Lab'InSight Toxicological Risk Assessment présentation ULG CHU 24.10.13

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Clinical, Forensic, Environmental
and Industrial Toxicology Service

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Lab'InSight Toxicological Risk Assessment présentation ULG CHU 24.10.13

  1. 1. Toxicological Risk Assessment An initiative of 24 October 2013 - UCL - Brussels (Woluwe) 1
  2. 2. Clinical, Forensic, Environmental and Industrial Toxicology Service Prof. Corinne CHARLIER University of Liège – CHU Sart Tilman Dr Raphaël DENOOZ Head of Laboratory 2
  3. 3. Fields of expertise and industrial targets Fields of expertise • Therapeutic drug monitoring of conventionally and non• • • • conventionally measured drugs Pharmacokinetic studies for drugs of abuse Influence of endocrine disruptors on hormonal pathologies Markers of genetic susceptibility in industrial toxicology Oxidative stress Industrial applications fields • Drug administration and pharmaco-kinetics • Clinical toxicological studies • Risk assessment 3
  4. 4. Special equipments Examples • High-performance liquid chromatography with photodiode • • • • • • • array detection (3) High-performance liquid chromatography with fluometric detection (1) Ultra-performance liquid chromatography with photodiode array and fluometric detection (1) Ultra-performance liquid chromatography tandem mass spectrometry (1) High resolution liquid chromatography mass spectrometer (1) Gas chromatography coupled to tandem mass spectrometry (3) Inductively coupled plasma mass spectrometry (2), with collision reaction cell (1) FIMS – Flow Injection Mercury Systems (1) Very large and competitive equipment 4
  5. 5. Applied research projects Therapeutic Drug Monitoring • B-lactam drugs (Cefepim, Cefuroxim, Ceftazidim, Meropenem, • • • Piperacilline) Antifungal drugs (Ketoconazole, Itraconazole, Posaconazole, voriconazole) Antineoplastic agents (Imatinib, Nilotinib) Antiparasitic drugs (Albendazole) Epidemiology • • • • Phtalates, Parabens and Benzophenone-3 Bisphenol A, Triclosan and Nonylphenol Heavy metals (Cadmium, Arsenic, Mercury, Lead, …) PCB and organochlorine compounds 5
  6. 6. Services provided to companies Examples • Critical analysis of toxicological data before drug registration • Toxicokinetic or pharmacokinetic studies • Risk assessment for any type of chemical pollutants • REACH (Registration, Evaluation, Authorization and Restriction of Chemical – Human Toxicology) 6
  7. 7. Training proposals to companies • All separative methods applied to drugs or chemical products in biological samples (UPLC-HRMS, GC-MS/MS) • Validation of analytical methods following international criteria (FDA, …) • Accreditation processes following iso 17025 or 15189 7
  8. 8. Contacts University of Liège – CHU Sart Tilman Clinical, Forensic, Environmental and Industrial Toxicology Service Domaine universitaire du Sart-Tilman – Bâtiment B35 www.chuliege.be/toxicologie Prof. Corinne CHARLIER Head of Service c.charlier@chu.ulg.ac.be  +32 43 66 76 83 Phn Virginie MISTRETTA Head of Laboratory VI.Mistretta@chu.ulg.ac.be  +32 43 66 76 83 Dr Raphaël DENOOZ Head of Laboratory Raphael.Denooz@chu.ulg.ac.be  +32 43 66 88 16 8

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