. REFERENCES • MILLER’S ANESTHESIA • BARASH
  42. 42. THANKYOU……
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