May be cell-mediated immunological reaction directed at the peripheral nerves
Frequently preceded by viral infection, trauma, surgery or other immune system stimulation.
Humoral factors and cell-mediated immune phenomena have been implicated in the damage of myelin and/or the myelin-producing Schwann cells T-cell sensitization occurs which causes loss of myelin which disrupts nerve impulses
Loss of myelin, edema and inflammation of the affected nerves, causes a loss of neurotransmission to the periphery.
As a result of the cost, risk, and discomfort to the patient, plasma exchange is generally not used for ambulatory patients with mild disease or for patients whose symptoms are no longer progressing after three weeks