Bind to nuclear peroxisome proliferator-activating receptors (PPARs) involved in transcription of insulin responsive genes sensitization of tissues to insulin, plus in hepatic gluconeogenesis and triglycerides and insulin receptor numbers
Adverse effects: less hypoglycemia than sulfonylureas, but weight gain and edema reported
Adverse effects are nausea (about 44% of users) and vomiting and diarrhea. The nausea decreases with ongoing exenatide usage
Weight loss is reported in some users, presumably because of the nausea and anorectic effects. A serious and, in some cases, fatal adverse effect of exenatide is necrotizing and hemorrhagic pancreatitis.