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Advanced Orthopedic Technologies, Implants and Regenerative Products

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THE REPORT CONTAINSThe total market for advanced orthopedic technology and products was estimated to exceed $27.7 billion in 2009, from $26.4 billion the previous year (2008). By 2015, the advanced …

THE REPORT CONTAINSThe total market for advanced orthopedic technology and products was estimated to exceed $27.7 billion in 2009, from $26.4 billion the previous year (2008). By 2015, the advanced orthopedic technology and product market is likely to reach $32.4 billion, with average growth estimated at 2.7%. Worldwide, the bone repair and regenerative product market has increased over the past several years. In 2009, the market experienced an increase over the $2.9 billion in 2008 to reach $3.1 billion. Worldwide, the total joint replacement, implant and regenerative product markets generated approximately $23.2 billion in 2009,over $22.3 billion estimated for 2008INTRODUCTIONSTUDY GOALS AND OBJECTIVESThis report provides an overview of products in the advanced orthopedic market, offers detailed market analyses, and discusses competitive environments.The study includes information about significant products and players, issues and trends, as well as other data affecting the orthopedic device industry.REASONS FOR DOING THE STUDYWith technology advancements and a better understanding of the body, the orthopedic device market offers a range of highly complex and leading-edge products.They now are a significant part of the industry.While there are many conventional and generally less expensive products, new items and biotechnological advancements are beginning to revolutionize future growth of the orthopedic device market.The latest technological products are competing in a fast track market that looks to improve the quality of life for millions of individuals who need procedures such as hip and knee transplants.Ongoing patient management studies, combined with a drive to produce technologically superior products, will increase the number of patients who can benefit from developments in the advanced orthopedic product market.This study will provide readers with the knowledge needed to adequately view and assess this market and will provide insights into the market potentials, including trends that are, and will continue to drive this segment in the future.SCOPE OF THE REPORTThis study will be a helpful business tool providing a thorough evaluation of the advanced orthopedic market.Its geographic scope is global with special emphasis on the United States and the European Union.The report identifies markets in three general segments:Bone repair and regenerative productsCartilage and soft tissue repair and regenerative productsJoint replacement, implants, and regenerative products.Each market segment provides detailed information based on product categories, product use, forecasts, and competitive analyses.Advanced orthopedics deals with those products involving new techniques and therapies.They provide a significant patient outcome over traditional methods, as well as improving healing and lowering overall care costs.These products incorporate biotechnological advancements and improved methods for dealing with orthopedic injuries and conditions. Products in this study are considered to be at the forefront of orthopedic device technology.Products not considered advanced include external bracing, slings, casting materials etc.Those classified by industry experts as advanced orthopedic products include: human bone products and materials, bone growth stimulators, synthetic bone replacements, cartilage and soft tissue fixation systems, biologics/biomaterials, complex joint replacement devices, spine devices, and joint fluid replacements.METHODOLOGYThe information for this report was obtained through primary and secondary data collection methods.Primary sources included interviews with more than 50 key executives, product managers, clinical specialists and other related key personnel involved with the orthopedic industry.Secondary sources included published literature, investment reports, company literature, and various business journals that have emphases on orthopedic devices and related areas.Market data for this repo

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  • 1. Find Industry reports, Company profilesReportLinker and Market Statistics >> Get this Report Now by email!Advanced Orthopedic Technologies, Implants and RegenerativeProductsPublished on January 2011 Report SummaryTHE REPORT CONTAINSThe total market for advanced orthopedic technology and products was estimated to exceed $27.7 billion in 2009, from $26.4 billionthe previous year (2008). By 2015, the advanced orthopedic technology and product market is likely to reach $32.4 billion, withaverage growth estimated at 2.7%.Worldwide, the bone repair and regenerative product market has increased over the past several years. In 2009, the marketexperienced an increase over the $2.9 billion in 2008 to reach $3.1 billion.Worldwide, the total joint replacement, implant and regenerative product markets generated approximately $23.2 billion in 2009,over$22.3 billion estimated for 2008INTRODUCTIONSTUDY GOALS AND OBJECTIVESThis report provides an overview of products in the advanced orthopedic market, offers detailed market analyses, and discussescompetitive environments. The study includes information about significant products and players, issues and trends, as well as otherdata affecting the orthopedic device industry.REASONS FOR DOING THE STUDYWith technology advancements and a better understanding of the body, the orthopedic device market offers a range of highly complexand leading-edge products. They now are a significant part of the industry. While there are many conventional and generally lessexpensive products, new items and biotechnological advancements are beginning to revolutionize future growth of the orthopedicdevice market. The latest technological products are competing in a fast track market that looks to improve the quality of life formillions of individuals who need procedures such as hip and knee transplants.Ongoing patient management studies, combined with a drive to produce technologically superior products, will increase the number ofpatients who can benefit from developments in the advanced orthopedic product market. This study will provide readers with theknowledge needed to adequately view and assess this market and will provide insights into the market potentials, including trendsthat are, and will continue to drive this segment in the future.SCOPE OF THE REPORTThis study will be a helpful business tool providing a thorough evaluation of the advanced orthopedic market. Its geographic scope isglobal with special emphasis on the United States and the European Union. The report identifies markets in three general segments:Bone repair and regenerative productsCartilage and soft tissue repair and regenerative productsAdvanced Orthopedic Technologies, Implants and Regenerative Products Page 1/13
  • 2. Find Industry reports, Company profilesReportLinker and Market StatisticsJoint replacement, implants, and regenerative products.Each market segment provides detailed information based on product categories, product use, forecasts, and competitive analyses.Advanced orthopedics deals with those products involving new techniques and therapies. They provide a significant patient outcomeover traditional methods, as well as improving healing and lowering overall care costs. These products incorporate biotechnologicaladvancements and improved methods for dealing with orthopedic injuries and conditions.Products in this study are considered to be at the forefront of orthopedic device technology. Products not considered advancedinclude external bracing, slings, casting materials etc. Those classified by industry experts as advanced orthopedic products include:human bone products and materials, bone growth stimulators, synthetic bone replacements, cartilage and soft tissue fixation systems,biologics/biomaterials, complex joint replacement devices, spine devices, and joint fluid replacements.METHODOLOGYThe information for this report was obtained through primary and secondary data collection methods. Primary sources includedinterviews with more than 50 key executives, product managers, clinical specialists and other related key personnel involved with theorthopedic industry. Secondary sources included published literature, investment reports, company literature, and various businessjournals that have emphases on orthopedic devices and related areas.Market data for this report pertains to the world market in U.S. dollars at the manufacturers level. The base year of the report is 2010,with historical data provided for 2008 and 2009 and with forecast data provided for 2015. Historical, base year, and forecast data areprovided for each market segment of the report. Growth rates are determined through a compilation of data including past trends,future trends, demographics, incidence, mortality, products in research and development, current product growth, etc. Competitormarket share estimates are provided for each market segment for the 2010 base year.ABOUT THE AUTHORMelissa Elder is an experienced healthcare market analyst specializing in prescription and over-the-counter pharmaceuticals, medicaldevices, and emerging healthcare technologies. Ms. Elder has more than 15 years experience in the healthcare industry, specializingin market research for the past 12 years. This experience has given her substantial insights into pharmaceutical market analysis. Herwork in the medical community, including emergency room medical training and healthcare information system coordination, hasenhanced her ability to provide insight into many healthcare markets. Table of ContentChapter- 1: INTRODUCTIONSTUDY GOALS AND OBJECTIVES 1REASONS FOR DOING THE STUDY 1SCOPE OF THE REPORT 1METHODOLOGY 2RELATED BCC STUDIES 2ABOUT THE AUTHOR 3BCC ONLINE SERVICES 3DISCLAIMER 3DISCLAIMER (CONTINUED) 4Advanced Orthopedic Technologies, Implants and Regenerative Products Page 2/13
  • 3. Find Industry reports, Company profilesReportLinker and Market StatisticsChapter-2: SUMMARYSUMMARY 5SUMMARY (CONTINUED) 6SUMMARY TABLE GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, THROUGH 2015 ($MILLIONS) 7SUMMARY FIGURE ADVANCED ORTHOPEDIC TECHNOLOGY, IMPLANTS AND REGNERATIVE PRODUCTS, 2008-2015 ($MILLIONS) 8Chapter-3: INDUSTRY OVERVIEWHISTORY OF THE ORTHOPEDIC INDUSTRY 9ADVANCED ORTHOPEDIC MARKET DEVELOPMENT 9GOVERNMENT REGULATION OF DEVICES 10Regulation, Cost and Classification of Devices by Region 10Costs 10FIGURE 1 STANDARD SUBMISSION FEES AND EXPENDITURES FOR DEVICE APPROVALS PER COUNTRY, 2010 (FILINGFEES FOR 510(K) AND SIMILAR DEVICES 11United States (FDA) 11510(k) Exemptions 12TABLE 1 PARTS 862-892 OF 21 CFR 13Humanitarian Device Exemption (U.S.) 14TABLE 2 LISTING OF ORTHOPEDIC-RELATED CDRH HUMANITARIAN DEVICE EXEMPTIONS, CURRENT THROUGHSEPTEMBER 2010 15TABLE 2 (CONTINUED) 16TABLE 2 (CONTINUED) 17Investigational Device Exemption (IDE) 17Changes in FDA Advisor Roles 17Canada (Health Canada) 18Europe (MDD) 19Japan 20Japan (Continued) 21Australia 22TREATMENT SETTINGS 23Ambulatory Treatment Facilities 23TABLE 3 U.S. AMBULATORY VISITS ALL AGES BY FACILITY TYPE, 1996 AND 2006 (PER 100 POPULATION) 23TABLE 4 U.S. EMERGENCY ROOM VISITS BY INJURY LOCATION AND SPORT/ACTIVITY, 2006-2008 24Orthopedic Rehabilitation Facilities and Physical Therapy 24Orthopedic Surgeons 25TABLE 5 U.S. PHYSICIANS BY SELECTED SPECIALTY, 19802007 (THOUSANDS) 25Chapter-4: ISSUES AFFECTING THE MARKETINSURANCE AND REIMBURSEMENT ISSUES 26TABLE 6 MEDICARE REIMBURSEMENT RATES FOR COMMON ORTHOPEDIC PROCEDURES, 2009 ($) 27TABLE 7 HEALTH EXPENDITURES AS PERCENT OF GDP BY COUNTRY: 1980 TO 2006 (%) 28FIGURE 2 HEALTH EXPENDITURES AS PERCENT OF GDP BY COUNTRY: 1980 TO 2006 (%) 29MEDICAL DEVICE PRICING TRENDS 29MARKETING AND ADVERTISING ISSUES AND TRENDS 29LEADING MANUFACTURERS STRATEGIES 30Advanced Orthopedic Technologies, Implants and Regenerative Products Page 3/13
  • 4. Find Industry reports, Company profilesReportLinker and Market StatisticsManufacture, Distribution and Supply 31TABLE 8 ADVANCED ORTHOPEDIC MANUFACTURING AND SUPPLY FACILITIES 32Alphatec 33Biomet, Inc. 33DJO, Inc. 33Exactech 33LifeCell 34Orthovita 34Smith & Nephew 34Stryker 34Wright Medical 35Zimmer Holding 35Sales and Marketing 35TABLE 9 ADVANCED ORTHOPEDIC SALES, MARKETING AND ADMINISTRATIVE EXPENDITURES BY MANUFACTURER FORFISCAL YEARS 2009 AND 2010 ($ MILLIONS) 36TABLE 9 (CONTINUED) 37FIGURE 3 ADVANCED ORTHOPEDIC SALES, MARKETING AND ADMINISTRATIVE EXPENDITURES BY MANUFACTURER FORFISCAL YEARS 2009 AND 2010 ($ MILLIONS) 38Arthrocare 38Biomet, Inc. 38Exactech 39Genzyme Biosurgery 39Integra Life Sciences 39Orthovita 39Smith & Nephew 40Stryker 40Wright Medical 40Zimmer Holding 40Research and Development Trends 41TABLE 10 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED ORTHOPEDIC MANUFACTURERS ANDSUPPLIERS, 2008-2010 (ESTIMATED) ($ MILLIONS) 42FIGURE 4 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED ORTHOPEDIC MANUFACTURERS ANDSUPPLIERS, 2008-2010 ESTIMATED ($ MILLIONS) 43Acquisitions, Alliances, and Agreements 43Alphatec 43Baxter International, Inc. 44Exactech 44Integra Life Sciences 44Medtronic 45NuVasive 45Smith & Nephew 45Wright Medical 45Employee Snapshot and Distribution 46TABLE 11 EMPLOYEE DISTRIBUTION FOR ORTHOPEDIC MANUFACTURERS AND SUPPLIERS, 2009 ($ MILLIONS) 46MEDICAL TOURISM IMPACT ON THE ORTHOPEDIC MARKET 47TABLE 12 HIP REPLACEMENT: GLOBAL COST VARIATIONS, 2008 DATA 48FIGURE 5 HIP REPLACEMENT: GLOBAL COST VARIATIONS, 2008 48TABLE 13 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 49FIGURE 6 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 50TABLE 14 WORLD HEALTH ORGANIZATION RANKING OF HEALTHCARE SYSTEMS, TOP 50 51Advanced Orthopedic Technologies, Implants and Regenerative Products Page 4/13
  • 5. Find Industry reports, Company profilesReportLinker and Market StatisticsTABLE 14 (CONTINUED) 52DEMOGRAPHICS AND AGING POPULATIONS 52World Demographics 52TABLE 15 ESTIMATED WORLD POPULATION AND ANNUAL GROWTH BY SELECTED AGE GROUP AND SELECTED YEARS,THROUGH 2030 (MILLIONS) 53FIGURE 7 ESTIMATED WORLD POPULATION BY SELECTED AGE GROUP AND SELECTED YEARS, 2000-2030 (MILLIONS) 53TABLE 16 WORLD POPULATION BY SELECTED COUNTRIES, THROUGH 2015 (MILLIONS) 54FIGURE 8 WORLD POPULATION BY SELECTED COUNTRIES, 2008-2015 (MILLIONS) 55U.S. Demographics 55TABLE 17 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP, 1900 TO 2050 (THOUSANDS) 56FIGURE 9 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP, 1900 TO 2050 (THOUSANDS) 56Gender, Age, and Life Expectancy 57TABLE 18 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH PROJECTIONS BY SEX, 2000 AND 2020(YEARS) 57FIGURE 10 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH PROJECTIONS BY SEX, 2000 AND 2020(YEARS) 58INCIDENCE OF ORTHOPEDIC CONDITIONS 58Osteoarthritis 58Rheumatoid Arthritis 59Ankylosing Spondylitis 59Fibromyalgia 59Gout 60Scleroderma 60Lupus 60Bursitis and Tendonitis 60Osteoporosis 61Low Bone Mass 61TABLE 19 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE GLOBAL ORTHOPEDICINDUSTRY, AVERAGE FIGURE, 20082010 (MILLIONS) 61TABLE 19 (CONTINUED) 62FIGURE 11 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE GLOBAL ORTHOPEDIC INDUSTRY,AVERAGE FIGURE 20082010 (%) 62FIGURE 11 (CONTINUED) 63ORTHOPEDIC PROCEDURE VOLUMES IN THE UNITED STATES 63FIGURE 12 NUMBER OF U.S. HIP REPLACEMENT PROCEDURES, 20002010 (THOUSANDS) 64FIGURE 13 NUMBER OF U.S. KNEE REPLACEMENT PROCEDURES, 20002010 64FIGURE 13 (CONTINUED) 65FIGURE 14 NUMBER OF U.S. SPINAL FUSION PROCEDURES, 20002010 (THOUSANDS) 65FIGURE 15 NUMBER OF U.S. PHYSICIAN VISITS FOR ROTATOR CUFF PROBLEMS, 20002010 (MILLIONS) 66RISING ORTHOPEDIC INCIDENCE AND EVOLVING LIFESTYLE TRENDS 66Overweight and Obesity 66TABLE 20 U.S. AGE-ADJUSTED PERCENT DISTRIBUTION OF BODY MASS INDEX (BMI) AMONG PERSONS 18 YEARS ANDOVER BY SELECTED CHARACTERISTICS, 2003-2006 67FIGURE 16 OBESITY PERCENTAGES BY COUNTRY, 2006 (%) 68Smoking 69TABLE 21 PERCENT OF SMOKERS IN THE U.S. POPULATION 18 AND OLDER BY AGE AND SEX, 2007 69TABLE 22 DAILY TOBACCO CONSUMPTION BY COUNTRY: 1990 COMPARED TO 2006 70Sedentary Lifestyle 70TABLE 23 PERCENT OF U.S. ADULTS ENGAGING IN PHYSICAL ACTIVITY AND FITNESS BY SELECTED CHARACTERISTICS,2006 71Advanced Orthopedic Technologies, Implants and Regenerative Products Page 5/13
  • 6. Find Industry reports, Company profilesReportLinker and Market StatisticsNutrition 71COMPARISON OF BONE MINERAL DENSITY LEVELS IN POPULATIONS 71Comparison of Bone Mineral (Continued) 72Chapter-5: TECHNOLOGYINTRODUCTION 73PATENT TRENDS 73ORTHOPEDIC PATENTS BY YEAR 73TABLE 24 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 19952010* 74FIGURE 17 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 19952010* 75INTERNATIONAL PATENTS BY COUNTRY OF ORIGIN 75TABLE 25 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 19762010 76FIGURE 18 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 19762010 76PATENT TRENDS BY ASSIGNEE 77TABLE 26 ADVANCED ORTHOPEDIC PATENT INFORMATION BY ASSIGNEE 77TABLE 26 (CONTINUED) 78TABLE 26 (CONTINUED) 79TABLE 26 (CONTINUED) 80FIGURE 19 TOTAL NUMBER OF PATENTS HELD, BY ASSIGNEE 81Biomet 81ConMed 82DePuy 82Encore Medical (now DJO Surgical) 82Exactech 82Medtronic Sofamor Danek 83Smith & Nephew 83Stryker 83Synthes 84Warsaw Orthopedic 84Wright Medical 85Zimmer 85ADVANCED ORTHOPEDIC TECHNOLOGIES 85Bone Growth Stimulation Devices 86Orthopedic Growth Factors 86Transcutaneous Electrical Nerve Stimulation Units (TENS) 87Light Therapy (Light-Emitting Diodes and Infrared) 87Light Therapy (Continued) 88Thermal Imaging 89Nanotechnology and Microprocessors 89Digital X-rays 90Bone Density Improvements 90High-resolution Cartilage Imaging 90Stem Cells 91Government Limitations 91Embryonic Stem Cells 92Adult Stem Cells 92Bone Technology and Stem Cells 92Synthetic Bone Grafting 93Bone Modeling for Osteoporotic Spinal Fracture Testing 93Advanced Orthopedic Technologies, Implants and Regenerative Products Page 6/13
  • 7. Find Industry reports, Company profilesReportLinker and Market StatisticsAdvanced Mechanical Implant Creation 93Advanced Mechanical (Continued) 94Chapter-6: BONE REPAIR AND REGENERATIVE PRODUCTSSEGMENT OVERVIEW 95BONE GRAFTS 95TABLE 27 BONE GRAFT PRODUCTS AND MATERIALS 96TABLE 27 (CONTINUED) 97PROCEDURES USING BONE GRAFTS 97PRODUCT DESCRIPTIONS 97HUMAN BONE PRODUCTS 98TABLE 28 HUMAN BONE PRODUCTS AND COMPETITORS 98Biomet 99DePuy 99Exactech 99Integra Life Sciences 99LifeCell, Inc. 100Medtronic 101Smith & Nephew 101Wright Medical 101Zimmer Holding 102BONE GROWTH STIMULATORS 102TABLE 29 BONE GROWTH STIMULATOR (BIOLOGICAL) PRODUCTS AND COMPETITORS 102TABLE 30 BONE GROWTH STIMULATOR (ELECTRICAL/ULTRASOUND DEVICES) PRODUCTS AND COMPETITORS 103Biomet 103DJO, Inc. 103Medtronic 104NuVasive 105Orthofix International 105Smith & Nephew 106Stryker 106SYNTHETIC BONE REPLACEMENTS 107TABLE 31 SYNTHETIC BONE REPLACEMENT PRODUCTS AND COMPETITORS 107TABLE 31 (CONTINUED) 108Apatech 108Biomet 108DePuy 108Exactech 109Integra Life Sciences 109Medtronic 109Orthovita 109Smith & Nephew 110Stryker 110Synthes 110Wright Medical 110Zimmer Holdings, Inc. 111NEW DEVELOPMENTS 111ALPHATEC 111KAKEN PHARMACEUTICALS CO, LTD. 111Advanced Orthopedic Technologies, Implants and Regenerative Products Page 7/13
  • 8. Find Industry reports, Company profilesReportLinker and Market StatisticsORTHOVITA 111MARKET ANALYSIS 112MARKETS BY PRODUCT TYPE 112Markets by Product Type (Continued) 113TABLE 32 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET, THROUGH 2015 ($ MILLIONS) 114FIGURE 20 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET, 2008-2015 ($ MILLIONS) 114SALES DISTRIBUTION BY PROCEDURE TYPE 114TABLE 33 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY PROCEDURE TYPE, 2010 (%/$MILLIONS) 115FIGURE 21 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 ($MILLIONS) 115MARKETS BY WORLD REGION 116TABLE 34 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 (%/$MILLIONS) 117FIGURE 22 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 (%)117LEADING SUPPLIERS AND PARTICIPANTS 117Leading Suppliers and Participants (Continued) 118TABLE 35 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2010 (%/$MILLIONS) 119FIGURE 23 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2010 ($MILLIONS) 120Chapter-7: CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTSSEGMENT OVERVIEW 121PRODUCT DESCRIPTIONS 122FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES 122TABLE 36 FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES AND MARKETERS 122TABLE 36 (CONTINUED) 123Arthrex 124ArthroCare 124Biomet 124Conmed Linvatec 124Covidien 125DePuy 125Integra Life Sciences 126Ortheon Medical 126Smith & Nephew 126Stryker 127Zimmer Holding 127BIOLOGICS AND BIOMATERIALS 127TABLE 37 CARTILAGE AND SOFT TISSUE BIOLOGICS AND BIOMATERIALS SEGMENT 127Aesculap 128Biomet 128DePuy 128Genzyme Biosurgery 128Integra Life Sciences 128LifeCell, Inc. 129Organogenesis 129Advanced Orthopedic Technologies, Implants and Regenerative Products Page 8/13
  • 9. Find Industry reports, Company profilesReportLinker and Market StatisticsStryker 129Synovis 129Wright Medical 129Zimmer Holding 130NEW DEVELOPMENTS 130Arthrocare 130Wright Medical 130Zimmer 130MARKET ANALYSIS 131MARKETS BY PRODUCT TYPE 131Markets by Product Type (Continued) 132TABLE 38 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS MARKET, THROUGH 2015 ($MILLIONS) 133FIGURE 24 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS MARKET, 2008-2015 ($MILLIONS) 133MARKETS BY WORLD REGION 133TABLE 39 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER SOFT TISSUE REPAIR ANDREGENERATIVE PRODUCTS BY REGION, 2010 (%) 134FIGURE 25 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER SOFT TISSUE REPAIR ANDREGENERATIVE PRODUCTS BY REGION, 2010 (%) 135LEADING SUPPLIERS AND PARTICIPANTS 135Leading Suppliers and (Continued) 136TABLE 40 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BYCOMPETITOR REVENUES, 2010 (%/$ MILLIONS) 137FIGURE 26 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BYCOMPETITOR REVENUES, 2010 ($ MILLIONS) 137Chapter-8: JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTSSEGMENT OVERVIEW 138SEGMENT OVERVIEW (CONTINUED) 139PRODUCT DESCRIPTION 140Hip Replacements 140TABLE 41 HIP REPLACEMENT PRODUCT SUPPLIERS 141Biomet 141DePuy 142DJO, Inc. 142Exactech 143Smith & Nephew 143Stryker 144Wright Medical 145Zimmer Holding 145Knee Replacements 146TABLE 42 KNEE REPLACEMENT PRODUCT SUPPLIERS 146Biomet 146DePuy 147DJO, Inc. 147Exactech 147Smith & Nephew 148Stryker 148Advanced Orthopedic Technologies, Implants and Regenerative Products Page 9/13
  • 10. Find Industry reports, Company profilesReportLinker and Market StatisticsWright Medical 149Zimmer Holding 149Spine Replacements 150TABLE 43 SPINE REPLACEMENT PRODUCT SUPPLIERS 150Aesculap 151Alphatec 151Biomet Spine 151DePuy Spine 152Exactech 152Integra Life Sciences (Integra Spine) 152Medtronic 153Orthofix International 154Stryker 154Synthes 155Zimmer 155Other Extremity Replacements and Joint Products 156TABLE 44 OTHER EXTREMITY REPLACEMENTS, JOINT PRODUCT SUPPLIERS 156Biomet 156DePuy 157DJO, Inc. 157Exactech 157Small Bone Innovations 158Stryker 158Wright Medical 158Zimmer Holding 159Biological Joint Products and Other Related Devices 159TABLE 45 BIOLOGICAL JOINT PRODUCTS AND OTHER RELATED DEVICES 160Bioniche Pharma (Mylan) 160DePuy 160Ferring Pharmaceuticals 161Genzyme Biosurgery 161Sanofi-Aventis 161Smith & Nephew 162NEW DEVELOPMENTS 162Alphatec 162Biomet 163DePuy 163Genzyme Biosurgery 164Integra Life Sciences 164ConMed Linvatec 164Osiris Therapeutics 164NuVasive 165Wright Medical 165MARKET ANALYSIS 165MARKETS BY PRODUCT TYPE 166Markets by Product Type (Continued) 167TABLE 46 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT MARKETS, THROUGH 2015 ($ MILLIONS) 168FIGURE 27 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT MARKETS, THROUGH 2015 ($ MILLIONS) 168MARKETS BY WORLD REGIONS 169TABLE 47 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS,Advanced Orthopedic Technologies, Implants and Regenerative Products Page 10/13
  • 11. Find Industry reports, Company profilesReportLinker and Market Statistics2010 (%) 169FIGURE 28 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS,2010 (%) 170LEADING SUPPLIERS AND PARTICIPANTS 170LEADING SUPPLIERS AND PARTICIPANTS (CONTINUED) 171TABLE 48 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS BY COMPETITORREVENUES, 2010 ($ MILLIONS) 172FIGURE 29 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS BY COMPETITORREVENUES, 2010 ($ MILLIONS) 173Chapter-9: MARKET SUMMARYGLOBAL MARKET ANALYSIS 174TABLE 49 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, THROUGH 2015 ($ MILLIONS) 175FIGURE 30 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, 2008-2015 ($ MILLIONS) 176GEOGRAPHIC MARKET ANALYSIS 176TABLE 50 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION BY REGION, 2010 ($ BILLIONS) 177FIGURE 31 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION BY REGION, 2010 ($ BILLIONS) 178INDUSTRY PARTICIPANTS 178TABLE 51 ADVANCED ORTHOPEDIC TECHNOLOGY INDUSTRY PARTICIPANTS BY TYPE, 20092010 179INDUSTRY PARTICIPANTS (CONTINUED) 180TABLE 52 ADVANCED ORTHOPEDIC COMPETITORS MARKET SHARE ESTIMATES, 2010 ($ BILLIONS) 181FIGURE 32 DISTRIBUTION OF SALES BY COMPETITOR, 2010 ($ BILLIONS) 181Chapter-10: COMPANY PROFILESINTRODUCTION 182ARTHREX, INC. 182ARTHROCARE CORP. 183BIOMET, INC. 184CONMED LINVATEC 185DEPUY, INC. 185EXACTECH, INC. 186GENZYME BIOSURGERY 187INTEGRA LIFE SCIENCES 188MEDTRONIC SOFAMOR DANEK 188NUVASIVE, INC. 189ORTHOFIX INTERNATIONAL N.V. 190SMITH & NEPHEW, PLC 191STRYKER CORP. 191SYNTHES GMBH 192WRIGHT MEDICAL TECHNOLOGY, INC. 193ZIMMER HOLDINGS, INC. 194Chapter-11: APPENDIXAPPENDIX: LEADING PRODUCT MANUFACTURERS 195LEADING PRODUCT MANUFACTURERS 195LEADING PRODUCT MANUFACTURERS (CONTINUED) 196Advanced Orthopedic Technologies, Implants and Regenerative Products Page 11/13
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