«Yissum Introduces a Novel  Method for Treating CancerBased on a Protein Encoded by            HIV-1» «DNA repair gene inv...
FOR CANCER                     TREATMENT                  new findings by The Garvan Institute of    Research and developm...
DNA gene repair involved in        tumoursMGMT (gene)                  a biomarker of                  response to        ...
DNA gene repair involved in        tumoursMGMT (gene)                               In          expressed                 ...
DNA gene repair involved in        tumours    TUMOURS with low levels of    MGMT are more agressive but    also tend to re...
DNA gene repair involved in        tumours     Loss of MGMT expression may     contribute to the progressive     accumulat...
DNA gene repair involved in        tumours      ONAL PERS OP INION  Knowing genes involved in cancer ,  finding a cure is ...
Yissum Introduces a Novel Method   for Treating Cancer Based on a      Protein Encoded by HIV-1       ViF         (HIV-1  ...
Yissum Introduces a Novel Method  for Treating Cancer Based on a     Protein Encoded by HIV-1   Vif- derived peptide   pre...
Yissum Introduces a Novel Method  for Treating Cancer Based on a     Protein Encoded by HIV-1       The novel Vif peptide ...
Yissum Introduces a Novel Method  for Treating Cancer Based on a     Protein Encoded by HIV-1       An elevated DNA break-...
Yissum Introduces a Novel Method  for Treating Cancer Based on a     Protein Encoded by HIV-1        ONAL   PERS   OP INIO...
TI L I TY           CA LU    E DIM           Cancer is the second leading cause of            death in the world. Because ...
TI L I TY           CA LU    E DIM            The first steps in every investigation             stimulates investigator t...
TI L I TY           CA LU    E DIM             Discover genes that are expressed             in different kind of cancer h...
TI L I TY           CA LU    E DIM             The treatment with proteins             with no know essential             ...
BIBLIOGRAPHYDNA repair gene involved in tumours(sciencealert, 30 JULY 2012 ) Yissum Introduces a Novel Method for Treating...
Plegablemolecular2012
Plegablemolecular2012
Plegablemolecular2012
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Plegablemolecular2012

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2012

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Plegablemolecular2012

  1. 1. «Yissum Introduces a Novel Method for Treating CancerBased on a Protein Encoded by HIV-1» «DNA repair gene involved in tumours» Sara Sofia Buelvas Londoño Medical Student III Semester Molecular Biology- Lina Martinez S. August 12th 2012 UPB.
  2. 2. FOR CANCER TREATMENT new findings by The Garvan Institute of Research and development Medical research Company of the Hebrew University of Jerusalem consist consistExpression levels of DNA repair gene ViF: a isolated protein (MGMT) may play a from HIV-1 can be use significant role in to increase thetumour progression sensitivity of cancer and indicates cells to radiotherapy resistance to and chemotherapy chemotherapy
  3. 3. DNA gene repair involved in tumoursMGMT (gene) a biomarker of response to temozolomide, a chemotherapeutic agent. may also play a significant role in tumour progression
  4. 4. DNA gene repair involved in tumoursMGMT (gene) In expressed different in pituitary levels tumours. HIG LOW H
  5. 5. DNA gene repair involved in tumours TUMOURS with low levels of MGMT are more agressive but also tend to respond to chemotherapy because the gene can’t no longer undo the damage caused by the drug-
  6. 6. DNA gene repair involved in tumours Loss of MGMT expression may contribute to the progressive accumulation of genetic mutations and cellular proliferation that occurs.
  7. 7. DNA gene repair involved in tumours ONAL PERS OP INION Knowing genes involved in cancer , finding a cure is easier and kwowing the response that some cancers have is veryhelpful to give a determinated kind of treatment.
  8. 8. Yissum Introduces a Novel Method for Treating Cancer Based on a Protein Encoded by HIV-1 ViF (HIV-1 protein) inhibits DNA repair specifically in activatedsmall peptide hematopoietic cellsderived from the following exposure toHIV-1 Vif protein ionizing radiation. rendering them more susceptible to radiotherapy and chemotherapy.
  9. 9. Yissum Introduces a Novel Method for Treating Cancer Based on a Protein Encoded by HIV-1 Vif- derived peptide prevents DNA repair by inhibiting a protein : A3G responsible for anti- viral innate immunity and also plays a role in DNA repair in lymphoid and myeloid malignancies.
  10. 10. Yissum Introduces a Novel Method for Treating Cancer Based on a Protein Encoded by HIV-1 The novel Vif peptide has already been shown to significantly increase the efficiency of radiation therapy in cultured lymphoma and myeloma cells beacause the inhibition of the protein don’t let the cells being repair.
  11. 11. Yissum Introduces a Novel Method for Treating Cancer Based on a Protein Encoded by HIV-1 An elevated DNA break-repair capacity in several cancer cells often leads to radiation resistance and severely limits the efficacy of radiation treatment and chemotherapy, for this reason is important the novel method of repair inhibition.
  12. 12. Yissum Introduces a Novel Method for Treating Cancer Based on a Protein Encoded by HIV-1 ONAL PERS OP INION This study is a new oportunity for the management of cancer, it gives another perspective for the treatment and a very big advance in the search of the cancer cure.
  13. 13. TI L I TY CA LU E DIM Cancer is the second leading cause of death in the world. Because of that the knowledge of all the components is really important for the management of the desease.
  14. 14. TI L I TY CA LU E DIM The first steps in every investigation stimulates investigator to continue researching and find results usefull to the humanity, so this novel methods can be improved for the human benefit.
  15. 15. TI L I TY CA LU E DIM Discover genes that are expressed in different kind of cancer helps to know what treatment is more effective or view if the cells have an adecuate response to the chemotherapy
  16. 16. TI L I TY CA LU E DIM The treatment with proteins with no know essential functions involving normal cell physiology may have minimal side effects, a very important fact for the patients .
  17. 17. BIBLIOGRAPHYDNA repair gene involved in tumours(sciencealert, 30 JULY 2012 ) Yissum Introduces a Novel Method for Treating Cancer Based on a ProteinEncoded by HIV-1 (marketwatch, 9 JULY 2012) MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB.Fac. de Medicina, 2006. 208 p.

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