SPECIALIZATIONS                OF          EPITHELIAL CELLS• BASAL• APICAL• LATERAL
APICAL DOMAIN• STRUCTURAL MODIFICATION – CILIA – MICROVILLI – STEROCILIA• SPECIFIC ENZYMES (HYDROLASES)• ION CHANNELS• CAR...
BASAL DOMAIN• BASEMENT MEMBRANE• JUNCTIONS b/w cells & extra cellular         structures• INFOLDINGS OF PLASMA MEMBRANE
BASEMENT MEMBRANE• SHEET LIKE EXTRACELLULAR  MATERIAL• PAS +ve• BASAL LAMINA & RETICULAR LAMINA• TWO BASAL LAMINA
BASAL LAMINA• E/M 20-30nm• BASAL LAMINA A LAMINA DENSA B/W  2 LAMINA LUCIDA/ RARA• COMPONENTS SECRETED BY  EPITHELIAL CELL...
RETICULAR LAMINA• RETICULAR FIBERS TYPE III• UNDER LYING CONNECTIVE TISSUE• COARSE ALL DIRECTIONS
FUNCTIONS• STRUCTURAL  – attachment to underlying structures• BARRIER & FILTRATION  – Regulating movements• REGENERATION• ...
JUNCTIONS B/W CELLS &   EXTRACELLULAR    STRUCTURES    FOCAL ADHESION   HEMIDESMOSOMES
FOCAL ADHESION• ACTIN OF  CYTOSKELETON  into BASEMENT  MEMBRANE• THRU  TRANSMEMBRANE  PROTEIN INTEGRIN
HEMIDESMOSOMES• EPITHLIA subject to ABRASION SHEARING• CORNEA , SKIN, MUCOSA• HALF DESMOSOMES• ATTACHMENT PLAQUE• INTERMED...
HEMIDESMOSOMES•
INFOLDINGS OF BASAL PLASMA        MEMBRANE• FLUID  TRANSPORTING  CELLS• PCT , DCT,  STRIATED DUCTS• MITOCHONDRIA
LATERAL DOMAINS• APPOSED LATERAL DOMAINS• UNIQUE PROTEINS & LIPIDS• JUNCTIONAL COMPLEX    OCCLUDING JUNCTIONS    ANCHORING...
JUNCTIONAL COMPLEX• OCCLUDING JUNCTIONS    ZONULA OCLUDENS• ANCHORING JUNCTIONS   ZONULA ADHERENS   MACULA ADHERENCEBASAL ...
TIGHT JUNCTIONS          ZONULA OCCLUDENS•   APICAL BAND•   SERIES OF FOCAL ADHESION•   OCClUDENS--- ZO---- ACTIN•   BARRI...
ANCHORING JUNCTIONS         ZONULA ADHERENCE•   BELOW OCCLUDENS•   BAND reinforcing ZONULA OCCLUDENS•   20-30nm space•   T...
DESMOSOMES• MACULA ADHERENCE• STRONG ATTACHMENT• SPOT JUNCTIONS• INTERCELLULAR SPACE 30nm• TRANS MEMBRANE PROTEIN  CADHERI...
GAP JUNCTION                 NEXUS• COMMUNICATING JUNCTIONS• VARIOUS TISSUES (coordinated)    – EPITHELIUM, SMOOTH & CARDI...
Tissue part 4
Tissue part 4
Tissue part 4
Tissue part 4
Tissue part 4
Tissue part 4
Tissue part 4
Upcoming SlideShare
Loading in …5
×

Tissue part 4

1,185 views

Published on

Histology Notes

Published in: Education, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
1,185
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
17
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Tissue part 4

  1. 1. SPECIALIZATIONS OF EPITHELIAL CELLS• BASAL• APICAL• LATERAL
  2. 2. APICAL DOMAIN• STRUCTURAL MODIFICATION – CILIA – MICROVILLI – STEROCILIA• SPECIFIC ENZYMES (HYDROLASES)• ION CHANNELS• CARRIER PROTEINS
  3. 3. BASAL DOMAIN• BASEMENT MEMBRANE• JUNCTIONS b/w cells & extra cellular structures• INFOLDINGS OF PLASMA MEMBRANE
  4. 4. BASEMENT MEMBRANE• SHEET LIKE EXTRACELLULAR MATERIAL• PAS +ve• BASAL LAMINA & RETICULAR LAMINA• TWO BASAL LAMINA
  5. 5. BASAL LAMINA• E/M 20-30nm• BASAL LAMINA A LAMINA DENSA B/W 2 LAMINA LUCIDA/ RARA• COMPONENTS SECRETED BY EPITHELIAL CELLS – TYPE IV COLLAGEN, – GLYCOPROTEINS – PROTEOGLYCAN – ANCHORING FIBRILS (VII) BL & RL
  6. 6. RETICULAR LAMINA• RETICULAR FIBERS TYPE III• UNDER LYING CONNECTIVE TISSUE• COARSE ALL DIRECTIONS
  7. 7. FUNCTIONS• STRUCTURAL – attachment to underlying structures• BARRIER & FILTRATION – Regulating movements• REGENERATION• Information for cell to cell interaction• CELL POLIFERATION & DIFF. – Binding & concentrating growth factor
  8. 8. JUNCTIONS B/W CELLS & EXTRACELLULAR STRUCTURES FOCAL ADHESION HEMIDESMOSOMES
  9. 9. FOCAL ADHESION• ACTIN OF CYTOSKELETON into BASEMENT MEMBRANE• THRU TRANSMEMBRANE PROTEIN INTEGRIN
  10. 10. HEMIDESMOSOMES• EPITHLIA subject to ABRASION SHEARING• CORNEA , SKIN, MUCOSA• HALF DESMOSOMES• ATTACHMENT PLAQUE• INTERMEDIATE FILAMENT INTO BASEMENT MEMBRANE• PROTEIN INTEGRIN ( CADHERIN)• EXTRACELLUALR COMPONENT OF INTEGRIN INTERACTS WITH LAMININ & TYPE IV COLLAGEN OF BASAL LAMINA
  11. 11. HEMIDESMOSOMES•
  12. 12. INFOLDINGS OF BASAL PLASMA MEMBRANE• FLUID TRANSPORTING CELLS• PCT , DCT, STRIATED DUCTS• MITOCHONDRIA
  13. 13. LATERAL DOMAINS• APPOSED LATERAL DOMAINS• UNIQUE PROTEINS & LIPIDS• JUNCTIONAL COMPLEX OCCLUDING JUNCTIONS ANCHORING JUNCTIONS COMMUNICATING JUNCTIONS• FOLDS / PROCESSES
  14. 14. JUNCTIONAL COMPLEX• OCCLUDING JUNCTIONS ZONULA OCLUDENS• ANCHORING JUNCTIONS ZONULA ADHERENS MACULA ADHERENCEBASAL focal adhesion, hemidesmosome
  15. 15. TIGHT JUNCTIONS ZONULA OCCLUDENS• APICAL BAND• SERIES OF FOCAL ADHESION• OCClUDENS--- ZO---- ACTIN• BARRIER luminal &intercellular space• INTEGRITY OF DOMAINS• IMPERMEABILITY number of fusions• LIMITED RESISTANCE TO MECHANICAL STRESS
  16. 16. ANCHORING JUNCTIONS ZONULA ADHERENCE• BELOW OCCLUDENS• BAND reinforcing ZONULA OCCLUDENS• 20-30nm space• TRANSMEMBRANE PROTEIN CADHERIN- CATENIN-ACTIN (actinin,vinculin)• MECHANICAL STABILITY• FACIA ADHERENCE SHEET LIKE, CELLS OTHER THAN EPITHELIA
  17. 17. DESMOSOMES• MACULA ADHERENCE• STRONG ATTACHMENT• SPOT JUNCTIONS• INTERCELLULAR SPACE 30nm• TRANS MEMBRANE PROTEIN CADHERIN FAMILY (desmoglein & collin)• ATTACHMENT PLAQUE (desmoplakin)• INTERMEDIATE FILAMENT
  18. 18. GAP JUNCTION NEXUS• COMMUNICATING JUNCTIONS• VARIOUS TISSUES (coordinated) – EPITHELIUM, SMOOTH & CARDIAC MUSCLE, NERVOUS• EXCHANGE(ions,regulatory mol.& small metabolite)• TWO CONNEXONS• Connexins 6 (dumbell)• HYDROPHILIC PORE 2nm

×