Genes Linked To Spread Of Breast CancerPresentation Transcript
Breast Cancer Facts
• One in eight women or 12.6% of all women
will get breast cancer in her lifetime.
• Breast cancer risk increases with age
and every woman is at risk.
• Every 13 minutes a woman dies of breast
• Seventy-seven percent of women with
breast cancer are over 50.
• Previous research found that COX2 and
HB-EGF are involved in the spread of
breast cancer to the lungs. The new
finding, that the genes also play a role
in its spread to the brain, might explain
the association of brain and lung relapse
in breast cancer patients, the
Risks of getting Breast
• Risks for breast cancer include family
history, atypical hyperplasia, delaying
pregnancy until age 30 of never
becoming pregnant, early menstruation
(before age 12), late menopause (after
age 55), current use or use in the last
ten years of oral contraceptives, and
daily consumption of alcohol.
• Smoking may lead to breast cancer
• Race may be a factor. More white
woman get it than African-American
• If you recently use birth control pills
you may have a higher risk.
• Not breast
• Being over
weight or obese
• Lack of exercise
When and How
• The spread, or metastasis, of breast
cancer to the brain typically occurs
years after a breast tumor has been
removed. Experts say this suggests that
the cancer cells initially lack the ability
to penetrate the blood-brain
barrier, which prevents the entry of
circulating cells and regulates the
transport of molecules into the brain
• Three genes linked to the spread of breast
cancer to the brain have been identified by
• New study found that two genes COX2 and HB-
EGF are prime breast cancer cells for entrance
into the brain.
• Another gene, ST6GALNAC5– which is normally
active in brain tissue– causes a chemical
reaction that creates a coating on the surface
of breast cancer cells that enhances their
ability to breach the blood-brain barrier.