High throughput screening drug discovery

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High Throughput Screening Market report (HTS) emphasizes on both the technology and product segments of HTS in biotechnology and pharmaceutical application areas. The major technologies analyzed include Ultra High Throughput Screening, High Content Screening, Bioinformatics and Microfluidics/Lab-On-a-Chip; and the major product segments encompass HTS Services and HTS Tools. The global markets for Novel High Throughput Screening Products and Cell Based Assays are also discussed in the report. Markets covered for Microfluidics and Bioinformatics pertain to the applications of HTS. The report provides essential information including market data, segmentation, market size, key trends, M&A, product developments, industry forecasts, corporate intelligence, and other relevant information. The report lists more than 600 companies that are engaged in HTS services and/or production of HTS tools/instruments. Major Contract Research Organizations serving HTS industry are also covered in the corporate directory section of this report. Estimations and predictions are graphically represented by region, by technology and by product segment. Compilation of Worldwide Patents and Research related to High Throughput Screening is also provided. A global perspective is presented along with regional analysis covering the regions of North America, Europe, Asia-Pacific and Rest of World. The market is analyzed in US Dollars and includes 112 exclusive exhibits. High throughput screening market size, market review, market shares, and other key market results and trends are analyzed. Need of the Study High Throughput Screening (HTS) is the process by which thousands of compounds that possess the potential of emerging as a new drug are tested using automated machines. The main objective of carrying out HTS is to remove the inactive compounds at the initial stage and accumulate the active compounds called hits. These hits are then put through various tests to obtain the leads. The process of HTS when employed on half a million compounds, for example, would provide 300 - 400 hits and this in turn would create 3 to 4 Leads. Ultra High Throughput Screening (uHTS) can be carried out in cell based assays under various physiological environments. This finds application in screening of libraries, holding compounds in millions. Due to various structural effects the primary hits are to be carefully evaluated. When counter screening is employed in cell assays with orthogonal structure, the false positives can be eliminated with ease. Varied read out expertise and cellular setting are utilized during the development of assays. When all these assays gets adapted to the 1536 microtiter plate, the process of counter screening at initial step of hit detection process can be accomplished. Thus early hit detection and lead profiling can be achieved. High Content Screening (HCS) is the latest drug discovery process that makes use of living cells for drug discovery. It is a highly sophist

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High throughput screening drug discovery

  1. 1. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 1 High Throughput Screening Global Market Size Scope of the Study This report gives an insight into High Throughput Screening (HTS) technologies, tools and services. The report covers HTS technologies including Ultra High Throughput Screening, High Content Screening, Bioinformatics and Lab-on-a-Chip/Micro fluidics. The study includes estimates and projections for the total global HTS market. The market covered for Micro fluidics and Bioinformatics pertains to the applications of HTS. Projections and estimates are also illustrated by region, by technology and by product segment. The report serves as a guide to HTS industry, covering more than 600 companies engaged in HTS studies/screening, products and services. Business profiles of 43 major global companies are discussed. Major Contract Research Organizations serving HTS industry are also covered in the corporate directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered. High Throughput Screening report is an ideal research tool providing strategic business intelligence to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies, contract research organizations, biotechnology companies and drug approval authorities in--  Gauging Competitive Intelligence  Identifying Key Growth Areas and Opportunities  Understanding Geographic Relevance to Product  Knowing Regional Market Sizes and Growth Opportunities and Restraints  Keeping Tab on Emerging Technologies  Equity Analysis  Tapping New Markets
  2. 2. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 2 Analytics and data presented in this report pertain to several parameters such as  Global and Regional Market Sizes, Market Shares, Market Trends  Product (Global and Regional) Market Sizes, Market Shares, Market Trends  Technology Trends  Corporate Intelligence  Key Companies by Sales, Brands, Products  Consumer Behavioral Patterns  Other Strategic Business Affecting Data
  3. 3. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 3 Research Methodology RI Technologies publishes business intelligence reports by going through a cycle of diligent research and analysis activity. Research is done using both online and offline resources. The study outline of this report is sketched on the following lines – global market analysis, regional market analysis, product segmentation, Global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is also helpful for doing market evaluations, and estimating the market size for the future. This report is uniquely researched and the methodology includes:  Need and Scope of Study  Product Definitions  Segmental Analysis  Regional Analysis  Exclusive Data Analytics  Corporate Intelligence  Feedback Right from concept to final compilation of this report, both primary and secondary research methods are applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the information for authentication of our own findings. Secondary research includes government publications, investment research reports, web based surveys, website information of both companies and markets, and other offline resources such as print publications and CDs. Our compilation of easy to navigate PDF reports are essential value addition resources for leading and growing companies.
  4. 4. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 4 II. REPORT SYNOPSIS Foreword High Throughput Screening (HTS) is the process by which thousands of compounds that possess the potential of emerging as a new drug are tested using automated machines. The main objective of carrying out HTS is to remove the inactive compounds at the initial stage and accumulate the active compounds called hits. These hits are then put through various tests to obtain the leads. The process of HTS when employed on half a million compounds, for example, would provide 300 - 400 hits and this in turn would create 3 to 4 Leads. Strategic partnerships between pharmaceutical and biotechnology companies are the order of the day, and the trend is increasing globally. Another significant trend is the alliances between Pharma and Biotech companies and information technology companies such as Microsoft, IBM, Oracle, Sun, and Infosys, etc. The computer platforms generated by such companies help in managing and analyzing the huge amounts of data produced through High Throughput Screening (HTS) and other computational techniques. Effective R&D strategy involves efficient data management and implementation plans. The new technologies promise improved efficacy, decreased toxicity in patients, and reduced time frames and expenditures. Changing business paradigms brought in by globalization and liberalization are making pharmaceutical companies change strategies for sustenance and growth. Many companies are venturing into HTS studies instead of going for alliances, to become self sufficient and reduce costs. The R&D wings are increasingly becoming target oriented to face the numerous challenges posed in the drug discovery and development industry. Technology and Product Segmentation Global HTS market is segmented by technology into Ultra High Throughput Screening, High Content Screening, Bioinformatics and Lab-on-a-Chip/Micro fluidics segments; and by products into HTS Services, HTS Tools, Other HTS Products and/or Services.
  5. 5. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 5
  6. 6. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 6 Global Market Analysis Global High Throughput Screening market is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, growing at a very high compounded annual growth rate (CAGR) of XX.XX % during the analysis period 2005-2020. Exhibit 1. High Throughput Screening – Global Value Market Estimations and Predictions (2005- 2020) in US$ Billion
  7. 7. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 7
  8. 8. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 8 III. MARKET DYNAMICS Global HTS Market Exhibit 2. High Throughput Screening – Global Market Estimations and Predictions (2005-2020) in US$ Million for North America, Europe, Asia-Pacific and Rest of World
  9. 9. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 9
  10. 10. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 10 Analysis by Technology Ultra High Throughput Screening Ultra High Throughput Screening (uHTS) is carried out in cell based assays under various physiological environments. This technology finds application in screening of libraries, holding compounds in millions. When counter screening is employed in cell assays with orthogonal structure, the false positives can be eliminated with ease. Exhibit 3. uHTS – Global Value Market Estimations and Predictions (2005-2020) in US$ Million for North America, Europe, Asia-Pacific, and Rest of World
  11. 11. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 11
  12. 12. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 12 Analysis by Product Segment HTS Services HTS Services market is projected to reach US$ XX.XX billion by 2020, registering a CAGR of XX.XX % during 2005-2020, from an estimated US$ XX.XX billion in 2010. The North America and Europe accounted for about XX.XX % and XX.XX % of global market for HTS tools in 2010 with estimated market worth US$ XX.XX billion and US$ XX.XX billion respectively. Asia-Pacific is projected to grow faster, compared to all other regions during the same period. Exhibit 4. High Throughput Screening Services – Global Value Market Estimations and Predictions (2005- 2020) in US$ Million for United States, Europe, Asia-Pacific, Canada and Rest of World
  13. 13. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 13
  14. 14. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 14 Global Market Analysis – Cell Based Assays Global market for Cell Based Assays was estimated at US$ XX.XX million in 2010 and is projected to reach US$ XX.XX billion by 2020. During the period 2005-2020, worldwide Cell Based Assays market is expected to register a CAGR of XX.XX %. Exhibit 5. Cell-Based Assays – Global Value Market Estimations and Predictions (2005-2020) in US$ Million
  15. 15. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 15
  16. 16. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 16 HIGH THROUGHPUT SCREENING – MARKET OUTLOOK Global HTS market is projected to grow at a high rate of XX.XX % compounded annually from 2005 through 2020. This growth is especially driven by the advancements in HTS technologies and the increasing usage of innovative techniques such as Bioinformatics and Lab-on-a-Chip/Microfluidics. The success of Human Genome Project and latest findings in genomics and proteomics are creating an enormous market for HTS by identifying huge number of drug targets. Currently, automation in HTS industry is in high gear. The companies are investing heavily in laboratory automation products such as HTS software, database systems, robotics arms and robot based workstations. The United States is projected to remain the leader in global HTS market until the end of the analysis period, slightly losing market share from of about XX.XX % in 2010 to XX.XX % in 2020. At the same time emerging markets including Europe and Asia-Pacific are expected to increase their global market shares. The European market for HTS is expected to register similar CAGR as that of Asia-Pacific during the analysis period. While the United States is reaching market saturation for HTS, many major companies including Biotage AB, Kibron Inc., Biacore International, Evotec AG, Cerep SA, ID Business Solutions Ltd., and Sygnis Pharma AG are driving the growth of the market in this region. The UK and Germany are expected to lead the market and account for more than half of the total European market. Switzerland, The Netherlands, France, Belgium, Sweden and Italy are projected to be the promising markets in the near future…..
  17. 17. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 17 IV. PRODUCT/TECHNOLOGY RESEARCH High Throughput Screening (HTS) is one of the several tools available for the discovery of a new drug. Paul Ehrlich used HTS almost a century ago to identify effective compounds for the treatment of syphilis. Majority of drugs in the market were discovered by using natural product screening. These drugs include anticancer agents, antibacterial agents and anti parasitic agents. Conventional screening methods proved to be ineffective in terms of cost, and screening lost its charm, during the late 1970s and 1980s, as innovative methods began to generate larger number of discovery leads. The process of utilization of screening technology on chemical compounds for therapeutical and pharmaceutical usage is being carried out globally for the past 35 years. The screening process utilizes the properties of chemical compounds which are made to react with other compounds, to accomplish the invention of the wonder drug. This can be considered as the journey of a chemical compound in transforming into an effective drug. The chemicals that do not comply with the primary screening process are rejected and kept in storage for some other pharmaceutical use. With increase in the varieties of diseases attacking mankind, the role of pharmaceutical industries is becoming more and more challenging. This has led to enormous improvement and sophistication in medicine discovery, pharmaceutical business, and research and development, etc. All these transformations in pharmaceutical industry have further developed the screening technology. The screening technology has undergone rapid changes to adapt to modern requirements. The main changes acquired in the screening technology encompass improvements in the instruments, machineries and testing procedures. Screening started to regain its importance in the pharmaceutical industry during the mid 1990s. Re- establishment of HTS is driven by the following factors:  Identification of large number of drug targets as a result of molecular genetics and recombinant DNA usage  Availability of cloned genes that have rejuvenated the screening procedures  Improvements in combinatorial chemistry that generate more compounds for screening  Technological advances in biotechnology that have led to the implementation of cost effective screening systems with the help of innovative detection systems  Automation in screening process that facilitate the screening of more samples in a short period of time  Computerized data handling and analysis
  18. 18. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 18 Exhibit 6. Global Market for Cell Based Assays (2005 & 2007): Percentage Breakdown of Market Shares for GE Healthcare, PerkinElmer, BD Biosciences, Beckman Coulter, Life Technologies, and Other About RI Technologies RI Technologies is a premier source of market research on the Biotechnology & Healthcare sector. We emphasize on factual insights and forecasts with maximum global coverage. RI Technologies is constantly monitoring the biotechnology & Healthcare industry, tracking market trends, and forecasting industry based on specialized analysis. The life sciences sector is an ever growing marketplace with emerging technologies in areas of discovery, design and development.
  19. 19. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 19 Research – As Good as the Methodology is!  Gauging Competitive Intelligence  Identifying Key Growth Areas and Opportunities  Understanding Geographic Relevance to Product  Knowing Regional Market Sizes and Growth Opportunities and Restraints  Keeping Tab on Emerging Technologies  Equity Analysis  Tapping New Markets © COPYRIGHT The copyright and publication rights to all RI Technologies' reports and other products are the property of the company. Plagiarism of any kind accounts to violation of copyright laws. Any type of reproduction of the material without express permission is not allowed. The buyer, under no circumstances, shall license, resell or repackage, or sell data without prior permission of the company. DISCLAIMER RI Technologies sells content in good faith. The company is not liable to the buyer for any implications arising out of the usage of data for any particular purpose. The company makes no representations or warranties for the accuracy or completeness of the data. While extreme caution and effort is practiced for data compilation and presentation, the company does not accept any responsibility for findings in the study which are a cumulative effort of primary and secondary research resources. The studies do not endorse or promote any product or company. RI Technologies, its affiliates, partners, distributors, and contractors are not liable for inaccuracies or incompleteness of the reports. User discretion is recommended for the usage of the data.
  20. 20. RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014 © RI Technologies - www.researchimpact.com Sample Page - 20

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