The Global Drug Delivery Market: Research Trends and Market Outlook

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The Global Drug Delivery Market: Research Trends and Market
Outlook
Published on May 2006

Report Summary

The drug delivery industry has in recent years become a key partner for pharmaceutical companies in their efforts to maximize the
patent lives of successful products. Drug delivery companies not only stand to benefit from patent expiry by providing their
reformulation services to pharmaceutical companies, but also by producing their own versions of branded products with improved
delivery mechanisms. Thus, post-patent expiry sales can be switched from the ethical manufacturer to the drug delivery sector.

The Global Drug Delivery Market: Research Trends and Market Outlook is an up-to-date guide that assesses the current state of the
drug delivery industry and its application to both the pharmaceutical and biotech industries. While the sector is still dominated by oral
technologies, drug delivery systems have expanded to include more novel devices such as needleless injectables, PEGylation
platforms and microelectromechanical devices. These technological advances extend the duration of a drug’s action, increase
delivery to target sites, reduce delivery to unwanted sites, and maximize drug absorption.

The expanding market for biotechnology and gene-based products, which by their very nature are difficult to administer, represents
an emerging opportunity for drug delivery technologies. These technologies are first expected to come to market as reformulations of
existing macromolecular therapies, such as insulin. This report analyzes the markets for oral, inhalable, injectable, transmucosal,
transdermal and niche drug delivery technologies as they apply to both biotech and traditional pharmacological compounds.

Key Features of This Report:A thorough overview of both marketed and emerging drug delivery technologies set to impact the
global pharmaceutical marketAnalysis of the opportunities and threats to the global drug delivery industryProfiles of drug delivery
companies along with key financial figures and technology/product portfolios Market analysis and outlook for the leading drug delivery
technologies, including oral, injectable, inhalable, transdermal, transmucosal and niche technologiesProfiles of key emerging drug
delivery technologies and profiles of leading companies, by type of technologyWho Should Buy This Report:Companies interested
in understanding the wider opportunities and challenges in the drug delivery industryPharma/biotech companies wishing to identify
potential drug delivery partnersCompanies with a need for an expansive overview of the drug delivery market and the R&D trends that
are driving the industry forward.

Table of Content

Table of Contents

1 Introducing the Field of Drug Delivery
1.1 The Value of Drug Delivery Systems
1.2 Drug Delivery and Product Differentiation
1.3 Drug Delivery and Patent Extension
1.4 The Optimal Time for Reformulation

The Global Drug Delivery Market: Research Trends and Market Outlook (From Slideshare) Page 1/10


1.5 Optimizing R&D Returns Through Drug Delivery
1.6 Opportunities and Threats to the Drug Delivery Sector
1.6.1 Opportunities for Growth in the Drug Delivery Sector
1.6.2 Threats to Additional Growth in the Drug Delivery Sector
1.7 Business Models of Drug Delivery Companies

2 An Overview of Drug Delivery Technologies
2.1 Oral Drug Delivery
2.1.1 Controlled Release
2.1.2 Sustained Release
2.1.3 Chronomodulation
2.1.4 Rapid Dissolving and Taste-masking Tablets
2.1.5 Macromolecular Drug Delivery
2.2 Inhalable Drug Delivery
2.2.1 Nebulizers
2.2.2 Metered Dose Inhalers (MDIs)
2.2.3 Dry Powder Inhalers (DPIs)
2.2.4 Limitations of Pulmonary Delivery Systems for Systemic Delivery
2.2.5 Aqueous Systems
2.3 Injectable Drug Delivery
2.3.1 Sustained Release Injectable Systems
2.3.2 Liposomal Systems
2.3.3 Needleless Systems
2.4 Transmucosal Drug Delivery
2.4.1 Buccal Delivery
2.4.2 Nasal
2.4.3 Rectal
2.4.4 Vaginal
2.5 Transdermal Drug Delivery
2.5.1 Passive Formulations
2.5.2 Active Formulations
2.6 Niche Technologies
2.6.1 Topical Systems
2.6.2 Gene Delivery
2.6.3 Implantable Systems
2.6.4 Drug Delivery Microchips
2.6.5 Nanotechnology

3 Drug Delivery Market Analysis
3.1 Key Market Segments
3.1.1 Oral Drug Delivery
3.1.1.1 Sales of Products Utilizing Oral Drug Delivery Technology
3.1.1.2 Key Therapeutic Areas for Oral Drug Delivery
3.1.1.3 Key Oral Drug Delivery Products Impacting Global Market
3.1.1.4 The Outlook for Oral Drug Delivery Technology
3.1.2 Inhalable Drug Delivery
3.1.2.1 Sales of Products Utilizing Inhalable Drug Delivery
3.1.2.2 Key Therapeutic Areas for Inhalable Drug Delivery



3.1.2.3 Key Inhalable Drug Delivery Products Impacting Global Market
3.1.2.4 The Outlook for Inhalable Drug Delivery Technology
3.1.3 Injectable Drug Delivery
3.1.3.1 Sales of Products Utilizing Injectable Drug Delivery Technology
3.1.3.2 Key Therapeutic Areas for Injectable Drug Delivery
3.1.3.3 Key Injectable Drug Delivery Products Impacting Global Market
3.1.3.4 The Outlook for Injectable Drug Delivery Technology
3.1.4 Transmucosal Drug Delivery
3.1.4.1 Sales of Products Utilizing Transmucosal Drug Delivery Technology
3.1.4.2 Key Therapeutic Areas for Transmucosal Delivery
3.1.4.3 Key Transmucosal Drug Delivery Products Impacting Global Market
3.1.4.4 The Outlook for Transmucosal Drug Delivery Technology
3.1.5 Transdermal Drug Delivery
3.1.5.1 Sales of Products Utilizing Transdermal Drug Delivery Technology
3.1.5.2 Key Therapeutic Areas for Transdermal Drug Delivery
3.1.5.3 Key Transdermal Drug Delivery Products Impacting Global Market
3.1.5.4 The Outlook for Transdermal Drug Delivery Technology
3.1.6 Niche Drug Delivery Technologies
3.1.6.1 Sales of Products Utilizing Niche Drug Delivery Technologies
3.1.6.2 Key Niche Drug Delivery Technology Product Impacting Global Market
3.1.6.3 The Outlook for Niche Drug Delivery Technologies

4 Emerging Drug Delivery Technologies: Oral Drug Delivery
4.1 Key Product Profiles
4.2 Key Company Involvement in the Field of Oral Drug Delivery
4.2.1 ALZA
4.2.2 Biovail
4.2.3 Cardinal Health
4.2.4 Depomed
4.2.5 Emisphere
4.2.6 Ethypharm
4.2.7 Penwest

5 Emerging Drug Delivery Technologies: Inhalable Drug Delivery
5.2 Key Company Involvement in the Field of Inhalable Drug Delivery
5.2.1 3M
5.2.2 Alkermes
5.2.3 Aradigm
5.2.4 Nektar
5.2.5 SkyePharma

6 Emerging Drug Delivery Technologies: Injectable Drug Delivery
6.2 Key Company Involvement in the Field of Injectable Drug Delivery
6.2.1 Alkermes
6.2.2 ALZA
6.2.3 Aradigm



6.2.4 Enzon
6.2.5 Ethypharm
6.2.6 Macromed
6.2.7 Nektar
6.2.8 QLT
6.2.9 SkyePharma

7 Emerging Drug Delivery Technologies: Transmucosal Drug Delivery
7.1 Key Company Involvement in the Field of Transmucosal Drug Delivery
7.1.1 Generex
7.1.2 Nastech
7.1.3 Pherin

8 Emerging Drug Delivery Technologies: Transdermal Drug Delivery
8.2 Key Company Involvement in the Field of Transdermal Drug Delivery
8.2.1 3M
8.2.2 Altea Therapeutics
8.2.3 ALZA
8.2.4 Noven

9 Emerging Drug Delivery Technologies: Niche Drug Delivery Technologies
9.2 Key Company Involvement in Niche Drug Delivery Technologies
9.2.1 ALZA
9.2.2 Connetics
9.2.3 Inovio
9.2.4 MacroChem
9.2.5 NexMed
9.2.6 pSivida
9.2.7 QLT
9.2.8 SkyePharma

10 Key Drug Delivery Company Profiles
10.1 3M
10.2 Alkermes
10.3 Altea Therapeutics
10.4 ALZA (Johnson & Johnson)
10.5 Aradigm
10.6 Bioject
10.7 Biovail
10.8 Cardinal Health
10.9 Cima Labs (Cephalon)
10.10 Connetics
10.11 CyDex
10.12 Delsite Biotechnologies (Carrington Laboratories)
10.13 Depomed
10.14 DOR BioPharma



10.15 DURECT
10.16 Emisphere
10.17 Enzon
10.18 Ethypharm
10.19 Generex
10.20 Inovio (formerly Genetronics)
10.21 IVAX
10.22 MacroChem
10.23 MacroMed
10.24 Nastech
10.25 Nektar
10.26 NexMed
10.27 Noven
10.28 Penwest
10.29 Pherin Pharmaceuticals
10.30 QLT
10.31 SkyePharma
10.32 Watson Pharmaceuticals

11 Leading Pharmaceutical Companies Utilizing Drug Delivery Technologies
11.1 Pfizer
11.2 GlaxoSmithKline
11.3 Sanofi-Aventis
11.4 Merck
11.5 Johnson & Johnson
11.6 AstraZeneca
11.7 Novartis
11.8 Bristol-Myers Squibb
11.9 Wyeth
11.10 Abbott Labs

List of Tables

Table 2.1 Drugs Suitable or Unsuitable for Controlled Release
Table 2.2 Advantages and Disadvantages of Transdermal Delivery
Table 2.3 Worldwide Government Funding for Nanotechnology R&D ($ mn)
Table 3.1 Key Oral Drug Delivery Products, 2004-2005 ($ mn)
Table 3.2 Leading Oral Drug Delivery Companies 2005, Key Products and Sales 2005 ($ mn)
Table 3.3 Key Inhalable Drug Delivery Products, 2004-2005 ($ mn)
Table 3.4 Key Injectable Drug Delivery Products, 2004-2005 ($ mn)
Table 3.5 Leading Injectable Drug Delivery Companies 2005, Key Products and Sales 2005 ($ mn)
Table 3.6 Key Transmucosal Drug Delivery Products, 2004-2005 ($ mn)
Table 3.7 Key Transdermal Drug Delivery Products, 2004-2005 ($ mn)
Table 3.8 Key Topical Drug Delivery Products, 2004-2005
Table 3.9 Key Niche Drug Delivery Products, 2004-2005 ($ mn)
Table 4.1 Key Oral Drug Delivery R&D Pipeline Drugs, 2006
Table 5.1 Key Inhalable Drug Delivery R&D Pipeline Drugs, 2006
Table 6.1 Key Injectable Drug Delivery R&D Pipeline Drugs, 2006



Table 6.2 SkyePharma's Injectables Pipeline
Table 7.1 Key Transmucosal Drug Delivery R&D Pipeline Drugs, 2006
Table 8.1 Key Transdermal Drug Delivery R&D Pipeline Drugs, 2006
Table 9.1 Key Topical Drug Delivery R&D Pipeline Drugs, 2006
Table 9.2 Key Niche Drug Delivery R&D Pipeline Drugs, 2006
Table 10.1 3M Key Financials, 2003-2005
Table 10.2 3M Drug Delivery Portfolio, 2006
Table 10.3 Alkermes Key Financials, 2003-2005
Table 10.4 Alkermes Drug Delivery Portfolio, 2006
Table 10.5 Altea Therapeutics Drug Delivery Portfolio, 2006
Table 10.6 ALZA Drug Delivery Portfolio, 2006
Table 10.7 Aradigm Key Financials, 2003-2005
Table 10.8 Aradigm Drug Delivery Portfolio, 2006
Table 10.9 Bioject Key Financials, 2003-2005
Table 10.10 Bioject Drug Delivery Portfolio, 2006
Table 10.11 Biovail Key Financials, 2003-2005
Table 10.12 Biovail Drug Delivery Portfolio, 2006
Table 10.13 Cardinal Health Key Financials, 2003-2005
Table 10.14 Cardinal Health Drug Delivery Portfolio, 2006
Table 10.15 Cephalon Key Financials, 2003-2005
Table 10.16 CIMA Labs Drug Delivery Portfolio, 2006
Table 10.17 Connetics Key Financials, 2003-2005
Table 10.18 Connetics Drug Delivery Portfolio, 2006
Table 10.19 CyDex Drug Delivery Pipeline, 2006
Table 10.20 Carrington Laboratories Key Financials, 2003-2005
Table 10.21 Depomed Key Financials, 2003-2005
Table 10.22 Depomed Drug Delivery Portfolio, 2006
Table 10.23 DOR BioPharma Key Financials, 2003-2005
Table 10.24 DOR BioPharma Drug Delivery Portfolio, 2006
Table 10.25 DURECT Key Financials, 2003-2005
Table 10.26 Durect Drug Delivery Portfolio, 2006
Table 10.27 Emisphere Key Financials, 2003-2005
Table 10.28 Emisphere Drug Delivery Portfolio, 2006
Table 10.29 Enzon Key Financials, 2003-2005
Table 10.30 Enzon Drug Delivery Portfolio, 2006
Table 10.31 Ethypharm Drug Delivery Portfolio, 2006
Table 10.32 Generex Key Financials, 2003-2005
Table 10.33 Generex Drug Delivery Portfolio, 2006
Table 10.34 Inovio Key Financials, 2003-2005
Table 10.35 Inovio Drug Delivery Portfolio, 2006
Table 10.36 IVAX Key Financials, 2003-2005
Table 10.37 IVAX Drug Delivery Portfolio, 2006
Table 10.38 MacroChem Key Financials, 2003-2005
Table 10.39 MacroChem Drug Delivery Portfolio, 2006
Table 10.40 MacroMed Drug Delivery Portfolio, 2006
Table 10.41 Nastech Key Financials, 2003-2005
Table 10.42 Nastech Drug Delivery Portfolio, 2006
Table 10.43 Nektar Key Financials, 2003-2005



Table 10.44 Nektar Drug Delivery Portfolio, 2006
Table 10.45 NexMed Key Financials, 2003-2005
Table 10.46 NexMed Drug Delivery Portfolio, 2006
Table 10.47 Noven Key Financials, 2003-2005
Table 10.48 Noven Drug Delivery Portfolio, 2006
Table 10.49 Penwest Key Financials, 2003-2005
Table 10.50 Penwest Drug Delivery Portfolio, 2006
Table 10.51 Pherin Pharmaceuticals Drug Delivery Portfolio, 2006
Table 10.52 QLT Key Financials, 2003-2005
Table 10.53 QLT Drug Delivery Portfolio, 2006
Table 10.54 SkyePharma Key Financials, 2003-2005
Table 10.55 SkyePharma Drug Delivery Portfolio, 2006
Table 10.56 Watson Pharmaceuticals Key Financials, 2003-2005
Table 10.57 Watson Pharmaceuticals Drug Delivery Portfolio, 2006
Table 11.1 Pfizer Key Financials, 2004-2005
Table 11.2 Pfizer Drug Delivery Portfolio, 2004-2005
Table 11.3 GlaxoSmithKline Key Financials, 2004-2005
Table 11.4 GlaxoSmithKline Drug Delivery Portfolio, 2004-2005
Table 11.5 Sanofi-Aventis Key Financials, 2004-2005
Table 11.6 Sanofi-Aventis Drug Delivery Portfolio, 2004-2005
Table 11.7 Merck Key Financials, 2004-2005
Table 11.8 Merck Drug Delivery Portfolio, 2004-2005
Table 11.9 Johnson & Johnson Key Financials, 2004-2005
Table 11.10 Johnson & Johnson Drug Delivery Portfolio, 2004-2005
Table 11.11 AstraZeneca Key Financials, 2004-2005
Table 11.12 AstraZeneca Drug Delivery Portfolio, 2004-2005
Table 11.13 Novartis Key Financials, 2004-2005
Table 11.14 Novartis Drug Delivery Portfolio, 2004-2005
Table 11.15 Bristol-Myers Squibb Key Financials, 2004-2005
Table 11.16 Bristol-Myers Squibb Drug Delivery Portfolio, 2004-2005
Table 11.17 Wyeth Key Financials, 2004-2005
Table 11.18 Wyeth Drug Delivery Portfolio, 2004-2005
Table 11.19 Abbott Labs Key Financials, 2004-2005
Table 11.20 Abbott Labs Drug Delivery Portfolio, 2004-2005

List of Graphs

Graph 3.1 Top 5 Products Utilizing Oral Delivery, Global Sales 2005 ($ mn)
Graph 3.2 Leading Oral Drug Delivery Companies, Combined Key Product Values 2005 ($ mn)
Graph 3.3 Key Therapeutic Areas of Emphasis for Oral Drug Delivery, # of Key Marketed Products
Graph 3.4 Top 5 Products Utilizing Inhalable Delivery, Global Sales 2005 ($ mn)
Graph 3.5 Inhalable Drug Delivery Market Share, by Technology 2005 ($ mn)
Graph 3.6 Top 5 Products Utilizing Injectable Delivery, Global Sales 2005 ($ mn)
Graph 3.7 Leading Injectable Drug Delivery Companies, Combined Key Product Values 2005 ($ mn)
Graph 3.8 Top 5 Products Utilizing Transmucosal Delivery, Global Sales 2005 ($ mn)
Graph 3.9 Leading Developers of Transmucosal-Based Therapeutics 2005 ($ mn)
Graph 3.10 Leading Transdermal Drug Delivery Companies, by # of Products on Market
Graph 3.11 Key Therapeutic Areas of Emphasis for Transdermal Drug Delivery, # of Key Marketed Products



Graph 4.1 Leading Companies Active in Oral Drug Delivery Development
Graph 4.2 Leading Indications for Oral Drug Delivery Products in Development
Graph 5.1 Leading Companies Active in Inhalable Drug Delivery Development
Graph 6.1 Leading Companies Active in Injectable Drug Delivery Development
Graph 7.1 Leading Companies Active in Injectable Drug Delivery Development
Graph 8.1 Leading Companies Active in Transdermal Drug Delivery Development
Graph 9.1 Leading Companies Active in Niche/Topical Drug Delivery Development

List of Figures

Figure 1.1 Optimal Time for Reformulation
Figure 1.2 Growth Prospects in the Drug Delivery Sector
Figure 6.1 Advanced PEGylated Drug Molecules
Figure 9.1 Connetics' VeraFoam Clinical Study Results


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