Prions and Viroids, Prions research report

RITMIR019: Prions – A Market Insight Report, July 2013
© RI Technologies - www.researchimpact.com Sample Page - 1
PRIONS MARKET SIZE
Scope of the Study
Prions report gives an insight into the market for Prion Deactivation technologies, Post Mortem Testing for
BSE and Prion Reduction Filters. The Prion related products include BSE detection test Kits, Deactivation
/Inactivation technologies, Reagents and Services. The study includes estimates and projections for the
global BSE Post Mortem Testing Market. Projections and estimates are also illustrated by geographic region
encompassing North America, Europe, Japan and Rest of World.
Business profiles of 24 major companies are discussed in the report. The report serves as a guide to global
Prion Detection, Reduction and Inactivation Market as it covers more than 120 companies that are engaged
in research for development of antemortem BSE and CJD test kits, development and supply of BSE Test kits
and development of prion Reduction Filters. Information related to recent product releases, product
developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report.
Prions report is an ideal research tool providing strategic business intelligence to the corporate sector. This
report may help strategists, investors, laboratories, pharmaceutical companies, contract research
organizations, biotechnology companies and drug approval authorities in-
 Gauging Competitive Intelligence
 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
Analytics and data presented in this report pertain to several parameters such as -
 Global And Regional Market Sizes, Market Shares, Market Trends
 Product (Global And Regional) Market Sizes, Market Shares, Market Trends
 Technology Trends
 Corporate Intelligence
 Key Companies By Sales, Brands, Products
 Consumer Behavioral Patterns

 Other Strategic Business Affecting Data
Research Methodology
RI Technologies publishes business intelligence reports by going through a cycle of diligent research and
analysis activity. Research is done using both online and offline resources. The study outline of this report is
sketched on the following lines - global market analysis, regional market analysis, product segmentation,
global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape,
technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is
also helpful for doing market evaluations, and estimating the market size for the future.
This report is uniquely researched and the methodology includes:
 Need and Scope of Study
 Product Definitions
 Segmental Analysis
 Regional Analysis
 Exclusive Data Analytics
 Corporate Intelligence
 Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are
applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the
information for authentication of our own findings. Secondary research includes government publications,
investment research reports, web based surveys, website information of both companies and markets, and
other offline resources such as print publications and CDs.
Our compilation of easy to navigate PDF reports are essential value addition resources for leading and
growing companies.

II. REPORT SYNOPSIS
Prions are considered unique as they replicate without the presence of nucleic acids. These are observed to
replicate by modifying neighboring prions to conform to the required shape. After the completion of the
protein reconfirmation the modified or mutated prion becomes infective.
In 1982, Stanley B. Prusiner, a professor at University of California, San Francisco coined the word “Prions”
for referring to proteinaceous infectious particles.
These particles have no other content except proteins. Therefore, they are identified as a separate category
of particles like virions, which term refers to virus containing infectious materials.
The reason that prions are gaining importance is because they cause certain neurodegenerative diseases in
animals and humans, which are incurable as of date. Creutzfeldt-Jakob disease in humans and Bovine
spongiform encephalopathy (mad cow disease) are two such examples. The infected person or animal dies
within months or even weeks after the symptoms start surfacing.
Physicist J.S. Griffith and radiation biologist Tikvah Alper were the first to suggest that infectious particles
comprised only of proteins cause some of the transmissible spongiform encephalopathies.
This disease was detected in the early 1970’s and the researcher involved in the extensive research of this
disease Mr. Carleton Gajdusek was awarded Nobel Prize for Medicine in 1976.
Transmissible spongiform encephalopathy [TSE] is a neurodegenerative disease caused by an altered form
of a cellular prion protein [PrPC]. The disease is expressed as bovine spongiform encephalopathy [BSE] in
cattle, scrapie in sheep, chronic wasting disease [CWD] in elk and deer, and Creutzfeldt-Jakob disease [CJD]
in humans.
The scientists across the world are anxiously waiting to unearth a link between the disease scrapie, which is
commonly found in the goats and sheep with that of other diseases like bovine spongiform encephalopathy
(BSE) and variant Creutzfeldt-Jakob disease (vCJD). This is expected to bring about a revolution in the field
of both agriculture and pharmaceutical developments. The very information pertaining to this research
created a widespread impact on the pharmaceutical industries and its development can be witnessed in
proportion. The disease is caused by mutated prions, and is not similar to other diseases that affect human
beings and domestic animals. The main responsibility to control this disease is vested with the
pharmaceutical industry and it is influenced in several ways.
The following steps are to be ensured to restrict the disease progression:
 The main aim is to restrict the disease in the geographical area where it is found without further
expansion to other areas and the ultimate aim would be eliminate the disease completely.
 Further, it is also mandatory to evaluate continual risk assessment with respect to the product
imported.
 The programmes that promote the use of TSE free animals are to be widely encouraged.
Majority of the diagnostic antibodies utilized in the bio manufacturing process across the world are
extracted from goats or sheep. The research carried out in this area indicates that the presence of scrapie
in blood products cannot be ignored. The serum, plasma of these animals needs to be subjected to
intensive scrutiny before they are introduced into the diagnostic marketplace. The international regulatory

bodies involved in the scrutiny of such products recommend the use of TSE-free animals for diagnostics and
pharmaceutical practices.
Exhibit 1. Mammalian Agents of Spongiform Encephalopathies, ICTVdb Code, Disease Name, Natural
Host, Prion Name and PrP Iso Form
ICTVdb Code Disease Name Natural Host Prion Name PrP Iso Form
90.001.0.01.001. Scrapie Sheep and goats Scrapie prion OvPrPSc
90.001.0.01.002. Transmissible mink encephalopathy (TME) Mink TME prion MkPrPSc
90.001.0.01.003. Chronic wasting disease (CWD) Elk, White-tailed deer, Mule
Deer and Red Deer
CWD prion MDePrPSc
90.001.0.01.004. Bovine spongiform encephalopathy (BSE) Cattle BSE prion BovPrPSc
90.001.0.01.005. Feline spongiform encephalopathy (FSE) Cats FSE prion FePrPSc
90.001.0.01.006. Exotic ungulate encephalopathy (EUE) Nyala and greater kudu EUE prion NyaPrPSc
90.001.0.01.007. Kuru Humans Kuru prion HuPrPSc
90.001.0.01.008. Creutzfeldt-Jakob disease (CJD) Humans CJD prion HuPrPSc
(New) Variant Creutzfeldt-Jakob disease (vCJD,
nvCJD)
Humans vCJD prion HuPrPSc
90.001.0.01.009. Gerstmann-Sträussler-Scheinker syndrome
(GSS)
Humans GSS prion HuPrPSc
90.001.0.01.010. Fatal familial insomnia (FFI) Humans FFI prion HuPrPSc
© RIT, 2013
General Definitions
Genetic Disorder: The pathological condition caused by a chromosomal aberration or by absence of gene of
a defective gene.
Sporadic Disease: Disease occurring at irregular intervals; having no order or pattern in time.
Iatrogenic Disease: An iatrogenic disease may be inadvertently caused by a physician or surgeon or by a
medical or surgical treatment or a diagnostic procedure.

Global Market Analysis
Deactivation Technologies
Global Prion Deactivation Technologies market is projected to reach about US$ XX.XX billion by 2020 from
an estimated US$ XX.XX million in 2012, growing at a compounded annual growth rate (CAGR) of XX.XX %
during the analysis period of 2005-2020.
Exhibit 2. Prion Deactivation Technologies - Global Value Market Estimations & Predictions (2005-2020)
in US$ Million
Year Value
2005 XX.XX
2006 XX.XX
2007 XX.XX
2008 XX.XX
2009 XX.XX
2010 XX.XX
2011 XX.XX
2012 XX.XX
2013 XX.XX
2014 XX.XX
2015 XX.XX
2016 XX.XX
2017 XX.XX
2018 XX.XX
2019 XX.XX
2020 XX.XX
CAGR% XX.XX
© RIT Figures, 2013
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million

BSE Post Morterm Testing
Global BSE Post Mortem Testing market is projected to reach about US$ XX.XX million by 2020 from an
estimated US$ XX.XX million in 2012, growing at compounded annual growth rate (CAGR) of XX.XX % during
the analysis period of 2005-2020.
Exhibit 3. BSE Post Mortem Testing - Global Value Market Estimations & Predictions (2005-2020) in US$
Million
Year Value
2005 XX.XX
2006 XX.XX
2007 XX.XX
2008 XX.XX
2009 XX.XX
2010 XX.XX
2011 XX.XX
2012 XX.XX
2013 XX.XX
2014 XX.XX
2015 XX.XX
2016 XX.XX
2017 XX.XX
2018 XX.XX
2019 XX.XX
2020 XX.XX
CAGR% XX.XX
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million

III. MARKET DYNAMICS
Market Overview
The scientists across the world are anxiously waiting to unearth a link between the disease scrapie, which is
commonly found in the goats and sheep with that of other diseases like bovine spongiform encephalopathy
(BSE) and variant Creutzfeldt-Jakob disease (vCJD). This is expected to bring about a revolution in the field
of both agriculture and pharmaceutical developments.
The serum, plasma of animals used for preparing antibodies needs to be subjected to intensive scrutiny
before they are introduced into the diagnostic marketplace. The international regulatory bodies involved in
the scrutiny of such products recommends the use of TSE-free animals for diagnostics and pharmaceutical
practices thus increasing market for Prion Reduction and Deactivation technologies.
European Union has imposed very stringent measures for controlling TSE infections in domestic animals.
Slaughterhouses in EU are required to test for BSE even the healthy cattle that are 30 years or more of age.
From the cattle that die on the farm, those that are 24 months or more of age have to be tested for BSE.
Out of the cattle being sent for rendering, those that are 24 months and above of age, are to be tested for
presence of BSE infection before rendering. Apart from these, any cattle, which displays any physical
symptom of BSE, has to be tested, irrespective of the age thus increasing the market for BSE testing in
Europe.
Only 10% of cows are tested for BSE in the US. The new US policy is a sharp contrast to the measures taken
by countries such as Japan, where 100 percent of cows are tested for BSE infection at the time of
slaughtering, to ensure that the meat is safe for human consumption. Japan insists that all the cattle be
tested at the time of slaughter.
Prion Reduction Filters – Global Market Analysis
Global market for Prion Reduction Filters is projected to reach about US$ XX.XX million by 2020 from an
estimated US$ XX.XX million in 2012, growing at a Compounded Annual Growth Rate (CAGR) of XX.XX %
during the analysis period, 2005-2020.
Europe was estimated as the largest market for Prion Reduction Filters in 2012 with a share of XX.XX %
valued at US$ XX.XX million and is projected to reach US$ XX.XX million by 2020 to retain its position with a
share of XX.XX %.
North America is projected to be the second largest market with a market share of XX.XX % in 2020.
Japanese market for Prion Reduction Filters is valued at US$ XX.XX million with a market share of XX.XX % in
2010 and is projected to reach US$ XX.XX million by 2020.

Exhibit 4. Prion Reduction Filters - Global Value Market Estimations & Predictions (2005-2020) by
Geographic Regions for Europe, North America, Japan and Rest of World in US$ Million
Year /Region Europe North America Japan Rest of World Total
2005 XX.XX XX.XX XX.XX XX.XX XX.XX
CAGR% XX.XX XX.XX XX.XX XX.XX XX.XX
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million
Europe North America Japan Rest of World

IV. PRODUCT/TECHNOLOGY RESEARCH
Exhibit 5. Preventive Measures against the Introduction and Spread of BSE in the EU
Year Events
April 9, 1990 Animals to be slaughtered are required to be inspected by veterinarians to prevent entry into
food and feed chains
July, 1994 (MBM) Mammalian Bone meal was banned from feeding to sheep, goat and cattle.
January 1, 1995 For treatment of animal waste processing standards are implemented.
April 1, 1997 For the production of MBM from animal waste pressure cooking regulations are
implemented(133 °C/3 bars/20 minutes)
October 2000 EU mandated SRMs are to be removed from goats, cattle, sheep from animal and human food
chains through out Europe.
January 2001 Use of animal protein for the production of feed for animals
is banned.
March 2001 Vertebral column, intestine of bovines are included in the list of SRM
July 2001 Animals with high probability of receiving the same infected feed as the BSE cases are culled.
Due to potential of maternal transmission latest born offspring of the female BSE cases are
culled.
*(SRMs) includes Spinal Cord, Brain, Eyes, Tonsils, Parts of Intestine
© RIT, 2013
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 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
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