Learning Set 3: Lesson 1

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Learning Set 3: Lesson 1

  1. 1. Proteins Move Based on Size lactase tyrosinase Learning Set 3 : Lesson 1 : Slide 1
  2. 2. Analyzing LDL receptor A B C LDL receptor Why did these LDL receptor proteins move Normal LDL Receptors farther down the columns?George’s LDL Receptors Learning Set 3 : Lesson 1 : Slide 2
  3. 3. What Is The Difference Here?Sequence of amino acids in LDL receptor protein: Column A MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDC EDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDC KDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLV AQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTE VASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIV VDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVR ALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDV Column B VCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTL DRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADT KGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVN GGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQY LCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSH QALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLED DV Column C MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDC EDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDC KDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLV AQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTK Learning Set 3 : Lesson 1 : Slide 3
  4. 4. DNA Location Learning Set 3 : Lesson 2 : Slide 4
  5. 5. Chromosomes Learning Set 3 : Lesson 2 : Slide 5
  6. 6. Pieces to DNA Model6 T (Orange) 1 base 12 spacers 1 cap6 A (Blue) (light brown) (transparent) (white)6 G (Green)6 C (Yellow) 1 rod (grey) 2 side chains composed of alternating deoxyribose (red) and phosphate (purple) Learning Set 3 : Lesson 3 : Slide 6
  7. 7. DNA Base PairsGiven DNA Matching DNA Strand T G G C G C T G T G Learning Set 3 : Lesson 3 : Slide 7
  8. 8. Pieces to LDL Receptor Protein DNA Model Learning Set 3 : Lesson 3 : Slide 8
  9. 9. Marshmallow Color KeyMarshmallow Color Chemical BaseOrange Thymine (T)Pink Adenine (A)Green Guanine (G)Yellow Cytosine (C) Learning Set 3 : Lesson 3 : Slide 9
  10. 10. Step by Step PicturesStep #1: Learning Set 3 : Lesson 3 : Slide 10
  11. 11. Step by Step Pictures (cont.)Step #2: Learning Set 3: Lesson 3: Slide 11
  12. 12. Step by Step Pictures (cont.)Step #3: Learning Set 3 : Lesson 3 : Slide 12
  13. 13. Chromosomes to DNA to Genes How small is small? Learning Set 3 : Lesson 4 : Slide 13
  14. 14. From DNA to ProteinsTranscription -Translation Learning Set 3 : Lesson 4 : Slide 14
  15. 15. From DNA to Proteins 1Transcription & Translation Overview Learning Set 3 : Lesson 4 : Slide 15
  16. 16. Symbols for Transcription - Translation Models Learning Set 3 : Lesson 4 : Slide 16
  17. 17. DNA vs. RNADNA RNA Learning Set 3 : Lesson 4 : Slide 17
  18. 18. DNA vs mRNADNA RNA Learning Set 3 : Lesson 4 : Slide 18
  19. 19. From DNA to Proteins 2Transcription & Translation Interactive Modeling Learning Set 3 : Lesson 4 : Slide 19
  20. 20. Coding Amino Acids RNA amino acid Learning Set 3 : Lesson 4 : Slide 20
  21. 21. LDL Receptor Learning Set 3 : Lesson 4 : Slide 21
  22. 22. Where are our genes? Learning Set 3 : Lesson 4 : Slide 22
  23. 23. Location of LDL Receptor Gene Learning Set 3 : Lesson 4 : Slide 23
  24. 24. LDL Receptor GeneSegmentfocused onin class Learning Set 3 : Lesson 3 : Slide 24
  25. 25. Marshmallow DNA ModelAC C G C GACAC Learning Set 3 : Lesson 4 : Slide 25
  26. 26. RNA Marshmallow Color KeyMarshmallow Color Chemical BaseWhite Uracil (U)Pink Adenine (A)Green Guanine (G)Yellow Cytosine (C) Learning Set 3 : Lesson 4: Slide 26
  27. 27. Coding Amino Acids RNA amino acid Learning Set 3 : Lesson 4 : Slide 27
  28. 28. Reviewing George’s Symptoms Familial Hypercholesterolemia (FH)• Very high cholesterol in blood• Waxy patches on the skin• Chest pain and heart attacks at a young age• Build up of fatty deposits on under skin and in arteries Knees and Fingers Coronary Artery: a heart artery Fatty Deposit Fatty Deposit 28 Learning Set 3 : Lesson 5 : Slide 28
  29. 29. George’s Family History George Heart attack: 25y Learning Set 3 : Lesson 5 : Slide 29
  30. 30. Why George had a Heart Attack Fatty Deposits Cross Section of In Coronary Artery Coronary Artery Tear in Normal artery wallFattyDeposit Fatty Narrowed deposits artery made in blocked by artery blood clot wall • Fatty deposits made in artery wall, high blood pressure • Arteries harden and narrow due to fat accumulation • Blood flow is reduced • Oxygen supply to heart reduced • Can cause chest pain heart attack or death in severe cases 30 Learning Set 3 : Lesson 5 : Slide 30
  31. 31. Cholesterol: Many RolesCholesterol Estrogen Testosterone Bile Acids 31 Learning Set 3 : Lesson 5 : Slide 31
  32. 32. Low density lipoprotein (LDL) Receptorcholesterol Cholesterol in LDL LDL Receptor outside cell Plasma Membrane cell inside cell Takes LDL into cell nucleus 32 Learning Set 3 : Lesson 5 : Slide 32
  33. 33. Analyzing George’s LDL receptorA B C LDL receptor George’s LDL receptor 34 Learning Set 3 : Lesson 5: Slide 34
  34. 34. Why did Rachel look at George’s DNA?One of George’schromosomes,chromosome 19, hadan arrow pointing atone spot on it. Thisarrow indicatedsomething wasdifferent at this spoton chromosome 19. What does DNA have to do with the LDL receptor that causes FH disease? 35 Learning Set 3 : Lesson 5 : Slide 35
  35. 35. Analyzing the Family’s DNAGeorge 36 Learning Set 3 : Lesson 5 : Slide 36

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