Poultry show manila 2010

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This presentation was made in Sept 2010 at Manila during the Poultry show. Target audience were nutritionists , poultry consultants and feed manufacturers

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Poultry show manila 2010

  1. 1. PHYTOCONSTITUENTS IN ANIMAL FEED AN OPPORTUNITY Dr (Capt) Tanweer Alam INDIA
  2. 2. Global trend <ul><li>Global Feed additive market to grow to $18 billion by 2014 </li></ul><ul><li>Largest contributor is the antibiotic/ anti bacterial (28%) and fastest growing is amino acid segment (6%) </li></ul><ul><li>Herbal/ Phytoconstituents based products market is catching up in an impressive manner (20% CAGR) </li></ul>Foodceo.com
  3. 3. Total number of research papers listed on PubMed containing the word &quot;phytoconstituents.&quot;
  4. 4. How the usage of Phytoconstituents based products have progressed ?
  5. 5. The Transition….. Ayurvedic Era <ul><ul><ul><li>Herbal Era </li></ul></ul></ul>Phytochemical Era
  6. 6. Conventional Approach of Phytoconstituent based product development: Ethno-medical information Development of prototype formulations Validation of safety & efficacy using invivo models Chemical fingerprinting Marketing
  7. 7. Modern Approach of Phytoconstituent based product development: Ethno-medical information Selection and standardization of in vitro assays Validation of safety and efficacy using in vivo models International marketing <ul><li>Screening program </li></ul><ul><li>Select plants </li></ul><ul><li>Select plant parts </li></ul><ul><li>Select solvent </li></ul>Bioactivity guided fractionation Development of prototype formulation (Based on compatibility studies) Standardization and Chemical fingerprinting
  8. 8. What’s the need? <ul><li>Secondary Metabolites are: </li></ul><ul><li>Unique to each plant & have therapeutic value </li></ul>Chemical Constituents Of Herbs Primary Metabolites Carbohydrate Fat Protein Secondary Metabolites Alkaloids Turpenoids Flavonoids Others
  9. 9. Factors affecting Sec Metabolites? Secondary Metabolites Part used Geographical factor Period, time & method of collection Storage Water availability Drying Packing and Transportation Age of the plant
  10. 10. Developing quality Phytoconstituent formulation <ul><li>A - SYNERGISM i.e., 2+ 2 = > 4 </li></ul><ul><li>B - ADDITIVITY i.e., 2 + 2 = 4 </li></ul><ul><li>C - ANTAGONISM i.e., 2 + 2 = < 4 </li></ul>B Increasing Concentration Of Herbal Extract - Y Increasing Concentration Of Herbal Extract - X A C
  11. 11. Reasons why Phytoconstituent based products are usage of choice across the world <ul><li>Growing credentials with validated results </li></ul><ul><li>Cost economy </li></ul><ul><li>High safety margin with no resistance development tendency </li></ul>
  12. 12. Growing credentials:Herbal Monographs <ul><li>Publication and availability of authoritative monographs by various organizations, improving the scientific credibility of herbs. </li></ul>
  13. 13. Indian Herbal Pharmacopoeia British Herbal Pharmacopoeia English Translation of German Commissions E monographs American Herbal Pharmacopoeia ( AHP ) World Health Organization (WHO) Europe Scientific Cooperative on Phytotherapy (ESCOP) United States Pharmacopoeia ( USP ) Confluence of Herbal Pharmacopoeia
  14. 14. Cost Economy <ul><li>Comparatively Less Gestation time of phytodiscovery </li></ul>
  15. 15. Pharmaceutical Research and Development (R & D) Process Definitions IND = Investigational New Drug Application FDA = U.S. Food and Drug Administration NDA = New Drug Application Source: www.Innovation.org
  16. 16. <ul><li>Evolving into a composite phytochemical based pharmaceutical major with presence in </li></ul><ul><li>Animal Health Products </li></ul><ul><li>Standardized Herbal Extracts </li></ul><ul><li>Human Health Supplements </li></ul><ul><li>Phytochemical Reference Standards </li></ul>INDIA
  17. 17. Our Accreditations <ul><li>R&D centre also holds reputed accreditations from </li></ul><ul><li>Department of Science & Technology, Government of India. </li></ul><ul><li>The research team has more than one dozen patents and </li></ul><ul><li>a few international patents on its herbal products. </li></ul>Kosher
  18. 18. Our Accreditations <ul><li>Contribution to USP and Indian Government Pharmacopoeia </li></ul>
  19. 19. <ul><li>Screening of biological activity for new usage </li></ul>Our predicted direction of herbal research
  20. 20. <ul><li>Maintenance of and access to germplasm collections and seed </li></ul>Our Predicted direction of herbal research
  21. 21. Role of Phytoconstituents <ul><li>As Performance Enhancer </li></ul>
  22. 22. <ul><li>Andrographis paniculata </li></ul><ul><ul><li>  </li></ul></ul>
  23. 23. <ul><li>Phyllanthus amarus </li></ul><ul><ul><li>Marker constituents: Phyllanthin & </li></ul></ul><ul><ul><li>Hypophyllanthin </li></ul></ul>
  24. 24. GLOBAL QUALITY TESTED & TRUSTED India Malaysia Japan USA & Italy
  25. 25. Country - Malaysia Field trial in commercial broilers (AA) – Dr.V.Raghavan, Seng Heng Chan Feed
  26. 26. Country - Japan Field trial in commercial broilers (Chanky) – Kohara Feed & Breeding Co. Ltd. Poultry Farm, Wakayama
  27. 27. Country - USA Field trial in commercial broilers – Dr. Danny Hooge, Utah State University, Logan –UT
  28. 28. Country - Italy Field trial in commercial broilers - Dr.Schienoni Milano
  29. 29. Source : World Poultry - V.15 # 11, 1999 MYCOTOXINS - A WORLDWIDE SCENARIO “ Food and Agriculture Organisation (FAO) of the UN estimated that 25% of the world's grain supply is contaminated with Mycotoxins ” . Liver in a good condition The target organ for the mycotoxins and attack of other chemical toxicants is LIVER . Liver in a good functional condition is very useful for basic detoxification mechanism and overall digestion & metabolic functions of the body. Zigbir has potent effect on the development & efficient functioning of liver under normal and challenged condition. MYCOTOXINS
  30. 30. HEPATOPROTECTION (Against FUNGAL TOXINS) Prof.D.Narahari,Ph.D., Prof. & Head, Poultry Science, Vety.College, Chennai
  31. 31. HEPATOPROTECTION (Against FUNGAL TOXINS) GROSS LESION - LIVER (e) ND H.I Titers BETTER FEED & FEEDING Gross pathology of liver of challenged untreated group (A) reveals hepatomegaly, severe discoloration, blunt edges and fragility. While the gross pathology of liver of the challenged treated group (B) is closer to the normal.
  32. 32. HEPATO PROTECTION (Against CHEMICAL TOXICANTS) Dr.Deben Sapcota Associate Professor Dept. of Poultry Science Assam Agricultural University
  33. 33. Utilization of Xanthophill Roche colour fan index basis
  34. 34. <ul><li>In broilers, to growth, weight gain, FCR livability </li></ul><ul><li>Enhance egg production ECR & minimise thin shell and egg breakage due to liver related problems </li></ul><ul><li>To maintain proper digestion, absorption, general health and, feed intake </li></ul><ul><li>To enhance hepatic functions </li></ul><ul><li>To protect the birds from aflatoxins and other feed related problems </li></ul>Which Spells Quality Usage
  35. 35. <ul><li>300 gms per ton of feed </li></ul><ul><li>Depending on the quality of feed ingredients and atmospheric moisture content, the dose may be increased upto 400 gms per tin of feed or as per the advice of the nutritionist. </li></ul>Broilers & Layers : Form day l continuously, till marketing. Which Spells Quality 25 kg multi layer bag. During high risk period Recommendation Presentation Mixing rate
  36. 36. Role of Phytoconstituents <ul><li>To replace bioactivity of Vitamin C </li></ul>
  37. 37. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Emblica officinalis Part used : Dried Fruits Main Uses : Immunomodulatory and Antioxidant (Suresh & Vasudevan, 1994). Active principle : Gallic acid Gallic acid Ursolic Acid Part used : Whole plant Main Uses : Immunomodulatory, Antistress (Sen et.al.,1992) Active principle: Ursolic acid Ocimum sanctum
  38. 38. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Emblica officinalis Gallic acid Chebulic acid Ellagic acid Chebulinic acid
  39. 39. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Known to be active in scavenging DPPH*, Superoxide anion * DPPH : diphenyl picrylhydrazyl (free radicals), turns colorless when reduced by antioxidant.
  40. 40. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C <ul><li>Chebulinic acid is shown to be active in DPPH and methyl linoleate oxidation models with 93 and 34 % inhibitory activity respectively in these models. </li></ul><ul><li>A total of 13 hydroxy groups representing chebulinic acid and is believed to be responsible for its powerful anti-oxidant activity (Klika KD et al . 2004). </li></ul>L-Ascorbic acid
  41. 41. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Potent Anti-oxidant Under stress free condition Phytocee-Under stressful condition A.T.Ps. Energy Free Radicals Scavenged S.O.D. More energy More A.T.Ps. Extra Free Radicals (> normal) Destroyed by Antioxidants The phytoactives of Phytocee possess a potent ability to donate H+ atom and acts as a natural anti-oxidant.
  42. 42. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Phytocee shows a potent free radical scavenging activity very similar to L-ascorbic acid (Vitamin 'C'). SCIENTIFIC VALIDATION: Anti-oxidant Activity Principle: DPPH [1,1-diphenyl-2-picryl hydrazyl] is a stable free radical with purple colour, the intensity of which is measured at 510nm spectrophotometrically. Antioxidants reduces DPPH to 1,1-diphenyl-2-picryl hydrazine, a colourless compound. 1, 1-diphenyl-2-picryl hydrazyl Purple colour 1, 1-diphenyl-2-picryl hydrazine Colourless Effect of L-Ascorbic acid & Phytocee on free scavenging activity Phytocee L Ascorbic acid
  43. 43. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Oxidative stress (OS) is one among the common stressors of cells. OS can result in membrane damage leading to several pathological effect. Reference: Chandarasekaran C.V., et al , Invitro efficacy and safety of poly-herbal formulations. Toxicol, invitro (2010), doi:10, 1016/j.tiv.2009, 11, 021. As per various research Phytocee exhibits an appreciable cellular anti-oxidant effect.
  44. 44. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Phytoactives of Phytocee Possess a proven immuno-modulating property against bacterial as well as viral infections An Immunomodulator Conclusion The results indicate that, both the products i.e., Phytocee and Vitamin-C (L-Ascorbic acid) possess the same macrophage phagocytosis stimulating activity. Therefore, Phytocee can replace Vitamin-C cent percent and restores the immune status of the bird under any stress or infective conditions. Effect of Phytocee and Vitamin 'C' on macrophage phagocytosis Phytocee / Vit. C (µg/ml) % Infected macrophages 0 100 500 83 ± 4 100 ± 0 100 ± 4 - 1.2 1.2 - 1.1 1.2 83 ± 4 96 ± 1 100 ± 1 Phytocee Vit. C Phytocee Vit. C
  45. 45. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C <ul><li>The phytoactives of </li></ul><ul><li>Phytocee are very stable at </li></ul><ul><li>high thermal temperature </li></ul><ul><li>under moist & dry heat </li></ul><ul><li>conditions. </li></ul><ul><li>Possesses long lasting </li></ul><ul><li>activity when stored under </li></ul><ul><li>normal room temperature . </li></ul>Thermostability TRACK C1: Phytocee Control sample without heat treatment TRACK T1: Phytocee Heated at 105 0 C for 30 minutes TRACK T2: Phytocee Heated at 105 0 C for 1 hour TRACK T3: Phytocee Heated at 105 0 C for 2 hours Laboratory Test Report Sample heated at 105 0 C for 30 minutes, 1 hour and 2 hours 254 nm 366 nm Visible Visible after derevitisation
  46. 46. Herbal Poultry Feed Supplement for Replacing Synthetic Vitamin C Usage <ul><li>To optimize: </li></ul><ul><li>Body resistance, thereby livability </li></ul><ul><li>Egg production and shell quality </li></ul><ul><li>Fertility and hatchability in breeders </li></ul><ul><li>Overall performance of birds </li></ul>Mixing Rate 1:1 replacement of synthetic Vitamin C or as directed by the nutritionist 1 kg and 5 kg Availability
  47. 47. More Phytoconstituents options For Replacement of Synthetic Methionine & Equivalent

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