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Mr. Jerry Heneghan, Director of HumanSim Product Development,
Applied Research Associates, Inc. (ARA)
28 January 2014
1	
 ...
•  TATRC Funded Project: W81XWH-13-2-0068
•  “This work is supported by the US Army Medical Research
and Materiel Command....
•  Director of Product Development "BioGears	
  is	
  a	
  project	
  of	
  great	
  importance	
  to	
  the	
  
for
medic...
•  BioGears has four main
parts a physiology engine,
common data model,
extensive documentation
and BioGearsEngine.com
tha...
BioGears: Project Goals
•  Create a publicly available physiology research
platform that enables accurate and consistent
s...
•  ARA is the prime contractor
•  We have a mix of engineers, computer scientists and
biomedical personnel contributing to...
BioGears: Anticipated Schedule
2013	
  
Current
Progress

2014	
  

Milestone: Project Kick Off (Sept 15, 2013)
Creation o...
BioGears: Engine Capabilities
• 
• 
• 
• 
• 
• 

•  Features:

Blood Chemistry
Cardiovascular
Energy
Fluids
Respiratory/Ga...
BioGears: Engine Methodology
•  Systems use a circuit representation or lumped parameter
approach composed of compartments...
BioGears: Engine Methodology Example

70

12

68

8

66

4

64
800

10	
  

900

1000

Time
Time

1100

1200

BioGearsEngi...
BioGears: Software Common Data Model (CDM)
•  Object Oriented Design of class structures that provides a
unified set of da...
BioGears: Envisioned Users
Engine	
  Integrator	
  

BioGears	
  Contributor	
  

External	
  Model/	
  
Engine	
  Develop...
BioGears: Software Deliverables
•  Software Development Kit (SDK) (Targets: Integrator)
• 
• 
• 
• 
• 

Built Binaries and...
BioGears: Showcase Scenarios
•  Male, 25 y/o, high level of physical
conditioning
•  Actions/Interventions: Performing str...
BioGears: Showcase Scenarios contd.
•  Female, 17 y/o, exposure elements

•  Male 22 y/o, massive trauma
resulting in hemo...
•  Under Development
•  Learn about the engine and
the BioGears project
•  Download the engine (mini
build 2014, beta buil...
BioGears: How to Contribute
•  Source Code:
•  Primary trunk and contributor branches available via Google Code
•  Link to...
BioGears: Conference 2015

•  How to use BioGears in your application
•  How you can contribute to the ongoing body of kno...
19	
  

BioGearsEngine.com
Copyright 2014. All rights reserved. Applied Research Associates, Inc.

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BioGears Open Source Human Physiology Engine IMSH2014 Conference

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BioGears is an open source, comprehensive, extensible human physiology engine that will drive immersive medical education and training technologies. The BioGears physiology engine platform will allow for distributed collaboration and consistent simulation across the medical training community. http://biogearsengine.com/

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Transcript of "BioGears Open Source Human Physiology Engine IMSH2014 Conference"

  1. 1. Mr. Jerry Heneghan, Director of HumanSim Product Development, Applied Research Associates, Inc. (ARA) 28 January 2014 1   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. Open-Source Physiology Model for Simulation-Based Training
  2. 2. •  TATRC Funded Project: W81XWH-13-2-0068 •  “This work is supported by the US Army Medical Research and Materiel Command.” •  “The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.” •  Unreal® Engine Licensing (UnrealEngine.com) •  I am the Unreal licensing manager in the government vertical 2   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. Disclaimers
  3. 3. •  Director of Product Development "BioGears  is  a  project  of  great  importance  to  the   for medical  simula:on  community  and  the   HumanSim® at ARA advancement  of  immersive  medical  technologies.   •  Founder and former CEO of Our  team  looks  forward  to  crea:ng  the  most   Virtual Heroes, Inc. acquired ’09 comprehensive,  open  source  mathema:cal  model   •  Executive Producer for America’s of  human  physiology  available.”  –  Mr.  Jerry   Heneghan   Army Game •  Program manager in the Technology Assisted Learning Division of the Research Triangle Institute (RTI) - focused on the game technologies for healthcare training and education •  Game producer at Tom Clancy’s Red Storm Entertainment •  Started his career in the military and served as a U.S. Army Aviator (AH-64 pilot) in assignments all over the world •  Holds an M.B.A. from the Fuqua School of Business at Duke University and a B.S. in engineering from the U.S. Military Academy 3   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. BioGears: Principal Investigator
  4. 4. •  BioGears has four main parts a physiology engine, common data model, extensive documentation and BioGearsEngine.com that gives everyone access to state-of-the-art physiology modeling software. •  Both the common data model and the physiology engine will be open source. 4   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. What is BioGears?
  5. 5. BioGears: Project Goals •  Create a publicly available physiology research platform that enables accurate and consistent simulated physiology across training applications •  Lower the barrier to create medical training content •  Engage the community to develop and extend physiology models •  Meet the training needs of the military •  Expand the body of knowledge regarding the use of simulated physiology for medical education 5   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  The goals of BioGears are:
  6. 6. •  ARA is the prime contractor •  We have a mix of engineers, computer scientists and biomedical personnel contributing to BioGears •  Bryan Bergeron, M.D. (www.bryanbergeron.com) •  We are identifying additional partners who have expertise specifically in the areas of pharmacokinetics, and modeling of chronic conditions •  We are seeking an experienced physiology modeler to join ARA’s team •  For more information please see www.careers.ara.com 6   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. BioGears: Project Team
  7. 7. BioGears: Anticipated Schedule 2013   Current Progress 2014   Milestone: Project Kick Off (Sept 15, 2013) Creation of Common Data Model Rearchitecture of Physiology Engine Base System Development Base System Validation 2015   Feature Development Feature Validation Community Outreach Milestone: Beta Build Release and Users’ Group Conference (Fall 2015) 2016   2017   7   Engine Maintenance Continued Community Involvement Publications (2017) Website Maintenance Only BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. Milestone: Mini Build Release and Website Launch (Sept 2014)
  8. 8. BioGears: Engine Capabilities •  •  •  •  •  •  •  Features: Blood Chemistry Cardiovascular Energy Fluids Respiratory/Gas Exchange Renal •  Hemorrhage •  Smoke Inhalation •  Exercise •  Additional Systems •  Anesthesia Machine •  ECG •  Drug Administration 8   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Physiology Systems:
  9. 9. BioGears: Engine Methodology •  Systems use a circuit representation or lumped parameter approach composed of compartments •  Interface commands allow users to trigger events that the systems reacts to 9   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Systems then monitor compartment information to trigger physiological responses and feedback mechanisms
  10. 10. BioGears: Engine Methodology Example 70 12 68 8 66 4 64 800 10   900 1000 Time Time 1100 1200 BioGearsEngine.com 0 1300 Respiration Rate 16 Respiration Rate 20 72 Heart Heart Rate Rate 74 Respiration Heart Rate Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Inject Succinylcholine (muscle relaxant) •  Cardiovascular circuit transports around the body •  Appropriate compartment detects level and reduces spontaneous respirations and heart contractility •  Endocrine system releases hormones to increase heart rate and blood pressure once low arterial oxygen is detected •  Resistance and capacitance of the cardiovascular system compartments is modified in an effort to compensate/stabilize the body
  11. 11. BioGears: Software Common Data Model (CDM) •  Object Oriented Design of class structures that provides a unified set of data objects for physiology simulation •  Anatomy, Circuits, Compartments, Equipment, Patient, and Substances/Drugs •  This representation supports the structure, relationships, and organization of data, and provides a standard for data exchange •  Provides the link between physiological data and the mathematics needed to accurately represent and evaluate a series of systems and events 11   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Implemented in an eXtensible Markup Language (XML) schema
  12. 12. BioGears: Envisioned Users Engine  Integrator   BioGears  Contributor   External  Model/   Engine  Developer   Use  the  engine  as  is  via   the  API   Adds  systems  to  the   engine   Uses/extends  CDM  to   drive  their  model     Extends  func:onality   Ex.  Game  Developers   Replaces  systems  with   other  models   Runs  BioGears  engine   and  other  engine(s)  in   tandem     BioGears will be open source all code under the BSD 3 license •  •  •  12   Creates  customer  files   (pa:ents,  drugs,   command  lists,  etc)  as   input  to  BioGears   engine  for  research   purposes   Includes the CDM and Engine, plus other framework support BSD 3 license is a GPL-compatible software license that allows unlimited modification and/or redistribution of code and/or derived products for any purpose as long as its copyright notices and the license's disclaimers of warranty are maintained While it is encouraged that any modification or extension to the BioGears code base be made available to the community, under BSD 3, it is not required for modifications to be released to the community BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Researcher/  Educator  
  13. 13. BioGears: Software Deliverables •  Software Development Kit (SDK) (Targets: Integrator) •  •  •  •  •  Built Binaries and Headers Front facing Interface only access point Code Examples Doxygen style documentation for every interface/function Datasets: Patient, Drug, configuration files, etc •  Header, Code, and project files (makefiles, msvc projects, etc.) •  Full Doxygen style documentation inline for entire engine code base including functionality, references, assumptions etc. •  System Level Documents (Targets: Researcher, Contributor, Model Developer) •  Word Documents for each system •  Methodology of the system, good background information for papers and researchers •  Does not cover the workings of every subroutine in the code base 13   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Source Code (Targets: Integrator, Contributor, Model Developer, Researcher)
  14. 14. BioGears: Showcase Scenarios •  Male, 25 y/o, high level of physical conditioning •  Actions/Interventions: Performing strenuous exercise at high altitude. Results in heat stroke •  Assessments: Core temperature, sweat rate, pallor, heart rate •  Actions/Interventions: Administer drugs, intubate •  Assessments: Blood panel, respiration rate, ETCO2, Heart rate, BP, SPO2, PFT •  Male 60 y/o, hypertensive, diabetic, obese: •  Actions/Interventions: Drug administration •  Assessments: Blood Panel, Urine Panel, EKG, Retina Assessment 14   BioGearsEngine.com Sedation & Airway Images Project funded by TATRC Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Female, with Asthma, 12 hrs NPO, OR
  15. 15. BioGears: Showcase Scenarios contd. •  Female, 17 y/o, exposure elements •  Male 22 y/o, massive trauma resulting in hemorrhage, tension pneumothorax •  Actions/Interventions: Tourniquet Application, Needle Decompression, drug and fluid administration •  Assessments: Bleeding rate, heart rate, blood pressure, distal pulse, respiration rate 15   BioGearsEngine.com Combat Medic Images Project funded by Army RDECOM Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Actions/Interventions: Environment customization for heat loss and body insulation; variation of nutritional/ hydration state •  Assessments: Core /Peripheral temperature, Heart Rate, Respiration Rate
  16. 16. •  Under Development •  Learn about the engine and the BioGears project •  Download the engine (mini build 2014, beta build 2015) •  Connect with community members via forums •  Share scenario files, see how others are using the engine •  Sign Up for conference and project news 16   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. BioGearsEngine.com
  17. 17. BioGears: How to Contribute •  Source Code: •  Primary trunk and contributor branches available via Google Code •  Link to source provided at BioGearsEngine.com (first build available Fall 2014) •  Configuration and Data Files: •  Scenario files, patient files, drug files, etc, can be accessed and posted on BioGearsEngine.com •  Forum discussions, uploaded publication and other documents that discuss the use, validation, and extensions of the BioGears engine •  Example: •  A user can create a branch to model a new feature. Then discuss their contributions and provide configuration and analysis information via the website forums. 17   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  Analysis:
  18. 18. BioGears: Conference 2015 •  How to use BioGears in your application •  How you can contribute to the ongoing body of knowledge •  Demonstrating how BioGears is working in a medical training tool ARA is developing for the Army •  We are looking for interested parties to sign up to participate, speak and display. •  Please ‘sign up’ via BioGearsEngine.com to keep up with news about the project and the conference! 18   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. •  In Fall 2015 the BioGears team will hold a conference in the Raleigh/Durham area. •  The conference will coincide with our BioGears Engine Beta Build release and will focus on:
  19. 19. 19   BioGearsEngine.com Copyright 2014. All rights reserved. Applied Research Associates, Inc. QUESTIONS
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