3 solid dosage forms
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3 solid dosage forms

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3 solid dosage forms 3 solid dosage forms Document Transcript

  • QUALITY CONTOL AND QUALITY ASSURANCEOF VETERNERY DOSAGE FORMS3- SOLID ORAL DOSAGE FORMS:3.1-TABLETS:Tablets are solid preparations each containing a single dose of one or more active ingredients andusually obtained by compressing uniform volume ofparticles, some are prepared by molding.They are usually prepared by the aid of somepharmaceutical excipients (additives) to:- help in tableting procedure.- ensure that the drug will be released as intended.The term tablet (from the Latin tabuletta) isassociated with the appearance of the dosage form i.e. tablets are small disc-like or cylindricalspecimens).{ N.B. In European Pharmacopoeia, tablets are called"compressi" which reflect themethod of preparation.}Most tablets are used for oral administration of drugs,others are administered sublingually,buccaly or vaginally.Advantages of tablets:In U.K. Tablets represents about 46% of all other dosage forms.1- Compared to liquid dosage formschemical and physical stability2- Packaging in blister packs can also enhance thestability of tablets.3- They provide ancontent variabilityN K B R COLLEGE OF PHARMACY AND RESEARCH CENTRE,MEERUT Page 25
  • QUALITY CONTOL AND QUALITY ASSURANCEOF VETERNERY DOSAGE FORMS4- Low manufacturing cost.5- Easy to package and ship.6- Simple to identify. (or stamped to aid tablet recognition7- Manufacturing processes and techniques can provide tablets special propertiesexample enteric coatingsformulations.Disadvantages of tablets as a dosage form:1- Poor bioavailability of poorly soluble drugs or poorly absorbable drugs.2- Some drugs may cause local irritation effect harm GI mucosa.3- Some drugs resist compression into tablet.4- Difficulty in swallowing in some patients; pediatrics and geriatrics.5- In emergency cases, intravenous or intramuscular injections are more effective.3.2-Classification of tablets:3.2A- According to drug release rate from the ta classification):a- Immediate release (Conventional) tablet.b- Modified release tablet (Extended and Delayed release tablet).3.2B- According to method of manufacturing:a- Compressed tablet.b- Molded tablet. forms, tablets possess accurately measured dose andof the unit dose.Coatings can be colored recognition)3.2A- According to drug release rate from the tablet (USP classification):a- Immediate release (Conventional) tablet:The tablet is intended to be released rapidly afteradministration, or the tablet is dissolved and administered as solution. It is the most commontype and includes:N K B R COLLEGE OF PHARMACY AND RESEARCH CENTRE,MEERUT Page 26
  • QUALITY CONTOL AND QUALITY ASSURANCEOF VETERNERY DOSAGE FORMS • Disintegrating tablet • Chewable tablet • Sublingual tablet • Buccal tablet • Effervescent tabletb- Modified-release tablet:They have release features based on; time, course or location. They must be swallowed intact.Modified-release tablet1-Extended-release tablet 2- Delayed-release tabletDrug release is delayed due to physiological conditions e.g. pH (a lag period followed by normalrelease). The best example is enteric coatedtablets; the drug is released in the upper part of the small intestine after which the preparation haspassed the stomach.If the drug is sensitive to acid, or is irritant to the stomach lining, anentericcoating can be used.Allowing the reduction in dosing frequency.3.2B- According to method of manufacturing:a- Compressed tablet:It is obtained by compressing uniform volume of particles using "Tablet compression machine".Its used for large scale production.Tablet compression machineN K B R COLLEGE OF PHARMACY AND RESEARCH CENTRE,MEERUT Page 27
  • QUALITY CONTOL AND QUALITY ASSURANCEOF VETERNERY DOSAGE FORMSb- Molded tablet:Molding means shaping and hardening of semi-solid mixture of drug and excipients. It isobtained using "tablet mold". It is restricted for small-dose tablet and small-scale production. Tablet moldN K B R COLLEGE OF PHARMACY AND RESEARCH CENTRE,MEERUT Page 28