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Skin
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Skin
Skin
Skin
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Skin
Skin
Skin
Skin
Skin
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Skin
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Skin
Skin
Skin
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  • 1. Skin & Hair Research at the University of Bradford Prof. Des J Tobin Director of Medical Biosciences School of Life Sciences Personal Care Program Meeting (Yorkshire Chemical Focus Ltd.) Cedar Court, Wakefield. October 12, 2007
  • 2. Main Research Themes Cutaneous Biology (Skin & Hair) Vascular Biology Neurosciences Toxicology (Genetic/Reproductive; Natural Products)
  • 3. Institute of Pigmentary Disorders Prof. Karin Schallreuter Plastic Surgery & Burns Unit Prof. David Sharpe Team 13 Academics (+ 3 Hon.) 10 Post-Doctoral RAs 2 Plastic Surgery Fellows 16 PhD Students Cutaneous Biology Human Epidermis Human Hair Bulb 2nd Largest Academic Research Unit in Britain
  • 4. Skin Sciences - UoB Academic staff
  • 5. Cutaneous Biologists: Dr N Botchkareva, PhD (Hair Follicle growth & Pigmentation) (Lecturer in Biomedical Sciences – Ex-Senior Scientist P&G) Dr S Britland PhD (Wound healing and Point of Care therapeutics) (Reader in Cell Biology – Consultant for AGT Life Sciences) Prof. VA Randall PhD (Androgen-regulation of hair growth) (Prof. of Biomedical Sciences) Dr AM Snelling PhD (Skin Microbiology – infection control) (Senior Lecturer in Medical Microbiology – PZ Cussons, PALL) Dr MJ Thornton PhD (Estrogens and Skin/Hair Follicle) (Senior Lecturer in Biomedical Sciences) Prof. DJ Tobin PhD (Hair growth and pigmentation) (Professor of Cell Biology – Unilever, P&G, Reckitt Benckiser, DSM) Prof. AJ Thody PhD (Endocrinology of Skin pigmentation) (Prof. Emeritus of Experimental Dermatology – Stiefel Labs. Inc) Prof. JM Wood PhD (Biochemistry of Skin pigmentation) (Prof. Emeritus of Medical Biochemistry – Stiefel Labs Inc.)
  • 6. Clinician/Scientists in Skin: Prof. VA Botchkarev MD, PhD (Skin development/ Carcinogenesis) (Prof. of Cutaneous Biology – Ex-Boston Sch. of Medicine) Prof. KU Schallreuter MD (Skin Pigmentation in Health & Disease) (Prof. of Clinical & Experimental Dermatology – endowed chair by Stiefel Laboratories Inc.). Physical/Biological Chemistry/Biopharmaceutics: Dr M Bonner (Transdermal Delivery) Lecturer in Pharmaceutical Technology Dr A Nicolaou (Bioactive lipid function/lipidomics in skin/ UVR) Reader in Biological Chemistry - Lipid function In silico – Computational Modeling Prof. J Anwar (Lipid membranes & drug penetration enhancement Prof. of Computational Pharmaceutical Science (Unilever)
  • 7. Estrogens Cultured skin cells have estrogen receptors (brown) Estrogens promote wound healing (Diabetic foot ulcer) Normal skin homeostasis Wound Healing Wound healing in Diabetes Pigmentation & Melanoma Hair Growth Sex Hormones & Human Skin Dr M Julie Thornton Senior Lecturer in Biomedical Sciences Tel: (01274)235517 Email: m.j.thornton@bradford.ac.ukk
  • 8. Androgens (testosterone) Balding, Acne etc. (new arrival ‘Syntopix’ @ IPI) Prof. Valerie A Randall Professor of Biomedical Sciences Tel: (01274)233574 Email: V.A.Randall@bradford.ac.uk Sex Hormones & Human Skin
  • 9. Skin Development, Regeneration & Carcinogenesis Chemotherapy-induced Hair loss Skin development Carcinogenesis Prof. Vladimir A Botchkarev Professor of Cutaneous Biology Tel: (01274)233499 Email: V.A.Botchkarev@bradford.ac.uk
  • 10. Skin & Hair Pigmentation
  • 11. Treatment of Pigmentary Disorders Prof. Karin U Schallreuter Professor of Clinical & Experimental Dermatology Tel: (01274)233527 Email: K.Schallreuter@bradford.ac.uk RepigmentationRepigmentation of facial vitiligo after reduction ofof vitiligo after reduction of HH22OO22 with pseudocatalase PCwith pseudocatalase PC --KUSKUS www.vitiligo.eu.com Institute for Pigmentary Disorders in Association with University of Greifswald/Germany and University of Bradford Clinical and Experimental Dermatology Bradford, BD7 1DP, UK
  • 12. Can we preferentially regulate Skin vs Hair Colour?Can we preferentially regulate Skin vs Hair Colour? Melanocytes as Proxy for Neurons inMelanocytes as Proxy for Neurons in neurodegenerationneurodegeneration EMc HFMc Prof. Desmond J Tobin Professor of Cell Biology; Tel (01274)233585 Email: d.tobin@bradford.ac.uk Prof. Desmond J Tobin Professor of Cell Biology; Tel (01274)233585 Email: d.tobin@bradford.ac.uk
  • 13. Hair follicle-derived fibroblasts: Preferred wound-healing cells Hair Follicle Fibroblasts contribute to Wound HealingHair Follicle Fibroblasts contribute to Wound Healing Modulation of Wound Healing by HF fibroblasts, maggot enzyme (@ AGT) etc. Prof. Desmond J Tobin Professor of Cell Biology; Tel (01274)233585 Email: d.tobin@bradford.ac.uk Dr Steve T Britland Reader in Pharmacology Tel: (01274)234695 Email: s.t.britland@bradford.ac.ukk Dr M Julie Thornton Senior Lecturer in Biomedical Sciences Tel: (01274)235517 Email: m.j.thornton@bradford.ac.ukk Hair Growth InhibitionHair Growth Inhibition -- In vitro test modelsIn vitro test models http://www.agtsciences.com/ Prof. Desmond J Tobin Professor of Cell Biology; Tel (01274)233585 Email: d.tobin@bradford.ac.uk
  • 14. Medical Microbiology Dr Anna M Snelling Senior Lecturer in Microbiology Tel: (01274)235933 Email: A.M.Snelling@bradford.ac.uk
  • 15. Genetic & Reproductive Studies The UV Sensitivity Diagnostic Test – Melanoma Patents filed Prof Diana Anderson Professor of Biomedical Sciences Tel: (01274)233569 Email: D.Anderson1@bradford.ac.uk
  • 16. In silico – Computational Modeling of Skin & Biomembranes Prof. J Anwar (Lipid membranes & drug penetration enhancement Prof. Jamshed Anwar Prof. of Computational Pharmaceutical Science Telephone: (01274) 236145 Email: j.anwar@bradford.ac.uk http://www.ipi.ac.uk/research/computational-laboratory/
  • 17. Trans-dermal Delivery Biopharmaceutics: Drugs delivered via topical/ transdermal. Circumvent skin barrier via chemical/ electrical methods to maximise bioavailability of drugs via skin, and promote delivery of challenging molecules via this route Potential for drug delivery by ‘shunt route’ in skin (hair follicles and sweat glands). Augmentation of skin barrier for the prevention of water loss. Dr Michael Bonner Lecturer in Pharmaceutical Technology Tel: (01274) 233219 Email: m.bonner@bradford.ac.uk http://www.ipi.ac.uk/abo ut/staff/individual/176/
  • 18. Polymer Center of Industrial Collaboration/ Interdisciplinary Research Centre [School of EDT (incl. Bradford Engineering Consultancy)] Comprehensive Rheological Characterisation expertise and facilities, to evaluate and develop the properties of topical creams/liquids/gels etc. Rheological evaluation of skin cream under a wide range of conditions, possible mechanical/chemical interactions with the polymers used for the dispenser and physical performance of the delivery system. One of Britain’s largest polymer centres for research into advanced polymer processing with main activities within Chemicals and Plastics-related sectors Fibre processing to produce highly specified polymer filaments /arrays (with tailored mechanical properties and dimensional control) most useful for development of toothbrush head technology (oral care). Dr J McGrath Tel: (01274) 233624 E-mail: j.c.mcgrath@bradford.ac.uk Commercial Manager - Polymer CIC
  • 19. Forensics & Bioarcheology of Hair Hair: Contains diet, status, ethnicity, identity data etc. Dr Andrew Wilson Lecturer in Archaeological Sciences Tel: (01274) 235351 Email: A.S.Wilson2@Bradford.ac.uk http://www.brad.ac.uk/AGES/Research/

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