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Environmental, economic and business goals are driving interest in the use of alternative fuels in many combustion applications, including gas turbines, boilers and burners. These new fuels present technical and design challenges that require new understanding and tools for the combustor designer, in particular a heavy emphasis on combustion simulation. Unfortunately, traditional combustion and flow simulation strategies oversimplify the combustion process into a single, or reduced, set of chemical steps. Newer, more advanced simulation tools connect Computational Fluid Dynamics (CFD) simulation and detailed chemistry to provide the complexity and accuracy needed to simulate key combustion parameters in alternative fuels.