Bone

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Bone

  1. 1. BONE IS A SPECIALIZED FORMOF CONNECTIVE TISSUE MINERALIZATION OF MATRIX VASCULARITY DYNAMIC
  2. 2. COMPONENTS CELLS OSTEOGENIC OSTEOBLAST OSTEOCYTE OSTEOCLAST MATRIX ORGANIC INORGANIC
  3. 3. OSTEOGENIC CELLS STEM CELLS MESENCHYMAL DIVISION & PROLIFERATION FLATTENED, ELONGATED CELLS EXTERNAL & INTERNAL SURFACES OF BONE (PERIOSTEAL, ENDOSTEAL, HAVERSION CANAL)
  4. 4. OSTEOBLAST BONE FORMING CELLS SINGLE LAYER ON SURFACES OF BONE(MATURING OR REMODELLING) ACTIVE OR INACTIVE FUNCTIONS  PRODUCE MATRIX -------OSTEOID  DEPOSITION OF INORGANIC COMPONENETS  HORMONAL REGULATION OF BONE RESORPTION (RECEPTORS PTH & VIT D3)
  5. 5. OSTEOCYTE MAJOR CELLS OF MATURE BONE TRAPPED OSTEOBLAST STELLATE CELLS WITH PROCESSES LACUNAE, CANLICULI LIGHTLY BASOPHILIC WITH FEW ORGANELLES MATRIX TURNOVER, BONE SENSOR
  6. 6. OSTEOCLAST PHAGOCYTIC, MONOCYTIC ACTIVE RESORPTION SITE (HOWSHIP LACUNAE) MULTINUCLEATED, LIGHTLY BASOPHILIC E/M 3 ZONES ZONE I RUFFLED BORDER CLEAR ZONE ZONE II MITOCHONDRIA & LYSOSOMES ZONE III NUCLEI rER, GOLGI complex
  7. 7. MATRIX ORGANIC COLLAGEN FIBERS PROTEOGLYCANS GLYCOPROTEINS INORGANIC MINERAL SALTS
  8. 8. COLLAGEN FIBER 30—40% TYPE I OSTEOBLAST FASICLES OR GROUPS CLOSELY LINKED ( //, at an angle) makes bone STRONGER & INERT GAPS BETWEEN TROPOCOLLAGEN LARGER CONTAINING CRYSTALS ( 2/3 OF MINERAL CONTENT) ASSOCIATED WITH OSTEO NECTIN FUNCTIONS MECHANICAL STRENGTH, NUCLEATION SITE,
  9. 9. GLYCOPROTEINS OSTEONECTIN PHOSPHORYLATED GLYCOPROTEINS ADHESION OF COLLAGEN FIBER TO CRYSTALS & OSTEOCYTES OSTEOCALCIN Ca DEPOSITION
  10. 10. MINERAL SALTS 60-70% Ca, phosphate, Mg, Zn Na NEEDLE SHAPED CRYSTALS (HYDROXY APATITE ) CRYSTALLINE & NONCRYSTALLINE // TO LONG AXIS OF FIBERS GAPS B/W TROPOCOLLAGEN
  11. 11. PREPARATION OF TISSUE DECALCIFIED REMOVAL OF MINERAL CONTENT THROUGH CHELATING AGENTS EMBEDDED, SECTIONED, STAINED GROUND BONE
  12. 12. CLASSIFICATION OF BONEarrangements of different components LAMELLAR COMPACT SPONGY NON LAMELLAR PRIMARY BONE
  13. 13. PRIMARY BONE IMMATURE, NON LAMELLAR,WOVEN BONE TEMPORARY, EMBRYONIC DEVELOPMENT ADULTS SPECIFIC LOCATIONS NON LAMELLAR LOW MINERAL CONTENT HIGH CONTENT OF OSTEOCYTES
  14. 14. SECONDRY BONE LAMELLAR, MATURE, ADULT LAMELLAE OF MATRIX COMPACT & SPONGY
  15. 15. COMPACT BONE DIAPHYSIS OF LONG BONE MEDULLARY CAVITY PERIOSTEUM & ENDOSTEUM (SHARPEYS FIBER) OUTER CIRCUMFERENTIAL LAMELLAE HAVERSION SYSTEM VOLK MAN CANAL INTERTISTIAL LAMELLAE INNER CIRCUMFERENTIAL LAMELLAE
  16. 16. COMPACT BONE OSTEON HAVERSION SYSTEM HAVERSION CANAL CONCENTRIC LAMELLAE OF MATRIX SEPARATED BY THIN PLATES OF MATRIX HIGH MINERAL & LOW ORGANIC LACUNAE & CANALICULI CEMENT LINE
  17. 17. Spongy bone Ends of long bone LAMELLAR Same arrangement of cells & matrix Bony trabeculae Marrow spaces lined by endosteum Diffusion
  18. 18.  RICKETS OSTEOMALACIA OSTEOPOROSIS OSTEOPETROSIS VITAMIN D, A, C
  19. 19. OSSIFICATION
  20. 20. INTRAMEMBRANOUS (directmineralization of highly vascularized C.T) FLAT BONES MAXILLA, MANDIBLE,CLAVICLE PRIMARY CENTER OF OSSIFICATION AGGREGATION & VASCULARIZATION DIFFERENTIATION (POLARITY) OSTEOID CALCIFICATION SEVERAL SUCH GROUPS FORMING STRIPS OF MATRIX FUSE PENETRATION BY BLOOD VESSELS SPONGY BONE THE PROCESS SLOWS DOWN THICKENING OF TRABECULAE & NARROWING OF VASCULAR SPACES IN COMPACT BONE PRIMARY & SECONDRY OSTEONS PERIOSTEUM & ENDOSTEUM
  21. 21. PARTS OF A DEVELOPING BONE EPIPHYSIS DIAPHYSIS METAPHYSIS
  22. 22. INTRACARTILAGENOUS
  23. 23. INTRACARTILAGENOUSDIAPHYSIS SHORT & LONG BONES MINIATURE CARTILAGE MODEL PRIMARY CENTER OF OSSIFICATION PRIMARY AREOLAE PERIOSTIUM BONE COLLAR PERIOSTEAL VASCULAR BUDS SEC. AREOLAE (TRABECULAE CALCIFIED CARTILAGE & AN OUTER LAYER OF BONE) PRIMITIVE MEDULLARY CAVITY (OSTEOCLASTIC EROSION) MATURE BONE MARROW DEVELOPMENT OF HAVERSION SYSTEM
  24. 24. HAVERSION SYSTEM VASCULARIZATION TUNNEL DEPOSITION OF BONE
  25. 25. EPIPHYSEAL PLATE ORGANIZED REGION OF RAPID GROWTH BETWEEN EPIPHYSIS & DIAPHYSIS INTERSTITIAL & APPOSITIONAL GROWTH ZONE OF CARTILAGE GROWTH CARTILAGE TRANSFORMATION OSSIFICATION REMODELLING
  26. 26. EPIPHYSIS APPOSITIONAL GROWTH INTERSTITIAL GROWTH SECONDRY CENTRE OF OSSIFICATION RADIAL ORGANIZATION OF ZONES
  27. 27. CALCIFICATION > CONC OF Ca BINDING WITH OSTEOCALCIN OSTEOBLAST secrete ALK. PO4 CLEAVES PO4 FROM MATRIX CRYSTALLISATION OF CaPO4

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