“ The current study was conducted to determine whether women of gestational diabetes mellitus (GDM) had any history of polycystic ovarian syndrome (PCOS) and its associated symptoms in comparison to the females having no gestational diabetes mellitus, so if women with polycystic ovarian syndrome are treated properly, incidence of development of gestational diabetes mellitus would likewise decrease.”
To compare sociodemographic and anthropometric profiles of women with gestational diabetes mellitus (GDM) to their controls.
To relate the occurrence of clinically diagnosed polycystic ovarian syndrome (PCOS) with gestational diabetes mellitus (GDM).
To describe gynecological profile of polycystic ovarian syndrome in women with gestational diabetes mellitus (GDM) and controls.
case control study
Prenatal care clinics of ABBASI SHAHEED and LADY DUFFERIN HOSPITAL.
140 pregnant ladies,
Cases of GDM = 35
controls = 105
3 months ( 28 th April to 30 th June 2008).
Diagnosis of GDM :
GDM was verified by serial blood glucose recording and latest OGTT .
Verification of PCOS
late menarche, prolonged menstrual cycle , obesity , acne , hair growth of male pattern and an ultrasound showing multiple cyst in ovaries.
Pregnancy, age ranges between 16 to 35 and low and middle socioeconomic group.
Women who had established diabetes mellitus before pregnancy.
Purposive non probability.
Socio-demographic, Anthropometric, Clinical , Obstetrical and
Statistical Analyses :
Using SPSS 13.0 version and Chi square test and T test were applied
COMPARISION OF AGES Age in Years
It was found that 51% of cases and 15% of controls had weight more than 74kg and it was estimated to be more than their expected weight for gestational period.
The mean weight gain of gestational diabetic ladies during same period of gestation was 10.2kg as compared to 6.7kg of controls showing a significant difference of <.000.
AMONG CASES Almost 51% of cases and 56% of controls belonged to lower middle socioeconomic status (p<0.761) SOCIOECONOMIC DISTRIBUTION 56.6 31.4 12.4 31.9 51.4 17.1 Upper middle Low Lower middle AMONG CONTROLS
Out of 35 cases,
22%(08) gave clinical history of PCOS.
46% had family history of diabetes.
49% were found to be obese.
Out of 105 controls,
4.7%(05) gave clinical history of PCOS.
6% had family history of diabetes.
19% were found to be obese.
OBSTETRICAL PROFILE OF CASES & CONTROLS
COMPARISON OF WEIGHT OF PREVIOUSLY DELIVERED CHILD
COMPARISON OF MISCARRAIGES No of miscarriages
GYNAECOLOGICAL PROFILE OF CASES & CONTROLS
AGE OF MENARCHE
Mean age of menarche
In cases=15 years
In controls=13 years
Mean age of menarche was found to be significantly higher (p<.004) among cases of GDM as compared to their controls.
22% of cases of GDM were proved to be suffering from PCOS in comparison to 4.6% of controls with Odds ratio of 5.92 GROUP OF PREGNANT LADIES TOTAL O.R CASES OF GDM CONTROLS WITH PCOS 8 5 13 5.92 WITHOUT PCOS 27 100 127 TOTAL 35 105 140
Gestational diabetes mellitus is 5.9 times more associated with clinically diagnosed polycystic ovarian syndrome as compared to their controls. Age of 30 and more along with obesity were found to be the covariates .”
It is also necessary to carry out different studies to high light other risk factors for GDM.
It is necessary to perform a prospective controlled study dealing with the risk of pathological pregnancies in women with PCOS.
Further studies regarding role of conservative treatment in management of PCOS for better pregnancy outcome, need to be conducted.
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