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Presentation1stmulant cns Presentation1stmulant cns Presentation Transcript

  • The CNS stimulants mostly produced a generalized action which may Produce convulsion at higher doses.
  • TYPE OF DRUGS NAME OF DRUGS  ANALEPTICS PICROTOXIN,PENTYLENE TETRAZOLE,MEDAFINIL, DOXAZEPAM HYDROCHLORIDE.  METHYLXANTHINES : CAFFINE,THEOPHYLLENE, THE OBROMINE.  CENTRAL SYMPATHOMIMETIC AGENTS : AMPHETAMINE, METHAMPHETAMINE, PHENTERMINE,BENZOPHETAMI NE, FENFLURAMINE  ANTIDEPRESSANTS : a) MONO AMINE OXIASE INHIBITORS PHENELZINE SULFATE,TRANYLCYPROMINE SULFATE b)TRICYCLIC ANTIDEPRESSANTS IMIPRAMINE,DESIMIPRAMINE, CLOMIPRAMINE, AMITRYPTILENE
  • 1.The traditional analeptics are potent and non-selective. 2.They can be illustrated by a)picrotoxin & b) PTZ 3.BOTH OF THEM ARE OBSOLATED NOW. 4.But used in research purpose. 5.Newer agents a)modafinil & b)doxapram are selective 6.These two are used in narcolepsy and as respiratory stimulant.
  • References : 1.Wilson & Gisvold’s Organic Medicinal and Pharmaceutical chemistry 2.Essentials of Medical Pharmacology -KD TRIPATHY