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Functioning of gene regulatory systems is supplemented greatly by the dynamic behavior of the cell. Investigations into such dynamic behavior may provide a better understanding of the biological ...
Functioning of gene regulatory systems is supplemented greatly by the dynamic behavior of the cell. Investigations into such dynamic behavior may provide a better understanding of the biological control systems and make its analysis rather undemanding. Systems biology, as a holistic approach for studying biological systems contributed much to this area. It uses mathematical modeling and simulation for analyzing such dynamic interactions between system components and thereby explains the overall behavior of the system. The approach can also be adopted for studying of biological control systems. Transcription regulatory network is one such control system comprising of repressor, activator and protein as the components. These components interact with each other in various ways to yield a desired output. These different interactions give rise to different structural motifs. Here, we develop a general model for various feasible structures with combination of repressors and activators to correlate with a desired output. The outputs range from transient to graded response. The various motifs were analyzed with different objectives correlated to existing natural motifs. The bistability of the existing motifs were also analyzed using the models developed. The results of bistability analysis show that the systems can have two stable states under the influence of positive feedback loops and hybrid binding of both the transcription factors. The work can be used for the analysis of the objectives behind the specific structural design of the motifs.
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