Elizabeth Iorns - How Science Exchange promotes Open Science

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Presentation by Science Exchange CEO Elizabeth Iorns at the Oxbridge Biotech Roundtable on "The Emerging Field of Open Science"

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  • Elizabeth Iorns - How Science Exchange promotes Open Science

    1. 1. Elizabeth Iorns, Ph.D. Co-Founder & CEO
    2. 2. What is Science Exchange?Science Exchange is a marketplace forscientists to list, discover, and accessscientific services from any institution inthe world. COMPANY VITALS COMPANY METRICS Inception: May 2011 +800 experiment types Headquar ters: Palo Alto, CA +1,000 providers Investors: Andreessen Horowitz, angel investors +250,000 visits
    3. 3. What is Science Exchange?Science Exchange provides open accessto specialized research infrastructure andexper tise at top research institutionsCurrently >1,000 providers from >200 US research institutions Sample facilities
    4. 4. How Science Exchange works!   1 Search for an experiment type. ! Search for a scientific service, by experiment type. Over 800 different services currently listed.
    5. 5. How Science Exchange works!   2 Choose a service provider. ! Compare service offerings from more than 1000 core facilities. Pricing information and ability to filter by location is provided
    6. 6. How Science Exchange works!   3 Submit a service request. ! Request an estimate from your chosen facility.
    7. 7. How Science Exchange works!   4 Accept a service quote. ! Get notified of service offerings via email, and our online system. Accept an estimate from your chosen provider.
    8. 8. How Science Exchange works!   5 Communicate with your provider. ! Receive updates, ask questions, exchange data. Easy payment via Science Exchange, an approved vendor within university purchasing systems.
    9. 9. OUNT E AC C o m UR FRE hange .c T E YO c e e x cCREA //scienAT http:
    10. 10. So what does this have to do with Open Science?
    11. 11. Some key goals of Open Science➡ Transparency➡ Access➡ Efficiency➡ Reproducibility
    12. 12. Some key goals of Open Science➡ Transparency ✔➡ Access ✔➡ Efficiency ✔➡ Reproducibility ✔
    13. 13. Some key goals of Open Science➡ Transparency ✔➡ Access ✔➡ Efficiency ✔➡ Reproducibility ✔
    14. 14. TransparencyPrices vary dramatically for the same serviceAverage difference of 74% from highest-priced to lowest-pricedprovider on Science Exchange:➡ DNA Sequencing: prices range from $3 per sample to >$12 per sample➡ Mass spectrometr y: $50 per sample to $350 per sample➡ Microarray analysis: $180 per sample to $700 per sample➡ Bioinformatics analysis: prices range from $60 per hr to $150 per hour
    15. 15. Transparency $500 $1,00 $1,50 $2,00 $2,50 $3,00 $3,50 $4,00 0 0 0 0 0 0 0SNP Array for GWASNGS library generationNGS paired end HiSeq 2000Sanger DNA sequencingIllumina microarrayAffymetrix microarrayBioinformaticsIHC of tissue sectionsTransgenic mouse production
    16. 16. Transparency “BY USING SCIENCE EXCHANGE WE WERE ABLE TO SAVE HALF THE COST ON THIS PARTICULAR TYPE OF EXPERIMENT”
    17. 17. Some key goals of Open Science➡ Transparency ✔➡ Access ✔➡ Efficiency ✔➡ Reproducibility ✔
    18. 18. Access
    19. 19. Access You can outsource pretty much any type of experiment:production of viruses fortransduction experiments acquisition of tissue for studies on clinicalgeneration of stable cell lines samples generation of transgenic miceprotein
    20. 20.  production
    21. 21.   conduction of animal studies including xenograft studies behavioral studies and neurological studies etc etc etc...
    22. 22. Some key goals of Open Science➡ Transparency ✔➡ Access ✔➡ Efficiency ✔➡ Reproducibility ✔
    23. 23. EfficiencyFor most experiments there are true specialistswho are better and cheaper than other options(e.g. DIY)
    24. 24. Efficiency Bill fo PCR pr DIY TA c roduc loning ts of TOPO rxn)... TA clonin .......... g .......... kit (20 $31 PCR ( .......$4 100 rx 60 n)...... Ligase ........$ (30 rx 78 vs. n)...... Comp ........$ 99 rxn)... etent cells .......... (10 .......... Minip .......$2 rep ki 17 rxn)... .......... t (50 per rxn .......... Restri .........$ ction 84 (100u l)....... enzyme .......... Agaro .......... Ethid etc, et se gel ium b (50g). .......$2 $53 65 outsourced c.... romide etc, etc, Total cost... .......... Total ..$1,00 cost (p 0’s er rxn .......... ) .......... .......... ......$ 5 5
    25. 25. EfficiencyScience Exchange was established to improve theefficiency of scientific researchWe believe scientific specialization is essential for efficiency:➡ no single scientist can master all techniques or purchase all equipment➡ no single university can provide all core facilities = a marketplace for core facilities
    26. 26. EfficiencyScience Exchange promotes open access to expertprovidersImproves collaboration with experts at core facilities CROs:➡ No requirement to purchase duplicate equipment➡ No need to learn highly specialized one-off techniquesProvides one central, efficient solution:➡ Ensures researchers know where to go➡ Tracks usage efficiency of research spending as an important metric
    27. 27. Some key goals of Open Science➡ Transparency ✔➡ Access ✔➡ Efficiency ✔➡ Reproducibility ✔
    28. 28. ReproducibilityQuality of academic research is under scrutiny:➡ ~80% of academic studies1,2,3 reported not reproducible➡ 10x increase in retracted publications over past decadeImplications for quality:➡ Lack of academic reproducibility results in lack of new therapies➡ Bayer halted 65% of target validation projects in 2011➡ Drug development estimated at ~$4B per NME1. Drug development: Raise standards for preclinical cancer research. Begley CG, Ellis LM. Nature. 2012; 483(7391):531-3.2. Reliability of new drug target claims called into question. Mullard A. Nat Rev Drug Discov. 2011; 10(9):643-4.3. Claims of sex differences: an empirical assessment in genetic associations. Patsopoulos NA, Tatsioni A, Ioannidis JP. JAMA. 2007; 298(8):880-93.
    29. 29. Reproducibility solutionUse specialists to enhance the quality of researchDistribute research among multiple sites➡ prevents single investigator biasReplicate key data at independent sites➡ reward high quality reproducible research
    30. 30. What does Science Exchange meanfor your research?➡ Increased speed➡ Decreased cost➡ Better quality
    31. 31. elizabeth@scienceexchange.com Twitter @elizabethiorns

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