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The Future of Nutrigenomics: New opportunities in personalized
nutrition and food-pharma collaboration
Published on January 2010

                                                                                                                              Report Summary

Nutrigenomics explores how nutrients or bioactive dietary compounds can influence gene expression and an individuals risk to certain
diseases. Nutrigenetics is the study of how variations in an individual's genetic makeup can increase or decrease the need for a
specific nutrient or bioactive food component.
Nutrigenomics has the potential to impact various parts of the food chain including the genetic modification of crops and animal feeds,
the development of nutrigenomic tests to monitor food safety and personalization of diets, as well as the identification of nutritional
supplements and nutrigenomic based products which may offer potential health benefits.
The consumer environment is driving growth in the Nutrition & Health market. Over the past decade, consumers have become more
concerned for their health and are increasingly inclined to invest in DTC nutrigenetic tests to assess their risk of disease and obtain
dietary advice. Healthcare providers too, are keen to shift some of the burden of healthcare costs to individuals and recognize that the
personalization of nutrition may be beneficial. The Health and nutrition market is currently worth around $485 billion.
This report reviews the business strategies of leading companies regarding the adoption of nutrigenomic technologies and
establishment of public-private partnerships as well as potential opportunities for biomarker discovery with the pharma and diagnostic
industry to personalize nutrition and medicine.




Key features of this report



' Identify leading academic groups and companies at the forefront of the nutrigenomic research who will drive the market towards a
more personalized approach to nutrition and disease prevention.
' Assess the nutrigenomic testing market, leading companies and its role in empowering consumers to take a more active role in
making dietary decisions and maintaining their health status
' Review the backgrounds, strategies and business models of companies and assess potential opportunities to collaborate with the
pharma and diagnostic industry.



Scope of this report



' Identify the companies leading the field in nutrigenomic research from ingredient & food manufacturers to nutrigenomic testing
companies
' Review their key products and business alliances which enable them to participate in this evolving field of science
' Identify points of convergence of the pharma, diagnostic and food and drinks markets which may offer new opportunities for co
development
' Review market drivers regarding the adoption of nutrigenomic information and the personalization of nutrition.



Key Market Issues


The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration                                     Page 1/7
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ReportLinker                                                                                                    and Market Statistics


' The food market is changing: Over the past decade, consumers have become more concerned for their health and wellbeing. The
roll of the food and drinks industry is changing and shifting towards a more benefit driven and preventative approach. In order to
respond to market dynamics the companies have needed to adopt an 'open network' model to gain access to innovative research and
technologies which will drive future product development.
' Nutrigenomics & pharmacogenomics are related in their approach to identify subpopulations that respond to treatment/nutrition. The
application of these technologies may lead to the identification of old and new ingredients that have beneficial effects for specific
consumer groups, helping to maintain health and wellness and leading to the personalization of treatment and diets. The scientific
evidence is mounting however, large scale clinical studies are needed to reinforce data which can be utilized initially in dietary
guidance and latterly to support health claims.
' Nutrigenomic testing marketing is growing and has been fueled by consumer concerns for their health and the demand for genomic
information. Increasingly,consumers are inclined to invest in DTC nutrigenomic tests to assess their health status and obtain dietary
guidance. This market is currently estimated to be worth US$730 million and growing by 20% per annum.


Key findings from this report



' The food and drinks industry has been undergoing major regulatory changes during the last few years, particularly with respect to
health and dietary claims. Added to this, the adoption and application of nutrigenomic technologies, may provide additional clinical
data to substantiate claims and provide new opportunities to develop products which target consumer sub groups. This may require
further adjustments in the regulatory framework to stimulate innovation but ensure consumer safety.
' There are significant market opportunities for the development of nutrigenomic tests and products which target consumer groups.
Successful products will need to be supported by robust and reproducible clinical studies - these will cost time and money and will
only be feasible through public / private collaborations. The results will enable the manufacturer to clearly differentiate themselves and
target specific groups ' leading to fragmentation of the market and a shift in he healthcare paradigm from treatment towards
prevention.
' Synergies exist between the food and drinks industry and the pharma and diagnostic industry that may create opportunities (e.g.
biomarker discover) but also lead to conflicts as the food manufacturers aim to keep consumers healthier for longer forcing pharma to
switch to a more preventative strategy by targeting lifestyle disease (e.g. obesity) as their pool of unhealthy ill patients contracts.


Key questions answered



' Which companies are involved in nutrigenomic testing and how may they influence the uptake of personalised nutrition'
' How are Health and Nutrition market leaders applying nutrigenomic research in their R&D programs to develop new products or
create new marketing opportunities'
' What potential opportunities exist between the food and drinks industry and the pharma and diagnostic industry to co-develop
biomarkers for the development of personalised nutrition and medicine.




Companies mentioned
BASF, Chr. Hansen, DSM, Danone, Nestlé, Unilever, GeneLink, Gene Smart, Genova Diagnostics, Interleukin Genetics Inc,




                                                                                                                               Table of Content

Table of Contents
The Future of Nutrigenomics


The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration                                     Page 2/7
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Executive summary 10
Defining nutrigenomics 10
Market drivers 11
Collaborative nutrigenomic research & consortia 12
Leading food & drinks companies: nutrigenomic strategies 13
Leading nutrigenomic testing companies 14
Opportunities: convergence of pharma & diagnostics 15
Challenges: regulation, ethical & IP issues 16
Conclusions 17
Chapter 1 Defining nutrigenomics 20
Summary 20
Introduction 21
'Omic technologies 23
Nutrigenomics and the food & drinks industry 26
Nutrigenomics & food products 28
Nutrigenomics & personalized nutrition 28
Report outline 29
Chapter 2 Market drivers 32
Summary 32
Introduction 33
Drivers for personalized nutrition 34
Healthy aging 34
Consumer demographics 36
Chronic non-communicable disease 38
Urbanization and the emerging markets 40
Global health economics 41
Conclusions on drivers for personalized nutrition 42
Chapter 3 Collaborative nutrigenomic research & consortia 46
Summary 46
Introduction 47
Nutrigenomic research consortia 47
Nutrigenomic research in the EU 49
The European Nutrigenomics Organization (NuGO) 49
DiOGenes 51
TI Food and Nutrition 51
Vision EpiFood Project 53
Canada Foundation for Innovation (CFI) 53
Public-private in age-related diseases 53
Nutrigenomic research in the US 55
Public-private partnership: genetically modified crops 57
Nutrigenomic research across the world 58
International Society of Nutrigenetics/Nutrigenomics (ISNN) 58
Conclusions 59
Chapter 4 Leading food & drinks companies: nutrigenomic strategies 62
Summary 62
Introduction 63
Ingredients manufacturers approach to nutrigenomics 64
BASF 64
Chr Hansen 66
DSM 69


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Food manufacturers' approach to nutrigenomics 73
Group Danone 73
Nestlé 76
Unilever 78
Pharma industry M&A in consumer nutrition 80
The evolving open network model 82
Co-development opportunities 86
Areas for market growth & time scales 88
Conclusions 90
Chapter 5 Leading nutrigenomic testing companies 94
Summary 94
Introduction 95
Market leaders 95
23andme.com 97
GeneLink 98
Gene Smart 98
Genova Diagnostics 99
Interleukin Genetics Inc 100
WellGen Inc. 102
Conclusions 104
Chapter 6 Opportunities: convergence of pharma & diagnostics 108
Summary 108
Introduction 109
Nutrigenomics vs pharmacogenomics 110
Global health issues treatment vs prevention 115
Convergence of the pharmaceutical & diagnostic market 116
Conclusions 118
Chapter 7 Challenges: regulation, ethical & IP issues 120
Summary 120
Introduction 121
Regulation of nutrigenomic foods 122
Europe 123
Japan 124
Regulation of nutrigenomic tests 125
Ethical issues 127
Public awareness & perceptions 128
Intellectual Property 129
Conclusions 131
Chapter 8 Conclusions 134
Summary 134
The food & drinks market 135
Global genetic testing market 136
Market trends 136
Overall conclusions 137
Appendix 140
Primary research methodology 140
Acknowledgments 141
Glossary 142
Index 145
Bibliography 148


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Endnotes 151


List of Figures
Figure 1.1: Nutrigenetics and nutrigenomics 22
Figure 1.2: The 'omics technologies 24
Figure 1.3: The functional genomic tool box 26
Figure 1.4: Applications of nutrigenomics in the food chain 27
Figure 2.5: Drivers for the food & drinks industry 33
Figure 2.6: The ageing population a driver for personalized nutrition 35
Figure 2.7: Personalized nutrition targeting consumer segments 36
Figure 2.8: Population over 60: world and developed regions (1950-2050) 37
Figure 2.9: Nutritional challenges ' obesity & metabolic syndrome 38
Figure 2.10: Growth in consumers in developing & emerging countries (2008-2018) 40
Figure 2.11: Healthcare expenditure as a share of GDP (2006) 41
Figure 2.12: Target population of nutrigenomic based products 43
Figure 4.13: BASF approach to gene discovery 65
Figure 4.14: DSMs sales growth targeting four emerging business areas 70
Figure 4.15 DSMs R&D competencies 72
Figure 4.16 An International and interdisciplinary network 75
Figure 4.17 Diversify & de-risk through externalization 84
Figure 4.18 Open network model 85
Figure 4.19: Waves of nutrigenomic development 90
Figure 5.20: WellGen's nutrigenomic based discovery 103
Figure 6.21: Nutrigenomics vs pharmacogenomics 111
Figure 6.22: Relationship of drugs, disease, genes and gene products 113
Figure 8.23: Health and nutrition market segments (2009) 135
Figure 8.24: Nutrigenomic impact on personalized nutrition 139


List of Tables
Table 3.1: European Consortia and Nutrigenomic Research Programs 50
Table 3.2: Nutrigenomics Network Programs 55
Table 4.3: Stakeholders in nutrigenomic research and personalized nutrition 63
Table 4.4: Chr Hansen - strategic alliances & investments 67
Table 4.5: Nestlé nutrigenomic alliances & investments 77
Table 4.6: Divestment of Animal, Consumer & Medical Nutrition Divisions 80
Table 4.7: Consumer Health Divisions of Pharmaceutical Companies 81
Table 4.8: Alliance between Food, Pharma, Biotech and the Diagnostic Industries 82
Table 5.9: Categorization of genetic variations that may be included in nutrigenomic tests 96
Table 5.10: Categorization of genetic variations that may be included in nutrigenomic tests 97
Table 6.11: Known diet- gene interactions 112
Table 6.12: Known gene-nutrient interactions 114




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The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration

  • 1. Find Industry reports, Company profiles ReportLinker and Market Statistics >> Get this Report Now by email! The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Published on January 2010 Report Summary Nutrigenomics explores how nutrients or bioactive dietary compounds can influence gene expression and an individuals risk to certain diseases. Nutrigenetics is the study of how variations in an individual's genetic makeup can increase or decrease the need for a specific nutrient or bioactive food component. Nutrigenomics has the potential to impact various parts of the food chain including the genetic modification of crops and animal feeds, the development of nutrigenomic tests to monitor food safety and personalization of diets, as well as the identification of nutritional supplements and nutrigenomic based products which may offer potential health benefits. The consumer environment is driving growth in the Nutrition & Health market. Over the past decade, consumers have become more concerned for their health and are increasingly inclined to invest in DTC nutrigenetic tests to assess their risk of disease and obtain dietary advice. Healthcare providers too, are keen to shift some of the burden of healthcare costs to individuals and recognize that the personalization of nutrition may be beneficial. The Health and nutrition market is currently worth around $485 billion. This report reviews the business strategies of leading companies regarding the adoption of nutrigenomic technologies and establishment of public-private partnerships as well as potential opportunities for biomarker discovery with the pharma and diagnostic industry to personalize nutrition and medicine. Key features of this report ' Identify leading academic groups and companies at the forefront of the nutrigenomic research who will drive the market towards a more personalized approach to nutrition and disease prevention. ' Assess the nutrigenomic testing market, leading companies and its role in empowering consumers to take a more active role in making dietary decisions and maintaining their health status ' Review the backgrounds, strategies and business models of companies and assess potential opportunities to collaborate with the pharma and diagnostic industry. Scope of this report ' Identify the companies leading the field in nutrigenomic research from ingredient & food manufacturers to nutrigenomic testing companies ' Review their key products and business alliances which enable them to participate in this evolving field of science ' Identify points of convergence of the pharma, diagnostic and food and drinks markets which may offer new opportunities for co development ' Review market drivers regarding the adoption of nutrigenomic information and the personalization of nutrition. Key Market Issues The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Page 1/7
  • 2. Find Industry reports, Company profiles ReportLinker and Market Statistics ' The food market is changing: Over the past decade, consumers have become more concerned for their health and wellbeing. The roll of the food and drinks industry is changing and shifting towards a more benefit driven and preventative approach. In order to respond to market dynamics the companies have needed to adopt an 'open network' model to gain access to innovative research and technologies which will drive future product development. ' Nutrigenomics & pharmacogenomics are related in their approach to identify subpopulations that respond to treatment/nutrition. The application of these technologies may lead to the identification of old and new ingredients that have beneficial effects for specific consumer groups, helping to maintain health and wellness and leading to the personalization of treatment and diets. The scientific evidence is mounting however, large scale clinical studies are needed to reinforce data which can be utilized initially in dietary guidance and latterly to support health claims. ' Nutrigenomic testing marketing is growing and has been fueled by consumer concerns for their health and the demand for genomic information. Increasingly,consumers are inclined to invest in DTC nutrigenomic tests to assess their health status and obtain dietary guidance. This market is currently estimated to be worth US$730 million and growing by 20% per annum. Key findings from this report ' The food and drinks industry has been undergoing major regulatory changes during the last few years, particularly with respect to health and dietary claims. Added to this, the adoption and application of nutrigenomic technologies, may provide additional clinical data to substantiate claims and provide new opportunities to develop products which target consumer sub groups. This may require further adjustments in the regulatory framework to stimulate innovation but ensure consumer safety. ' There are significant market opportunities for the development of nutrigenomic tests and products which target consumer groups. Successful products will need to be supported by robust and reproducible clinical studies - these will cost time and money and will only be feasible through public / private collaborations. The results will enable the manufacturer to clearly differentiate themselves and target specific groups ' leading to fragmentation of the market and a shift in he healthcare paradigm from treatment towards prevention. ' Synergies exist between the food and drinks industry and the pharma and diagnostic industry that may create opportunities (e.g. biomarker discover) but also lead to conflicts as the food manufacturers aim to keep consumers healthier for longer forcing pharma to switch to a more preventative strategy by targeting lifestyle disease (e.g. obesity) as their pool of unhealthy ill patients contracts. Key questions answered ' Which companies are involved in nutrigenomic testing and how may they influence the uptake of personalised nutrition' ' How are Health and Nutrition market leaders applying nutrigenomic research in their R&D programs to develop new products or create new marketing opportunities' ' What potential opportunities exist between the food and drinks industry and the pharma and diagnostic industry to co-develop biomarkers for the development of personalised nutrition and medicine. Companies mentioned BASF, Chr. Hansen, DSM, Danone, Nestlé, Unilever, GeneLink, Gene Smart, Genova Diagnostics, Interleukin Genetics Inc, Table of Content Table of Contents The Future of Nutrigenomics The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Page 2/7
  • 3. Find Industry reports, Company profiles ReportLinker and Market Statistics Executive summary 10 Defining nutrigenomics 10 Market drivers 11 Collaborative nutrigenomic research & consortia 12 Leading food & drinks companies: nutrigenomic strategies 13 Leading nutrigenomic testing companies 14 Opportunities: convergence of pharma & diagnostics 15 Challenges: regulation, ethical & IP issues 16 Conclusions 17 Chapter 1 Defining nutrigenomics 20 Summary 20 Introduction 21 'Omic technologies 23 Nutrigenomics and the food & drinks industry 26 Nutrigenomics & food products 28 Nutrigenomics & personalized nutrition 28 Report outline 29 Chapter 2 Market drivers 32 Summary 32 Introduction 33 Drivers for personalized nutrition 34 Healthy aging 34 Consumer demographics 36 Chronic non-communicable disease 38 Urbanization and the emerging markets 40 Global health economics 41 Conclusions on drivers for personalized nutrition 42 Chapter 3 Collaborative nutrigenomic research & consortia 46 Summary 46 Introduction 47 Nutrigenomic research consortia 47 Nutrigenomic research in the EU 49 The European Nutrigenomics Organization (NuGO) 49 DiOGenes 51 TI Food and Nutrition 51 Vision EpiFood Project 53 Canada Foundation for Innovation (CFI) 53 Public-private in age-related diseases 53 Nutrigenomic research in the US 55 Public-private partnership: genetically modified crops 57 Nutrigenomic research across the world 58 International Society of Nutrigenetics/Nutrigenomics (ISNN) 58 Conclusions 59 Chapter 4 Leading food & drinks companies: nutrigenomic strategies 62 Summary 62 Introduction 63 Ingredients manufacturers approach to nutrigenomics 64 BASF 64 Chr Hansen 66 DSM 69 The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Page 3/7
  • 4. Find Industry reports, Company profiles ReportLinker and Market Statistics Food manufacturers' approach to nutrigenomics 73 Group Danone 73 Nestlé 76 Unilever 78 Pharma industry M&A in consumer nutrition 80 The evolving open network model 82 Co-development opportunities 86 Areas for market growth & time scales 88 Conclusions 90 Chapter 5 Leading nutrigenomic testing companies 94 Summary 94 Introduction 95 Market leaders 95 23andme.com 97 GeneLink 98 Gene Smart 98 Genova Diagnostics 99 Interleukin Genetics Inc 100 WellGen Inc. 102 Conclusions 104 Chapter 6 Opportunities: convergence of pharma & diagnostics 108 Summary 108 Introduction 109 Nutrigenomics vs pharmacogenomics 110 Global health issues treatment vs prevention 115 Convergence of the pharmaceutical & diagnostic market 116 Conclusions 118 Chapter 7 Challenges: regulation, ethical & IP issues 120 Summary 120 Introduction 121 Regulation of nutrigenomic foods 122 Europe 123 Japan 124 Regulation of nutrigenomic tests 125 Ethical issues 127 Public awareness & perceptions 128 Intellectual Property 129 Conclusions 131 Chapter 8 Conclusions 134 Summary 134 The food & drinks market 135 Global genetic testing market 136 Market trends 136 Overall conclusions 137 Appendix 140 Primary research methodology 140 Acknowledgments 141 Glossary 142 Index 145 Bibliography 148 The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Page 4/7
  • 5. Find Industry reports, Company profiles ReportLinker and Market Statistics Endnotes 151 List of Figures Figure 1.1: Nutrigenetics and nutrigenomics 22 Figure 1.2: The 'omics technologies 24 Figure 1.3: The functional genomic tool box 26 Figure 1.4: Applications of nutrigenomics in the food chain 27 Figure 2.5: Drivers for the food & drinks industry 33 Figure 2.6: The ageing population a driver for personalized nutrition 35 Figure 2.7: Personalized nutrition targeting consumer segments 36 Figure 2.8: Population over 60: world and developed regions (1950-2050) 37 Figure 2.9: Nutritional challenges ' obesity & metabolic syndrome 38 Figure 2.10: Growth in consumers in developing & emerging countries (2008-2018) 40 Figure 2.11: Healthcare expenditure as a share of GDP (2006) 41 Figure 2.12: Target population of nutrigenomic based products 43 Figure 4.13: BASF approach to gene discovery 65 Figure 4.14: DSMs sales growth targeting four emerging business areas 70 Figure 4.15 DSMs R&D competencies 72 Figure 4.16 An International and interdisciplinary network 75 Figure 4.17 Diversify & de-risk through externalization 84 Figure 4.18 Open network model 85 Figure 4.19: Waves of nutrigenomic development 90 Figure 5.20: WellGen's nutrigenomic based discovery 103 Figure 6.21: Nutrigenomics vs pharmacogenomics 111 Figure 6.22: Relationship of drugs, disease, genes and gene products 113 Figure 8.23: Health and nutrition market segments (2009) 135 Figure 8.24: Nutrigenomic impact on personalized nutrition 139 List of Tables Table 3.1: European Consortia and Nutrigenomic Research Programs 50 Table 3.2: Nutrigenomics Network Programs 55 Table 4.3: Stakeholders in nutrigenomic research and personalized nutrition 63 Table 4.4: Chr Hansen - strategic alliances & investments 67 Table 4.5: Nestlé nutrigenomic alliances & investments 77 Table 4.6: Divestment of Animal, Consumer & Medical Nutrition Divisions 80 Table 4.7: Consumer Health Divisions of Pharmaceutical Companies 81 Table 4.8: Alliance between Food, Pharma, Biotech and the Diagnostic Industries 82 Table 5.9: Categorization of genetic variations that may be included in nutrigenomic tests 96 Table 5.10: Categorization of genetic variations that may be included in nutrigenomic tests 97 Table 6.11: Known diet- gene interactions 112 Table 6.12: Known gene-nutrient interactions 114 The Future of Nutrigenomics: New opportunities in personalized nutrition and food-pharma collaboration Page 5/7
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