Research Facilities

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  • Replace with picture of building???
  • To the south and west is Boyle Heights, a Latino neighborhood east of downtown LA 2007 Notes – I added an arrow and note indicating where UCLA would be relative to here – does any one know roughly how many miles to ucla from there? Might be good to add next to UCLA text
  • Perhaps change format to be like following slide – some text and a picture of exam room AND then a second slide with text and picture of snack room and frig? Exam room picture – at 1:09 or 1;20 (use one here and one later)
  • Rather than listing here – have slide say only specialized technologies Then following with pictures Ultrasound – at 4:37 on video DEXA at 7:57 Fundus at 8:43 Spirometry at 10:14
  • NEED picture of first floor lab.
  • Can we get a picture of the 6 workstation set up?
  • Replace this with 2 slides in format of following slide Experienced study coordinators (4), data collectors (9), and recruiters (3) Many staff bilingual (Spanish (7), Mandarin (3), Cantonese (2), Vietnamese (1), Farsi (2)) Certified phlebotomists (2), medical assistants (5), laboratory assistants (2) & DEXA technicians (2)
  • Can we get picture of data room
  • Picture of Van with participants entering? OR exiting at UCLA?
  • Heather – I think we may want to have “at hand” some more details about this for the group – to provide better sense of volume of actual activity out there can you provide rough estimates of study sample sizes – I think we might want to indicate how many subjects are being “handled/seen” as part of these various studies Can you provide list of actual currently active Pharmaceutical trials AND number “pending” if any are in pipeline to be activated Preethi’s programs – are those the 2 pilots (any others) THOSE ARE THE PILOTS MESA: ORIGINAL N=1277, EXAM 4 N=1050 DPPOS: ORIGINAL DPP N=250; DPPOS N=188; NOW N=155 MESA AIR: 200 DE NOVO TARGET; 50 RECRUITED TO DATE CURRENT CLIN TRIALS: ACCOMPLISH – EXTENSION TO VISITS 9-12, 25 PPTS ILLUMINATE – N=2 PPTS CLOSED BUT DATA CLEANING: NOVO NORDISC, METEOR, SIENNA 2 PENDING: PFIZER A5091031 N=10 PPTS, 2 NOVARTIS STUDIES N=10 EACH
  • Heather – I think we may want to have “at hand” some more details about this for the group – to provide better sense of volume of actual activity out there can you provide rough estimates of study sample sizes – I think we might want to indicate how many subjects are being “handled/seen” as part of these various studies Can you provide list of actual currently active Pharmaceutical trials AND number “pending” if any are in pipeline to be activated Preethi’s programs – are those the 2 pilots (any others) THOSE ARE THE PILOTS MESA: ORIGINAL N=1277, EXAM 4 N=1050 DPPOS: ORIGINAL DPP N=250; DPPOS N=188; NOW N=155 MESA AIR: 200 DE NOVO TARGET; 50 RECRUITED TO DATE CURRENT CLIN TRIALS: ACCOMPLISH – EXTENSION TO VISITS 9-12, 25 PPTS ILLUMINATE – N=2 PPTS CLOSED BUT DATA CLEANING: NOVO NORDISC, METEOR, SIENNA 2 PENDING: PFIZER A5091031 N=10 PPTS, 2 NOVARTIS STUDIES N=10 EACH
  • Heather – I think we may want to have “at hand” some more details about this for the group – to provide better sense of volume of actual activity out there can you provide rough estimates of study sample sizes – I think we might want to indicate how many subjects are being “handled/seen” as part of these various studies Can you provide list of actual currently active Pharmaceutical trials AND number “pending” if any are in pipeline to be activated Preethi’s programs – are those the 2 pilots (any others) THOSE ARE THE PILOTS MESA: ORIGINAL N=1277, EXAM 4 N=1050 DPPOS: ORIGINAL DPP N=250; DPPOS N=188; NOW N=155 MESA AIR: 200 DE NOVO TARGET; 50 RECRUITED TO DATE CURRENT CLIN TRIALS: ACCOMPLISH – EXTENSION TO VISITS 9-12, 25 PPTS ILLUMINATE – N=2 PPTS CLOSED BUT DATA CLEANING: NOVO NORDISC, METEOR, SIENNA 2 PENDING: PFIZER A5091031 N=10 PPTS, 2 NOVARTIS STUDIES N=10 EACH
  • Research Facilities

    1. 1. Research Facilities & Resources
    2. 2. Overview <ul><li>Community-based research clinic in San </li></ul><ul><li>Gabriel valley </li></ul><ul><li>Well-developed infrastructure and facilities </li></ul><ul><li>DOM resource administered by Division of </li></ul><ul><li>Geriatrics </li></ul><ul><li>Growing links with other DOM and SOM core research resources </li></ul>
    3. 3. RCA 10 Pasadena South El Monte Eagle Rock 710 110 210 134 Monterey Park Temple City Arcadia South Pasadena San Gabriel Altadena Highland Park San Marino Rosemead Boyle Heights UCLA LA County-USC Hosp
    4. 4. Facilities <ul><li>Clinic space: 2 suites of exam/procedure rooms </li></ul><ul><ul><li>Large: 8 pt rooms; Small: 6 pt rooms </li></ul></ul><ul><ul><li>Each has scales, stadiometers, sphygs, phlebotomy station, locker room </li></ul></ul><ul><li>Snack room </li></ul><ul><li>Kitchen for food storage </li></ul>
    5. 5. Facilities <ul><li>Specialized technologies </li></ul><ul><ul><li>Ultrasound </li></ul></ul><ul><ul><li>ECG </li></ul></ul><ul><ul><li>Fundus photography </li></ul></ul><ul><ul><li>DEXA (Hologic 4500) </li></ul></ul><ul><li>Secure medication storage </li></ul><ul><ul><li>Regular inventory </li></ul></ul><ul><ul><li>Experienced with automatic phone dispensing </li></ul></ul>
    6. 6. Facilities <ul><li>Laboratory </li></ul><ul><ul><li>Refrigerated centrifuge </li></ul></ul><ul><ul><li>-20 °C and –80 °C storage freezers (limited) </li></ul></ul><ul><ul><li>CLIA certified </li></ul></ul>
    7. 7. <ul><li>Educational </li></ul><ul><ul><li>Flexibly configured classrooms </li></ul></ul><ul><ul><li>Grouped workstations for 6 participants </li></ul></ul><ul><ul><li>Audiovisual equipment </li></ul></ul><ul><li>Telephone / in-person surveying </li></ul><ul><ul><li>6-line phone bank available </li></ul></ul><ul><li>Community-based data collection </li></ul><ul><ul><li>Headquarter staff with easier access to community sites such as schools and senior centers </li></ul></ul><ul><ul><li>Offices linked to UCLA infrastructure </li></ul></ul>Facilities
    8. 8. <ul><li>Experienced study coordinators, data collectors, and recruiters </li></ul><ul><li>Many staff bilingual (Spanish, Mandarin, Cantonese, Vietnamese, Farsi) </li></ul><ul><li>Certified phlebotomists, medical assistants, laboratory assistants & DEXA technicians </li></ul>Staff Resources
    9. 9. <ul><li>Data processing and management </li></ul><ul><li>Regulatory and fund management </li></ul><ul><li>Nutritionists </li></ul><ul><li>Specialized software development (Available through OAIC-ROC) </li></ul>Staff Resources
    10. 10. <ul><li>2 passenger vans & staff drivers for transporting participants </li></ul><ul><li>Free parking </li></ul><ul><li>Handicap access </li></ul><ul><li>Convenient public transportation </li></ul>Accessibility
    11. 11. Research Support Services <ul><li>Initial evaluation meeting </li></ul><ul><ul><li>Feasibility for RCA, resource needs/availability, costs </li></ul></ul><ul><li>Proposal preparation </li></ul><ul><ul><li>Operations budget & justification, boilerplate text </li></ul></ul><ul><li>Project implementation </li></ul><ul><ul><li>Staffing, training, certification </li></ul></ul><ul><ul><li>Coordination with other RCA projects (staff, space, transportation, other resources/equipment) </li></ul></ul><ul><ul><li>IRB correspondence </li></ul></ul>
    12. 12. <ul><li>Westwood GCRC/proposed CTSI </li></ul><ul><li>Office of Clinical Trials </li></ul><ul><li>UCLA Older Adults Independence Center </li></ul><ul><ul><li>4 research cores: Research Operations, Recruitment, Analysis/Cost-Effectiveness, Inflammatory Biology </li></ul></ul><ul><li>In development: </li></ul><ul><ul><li>Resource Center for Minority Aging Research </li></ul></ul><ul><ul><li>UCLA-Harbor GCRC </li></ul></ul>Linkages
    13. 13. <ul><li>Through OAIC Research Operations Core </li></ul><ul><li>Help with quality control flow </li></ul><ul><ul><li>Development of protocols & manuals </li></ul></ul><ul><ul><li>Design training and certification sessions </li></ul></ul><ul><ul><li>Data flow and review analysis </li></ul></ul><ul><li>Data entry application and design </li></ul><ul><ul><li>Analysis of data forms for collection & entry </li></ul></ul><ul><ul><li>Pepper Informatics </li></ul></ul>Data Management Expertise
    14. 14. Current Studies <ul><li>Multi-Ethnic Study of Atherosclerosis (MESA) (PI: Karol Watson) + affiliated ancillary studies </li></ul><ul><ul><li>Longitudinal study of 4 ethnic groups </li></ul></ul><ul><ul><li>Observational study started in 2001 </li></ul></ul><ul><ul><li>Physical exam, interviews, imaging, phlebotomy </li></ul></ul><ul><ul><li>Ancillary studies consist of similar exams </li></ul></ul><ul><li>MESA Air (PI:Adrian Casillas) </li></ul><ul><ul><li>Original MESA cohort plus new Riverside & Santa Monica residents, 2006-2007 </li></ul></ul><ul><ul><li>Exam similar to MESA, adding air quality monitoring </li></ul></ul>
    15. 15. Current Studies <ul><li>Diabetes Prevention Project – Outcome Study (DPPOS) (PI: Karol Watson) </li></ul><ul><ul><li>Originally randomized trial for diabetes prevention through metformin or lifestyle intervention </li></ul></ul><ul><ul><li>Physical exam, interviews, phlebotomy </li></ul></ul><ul><ul><li>Behavior interventions and health education </li></ul></ul><ul><li>Diabetes education programs (PI: Preethi Srikanthan) </li></ul><ul><ul><li>Two small pilots examining feasability of computer-based education modules to Mexican-Americans </li></ul></ul>
    16. 16. Current Studies <ul><li>Pharmaceutical trials (PIs: Karol Watson & Christine Darwin) </li></ul><ul><ul><li>Trials for a variety of sponsors (Novartis, Novo Nordisc) targeting outcomes related to diabetes or cardiovascular health </li></ul></ul><ul><ul><li>Dispense medication & conduct physical exams as indicated by protocol </li></ul></ul>
    17. 17. Costs <ul><li>Costs competitive with on-campus costs </li></ul><ul><ul><li>On campus 54% IDC ~ off campus facility fees + 26% IDC </li></ul></ul><ul><ul><li>Direct personnel costs are fee for service (e.g., interviewers, phlebotomists) </li></ul></ul><ul><li>Small projects may have facility fees waived </li></ul>
    18. 18. Summary <ul><li>Location </li></ul><ul><ul><li>Access to diversity of ethnic communities </li></ul></ul><ul><li>Facilities </li></ul><ul><ul><li>Clinic & classroom space, phlebotomy, lab w/ temporary specimen storage, ultrasound, DEXA, ECG </li></ul></ul><ul><li>Staff </li></ul><ul><ul><li>Experienced multi-lingual project directors and research staff, data management staff and software </li></ul></ul>
    19. 19. For further information, contact Heather McCreath, PhD (310) 267-0848 e-mail: [email_address] 330 S. Garfield, Suite 308 Alhambra, CA 91801 (626) 979-4920

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