Junhua Yan

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Junhua Yan

  1. 1. Junhua Yan Apt. 819, 222 ELM ST., Toronto, ON M5T 1K5 416-616-8687(Cell) yan_junhua@yahoo.com OBJECTIVE Seeking a development chemical software position that can best utilize my over ten years of experience in Organic Chemistry, Analytical Chemistry and Software Programming. EMPLOYMENT EXPERIENCE Chief of Senior Research Scientist (2004 – 2005) Beijing Pharmacy Tech. CO., Ltd., Beijing, CHINA Primary Responsibilities: • Led a group to synthesize zolmitriptan with new synthesis route to improve its overall yield and purity. The target compound has been on scales of up to 1Kg. • Designed a new synthesis route to synthesize resveratrol (trans-3,4',5-trihydroxystilbene). The starting materials and chemical reagents were very cheap and no tough experiment condition was needed. • Modified the structure of known medicine which was extracted from Chinese plant and had lower water dissolution. A modified compound had very good dissolution in water and its activity was better than the original from the animal experiment. • Led the Department of Organic Synthesis and made a technique decision for the company. Research Assistant (2003 - 2004) College of Pharmacy, University of Michigan, Ann Arbor, Michigan Primary Responsibilities: • Synthesized some phosphate compounds to study the mechanism of enzyme reaction with biological methods. • Established and maintained the inventory of chemicals in the lab with the software FileMaker Pro 6.0. • Organized the laboratory and maintained some instruments. Research Assistant (2001 - 2002) College of Pharmacy, Ohio State University, Columbus, Ohio 1
  2. 2. Primary Responsibilities: • Synthesized a series of boron compounds as potential Boron Neutron Capture Therapy (BNCT) agents. • Developed software Isotope Pattern Calculator 4.0, which is most popular software among same function software. Please check it on http://www.geocities.com/junhuayan/pattern.htm • Established the database of hundreds of compounds synthesized in the lab with the software ISIS/BASE. • Maintained instruments in the lab to keep them to work well. Senior Software Developer (1998 – 2000) China Financial Information Technology Company, Ltd, Beijing, China Primary Responsibilities: • Designed and developed the Database System of Querying and Administrating Chemical Reagents with ASP(VBScript & JavaScript). • Designed and developed the Office-Auto Information System for China Financial Information Technology Company, Ltd with Lotus Notes 4.6.1. • Designed and developed the Office-Auto Information System for General Office of Ministry of Finance, China with Lotus Notes R5. • Designed and developed the Office-Auto Information System for the Finance Department of Caozhou, Guangdong Province, China with Lotus Notes R5. • Debugged and modified the Management of Finance and Accounting For Enterprise(SXKJ v3.2) with Power Builder 5.0. • Led a group to build MIS system and trained the administrators of Lotus Notes R5.0 and Microsoft Windows NT server 4.0. for Finance Department of Caozhou, Guangdong Province, China • Involved in developing the FOAS 2000 for Ministry of Finance of the People's Republic of China. • Mentored primary developers on Lotus Notes R5 and Powerbuilder. Research Associate (1992 – 1998) Beijing Institute of Pharmacology & Toxicology, Beijing, China Primary Responsibilities: • Designed and developed the Recording Time Smart, which could record and count the time everyone spent on browsing over the internet with Visual C++ 5.0 for the Beijing Institute of Pharmacology & Toxicology. • Designed and developed the Molecular Weight Calculator with Visual C++ 5.0. 2
  3. 3. • Designed and developed Molecular Weight Calculator for Combination Molecular Library with Visual C++ 5.0. • Designed and developed Database System of Querying and Administrating Chemical Reagents with Power Builder 6.5. • Designed and developed the System of Querying and Administrating Clients for the Centurywill Advertisement Company with Power Builder 6.5. • Responsible for software and hardware maintenance for Beijing Institute of Pharmacology & Toxicology and troubleshoot the office applications alongside network administration. • Gained experience in the usage and configuration of Microsoft Windows NT 4.0 (server & workstation), Lotus Notes 4.6, MS Office 97 Suite, Remote ISP access software, Internet Explorer 4.0, CS Chem Office 98(Chem3D, ChemFinder, ChemDraw), ISIS/Draw etc. • Designed and synthesized a series of heterocycle compounds as new potential detoxic. • Calculated the electric properties of heterocycle compounds with Computer Assisting Designing Pharmacy Technique on the SGI Graphic workstation. • Labeled some compounds with 3H by microwave labeling method. • Synthesized and labeled 3-(2-phenyl-2-cyclopentyl-2-hydroxyethoxy)[3-3H] quinuclidine and its derivatives. • Synthesized buspirone and its derivatives and labeled them with 2H successfully. • Led an organic synthesis group (4 persons). • Mentored postgraduate students the subject courses, 1H-NMR Spectrum, 13C-NMR Spectrum, Advanced Organic Chemistry. • Trained the staff in the Department of Organic Synthesis how to browse on the internet with Netscape Navigator and Microsoft Internet Explorer. Postgraduate (1989 – 1992) Beijing Institute of Pharmacology & Toxicology, Beijing, China Primary Responsibilities: • Designed and synthesized a series of diamino-dithiol(N2S2) complexes as new brain imaging agents. • Labeled diamino-dithiol(N2S2) complexes with 99 Tcm and got high labeling ratio and radioactive chemical purity. QUALIFICATIONS Computer: • Hardware IBM PC's 3
  4. 4. SGI Graphics Workstation Compaq 8000 series Windows NT server • O. S. MS Windows (NT 4.0, 95,98, Me, 2000 and XP) Linux MS DOS Novell • Languages C++ Java C SQL BASIC Java Script Lotus Script ASP VBscript HTML VBA for MS Word • GUI MS Visual C++ 4.2, 5.0, 6.0 Power Builder 5.0, 6.0, 6.5, 7.0 Lotus Notes 4.6.1, R5 Visual Basic 5.0, 6.0 • Database SQL Anywhere 5.0 dBase III,IV Microsoft SQL Server 6.5, 7.0 Microsoft Access 2.0 Microsoft Excel 5.0, 9x, 2000, 2003, XP Informix 7.0 • Tools Lotus Notes 4.6.1, 5.0 InstallShield Professional 5.0, 5.5 Microsoft Office 9x, 2K, 2003, XP Microsoft InterDev 6.0 Lotus 1-2-3 WordPerfect CS Chem Office 98, 2000, 2005 ISIS/Draw 4
  5. 5. Netscape Navigator (all versions) Internet Explorer (all versions) Opera (all versions) FrontPage 98 (all versions) Other: WinZip(all versions) Adobe PhotoShop(all versions) Cute FTP (all versions) WS FTP(all versions) • Methodology Design Patterns, OOP • Over 3 years experience developing software, administrating, troubleshooting and maintaining operating systems and hardware in a LAN and WAN environment. • A very strong studying ability. • Strong teamwork skills. Chemistry: • A strong background in organic chemistry and medicinal chemistry, including the ability to conduct multi-step synthesis sequences, chromatographic purification (Flash Column Chromatography, Preparative TLC,TLC) and spectral interpretations. • A strong experience in synthesizing and labeling compounds with radioisotopes and stable isotope. Such as 99Tcm, 3H and 2H. • A strong experience in laboratory skills, including knowledge of modern analytical instrument of UV spectrometer, IR spectrometer, GC-MS, HPLC and NMR etc. • Some skills in pharmacological experiments in vitro and in vivo. • Clear written and oral communication skills in English. • Ability to work effectively, independently and develop strong collaborative relationships with colleagues. EDUCATION 08/1989 - 07/1992 Beijing Institute of Pharmacology & Toxicology, China M.S. Medicine Chemistry, Graduation Date: 07/1992 09/1985 - 07/1989 5
  6. 6. JianXi Normal University, NanChang, JiangXi Province, China B.S. Chemistry, Graduation Date: 07/1989 HONOURS AND AWARDS • The second prize of Science Technique Progress Award in the Ministry of Public Health, China. 1998. • The second prize of Computer Intelligence Competition Award in the Academy of Medical Science, Beijing, China. 1997. MAIN PUBLICATIONS 1. Youngjoo Byun, Junhua Yan, Ashraf S. Al-Madhoun, Jayaseharan Johnsamuel, Weilian Yang, Rolf F. Barth, Staffan Eriksson and Werner Tjarks. Synthesis and Biological Evaluation of Neutral and Zwitterionic 3-Carboranyl Thymidine Analogues (3CTAs) for Boron Neutron Capture Therapy. J. Med. Chem., 2005, 48(4): 1188-1198. 2. Byun, Y.; Yan, J.; Al-Madhoun, A. S.; Johnsamuel, J.; Yang, W.;Barth, R. F.; Eriksson, S.; Tjarks, W. The synthesis and biochemical evaluation of thymidine analogues substituted with nido carborane at the N-3 position. Appl. Radiat. Isot. 2004, 61:1125-1130. 3. Jayaseharan Johnsamuel, Nisha Lakhi, Ashraf S. Al-Madhoun, Youngjoo Byun, Junhua Yan, Staffan Eriksson and Werner Tjarks. Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties. Bioorg. Med. Chem. 2004, 12 (18): 4769-4781. 4. Junhua Yan, Charlotta Naeslund, Ashraf S. Al-Madhoun, Werner Tjarks et al. Synthesis and Biological Evaluation of 3’-Carboranyl Thymidine Analogues. Bioorg. Med. Chem. Lett. 2002, 12 (16): 2209-2212. 5. Ashraf S. Al-Madhoun, Jayaseharan Johnsamuel, Junhua Yan, Weihua Ji, Jianghai Wang, Werner Tjarks, et al. Synthesis of a Small Library of 3-(Carboranylalkyl)thymidines and Their Biological Evaluation as Substrates for Human Thymidine Kinases 1 and 2. J. Med. Chem. 2002, 45(18): 4018-4028. 6. Sudimack, J.J.; Adams, D.; Rotaru, J.; Shukla, S.; Yan, J.; Sekido, M.; Barth, R.F.; Tjarks, W., et al. Folate Receptor-Mediated Liposomal Delivery of a Lipophilic Boron Agent to Tumor Cells in Vitro for Neutron Capture Therapy. Pharm. Res., 2002, 19(10): 1502-1508. 7. Yan Junhua, Li Deyou, Chen Lanfu, et al. Progress in development of diamino-dithiol complexes as brain imaging agent. Isotopes. 1998, 11(1): 56-66 99 8. Yan Junhua, Li Deyou, Chen Lanfu, et al. The Tcm-labeling of diamino-dithiol complexes as 6
  7. 7. brain imaging agents and preliminary bio-distribution. Isotopes. 1997, 10(2): 78-83 9. Li Deyou, Yan Junhua, Wu Liang, Chen Lanfu, et al. Preparation of 3-(2-phenyl-2-cyclopentyl-2- hydroxyethoxy)[3-3H]quinuclidine. Isotopes. 1996, 9(3): 151-153 10. Yan Junhua, Chen Lanfu, Li Deyou, et al. Synthesis of diamino-dithiol complexes as new brain imaging agents. Chinese Journal of Medicinal Chemistry. 1992, 2(4): 1-9 ABSTRACTS 1. A.S. Al-Madhoun, W. Ji, J. Johnsamuel, J. Yan, N. Lakhi, W. Tjarks, et al. The Biological Evaluation of a Small Library of 3-(Carboranylalkyl) thymidines as Substrates for Human Thymidine Kinases 1 and 2. Research and Development in Neutron Capture Therapy, Proceedings of the 10th International Congress on Neutron Capture Therapy. Essen, Germany, Septermber 8-13, 2002. 2. Yan Junhua, Chen Lanfu, Li Deyou, et al. Study of the methods of synthesizing and labeling diamino-dithiol complexes. The second National Conference of Labeling Compounds. Guiyang, China, Oct., 1992. REFERENCES Available upon request. 7

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