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Today’s market opportunities for combustion systems require focus on high-efficiency, low emissions and fuel-flexibility. In three previous white papers , we have discussed how use of detailed chemical kinetics in combustion simulation can provide accurate emissions predictions, simulate fuel effects and help gain insight into instability phenomena like Lean Blow Off (LBO). All of these topics focus on the use of high-fidelity chemistry simulation models for advanced combustion simulation by using highly accurate and detailed kinetics mechanisms. This white paper describes what a detailed kinetics mechanism is, how it is developed and validated and how it can be used in high-fidelity combustion simulation models to accelerate advanced combustion technology development.