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General Concepts Lung Cancer• Leading death cause from cancer• 90% Smoking related• ALL LC are associated w Smoking• Nonsmoker = Adenocarcinoma• Smokers = 10 times higher risk than Nonsmokers• Smoking Cessation decreases the risk, but NEVER to a Non Smoker!• No screening tests N Engl J Med 2008, 359: 1367-1380
MANAGEMENT QUESTIONS AFTER LCDIAGNOSIS:• Is the LC Ressectable?1. Thorax CT2. MRI3. PET Scan• If the LC is ressectable, is the patient a surgical candidate?1. PFTs: FEV1> 50%?• Remember: Many LC are also COPD patientsLung Cancer screening results: Easily Misunderstaood. Mayo Clin Proc 2007;82: 14-15 / BTS Guidelines on the selection of patients with Lung Cancer forsurgery. Thorax 2001; 56: 89-108
Annotated BibliographyClinical Guidelines:• Alberts WM, American College of Chest Physicians. Diagnosis and management of lung cancer. ACCP evidence- based guidelines. Chest 2007; 132: 1S- 422SScreening• Survival of patients with stage I Lung Cancer detected of CT screening. N Engl J Med 2006, 355: 1763-1771Smoking• Wilson JF. In the Clinic. Smoking Cessation. Ann Intern Med 2007; 146:ITC2-1 – ITC2-16
THANK YOU Dr. Marcos Nascimento, Md UCF Voluntary Professor www.pulmaosa.com.br