RABIESRABIES
• It is an acute
• Highly fatal viral dis: of CNS
Transmitted to man by:
• Bites
OR
• Licks of rabid animals
• Primarily a Zoonotic disease of warm
blooded animal
• such as :-
• Dogs,
• wild cats,
• Jackals,
• wolves etc.
Source of InfectionSource of Infection
• Saliva of Rabid animal
Host FactorsHost Factors
• All warm blooded animals including man.
• Rabies in man is a dead-end infection.
Mode of TransmissionMode of Transmission
1. ANIMAL BITES
2. LICKS
3. AEROSOL
4. PERSON TO PERSON
AgentAgent
(LYSSAVIRUS type I)(LYSSAVIRUS type I)
Rhabdoviridae type IRhabdoviridae type I
• It is Bullet shaped Neurotrop...
Bullet shaped
Types of Rabies virusTypes of Rabies virus
STREET VIRUS
Definition: the virus
recovered from
naturally occurring
cases of ...
RESERVOIR OF INFECTIONRESERVOIR OF INFECTION
1) URBAN RABIES:
From Dogs and
cats.
2)2) WILD LIFE RABIESWILD LIFE RABIES::
From jackals and foxes.From jackals and foxes.
3)3) BAT RABIESBAT RABIES::
Vampire bats which live on the blood of animals andVampire bats which live on the blood of ani...
• History of Rabies Virus
• Man described the disease in 2300 B.C.
• The origin “rabhas”, meaning “to do
violence” comes f...
History of the Rabies VirusHistory of the Rabies Virus
•Outbreak of rabies in Europe
in 20th
century spawned the
Vampire m...
History of the Rabies VirusHistory of the Rabies Virus
• Since Roman times, man established the
link between the infectivi...
History of the Rabies VirusHistory of the Rabies Virus
• Louis Pasteur was the first person to
diagnose that rabies target...
EpidemiologyEpidemiology
87 countries contain Rabies, but more
cases are reported in Asia.
In Indo-Pakistan rabies is a ma...
• Estimated Annual Human Rabies Cases
2005
• North America 4 - 8
• Europe 10 - 20
• Latin America 200 - 400
• Africa 500 -...
• FREE RABIES ZONE:
• Australia,
• China,
• Iceland,
• Ireland,
• Japan,
• New Zealand etc
• INCUBATION PERIOD:
• normally it is 3 - 8 wks
• may be short that is 4 days
• or may be prolonged for years.
PATHOGENESISPATHOGENESIS
CLINICAL PICTURECLINICAL PICTURE
1. Prodromal symptoms
Headache, malaise, sore throat, low
fever, pain at the site of bite...
Hydrophobia ( Fear of water)
sight or sound of water may produce
spasm
the duration of illness is 2-3 days may
be prolonge...
(summary(summary))
Transmission of RabiesTransmission of Rabies
Cl:PictureCl:Picture
• The rabies infection and the sympto...
DIAGNOSISDIAGNOSIS
1. History
2. Sign and symptom
3. Examination
4. Detection of Antigen by taking Skin
Biopsy using Immun...
Control MeasuresControl Measures
• Notification
• Isolation
• Disinfection
• Immunization
Prevention of human rabiesPrevention of human rabies
post Exposure prophylaxispost Exposure prophylaxis
1. General conside...
c, Suturing
d, Anti Rabies Serum
e, Antibiotic and ATS
f, Observe the animal for 10 days
• 3, Immunization
• 1,NERVOUS TISSUE VACCINE (NTV
2, Human diploid cell vaccine
(HDCV)
Vaccines for immunizationVaccines for immunization
Definition:
it is fluid or dried preparation of
Rabies “Fixed” virus gr...
Type of VaccineType of Vaccine
NERVOUS TISSUE VACCINE (NTV)
a. Derived from adult animal nervous
tissue eg. Sheep
b. Deriv...
Type of Vaccine (conti)Type of Vaccine (conti)
Duck Embryo Vaccine (DEV)
Type: Killed viral vaccine
Dose: 1 ml S/C ( Ant. ...
Type of Vaccine (conti)Type of Vaccine (conti)
CELL CULTURE VACCINES
a. Human diploid cell vaccine (HDCV)
b. Second genera...
PASSIVE IMMUNIZATIONPASSIVE IMMUNIZATION
• Horse Anti Rabies serum: 40 iu / kg at
0 day
• Human rabies immunoglobin (HRIG)...
Classification Of ExposuresClassification Of Exposures
1. Class I (slight Risk) 07 injection
a. Licks on healthy unbroken ...
IMMUNITYIMMUNITY
• Duration of Immunity is upto 06
month
• If again bite by rapid animal than
dose according to blood titr...
General measuresGeneral measures
• Regist:,licensing & taxation of dog.
• Muzzling of dogs
• Yearly mass vaccination of do...
Pre-Exposure Prophylaxis
• It is done in persons who have high risk of
repeated exposures.
Animal Handlers
Wildlife office...
Rabies in DogsRabies in Dogs
• Incubation period: 3-8 wks.
• Clinical features: Rabies in dogs may manifest
itself in two ...
b. Dumb Rabies.
i. The excitative or irritative stage is
lacking.
ii. The disease is predominantly paralytic.
iii. Dog wit...
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
Leconrabies 120309125912-phpapp01
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Leconrabies 120309125912-phpapp01

  1. 1. RABIESRABIES • It is an acute • Highly fatal viral dis: of CNS Transmitted to man by: • Bites OR • Licks of rabid animals
  2. 2. • Primarily a Zoonotic disease of warm blooded animal • such as :- • Dogs, • wild cats, • Jackals, • wolves etc.
  3. 3. Source of InfectionSource of Infection • Saliva of Rabid animal
  4. 4. Host FactorsHost Factors • All warm blooded animals including man. • Rabies in man is a dead-end infection.
  5. 5. Mode of TransmissionMode of Transmission 1. ANIMAL BITES 2. LICKS 3. AEROSOL 4. PERSON TO PERSON
  6. 6. AgentAgent (LYSSAVIRUS type I)(LYSSAVIRUS type I) Rhabdoviridae type IRhabdoviridae type I • It is Bullet shaped Neurotropic RNA virus
  7. 7. Bullet shaped
  8. 8. Types of Rabies virusTypes of Rabies virus STREET VIRUS Definition: the virus recovered from naturally occurring cases of rabies is called “street virus” Sources: it is naturally occurring virus. It is found in saliva of infected animal. FIXED VIRUS Definition: the virus which has a short, fixed and reproducible incubation period is called “fixed virus Sources: it is prepared by repeated culture in brain of rabbit.
  9. 9. RESERVOIR OF INFECTIONRESERVOIR OF INFECTION 1) URBAN RABIES: From Dogs and cats.
  10. 10. 2)2) WILD LIFE RABIESWILD LIFE RABIES:: From jackals and foxes.From jackals and foxes.
  11. 11. 3)3) BAT RABIESBAT RABIES:: Vampire bats which live on the blood of animals andVampire bats which live on the blood of animals and men. These are one of the main causes of the death ofmen. These are one of the main causes of the death of bovine, around 0.5 to 1 million per year.bovine, around 0.5 to 1 million per year.
  12. 12. • History of Rabies Virus • Man described the disease in 2300 B.C. • The origin “rabhas”, meaning “to do violence” comes from ancient Indian Sanskrit dating 3000 B.C.
  13. 13. History of the Rabies VirusHistory of the Rabies Virus •Outbreak of rabies in Europe in 20th century spawned the Vampire myth- linked to bats. •Rabies epidemic in 13th century France. •Rabies is commonly spread by bats and wolves and other wildlife like foxes.
  14. 14. History of the Rabies VirusHistory of the Rabies Virus • Since Roman times, man established the link between the infectivity of a rabid dogs saliva and the spread of the disease. • Because there is no cure for rabies, those that had been bitten by a rabid dog would commonly commit suicide to avoid the painful death that would inevitably follow.
  15. 15. History of the Rabies VirusHistory of the Rabies Virus • Louis Pasteur was the first person to diagnose that rabies targeted the CNS. • Also determined that nervous tissue of an infected human or animal also contained the virus. • In 1890 created the rabies vaccine and saved 9 year old Joseph Meister after he had been bit by a rabid dog.
  16. 16. EpidemiologyEpidemiology 87 countries contain Rabies, but more cases are reported in Asia. In Indo-Pakistan rabies is a major public health problem mainly due to presence of a large no: of stray dogs. More than 30,000 people died of Rabies every year in Asia. Every year 10 million people require treatment and protection from Rabies which is great Financial loss.
  17. 17. • Estimated Annual Human Rabies Cases 2005 • North America 4 - 8 • Europe 10 - 20 • Latin America 200 - 400 • Africa 500 - 1,000 • Asia 30,000 - 40,000
  18. 18. • FREE RABIES ZONE: • Australia, • China, • Iceland, • Ireland, • Japan, • New Zealand etc
  19. 19. • INCUBATION PERIOD: • normally it is 3 - 8 wks • may be short that is 4 days • or may be prolonged for years.
  20. 20. PATHOGENESISPATHOGENESIS
  21. 21. CLINICAL PICTURECLINICAL PICTURE 1. Prodromal symptoms Headache, malaise, sore throat, low fever, pain at the site of bite 2. Excitation Symptoms sensory sys: involvement Aero phobia, excitation of N.S. Motor sys: inv: increase reflexes, muscle spasm, Symp:inv: dilatation of Pupils. increase perspiration, salivation, and Lacrimation, Mental changes: fear of death, anger, irritability and depression
  22. 22. Hydrophobia ( Fear of water) sight or sound of water may produce spasm the duration of illness is 2-3 days may be prolonged to 5-6 days Stage of paralysis & coma DEATH / Recovery
  23. 23. (summary(summary)) Transmission of RabiesTransmission of Rabies Cl:PictureCl:Picture • The rabies infection and the symptoms that accompany it is classified by five stages: 1. Incubation (1-3 months) 2. Prodromal, where first symptoms occur 3. Acute neurological phase 4. Coma 5. Death or recovery
  24. 24. DIAGNOSISDIAGNOSIS 1. History 2. Sign and symptom 3. Examination 4. Detection of Antigen by taking Skin Biopsy using Immunofluorescence by virus isolation from Saliva & other secretions.
  25. 25. Control MeasuresControl Measures • Notification • Isolation • Disinfection • Immunization
  26. 26. Prevention of human rabiesPrevention of human rabies post Exposure prophylaxispost Exposure prophylaxis 1. General consideration:- Aim is to neutralize virus before entering CNS 2. LOCAL WOUND TREATMENT a, Cleansing of wound(soap & water) b, Chemical treatment: • Either Alcohol 400-700 ml /liter • Tincture Iodine • No more treatment with Ammonium compound • No Carbolic acid and Nitric acid as it leave very bad scar
  27. 27. c, Suturing d, Anti Rabies Serum e, Antibiotic and ATS f, Observe the animal for 10 days
  28. 28. • 3, Immunization • 1,NERVOUS TISSUE VACCINE (NTV 2, Human diploid cell vaccine (HDCV)
  29. 29. Vaccines for immunizationVaccines for immunization Definition: it is fluid or dried preparation of Rabies “Fixed” virus grown in the Neural tissue of Rabbits, Sheep, Goats, Mice or Rats OR in embryonated duck eggs OR in cell culture
  30. 30. Type of VaccineType of Vaccine NERVOUS TISSUE VACCINE (NTV) a. Derived from adult animal nervous tissue eg. Sheep b. Derived from suckling mouse brain Type: Killed viral vaccine Dose: 2.5 ml S/C (Ant. Abdominal wall) Schedule: 14 doses
  31. 31. Type of Vaccine (conti)Type of Vaccine (conti) Duck Embryo Vaccine (DEV) Type: Killed viral vaccine Dose: 1 ml S/C ( Ant. Abdominal wall) Schedule: 14 doses OD not available in Pakistan
  32. 32. Type of Vaccine (conti)Type of Vaccine (conti) CELL CULTURE VACCINES a. Human diploid cell vaccine (HDCV) b. Second generation tissue culture vaccine (non- Human) Type: Killed viral vaccine Dose: 1 ml IM Schedule: on 0, 3, 7, 14, 28 day, booster on day 90
  33. 33. PASSIVE IMMUNIZATIONPASSIVE IMMUNIZATION • Horse Anti Rabies serum: 40 iu / kg at 0 day • Human rabies immunoglobin (HRIG): 20 iu / kg around the wound and rest in IM on 0 day • Booster doses are essential whenever anti rabies serum is given with the vaccine
  34. 34. Classification Of ExposuresClassification Of Exposures 1. Class I (slight Risk) 07 injection a. Licks on healthy unbroken skin. b. Scratches without oozing of blood. 2. Class II (Moderate Risk) according to the Schedule plus one booster dose after 3 week a. Licks on fresh cuts. b. Scratches with oozing of blood. c. All bites except those on head, neck, face, palms and fingers. d. Minor wounds less than 5 in number. 3. Class III (Severe Risk) according to the Schedule plus Two booster dose one after one week and another 2 week a. all bites or scratches with oozing of blood on neck, head, face, palms and fingers. b. Lacerated wounds on any part of the body. c. Multiple wounds 5 or more in number. d. Bites from wild animals.
  35. 35. IMMUNITYIMMUNITY • Duration of Immunity is upto 06 month • If again bite by rapid animal than dose according to blood titre if more than 0.5 i.u. / ml than only two dose 0, 3 day if less than 0.5 i.u. / ml than 0, 3, 7 day
  36. 36. General measuresGeneral measures • Regist:,licensing & taxation of dog. • Muzzling of dogs • Yearly mass vaccination of dog • Destruction of stray dogs • Facilities for diagnosis of rabies in dogs • Destruction of wildlife where the animals are known to be the reservoir of infection. • Publicity
  37. 37. Pre-Exposure Prophylaxis • It is done in persons who have high risk of repeated exposures. Animal Handlers Wildlife officers Veterinarians Lab: staff working with rabies virus Protected by:- Cell-culture vaccine 1ml I/M OR 0.1ml I/D ( 0,7& 28day) Post-exposure R/ of persons (who have been vaccinated previously) HDC vaccine (1ml I/M 0,3 & 7 day 0
  38. 38. Rabies in DogsRabies in Dogs • Incubation period: 3-8 wks. • Clinical features: Rabies in dogs may manifest itself in two forms. a. Furious Rabies. This the typical mad-dog syndrome characterized by. i. change in behavior. ii. Tendency to run away from home, wander aimlessly and biting humans and animals. iii. Change in voice due to paralisis of laryngeal muscles. iv. Excessive salivation & foaming at the angle of the mouth. v. Paralysis of the whole body leading to coma & death.
  39. 39. b. Dumb Rabies. i. The excitative or irritative stage is lacking. ii. The disease is predominantly paralytic. iii. Dog withdraws itself from being seen or disturbed. iv. It elapses into a stage of sleepiness and dies in about 3 days.
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