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Liver cirrhosis

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  • 1. Presented By: Mohammed Sadriwala Mayur Gupta Mayur Tayade Submitted To:
  • 2. What is Cirrhosis?  Cirrhosis is a slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs, and naturally produced toxins. It also slows the production of proteins and other substances made by the liver.  According to the National Institutes of Health, cirrhosis is the 12th leading cause of death by disease.
  • 3. Causes  Fatty liver associated with obesity and diabetes.  Chronic viral infections of the liver (hepatitis types B, C, and D; Hepatitis D is extremely rare).  Blockage of the bile duct.  Repeated bouts of heart failure with fluid backing up into the liver.
  • 4. Symptoms Early symptoms include:  Fatigue and loss of energy  Poor appetite and weight loss  Nausea or belly pain  Small, red spider-like blood vessels on the skin As liver function worsens, symptoms may include:  Fluid buildup of the legs (edema) and in the abdomen (ascites)  Yellow color in the skin, mucus membranes, or eyes (jaundice)  Redness on the palms of the hands  Confusion or problems thinking  Small, red spider-like blood vessels on the skin
  • 5. Test & Diagnosis Tests to measure liver function:  Complete blood count  Prothrombin time  Liver function tests  Blood albumin level Other tests to check for liver damage include:  Computed tomography (CT) of the abdomen  Magnetic resonance imaging (MRI) of the abdomen  Endoscopy to check for abnormal veins in the esophagus or stomach  Ultrasound of the abdomen  You will need a liver biopsy to confirm the diagnosis.
  • 6. Treatment 1. PREVENTING FURTHER DAMAGE TO LIVER:  Consume balance diet  Multivitamin  Patient with PBC need additional Vit.D and Vit.K  Avoid alcohol containing drugs  Avoid NSAIDS like Ibuprofen.  In case of Hepatitis B or C induced Cirrhosis antiviral medication are given.  In autoimmune Hepatitis, Prednisone is given.  For the treatment of Portal Hypertension E.g. : UDCA ( Ursodeoxycholic Acid) Beta 2 Blockers (Propranolol with Isosorbide )
  • 7. 2) TREATING THE COMPLICATIONS OF LEVER CIRRHOSIS:  Edema and Ascites: For the treatment of Edema and Ascites DIURETIC drugs are used. E.g.- Spirinolactone Furosemide. * Too much diuretics use may lead to Kidney dysfunction. 3) PREVETION OF LEVER CANCER:  Ultrasound examination of Lever is suggested after every 6 months.  Measurement of cancer produced protein E.g.- Alpha fetoprotein in blood. 4) LEVER TRANSPLANT.
  • 8. Preventation There are several ways to reduce your risk of developing cirrhosis of the liver:  Don't abuse alcohol.  Be careful around synthetic chemicals, such as cleaning products and pesticides. If you come into contact with chemicals often, wear protective clothing and a facemask.  Get vaccinated against hepatitis B.  Eat a well-balanced, low-fat diet and take vitamins.