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Genes Linked To Spread Of Breast Cancer
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Genes Linked To Spread Of Breast Cancer

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  • 1. Breast Cancer Facts • One in eight women or 12.6% of all women will get breast cancer in her lifetime. • Breast cancer risk increases with age and every woman is at risk.
  • 2. Facts (cont.) • Every 13 minutes a woman dies of breast cancer. • Seventy-seven percent of women with breast cancer are over 50.
  • 3. Facts (cont.) • Previous research found that COX2 and HB-EGF are involved in the spread of breast cancer to the lungs. The new finding, that the genes also play a role in its spread to the brain, might explain the association of brain and lung relapse in breast cancer patients, the researchers said.
  • 4. Risks of getting Breast Cancer • Risks for breast cancer include family history, atypical hyperplasia, delaying pregnancy until age 30 of never becoming pregnant, early menstruation (before age 12), late menopause (after age 55), current use or use in the last ten years of oral contraceptives, and daily consumption of alcohol.
  • 5. Causes • Smoking may lead to breast cancer • Race may be a factor. More white woman get it than African-American • If you recently use birth control pills you may have a higher risk.
  • 6. Causes (Cont.) • Not breast feeding • Being over weight or obese • Lack of exercise
  • 7. When and How • The spread, or metastasis, of breast cancer to the brain typically occurs years after a breast tumor has been removed. Experts say this suggests that the cancer cells initially lack the ability to penetrate the blood-brain barrier, which prevents the entry of circulating cells and regulates the transport of molecules into the brain tissue.
  • 8. Research • Three genes linked to the spread of breast cancer to the brain have been identified by U.S. researchers. • New study found that two genes COX2 and HB- EGF are prime breast cancer cells for entrance into the brain. • Another gene, ST6GALNAC5– which is normally active in brain tissue– causes a chemical reaction that creates a coating on the surface of breast cancer cells that enhances their ability to breach the blood-brain barrier.
  • 9. Resources • http://www.cancer.org/docroot/CRI/content/ CRI_2_2_2X_What_causes_breast_cancer_5.a sp • http://news.yahoo.com/s/hsn/20090507/hl_h sn/geneslinkedtospreadofbreastcancer;_ylt=A mjeENlBTiHNmQWURQH.KQCJhMgF • http://womenshealth.about.com/cs/breastca ncer/a/breastcancfacts.htm