Tissue part 3

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Histology Notes

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Tissue part 3

  1. 1. Pseudo stratified• False stratified appearance• All cells resting on a basement membrane but not all of them reach the surface ( columnar & basal cell)• Nuclei are at variable level• No nuclei in the apical 1/3 of the cytoplasm• Associated with cilia & goblet cells
  2. 2. Transitional epithelium• Specialized epithelium• Urothelium• It can stretch greatly without losing its integrity• Undistended• Distended
  3. 3. UNDISTENDED L/M• 5 -6 LAYERS• BASAL LOW COLUMNAR CELLS• MIDDLE LAYER POLYHEDRAL & FLASK SHAPE CELLS• UPPER LAYER LARGE DOME SHAPE CELLS bulge into lumen dark pink line mono/binucleate indentations on under surface
  4. 4. Distended L/M• 2-3 layer• Basal low cuboidal• Surface cells approach a squamous form
  5. 5. CHARACTERISTICS• UNILAMINR• MITOTIC ACTIVITY• IMPERMEABLE• STRETCHING
  6. 6. ELECTRON MICROSCPE• All cells reach basal lamina through slender processes• Outer lipid layer Thick integral proteins – Plaques Uroplakin – Interplaque areas hinges• Concentration of microfilament – Internalization of membrane vesicle• Desmosomes between adjacent cells
  7. 7. CHARACTERISTICS• UNILAMINR MITOTIC ACTIVITY – All cells reach basal lamina through slender processes• IMPERMEABLE – Thicker outer layer of cell membrane – desmosomes• Ability to change surface area – Mucosal folding – Dome cells
  8. 8. GLANDULAR EPITHELIUM• UNICELLULAR• MULTICELLULAR ENDOCRINE aggregated cells form anastomosing cordswith interspersed capillaries EXOCRINE Architectural classification mode of secretion Type of secretion
  9. 9. Architectural
  10. 10. • Simple tubular straight large intestine coiled----sweat glands branched---cardiac end of stomach alveolar straight----urethra branched-----pyloric part of stomach• Compound tubular-----Brunner gland alveolar----excretory part tubuloalveolar---submandibular
  11. 11. MODE OF SECRETION• APOCRINE apical part of cell is lost with secretion modified sweat gland• MEROCRINE no part of cytoplasm is lost e.g. sweat gland• HOLOCRINE whole of the cell is lost e.g. sebaceous gland
  12. 12. TYPE OF SECRETION SEROUS & MUCOUS• Bluish purple • Pink• Nucleus round basal • Flat perpiheral• Cell out line not clear• Lumen indistinct • Clear• Basal basophilia • Distinct • No basal basophilia

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