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Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
Toshiaki Saida, M.D.
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Toshiaki Saida, M.D.

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  • 1. Toshiaki Saida, M.D., Ph.D. CURRICULUM VITAE PRESENT POSITION: Professor and Chairman Department of Dermatology Shinshu University School of Medicine Matsumoto, Japan OFFICE ADDRESS: 3-1-1 Asahi, Matsumoto 390-8621 Japan E-MAIL: tosaida@hsp.md.shinshu-u.ac.jp PHONE: +81-263-37-2643 FAX: +81-263-37-2646 HOME ADDRESS: 2-8-8-102 Sawamura Matsumoto 390-0877, Japan MARITAL STATUS: Married, One child DATE & PLACE OF BIRTH: July 5, 1943; Gunma Prefecture, Japan NATIONALITY: Japanese EDUCATION AND TRAINING: 1971 M.D., University of Tokyo, Tokyo, Japan 1971 Resident in Dermatology, University of Tokyo Hospital, Tokyo 1983 Ph.D., University of Tokyo Graduate School, Tokyo, Japan 1984 Visiting Fellow, Harvard-Massachusetts General Hospital, Boston APPOINTMENT: 1972 Assistant, Department of Dermatology, University of Tokyo Hospital 1975 Chief, Dermatology Clinic, Saitama Cancer Center Hospital 1980 Assistant Professor, Department of Dermatology, University of Tokyo Branch Hospital, Tokyo 1983 Associate Professor, Head of Department of Dermatology, University of Tokyo Branch Hospital, Tokyo 1985 Associate Professor, Department of Dermatology, Shinshu University School of Medicine, Matsumoto 1989 Professor and Chairman, Department of Dermatology, Shinshu University School of Medicine, Matsumoto 1989 Visiting Lecturer, Yamanashi Medical School 1989 Member of Committee of Safety Usage of Daily Life Articles, The Ministry of Health, Labor and Welfare 1993 Visiting Lecturer, Okayama University School of Medicine 1994 Visiting Lecturer, Toyama Medical College Saida CV 1
  • 2. 1994 Reviewer of Grants from Ministry of Education 1995 Chief Investigator (First Appointment), Melanoma Study Group in Japan 1996 President, 12th Annual Meeting of Japanese Skin Cancer Society 1997 President, 61st Annual Meeting of East Japan Dermatological Society 1998 Chairman of the Board, Japanese Skin Cancer Society 1999 Assistant Director of Shinshu University Hospital 2000 Member of Committee for Development of Guidelines for Cancer Treatment, Japan Society of Clinical Oncology 2000 Member of Consensus Board, Consensus Net Meeting on Dermoscopy (CNMD) 2000 2002 Scientific Faculty of 3rd European Symposium on Teledermatology, Graz, Austria 2002 Member of Committee of Clinical Oncology Database, Japan Society of Clinical Oncology 2002 Reviewer of Grants from the Japanese Society for the Promotion of Science 2003 Chairman of Institutional Review Board, Shinshu University Hospital 2003 Chief Investigator (Second Appointment), Melanoma Study Group in Japan 2004 Member of Working Group, Committee of Combination Therapy of Anticancer Drugs, The Ministry of Health, Labor and Welfare 2004 Reviewer of Grants from the Japanese Society for the Promotion of Science 2006 International Scientific Committee of the 1st Congress of International Dermoscopy Society, Naples, Italy 2006 President, 20th Annual Meeting of Japanese Pigment Cell Research 2008 Vice President, 5th International Melanoma Research Congress LICENSURE AND CERTIFICATE: 1971 National License of Physician (Registration No. 209645) 1977 Board of Dermatology (Certificate No. 1630) HONORS: 1991 Seiji Memorial Award from Lydia O’Leary Memorial Foundation 2003 The Best Doctors in Japan EDITORIAL ACTIVITY: 1993-1997 Editorial Advisor, Hifubyo-Shinryoh 1995-present Editorial Board, Japanese Journal of Clinical Oncology 1996-1999 Editor, Japanese Journal of Dermatology 1997-present Editor, Skin Cancer Saida CV 2
  • 3. 1998-present Associate Editor, International Journal of Clinical Oncology 2000-present Editorial Advisory Board, Journal of Dermatology 2005-present Editorial Board, Expert Review of Dermatology MEMBERSHIP OF SCIENTIFIC SOCIETY: Japanese Dermatological Association (Councilor) Japanese Skin Cancer Society (Chairman of the Board) Japanese Society for Investigative Dermatology (Councilor) Japan Society of Clinical Oncology (Councilor) Japan Dermatohistopathology Society (Member of the Board) Japanese Cancer Association (Councilor) Japanese Society for Pigment Cell Research (Member of the Board) American Academy of Dermatology Society for Investigative Dermatology American Society of Dermatopathology International Society of Dermatopathology International Dermoscopy Working Group International Society of Dermoscopy (Continetal Representative) Society for Melanoma Research (Committee on Membership) MAJOR SCIENTIFIC INTERESTS: Malignant Melanoma, Skin Cancers, Carcinogenesis, Dermoscopy, Dermatopathology, Tumor Immunology, Gene Therapy Saida CV 3
  • 4. PUBLICATIONS: Book/Journal Editions 1. Diagnosis and Management of Pigmented Skin Lesions. Monthly Book Derma No.17, 1998 (in Japanese) 2. A Guide to Histopathologic Diagnosis of Skin Diseases. Saida T, Nankodo, Tokyo, 2000 (in Japanese) 3. Diagnosis and Treatment of Malignant Melanoma. Saida T & Yamamoto A, Kanehara, Tokyo, 2001 (in Japanese) 4. Human Skin and hair in Immunodeficient Mice: Experimental Studeis and Clinical Applications. Ueyama Y, Saida T & Inokuchi S, Central Institute for Experimental Animals, Kawasaki, 2001 5. Histopathologic Diagnosis of Malignant Melanoma. Saida T, Manabe T, Kamide R, Mihara I & Takeuchi A, Bunkodo, Tokyo, 2002 (in Japanese) 6. Today’s Therapy in Dermatology 3rd edition, Saida T, Shiohara T, Miyachi Y & Watanabe S, Igaku-Shoin, Tokyo, 2002 (in Japanese) 7. General Rules for Clinical and Pathological Studies on Malignant Neoplasms of the Skin. Saida T, Takigawa M, Yamamoto A, Tuchida T & Uhara H, Kanehara, Tokyo, 2002 (in Japanese) 8. Saida T, Oguchi S, Miyazaki A. Dermoscopic findings in pigmented lesions of glabrous skin. In: Malvehy L and Puig S, editors. Principles of Dermoscopy, Barcelona: CEGE; 2002. Pp243-256. 9. Color Atlas of Dermoscopy, Saida T, Ohara K, Tuchida T, Tanaka M, Kanehara, Tokyo, 2003 (in Japanese) 10. Melanocytiv nevus, J Visual Dermatology 2(No.11), 2003 (in Japanese) 11. Grin CM, Saida T. Pigmented lesions of the palms and soles. In: Marghoob A, Braun R, Kopf A, editors. Atlas of dermoscopy. London (UK): Taylor & Francis; 2005. pp. 271-9. 17. 12. Saida T, Miyazaki A, Grin CM. Acro-lentiginous melanoma. In: Marghoob A, Braun R, Kopf A, editors. Atlas of dermoscopy. London (UK): Taylor & Francis; 2005. pp. 221-33. 13. Saida T, et al. Guidelines for management of cutaneous malignancies, Kanehara, Tokyo, 2007 (in Japanese) English Papers 1. Yamato T, Handa S, Yamakawa T, Saida T, Ikeda S. The urinary glycosaminoglycans in pachydermoperiostosis. Jpn J Exp Med 44: 19-24, 1974 2. Matsuda M, Saida T, Hasegawa R. Cryofibrinogen in the plasma of patients with skin ulcerative lesions on the legs: A complex of fibrinogen and cold insoluble globulin. Thrombosis Res 9: 541-552, 1976 Saida CV 4
  • 5. 3. Saida T, Ohara K, Hori Y, Tsuchiya S. Development of a malignant proliferating trichilemmal cyst in a patients with multiple trichilemmal cysts. Dermatologica 166: 203-208, 1983 4. Takubo K, Kanda Y, Ishii M, Nonose N, Saida T, Fujita K, Nakagawa H, FujiwaraM. Primary malignant melanoma of esophagus. Hum Pathol 14: 727- 730, 1983 5. Saida T, Tsuchiya S. Spontaneous partial regression of primary malignant melanoma with death due to metastases. Arch Dermatol 120: 1494-1496, 1984 6. Uno A, Hori Y, Saida T, Seki Y, Ohara K, Kukita A: Lectin-binding sites and patterns of melanin-producing cells. In: Biological, Molecular and Clinical Aspects of Pigmentation (ed. by Bagnara J, et al). pp.583-594, Tokyo: University of Tokyo Press, 1985 7. Uchiyama N, Shindo Y, Saida T. Perforating pilomatricoma. J Cutan Pathol 13: 312-318, 1986 8. Yamaji K, Matsui M, Saida T. Increased densities of Langerhans cells in the epidermis of skin tumor. J Dermatol 14: 20-24, 1987 9. Nakarai H, Saida T, Shibata Y, Irie RF, Kano K. Expression of heterophile Paul-Bunnell and Hanganutziu-Deicher antigens on human melanoma cell lines. Int Archs Allergy Appl Immunol 83: 160-166, 1987 10. Saida T, Uno A. Clonal variation in expression of p97 antigen in human melanoma cell lines detected by mixed passive hemagglutination. J Dermatol 14: 201-206, 1987 11. Saida T, Uno A, Hori Y. Detection of melanoma-associated antigen p97 in human malignant melanoma cell lines by immunoelectron microscopy. In: Cellular, Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy (ed. by Kano K, et al), pp.407-411, Tokyo: University of Tokyo Press, 1987, 12. Saida T, Iwata M. "Ectopic" extramammry Paget's disease affecting the lower aspect of the chest. J Am Acad Dermatol 17: 910-913, 1987 13. Yamaji K, Haniuda K, Shindo Y, Saida T. Squamous cell carcinoma developing in thermal keratosis. J Dermatol 15: 180-183, 1988 14. Kawachi S, Saida T, Uhara H, Uemura K, Taketomi T, Kano K. Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues. Int Archs Allergy Appl Immunol 85: 381-383, 1988 15. Saida T, Uhara H, Mikoshiba H. Phytohemagglutinin-binding sites in the skin: A useful histochemical marker of acrosyringium and distal portions of intradermal sweat ducts. Dermatologica 179: 25-28, 1989 16. Saida T. malignant melanoma in situ on the sole of the foot: Its clinical and histopathologic characteristics. Am J Dermatopathol 11: 124-130, 1989 Saida CV 5
  • 6. 17. Ikegawa S, Saida T, Obayashi H, Sasaki A, Esumi H, Ikeda S, Kiyohara Y, Hayasaka K, Ishihara K. Cisplatin combination chemotherapy in squamous cell carcinoma and adenoid cystic carcinoma of the skin. J Dermatol 16: 227-230, 1989 18. Saida T, Oshima Y. Clinical and histopathologic characteristics of early lesions of subungual malignant melanoma. Cancer 63: 556-560, 1989 19. Saida T, Okabe Y, Uhara H. Bowen's disease with invasive carcinoma showing sweat gland differentiation. J Cutan Pathol 16: 222-226, 1989 20. Shindo Y, Akiyama J, Yamaji K, Ishihara Y, Saida T, Takase Y. Establishment of a human dermatofibrosarcoma protuberans cell line: Cytological characteristics. J Dermatol 16: 355-360, 1989 21. Ikegawa S, Saida T, Takizawa Y, Tokuda Y, Ito K, Fujioka F, Sakaki Y, Uchida N, Arase S, Takeda K. Vimentin-positive squamous cell carcinoma arising in a burn scar: A highly malignant neoplasm composed of acantholytic round keratinocytes. Arch Dermatol 125: 1672-1676, 1989 22. Uhara H, Saito Y, Mukai K, Akao I, Furuya S, Hoshikawa T, Shimosato Y, Saida T. Detection of Epstein-Barr virus DNA in Reed-Sternberg cells of Hodgkin's disease using the polymerase chain reaction and in situ hybridization. Jpn J Cancer Res 81: 272-278, 1990 23. Saida T. Ikegawa S, Takizawa Y, Kawachi S. Immunohistochemical detection of heterophile Hanganutziu-Deicher antigen in human malignant melanoma. Arch Dermatol Res 282: 179-182, 1990 24. Saida T, Yoshida N, Ikegawa S, Ishihara K, Nakajima T. Clinical guidelines for the early detection of plantar malignant melanoma. J Am Acad Dermatol 23: 37-40, 1990 25. Saida T, Yoshida N. Guidelines for histopathologic diagnosis of plantar malignant melanoma: Two-dimentional coordination of maximum diameter of lesions and degrees of intraepidermal proliferation of melanocytes. Dermatologica 181: 112-116, 1990 26. Ikegawa S, Saida T, Ikeda S, Nakajima T, Ishihara K. Immunohistochemical studies of blood group antigens ABH in cutaneous angiosarcoma. Am J Dermatopathol 14: 100-106, 1992 27. Ishihara Y, Matsumoto K, Kawachi S, Saida T. Detection of early lesions of "ungual"malignant melanoma. Int J Dermatol 32: 44-47, 1992 28. Kawachi S, Saida T. Analysis of the expression of Hanganutziu-Deicher antigen in human malignant melanoma. J Dermatol 19: 827-830, 1992 29. Saida T, Dohi S, Sadaki M, Tokuda Y, Ikegawa S, Takasaki Y. Distribution patterns and frequency of proliferating cells in cutaneous keratinocytic neoplasms. J Am Acad Dermatol 26: 744-748, 1992 Saida CV 6
  • 7. 30. Tokuda T, Mukai K, Matsuno Y, Furuya S, Shimosato Y, Takasaki Y, Saida T, Ishihara K. Proliferating activity of cutaneous melanocytic neoplasms defined by a proliferating cell nuclear antigen labelling index. Arch Dermatol Res 284: 319-323, 1992 31. Matsumoto K, Kubo H, Saida T, Kobayashi H, Kitano K, Saito H, Matsui M. Lethal posttransfusion graft-versus-host disease. Dermatology 187: 38-41, 1993 32. Saida T, Ishihara Y, Tokuda Y. Effective detection of plantar malignant melanoma. Int J Dermatol 32: 722-725, 1993 33. Kubo M, Ohno S, Kato M, Isemura M, Tagami H, Saida T. Immunoelectron microscopic localization of fibronectin in cultured human keratinocytes. Arch Dermatol Res 286: 448-454, 1994 34. Saida T. The concept of de novo origin of cutaneous malignant melanoma. Eur J Dermatol 4: 252-254, 1994 35. Tokuda Y, Saida T, Mukai K, Takasaki Y. Growth dynamics of acquired melanocytic nevi: Higher reactivity of proliferating cell nuclear antigen in junctional and compound nevi than intradermal nevi. J Am Acad Dermatol 31: 220-224, 1994 36. Uhara H, Saida T, Ikegawa S, Yamazaki Y, Mikoshiba H, Nijoh S, Kitano K, Koh C-S. Primary cutaneous plasmacytosis: Report of 3 cases and review of the literature. Dermatology 189: 251-255, 1994 37. Nakura J, Wijsman EM, Miki T, Kamino K, Yu CE, Oshima J, Fukuchi K, Weber JL, Piussan C, Melaragno MI, Epstein CJ, Scappaticci S, Fraccaro M, Matsumura T, Murano S, Yoshida S, Fujiwara Y, Saida T, Ogihara T, Martin GM, Schllenberg GD. Homozygous mapping of the Werner syndrome locus (WRN). Genomics 23: 600-608, 1994 38. Saida T, Oguchi S, Ishihara Y. In vivo observation of magnified features of pigmented lesions on volar skin using videomacroscope. Arch Dermatol 131: 298-304, 1995 39. Takizawa Y, Saida T, Tokuda Y, Dohi S, Ikegawa S, Ueyama Y. Engraftment of precursor lesions of human cutaneous neoplasms onto C.B-17 SCID mice: A useful in vivo experimental model of carcinogenesis in human skin. Arch Dermatol Res 287: 237-247, 1995 40. Uhara H, Wang YL, Matsumoto S, Kawachi S, Saida T. Expression of subunit of guanine nucleotide-binding protein Go in Merkel cell carcinoma. J Cutan Pathol 22: 146-148, 1995 41. Ichikawa T, Saiki M, Kaneko M, Saida T. Squamous cell carcinoma arising in a verrucous epidermal nevus. Dermatology 193: 135-138, 1996 42. Kubo H, Abe J, Obata F, Nakajima H, Tunoda M, Ogawa A, Nakayama S, Saida CV 7
  • 8. Beck Y, Kohsaka T, Darrow TL, Abdel-Wahab Z, Saida T, Takiguchi M. Dual recognition of a human cytotoxic T-cell clone for melanoma antigens. Cancer Res 56: 2368-2374, 1996 43. Kuroda T, Kusama J, Iiijima K, Kaneko G, Fujimori Y, Saida T. Primary malignant melanoma of the rectum. J Gastroenterol 31: 437-440, 1996 44. Goddard KAB, Yu C-E, Oshima J, Miki T, Nakura J, Piussan C, Martin GM, Schllenberg GD, Wijsman EM, Saida T, members of the International Werner's Syndrome Collaborative Group. Toward localization of the Werner syndrome gene by linkage disequilibrum and ancestral haplotyping: Lessons learned from analysis of 35 chromosome 8p11.1-21 markers. Am J Hum Genet, 58: 1286-1302, 1996 45. Saida T. relationship between mole and malignant melanoma. Asian Med J 39: 645-651, 1996 46. Shimizu H, Takizawa Y, Mcgrath JA, Pulkkinen L, Christiano AM, Uitto J, Burgeson RE, Iwatsuki K, Niimi N, Noguchi M, Imayama S, Abe Y, Shirakawa Y, hagiwara S, Saida T, Ogawa H, Hashimoto I, Nishikawa T. Absence of R42X and R635X mutations in the LAMB3 gene in 12 Japanese patients with junctional epidermolysis bullosa. Arch Dermatol Res 289: 174-176, 1996 47. Wang Y-L, Uhara H, Yamazaki Y, Nikaido T, Saida T. Immunohistochemical detection of CDK4 and p16 proteins in cutaneous malignant melanoma. Br J Dermatol 134: 269-275, 1996 48. Matsumoto K, Saida T, Ferrone S. Human HMW-MAA mimicry anti-id mAb MK2-23 immunogenicity in syngeneic hosts of F(ab') fragments and chimeric antibody. In: Hori Y, et al (eds): Melanogenesis and Malignant Melanoma: Biochemistry, Cell Biology, Molecular Biology, Pathophysiology, Diagnosis and Treatment, Elsevier, Amsterdam, 1996, pp.111-118 49. Ichikawa T, Saiki M, Tokunaga S, Saida T. Scedosporium apiospermum skin infection in a patient with nephrotic syndrome. Acta Derm Venereol 77: 172-173, 1997 50. Saida T. Acral melanoma in association with melanocytic naevus. Melanoma Res 7: 78, 1997 51. Takizawa Y, Saida T, Tokuda Y, Dohi S, Wang YL, Urano K, Hioki K, Ueyama Y. New immunodeficient (nude-scid, beige-scid) mice as excellent recipients of human skin grafts containing intraepidermal neoplasms. Arch Dermatol Res 289: 213-218, 1997 52. Yu CE, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu YH, Mulligan J, Martin GM, Schellenberg GD. Saida, T, Werner's Syndrome Collaborative Group. Mutations in the consensus helicase domains of the Werner's syndrome gene. Am J Hum Genet 60: 330-341, 1997 Saida CV 8
  • 9. 53. Ichikawa T, Masumoto J, Kaneko M, Saida T, Sagara J, Taniguchi S. Moesin and CD44 expression in cutaneous melanocytic tumours. Br J Dermatol 138: 763-768, 1998 54. Ichikawa T, Masumoto J, Kaneko M, Saida T, Sagara J, Taniguchi S. Expression of moesin and its associated molecule CD44 in epithelial skin tumors. J Cutan Pathol 25: 237-243, 1998 55. Oguchi S, Saida T, Koganehira Y, Ohkubo S, Ishihara Y, Kawachi S. Characteristic epiluminescent microscopic features of early malignant melanoma on glabrous skin: A videomicroscopic study. Arch Dermatol 134: 563-568, 1998 56. Shimizu H, Takizawa, Y, Pulkkinen L, Zone JJ, Matsumoto K, Saida T, Uitto J, Nishikawa T. The 97 kD linear IgA bullous dermatosis antigen is not expressed in a patients with generalized atrophic benign epidermolysis bullosa with a novel homozygous G258X mutation in COL17A1. J Invest Dermatol 111: 887-892, 1998 57. Tokuda Y, Amagaii M, Taoita H, kawachi S, Ito T, Matsuyama I, Tsuchiya S, Saida T. A case of an inflammatory variant of epidermolysis bullosa acquisita: Chronic bullous dermatosis associated with non-scarring blisters and circulating IgG anti-type VII collagen antibody. Dermatology 197: 58-61, 1998 58. Fukuzawa M, Saida T. Pseudoaneurysm of the superficial temporal artery. Acta Derm Venereol 80: 65-66, 1999 59. Hayashi K, Kaneko H, Kawachi S, Saida T. Allergic contact dermatitis and osteomyelitis due to sternal stainless steel wire. Contact Dermatitis 41: 115, 1999 60. Ichikawa T, Itano N, Sawai T, Kimata K, Koganehira Y, Saida T, Taniguchi S. Increased synthesis of hyaluronate enhances motility of human melanoma cells. J Invest Dermatol 113: 935-939, 1999 61. Inagi R, Okuno T, Ito M, Chen J, Mori Y, Haque M, Zou P, Yagi H, Kiniwa S, Saida T. Yamanishi K. Identification and characterization of human herpesvirus 8 open reading frame K9 viral interferon regulatory factor by a monoclonal antibody. J Hum Virol 2: 63-71, 1999 62. Saida T. Histogenesis of malignant melanoma and its early detection. Asian Med J 42: 34-40, 1999 63. Saida T, Oguchi S. Usefulness of epiluminiscence microscopy in the diagnosis of pigmented lesions on the sole: an analysis using a videomicroscope. In: Dermatology at the Millennium (Dyall-Smith D, et al), pp.543-545, London: Parthenon Publishing, 1999 64. Saida T: malignant melanoma on the sole: how to detect the early lesions efficiently. Pigment Cell Res 13(suppl 8): 135-139, 2000 Saida CV 9
  • 10. 65. Cascinelli N, Herlyn M, Schneeberger A, Muwert C, Slominski A, Armstrong C, Belli F, Lukiewcz S, Maurer D, Ansel J. Saida T. What is the most promising strategy for the treatment of metastasizing melanoma? Exp Dermatol 9: 439-451, 2000 66. Saida T: Malignant skin neoplasms affecting aged persons: importance of its early detection. Asian Med J 43: 390-397, 2000 67. Kubo H, Matsumoto K, Funahashi M, Takagi H, Kitajima Y, Taniguchi S, Saida T: Sequential chemoimmunotherapy with cisplatin, IFN- and IL-2β inhibits the growth of B16-F1 melanoma in syngeneic mice. Melanoma Res 10: 223-229, 2000 68. Sakurai A, Ikeo Y, Saida T, Hashizume K. Frequency of facial angiofibromas in Japanese patients with multiple endocrine neoplasia type 1. Endocr J 47: 569-573, 2000 69. Kageshita T, Mizuno M, Ono T, Matsumoto K, Saida T, Yoshida J. Growth inhibition of human malignant melanoma transfected with the human IFN-β gene by means of cationic liposomes. Melanoma Res 11: 337-342, 2001 70. Saida T. Recent advances in melanoma research. J Dermatol Sci 24: 1-13, 2001 71. Ishihara K, Saida T, Yamamoto A. Updated statistical data of malignant melanoma in Japan. Int J Clin Oncol 6: 109-116, 2001 72. Kageshita T, Hamby CV, Ishihara T, Matsumoto K, Saida T, Ono T. Loss of -catenin expression associated with disease progression in malignantβ melanoma. Br J Dermatol 145: 210-216, 2001 73. Kiniwa Y, Fujita T, Akada M, Itoh K, Shofuda T, Suzuki Y, Yamamoto A, Saida T, Kawakami Y. Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma. Cancer Res 61: 7900-7907, 2001 74. Wakamatsu K, Kageshita T, Furue M, Hatta Y, Kiyohara Y, Nakayama J, Ono T, Saida T, Takata T, Tsuchida T, Uhara H, Yamamoto A, Yamazaki N, Naito A, Ito S. Evaluation of 5-S-cysteinyldopa as a marker of melanoma progression: 10 years’ experience. Melanoma Res 12: 245-253, 2002 75. Hayashi K, Okubo S, Watanabe T, Yamazaki Y, Horiuchi N, Saida T. Malignant melanoma on the sole showing prominent neural differentiation. Int J Dermatol 41: 247-249, 2002 76. Saida T, Oguchi S, Miyazaki A. Dermoscopy for acral pigmented lesions. Clin Dermatol 20: 279-285, 2002 77. Saida T, Oguchi S, Miyazaki A. Dermoscopic findings in pigmented lesions of glabrous skin. In: Principles of Dermoscopy (ed. by Malvehy & S. Puig), 243-256. Barcelona: CEGE, 2002 78. Uhara H, Saida T, Watanabe T, Takizawa Y. Lymphangitis of the foot: Saida CV 10
  • 11. Lymphatic drainage of the sole. J Am Acad Dermatol 46:502-504, 2002 79. Nobayashi M, Mizuno M Kageshita T, Matsumoto K, Saida T, Yoshida J. Repeated cationic liposome-mediated gene transfer enhanced transduction efficiency against murine melanoma cell lines. J Dermatol Sci 29: 206-213, 2002 80. Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T. Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma. Cancer Sci 94: 308-313, 2003 81. Koganehira Y, Takeoka M, Ehara T, Sasaki K, Murata H, Saida T, Taniguchi S. Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular muscle inside melanoma lesions: An adverse prognostic factor of malignant melanoma. Br J Dermatol 148: 971-980, 2003 82. Ryuke Y, Mizuno M, Natsume A, Suzuki O, Nobayashi M, Kageshita T, Matsumoto K, Saida T, Yoshida J. Growth inhibition of subcutaneous mouse melanoma and induction of natural killer cells by liposome-mediated interferon- gene therapy. Melanoma Res 13: 349-356, 2003β 83. Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F, Binder M, Cerroni L, De Rosa G, Ferrara G, Hofman-Wellenhof R, Landthaler M, Menzies SW, Pehamberger H, Piccolo D, Rabinovitz HS, Schiffner R, Staibano S, Stolz W, Bartenjev I, Blum A, Braun R, Cabo H, Carli P, De Giorgi V, Fleming MG, Grichnik JM, Grin CM, Halpern AC, Johr R, Katz B, Kenet RO, Kittler H, Kreusch J, Malvehy J, Mazzocchetti G, Olivieero M, Ozdemir F, Peris K, Perotti R, Perusquia A, Pizzichetta MA, Puig S, Rao B, Rubegni P, Saida T, Scalvenzi M, Seidenari S, Stanganelli I, Tanaka M, Westerhoff K, Wolf IH, Baun-Falco O, Kerl H, Nishikawa T, Wolff K, Kopf AW. Dermoscopy of pigmented skin lesions: Results of a consensus meeting via the internet. J Am Acad Dermatol 48: 679-693, 2003 84. Cochran AJ, Roberts AA, Saida T. The place of lymphatic mapping and sentinel node biopsy in oncology. Int J Clin Oncol 8: 139-150, 2003 85. Guan X, Sagara J, Yokoyama T, Koganehira Y, Oguchi M, Saida T, Taniguchi S. ASC/TMS-1, a caspase-1 activating adaptor, is downregulated by aberrant metylation in human melanoma. Int J Cancer 107: 202-208, 2003 86. Nagayama H, Sato K, Morishita M, Uchimura K, Oyaizu N, Inazawa T, Yamasaki T, Enomoto M, Nakaoka T, Nakamura T, Maekawa T, Yamamoto A, Shimada S, Saida T, Kawakami Y,Asano S, Tani K, Takahashi A, Yamashita N. Results of phase I clinical study using autologous tumor-lysate pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2. Melanoma Res Saida CV 11
  • 12. 13:521-530, 2003 87. Saida T, Miyazaki A, Grin CM. Acro-lentiginous melanoma. In: Atlas of Dermoscopy (ed. by Marghoob AA, Braun R, Kopf AW), New York: Parthenon Publishing, 2004 (in press) 88. Grin CM, Saida T, Braun R. Pigmented lesions of the palms and soles. In: Atlas of Dermoscopy (ed. by Marghoob AA, Braun R, Kopf AW), New York: Parthenon Publishing, 2004 (in press) 89. Rokuhara S, Saida T, Oguchi M, Matsumoto K, Murase S, Oguchi S: Number of acquired melanocytic nevi in Japanese melanoma patients and control subjects: A significant risk factor for non-acral melanoma but not for acral melanoma. J Am Acad Dermatol 50: 695-700, 2004 90. Saida T, Kawachi S, Takata M, Kurita H, Kurashina K, Kageshita T, Tonogi M, Okazaki Y, Yamane G, Takubo K, Ueyama Y: Histopathologic characteristics of malignant melanoma affecting mucous membranes: A unifying concept of histogenesis. Pathology 36: 404-413, 2004 91. Saida T, Miyazaki A, Oguchi S, Ishihara Y, Yamazaki Y, Murase S, Yoshikawa S, Tsuchida T, Kawabata Y, Tamaki K: Significance of dermoscopic patterns in detecting malignant melanoma on acral volar skin: Results of a multi-center study in Japan. Arch Dermatol 140: 1233-1238, 2004 92. Saida T, Miyazaki A, Grin CM. Acro-lentiginous melanoma. In: Atlas of Dermoscopy (ed. by Marghoob AA, Braun R, Kopf AW), London:Taylor & Francis, p221- 233, 2005 93. Grin CM, Saida T, Braun R. Pigmented lesions of the palms and soles. In: Atlas of Dermoscopy (ed. by Marghoob AA, Braun R, Kopf AW), London: London:Taylor & Francis, p271- 279, 2005 94. Tanaka K, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, Saida T, Honda H: Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int J Cancer 116: 624-633, 2005 95. Kato H, Hayashi K, Saida T, Kontani K, Nishizawa O: Urethral advancement procedure for reconstruction after excision of male parameatal melanoma in situ. Urol Int 74:183-4, 2005 96.Miyazaki A, Saida T, Koga H, Oguchi S, Suzuki T, Tsuchida T. Anatomical and histopathological correlates of the dermoscopic patterns seen in melanocytic nevi on the sole: A retrospective study. J Am Acad Dermatol 53: 230-6, 2005 97. Takata M, Goto Y, Ichii N, Yamaura M, Murata H, Koga H, Fujimoto A, Saida T: Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanoma. J Invest Dermatol 125: 318-322, 2005 Saida CV 12
  • 13. 98. Tanaka K, Ito A, Kobayashi T, Kawashima T, Shimada S, Matsumoto K, Saida T, Honda H: Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma. J Biosci Bioeng 100: 112-115, 2005 99. Takata M, Suzuki T, Ansai S, Kimura T, Shirasaki F, Hatta N, Saida T: Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPF): its usefulness as an adjunctive diagnostic tool for melanocytic tumors. J Dermatol Sci 40: 51-57, 2005 100. Yoshiura K, Nakaoka T, Nishishita T, Sato K, Yamamoto A, Shimada S, Saida T, Kawakami Y, Takahashi TA, Fukuda H, Imajoh-Ohmi S, Oyaizu N, Yamashita N: Carbonic anhydrase-II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy. Clin Cancer Res 11:8201-8207, 2005 111. Yamaura M, Takata M, Miyazaki A, Saida T: Specific dermoscopy patterns and amplifications of the cyclin D1 gene to define histopathologically unrecognizable early lesions of acral melanoma in situ. Arch Dermatol 141: 1413-1418, 2005. 112. Saida T: Lessons learned from studies of the development of early melanoma. Int J Clin Oncol 10: 371-374, 2005 113. Takata M, Saida T: Early cancers of the skin: clinical, histopathological, and molecular characteristics. Int J Clin Oncol 10: 391-397, 2005. 114. Makoto Higuchi, Toshihiko Agatsuma, Miwako Iizima, Yoriko Yamazaki, Toshiaki Saida, Tohru Ichikawa, Yuji Kamijo, Hideo Arakura, Kazuhiko Hora, Kendo Kiyosawa: A case of drug-induced hypersensitivity syndrome with multiple organ involvement treated with plasma exchange. Ther Apher Dial 9: 412-6, 2005 115. Ishihara Y, Saida T, Miyazaki A, Koga H, Tamiguchi A, Tsuchida T, Yoyama M, Ohara K: Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features. Am J Dermatopathol 28: 21-27, 2006. 116. Tokuda Y, Kawachi S, Murata H, Saida T: Chronic obesity lymphoedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema. Br J Dermatol 154: 157-161, 2006 117. Munakata N, Schuch N, Casiccia C, Kaneko M, Liu C-M, Jimbow K, Saida T, Nishigori C, Ogata K, Inafuku K, Hieda K, Cornain S, Ichihashi M, Kanoko M, Mulyadi K, Lestari S, Wirohadidjojo W, Bolsee D, Kazadzis S, Meyer-Rochow V: Biological monitoring of solar UV radiation at 17 sites in Asia, Europe and South America from 1999 to 2004. Photochem Photobiol 82:689-694, 2006 118. Zalaudek I, Argenziano G, Soyer HP, Corona R, Sera F, Blum A, Braun RP, Cabo H, Ferrara G, Kopf AW, Langford D, Menzies AW, Pellacani G, Peris Saida CV 13
  • 14. K, Seidenari S, The Dermoscopy Working Group (Saida T, et al): Br J Dermatol 154: 431-437. 2006 119. Malvehy J, Puig S, Argenziakno G, Marghoob AA, Soyer HP, The IDS Board Members (Saida T, et al): Dermoscopy report: Proposal for standardization: Results of a consensus meeting of the International Dermoscopy Society (IDS). J Am Acad Deramtol 2006 (in press) 120. Goto Y, Matsuzaki Y, Kurihara S, Shimizu A, Okada T, Yamamoto K, Murata H, Takata M, Aburatani H, Hoon DSB, Saida T, Kawakami Y: A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. Cancer Res 66:4443-4449, 2006 121. Takata M, Saida T. Genetic alteration in melanocytic tumors. J Dermatol Sci 43: 1-10, 2006 122. Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T: High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J Invest Dermatol 126: 2111-8, 2006 123. Iijima M, Uhara H, Ide Y, Sakai S, Onuma H, Muto M, Hayashi K, Mitsura F, Kobayashi S, Yoshizawa A, Saida T: Estrogen-receptor-alpha- positive extramammary Paget’s disease treated with hormonal therapy. Dermatology 213: 144-6, 2006 124. Saida T: Histogenesis of congenital and acquired melanocytic nevi: A unifying concept. Am J Dermatopathol 28: 377-379, 2006 Japanese Papers Published more than 500 articles in Japanese Saida CV 14

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