Relequa Analytical Systems Ltd is a technology company which manufactures and supplies a unique moisture profiling analytical instrument. The instrument gives rapid output data about the impact of moisture on pharmaceutical materials and products. The way that Relequa looks at moisture uptake and loss gives an analytical profile which provides powerful information not previously available to the pharmaceutical industry. By doing this, Relequa gives a new understanding about moisture problems and saves costs for our customers by reducing the time taken to solve such problems. The Relequa moisture profiling system is applicable for R&D, manufacturing development, and packaging development and performance. When Relequa is used for example in R&D formulations work, new characteristics about how moisture interacts with materials are learned, so that problems which might occur later in the manufacturing process can be pre-empted. The instrument can analyse materials in all forms including tablets, capsules, powders, liquids, gels and creams in both packed and free states. The instrument applies equally as well to any industry where materials and products are impacted by moisture.

1. Relequa® Analytical Systems Ltd
Solving moisture problems instantly – saving costs for the pharma industry
RELEQUA MOISTURE PROFILING SYSTEM

2. Equilibrium Relative Humidity (ERH)
The Relequa instrument exploits ERH technology:
“The ERH of a material is the %Relative Humidity of
the air surrounding it at the equilibrium point of
moisture absorption/desorption”
Relequa Analytical Systems (© 2008 – 2012)

3. Equilibrium Relative Humidity
ERH is then:
A dynamic state for a material in equilibrium when its rate
of moisture uptake is equal to the rate of free moisture
being released from the surface of the material
Relequa Analytical Systems (© 2008 – 2012)

4. How the Relequa System Works
 Moisture interaction / migration in a pharma product
environment is driven by the ERH of the product
material(s)
 As a result, changes in this environmental system (eg.
RH, temperature) can cause moisture interactions.
 These interactions can impact on chemical and physical
properties of the material.
 The degree of change is determined by the Relequa
system’s moisture profiling dynamics
Relequa Analytical Systems (© 2008 – 2012)

5. How the Relequa System Works
 Relequa’s analysis method works by detecting these
changes in immediate environmental conditions
 The output is the Moisture Profile:
Relequa Analytical Systems (© 2008 – 2012)

6. The Principles of ERH
The two principles of ERH are relevant to the
investigational capabilities of the Relequa Moisture
Profiling system
Relequa Analytical Systems (© 2008 – 2012)

7. The First Principle of ERH
 A material placed in an environment with %Relative
Humidity above its ERH will always take in moisture
from the environment with a typical profile type:
Moisture Uptake Profile
80
75
70
%RH
Decreasing %RH
65
60
55
Relequa Analytical Systems (© 2008 – 2012)

8. The Second Principle of ERH
 A material placed in an environment with %Relative
Humidity below its ERH will always give out in
moisture, provided that it has free moisture available to
do this, with a typical profile type:
Moisture Loss Profile
50
48
46
44
42
%RH
40 Increasing %RH
38
36
34
32
30
Relequa Analytical Systems (© 2008 – 2012)

9. Moisture Profiling for Problem Solving
Relequa provides powerful moisture problem solving data:
 Measurements are “real life”, reflecting processing and
laboratory conditions
 The information is a graphic output = Moisture Profile
 The powerful analytical information is provided by the
Moisture Profile dynamics – the absolute ERH values
are less important
 This “complete moisture profiling system” can always
determine the profile and the ERH
Relequa Analytical Systems (© 2008 – 2012)

10. Key Features - 1
 Graphic moisture profile output gives novel information about
the interaction of moisture with materials
 The system is designed for analysis in ambient conditions
reflecting the real life situation of pharmaceutical processing
 Instant test data compared with other moisture-related
analytical methods.
 Non-destructive test enabling the sample to be utilised for
further complementary investigations
 Dual sample chambers enabling comparative tests or facilitating
multi-sample testing
 Samples can be solids, powders, gels, creams, and liquids
requiring no special preparation
 Robust unit capable of high volume sample analysis over short
periods
Relequa Analytical Systems (© 2008 – 2012)

11. Key Features - 2
 Intuitive system software:
 User-friendly and requires no calculations
 “Sample Moisture Test” function assesses sample moisture
status in 15 minutes or less
 Integral “Moisture Profiling” function conducts a full sample
analysis and moisture profile
 “View Data” shows the moisture profile as the test is being
performed
 IQ/OQ/PQ documentation for installation with use of traceable
calibration standards
 Remote Data Acquisition
 CE approved
Relequa Analytical Systems (© 2008 – 2012)

12. Moisture Problems Solved
Outcome:
Relequa gives a new understanding about the impact of
moisture on pharmaceutical materials and products to
solve moisture problems quickly and save time and costs
for the industry
Relequa Analytical Systems (© 2008 – 2012)

13. Areas of Application
 R&D. Characterise material moisture interactions to
pre-empt later process problems
 Manufacturing development. As an existing moisture
problem solver and predictor
 Packaging development and performance. Solves
problems and helps in the choice of effective
packaging
Relequa Analytical Systems (© 2008 – 2012)

14. Case Study Examples
 Moisture release / uptake activity in tablets
 Cause of hydrolysis problems uncovered
 Moisture sensitivity in liquids
 Packaging problems with pharma products
 Stability testing
Relequa Analytical Systems (© 2008 – 2012)

15. Further Information
Visit our website, contact Relequa or our regional
representatives for more information:
 Relequa brochure
 Leaflet “How the Relequa System Works”
 Case studies
 Support service
Relequa Analytical Systems (© 2008 – 2012)

16. Relequa Analytical
Systems Ltd
Kilminion South, Ballinroad, Dungarvan,
Co Waterford, Ireland
T: +353 (0) 58 43760 / +353 (0) 66 976 2780
E: info@relequa.com W: www.relequa.com
Solving moisture problems instantly – saving
costs for the pharma industry
Relequa Analytical Systems (© 2008 – 2012)