CAS IB Biology 6.3 Defense Against Infectious Disease (Part 2)

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  • 1. Defense  Against  Infec.ous  Disease   Part  2   IB  Bio  12  
  • 2. Assessment  Statements Obj. 6.3.1 Define  pathogen.   1 6.3.2 Explain  why  an.bio.cs  are  effec.ve  against  bacteria  but  not  viruses.   3 6.3.3   Outline  the  role  of  skin  and  mucous  membranes  in  defense  against  pathogens.   2 6.3.4 Outline  how  phagocy.c  leucocytes  ingest  pathogens  in  the  blood  and  body  .ssues.   2 6.3.5 Dis6nguish  between  an#bodies  and  an#gens.   2 6.3.6 Explain  an.body  produc.on.   3 6.3.7 Outline  the  effects  of  HIV  on  the  immune  system.   2 6.3.8 Discuss  the  cause,  transmission  and  social  implica.ons  of  AIDS.   3 Command  terms:  hQp://i-­‐biology.net/ibdpbio/command-­‐terms/ Assessment  statements  from:  Online  IB  Biology  Subject  Guide
  • 3. 3  Main  Lines  of  Defense   1)  Physical  barriers   –  Skin,  mucous  membranes   2)  Non-­‐specific  immune  system   –  Phagocy.c  leukocytes   3)  An6gen-­‐specific  immune  system   –  Lymphocytes  (e.g.  B-­‐cells,  T-­‐cells,  Killer  cells)  
  • 4. An.bio.cs  are  ineffec.ve   against  viruses!   Over-­‐use  of  an.bio.cs  is  accelera.ng  the   evolu.on  of  more  harmful  bacteria.  We  are   running  out  of  an.bio.cs  that  work  and  are   selec.ng  for  diseases  such  as  MRSA.   h,p://www.youtube.com/watch?v=RedO6rLNQ2o An.bio.cs  are  designed  to  disrupt   structures  or  metabolic  pathways  in  bacteria   and  fungi:   •  cell  walls  and  membranes   •  DNA  synthesis  (replica.on)   •  RNA  polymerase   •  Transla.on     These  do  not  exist  or  are  very  different  in   viruses,  so  the  an.bio.c  will  have  no  effect.     Bacterial  drug  resisance,  from  Wiley  Essen#al  Biochemistry.  Find  out  more  here:   hQp://www.wiley.com/college/praQ/0471393878/student/ac.vi.es/bacterial_drug_resistance/index.html
  • 5. An.bio.cs  are  ineffec.ve   against  viruses!   Analyse  the  graph  below.  Over  .me,  outline   what  has  happened  to:   •  The  number  of  new  approved  an.bio.cs   •  The  diversity  of  new  approved  an.bio.cs     Suggest  reasons  for  your  answers.  Use  the  graph  to   write  your  own  DBQ  prac.ce  ques.ons.     Chlamydia  trachoma#s  bacteria.  Are  you  ready  for  the   end  of  an.bio.cs?  Guardian:  hQp://gu.com/p/2jxgj The  scariest  graph  you’ll  ever  see.  Read  the  ar#cle  by  Maryn  McKenna:   hQp://www.wired.com/wiredscience/2011/02/not-­‐many-­‐an.bio.cs/