Milano 16 luglio 2009
   Palazzo Besana
   ore 18.30


    Il futuro
      delle
cellule staminali

      CarloAlberto Red...
Diagramma di Valentin Häcker (1892)
con cellule staminali nell’embrione di Cyclops
Diagramma di Artur Pappenheim (1905)
per illustrare la ematopoiesi
Stem cell basic biology
Crescita e differenziamento

     neonato



           sviluppo                         adulto
          embrionale

    ...
Lialm Donaldson report, June 2000
SCAFFOLDS, CELLULE STAMINALI E
 BIOREATTORI PER LA PRODUZIONE DI
 TESSUTO OSSEO BIOINGEGNERIZZATO
F. Benazzo and the compo...
Punched Titanium



                                SEM 50 X




Anti-osteocalcin          SEM 450 X
surviving graft 10 ye ars after transplantation
 of human fetal dopamine neurons to the right
                    striatum...
1   106
!! Cytoplast !!




!! Cytoplast !!
TELOMERE’ LENGTH AT DIFFERENT TIME
       POINTS OF EXPANSION

WEEKS OF   KMESF    Kb
CULTURE

 0         17.7    8.8
+2  ...
retrotransfections (stemness & oncogenes)
Yamanaka and coworkers (2006/07): ≈1 on 5,000            ≈ 0.02%
Thomson and cow...
! ! !
biotechnology
stem cells
   cloning
NO
stem cells
objections to reproductive
         biotech




   We should not play God
HeLa cells
                        HeLa cells should be given the new species
                        name of Helacyton ga...
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
Darwin 1809-2009 Carlo Alberto Redi
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Darwin 1809-2009 Carlo Alberto Redi

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Conferenza di Carlo Alberto Redi "Il futuro delle cellule staminali" in occasione della Mostra Darwin 1809-2009

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Darwin 1809-2009 Carlo Alberto Redi

  1. 1. Milano 16 luglio 2009 Palazzo Besana ore 18.30 Il futuro delle cellule staminali CarloAlberto Redi Accademia dei Lincei Università degli Studi di Pavia Fondazione IRCCS Policlinico San Matteo - Pavia c.redi@smatteo.pv.it
  2. 2. Diagramma di Valentin Häcker (1892) con cellule staminali nell’embrione di Cyclops
  3. 3. Diagramma di Artur Pappenheim (1905) per illustrare la ematopoiesi
  4. 4. Stem cell basic biology
  5. 5. Crescita e differenziamento neonato sviluppo adulto embrionale zigote meiosi meiosi sperm fecondazione oocita
  6. 6. Lialm Donaldson report, June 2000
  7. 7. SCAFFOLDS, CELLULE STAMINALI E BIOREATTORI PER LA PRODUZIONE DI TESSUTO OSSEO BIOINGEGNERIZZATO F. Benazzo and the components of CIT
  8. 8. Punched Titanium SEM 50 X Anti-osteocalcin SEM 450 X
  9. 9. surviving graft 10 ye ars after transplantation of human fetal dopamine neurons to the right striatum Positron emission tomography scan Olle Lindvall, “Stem cell transplantation” Variazione della captazione di 18F- fluorodopa nei cervelli di pazienti con malattia di Parkinson dopo trapianto, dimostrato dall‘esame PET
  10. 10. 1 106
  11. 11. !! Cytoplast !! !! Cytoplast !!
  12. 12. TELOMERE’ LENGTH AT DIFFERENT TIME POINTS OF EXPANSION WEEKS OF KMESF Kb CULTURE 0 17.7 8.8 +2 21.1 10.4 +4 20.7 10.2 +5 18.6 9.8 +6 18.4 9.1 (FLOW-FISH)
  13. 13. retrotransfections (stemness & oncogenes) Yamanaka and coworkers (2006/07): ≈1 on 5,000 ≈ 0.02% Thomson and coworkers (2007): ≈ 1 on 10,000 ≈ 0.01% cytoplasts (insulinoma & stem cell extracts) Collas and coworkers (2004): ≈1 on 2 ≈ 50% Redi and coworkers (2007): ≈ 1 on 3,000 ≈ 0.03%
  14. 14. ! ! ! biotechnology stem cells cloning
  15. 15. NO stem cells
  16. 16. objections to reproductive biotech We should not play God
  17. 17. HeLa cells HeLa cells should be given the new species name of Helacyton gartleri. The cells are a genetic chimera of HPV18 and human cervical cells and now have a distinct, stable, non-human chromosome number. HeLa cells since 1951 self-replicating used in thousands biol exp Henrietta Lacks contribution to medicine 1920 - 1951 HeLa cells HeLa cancer cells have evolved into a self-replicating, single-cell life-form.

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