PPT Casali "TB and concomitant respiratory diseases"

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PPT Casali "TB and concomitant respiratory diseases", Symposium on TB, 15 October, V Session (Physicians & surgeons), Monza, Italy.

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PPT Casali "TB and concomitant respiratory diseases"

  1. 1. Università degli Studi di Perugia Azienda Ospedaliera “ S. Maria ” di Terni Cattedra di Malattie dell’Apparato Respiratorio U.C. di Malattie dell’Apparato Respiratorio Tubercolosi e patologie respiratorie concomitanti Monza, 15 ottobre 2011 Lucio Casali Mariano E. Crapa
  2. 2. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Latent TB Infection for Smoking Compared with Nonsmoking
  3. 3. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Clinical TB Disease for Ever Smoking Compared with Nonsmoking
  4. 4. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Mortality Due to TB for Smoking Compared with Nonsmoking
  5. 5. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Clinical TB Disease for Former Smoking Compared with Nonsmoking
  6. 6. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Clinical TB Disease for Passive Smoking Exposure Compared with Nonexposure
  7. 7. Tobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis Hsien-Ho Lin et Al. PLoS Medicine January 2007 | Volume 4 | Issue 1 Risk of Clinical TB Disease for Indoor Air Pollution Exposure Compared with Nonexposure
  8. 8. The convergence of the global smoking, COPD, Tuberculosis, HIV, and respiratory infection epidemics Richard N. van Zyl-Smit Eur Respir J 2010; 35: 27–33
  9. 10. Vitamin D and susceptibility of chronic lung diseases: role of epigenetics Isaac K.Sundar frontiers in pharmacology; respiratory pharmacology august2011;2-50 Role of vitamin D/VDR in environmental agent-mediated deregulation of cellular and molecular functions.
  10. 11. Vitamin D and the immune system: new perspectives on an old theme Martin Hewison Endocrinol Metab Clin North Am. 2010 June ; 39(2): 365–379
  11. 13. LA SEVERITA’ DELLA BPCO CORRELA CON L’AUMENTO DEL TrKA MA NON CON QUELLO DELp75
  12. 14. The convergence of the global smoking, COPD, Tuberculosis, HIV, and respiratory infection epidemics Richard N. van Zyl-Smit Eur Respir J 2010; 35: 27–33 Potential interactions between tobacco smoking, HIV, tuberculosis (TB) and chronic obstructive pulmonary disease (COPD) with resultant pulmonary disability. PCP: Pneumocystis jiroveci pneumonia.
  13. 15. Characteristics of patients suffering from tuberculosis in the presence and absence of COPD as a premorbid condition. COPD and the Risk of Tuberculosis - A Population-Based Cohort Study Malin Inghammar et Al. PLoS April 2010 | Volume 5 | Issue 4
  14. 16. COPD and the Risk of Tuberculosis - A Population-Based Cohort Study Malin Inghammar et Al. PLoS April 2010 | Volume 5 | Issue 4 Predictors of TB among individuals discharged with a prior diagnosis of COPD (n = 86,920). 1
  15. 17. The convergence of the global smoking, COPD, Tuberculosis, HIV, and respiratory infection epidemics Richard N. van Zyl-Smit Infect Dis Clin North Am. 2010 24(3): 693–703 Overview of the systemic and local effects of tobacco smoke on the immune system and pulmonary defence mechanisms against infection
  16. 18. Mediatori comuni tra TB e COPD Possibile elemento di connessione: Distruzione della matrice extra-cellulare (ECM) LAM rilascio MMP-9 e > espressione genetica di MM-1 e MMP-9 >MMP e MMP-7 nel granuloma Rottura ECM, >IL-8 ed altre citochine infiammatorie TNF- α stimola MMP-9 dai granulomi TB TIMP-1 soppresso in corso di Tb Chakrabarti B. et Al. 2007
  17. 19. Tuberculosis, bronchiectasis and chronic airflow obstruction Toni S. Jordan et Al. Respirology (2010) 15, 623–628 Causes of and associations with bronchiectasis
  18. 20. Endobronchial tuberculosis simulating bronchial asthma Y H Lee, Singapore Med J 2004 Vol 45(8) : 390 Chest radiograph shows a prominent left hilum but no pulmonary opacity
  19. 21. Endobronchial tuberculosis simulating bronchial asthma Y H Lee, Singapore Med J 2004 Vol 45(8) : 390 Axial CT image shows a faint infiltrate in the left upper lobe.
  20. 22. Endobronchial tuberculosis simulating bronchial asthma Y H Lee, Singapore Med J 2004 Vol 45(8) : 390 Bronchoscopic photograph shows swelling and infiltration of the trachea (arrow), producing a tumour-like appearance
  21. 23. Endobronchial tuberculosis simulating bronchial asthma Y H Lee, Singapore Med J 2004 Vol 45(8) : 390 Bronchoscopic photograph shows ulcerative and granular appearances (arrow) of other parts of the bronchial tree.
  22. 24. Endobronchial tuberculosis simulating bronchial asthma Y H Lee, Singapore Med J 2004 Vol 45(8) : 390 Follow-up bronchoscopy after completion of treatment shows residual stenosis (arrow) of the left main bronchus. Follow-up bronchoscopy shows marked stenosis (arrow) of the left upper lobe bronchus.
  23. 25. The Risk of Obstructive Lung Disease by Previous Pulmonary Tuberculosis in a Country with Intermediate Burden of Tuberculosis Sei Won Lee et Al. J Korean Med Sci 2011; 26: 268-273 Pulmonary function of subjects with or without TB lesion on CXR
  24. 26. The Risk of Obstructive Lung Disease by Previous Pulmonary Tuberculosis in a Country with Intermediate Burden of Tuberculosis Sei Won Lee et Al. J Korean Med Sci 2011; 26: 268-273 Proportion of subjects with TB lesion as the severity of airflow obstruction. % Pred, % of predicted value; TB, tuberculosis; FVC, forced vital capacity; FEV1, forced expiratory volume in one second
  25. 27. Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions Leena Von Hertzen et Al.J Allergy Clin Immunol December 1999 Prevalence of persistent asthma and allergic conditions among the study and control subjects by sex at the end of the mean follow-up of 30 years
  26. 28. Validity of the CA125 Level in the Differential Diagnosis of Pulmonary Tuberculosis Sefa Levent Ozsahin et Al. Jpn. J. Infect. Dis., 61, 68-69, 2008 Mean serum CA125 values of patient groups
  27. 29. Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections J. Fortún The Open Respiratory Medicine Journal, 2009, Volume 3 Basal and post-therapy (2-4 months) Ca-125 levels in 10 patients with pulmonary tuberculosis.
  28. 30. Possibile ruolo dell’infiammazione nel rapporto tra TB e cancro Speci reattive dell’ O 2 ed N attivate dai neutrofili possono legarsi al DNA provocando alterazioni del genoma I processi riparativi si associano a proliferazione cellulare con possibili errori nella replicazione cromosomica che può condurre ad ulteriori mutazioni del DNA La flogosi può essere vista come iniziatore e come promotore. Hui-Ying Liang et Al. Brenner RB. et Al. 2009
  29. 31. Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis Darren R. Brenner PLoS ONE March 2011 | Volume 6 | Issue 3 Pooled estimates of the risk associated with a previous diagnosis of tuberculosis, separated by smoking status (never smokers on top, smokers on bottom) and overal.
  30. 32. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review Hui-Ying Liang Int. J. Cancer: 125, 2936–2944 (2009) Forrest plot of relative risks (RR) of lung cancer associated with history of tuberculosis in the ‘‘Westernized country’’ and ‘‘ Not-westernized country’’ studies adjusted for smoking history. CI, confidence interval.
  31. 33. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review Hui-Ying Liang Int. J. Cancer: 125, 2936–2944 (2009) Forrest plot of lung cancer risks in never-smokers stratified by country/region. RR, relative risks, CI, confidence interval.
  32. 34. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review Hui-Ying Liang Int. J. Cancer: 125, 2936–2944 (2009) Forrest plot of relative risks (RR) of adenocarcinoma of the lung associated with history of tuberculosis stratified by country/region. CI, confidence interval
  33. 35. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review Hui-Ying Liang Int. J. Cancer: 125, 2936–2944 (2009) Forrest plot of relative risks (RR) of lung cancer associated with history of tuberculosis stratified by years since the diagnosis of tuberculosis. CI, confidence interval
  34. 37. No Anti TNF

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