Plantas medicinales chinas para el tratamiento del eczema atópico

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Plantas medicinales chinas para el tratamiento del eczema atópico

  1. 1. CHINESE HERBAL MEDICINE FOR ATOPIC ECZEMA Zhang W, Leonard T, Bath-Hextall F, Chambers CA, Lee C, Humphreys R, Williams HC This review should be cited as: Zhang W, Leonard T, Bath-Hextall F, Chambers CA, Lee C, Humphreys R, Williams HC. Chinese herbal medicine for atopic eczema (Cochrane Review). In: The Cochrane Library, Issue 1, 2006. Oxford: Update Software. A substantive amendment to this systematic review was last made on 25 August 2004. Cochrane reviews are regularly checked and updated if necessary. A B S T R A C T Background: Traditional Chinese herbal mixtures have been used to treat atopic eczema for many years. Their efficacy has attracted public attention and recently some clinical trials have been undertaken. Objective: To assess the effects of Chinese herbal mixtures in the treatment of atopic eczema. Search strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) ( January 2004), the Cochrane Skin Group Specialised Register (January 2004), MEDLINE (1966 to January 2004), EMBASE (1980 to January 2004), CINHL (1980 to January 2004) and a number of complementary medicine databases. In addition, the cited references of all trials identified and key review articles were searched. Pharmaceutical companies involved in oral traditional Chinese herbs and experts in the field were contacted. Selection criteria: Randomized controlled trials of Chinese herbal mixtures used in the treatment of atopic eczema. Data collection and analysis: Two reviewers independently applied eligibility criteria, assessed the quality of the trials and extracted data. Any discrepancies were discussed to achieve consensus. Main results: Four randomized controlled trials, with eight weeks for each phase, met the inclusion criteria. The trials randomized 159 participants aged from 1 to 60 years. The withdrawal rates ranged from 7.5% to 22.5% and no trial used intention to treat analysis. Three trials were randomized placebo controlled, two-phase cross- over designs assessing the same Chinese herbal mixture, Zemaphyte. In two of these three trials the reduction in erythema and surface damage was greater on Zemaphyte than on placebo, and participants slept better and expressed a preference for Zemaphyte. One trial also reported that participants itched less. The fourth trial was an open-label design comparing Zemaphyte in herbal form with Zemaphyte as a freeze dried preparation. There was a reduction in erythema and surface damage with both formulations, but no comparison between the two formulations was reported. Some adverse effects were reported in all four trials, but none were regarded as serious. Reviewers' conclusions: Chinese herbal mixtures may be effective in the treatment of atopic eczema. However, only four small poorly reported RCTs of the same product, Zemaphyte, were found and the results were heterogeneous. Further well-designed, larger scale trials are required, but Zemaphyte is no longer being manufactured. B A C K G R O U N D  Definition and epidemiology
  2. 2.  Atopic eczema or atopic dermatitis is an intensely itchy and erythematous (red) inflammatory skin disease, which usually involves the skin creases (Williams 1994). It is now the commonest inflammatory skin disease of childhood, affecting around 15% of school children in the UK (Emerson 1997; Kay 1994; Neame 1995). Although only 1% to 2% of adults are affected by atopic eczema, their disease is often more chronic and severe (Herd 1996). There is reasonable evidence to suggest that the prevalence of atopic eczema has increased two to three-fold over the last 30 years, for reasons which are unclear (Williams 1992a).  Causes  Studies with twins suggest that genetic factors are important in atopic eczema but other evidence strongly suggests that environmental factors are critical in disease expression (Williams 1995). Allergic factors, such as exposure to house dust mite may be important, but non-allergic factors such as exposure to irritants and infectious agents may also be important. Around 60% of children who have atopic eczema will improve by their early teens, although a small proportion will relapse again in early adulthood (Williams 1992b). Atopic eczema is strongly linked to hay fever and asthma, around 30% of children with atopic eczema will go on to develop asthma (Williams 1992b).  Impact  Measurement of the impact of skin disease on quality of life is important in our understanding and management of skin diseases. Several studies suggest that atopic eczema has a more profound effect on quality of life than other skin diseases, such as acne and psoriasis (Lewis-Jones 1995). Children may experience sleep disturbance due to the itch-scratch-itch cycle, and lack of confidence due to low self esteem. Families of sufferers also experience sleep loss (Reid 1995). People with atopic eczema require special clothing and bedding, may need to avoid activities such as swimming, and need frequent applications of greasy ointments (Reid 1995).  Treatment  Although there is currently no cure, various interventions exist to control symptoms. Conventional treatment consists of emollients and corticosteroids, both of which have been in use for over 30 years (Hoare 2000). Other treatments include wet wraps (damp, occlusive body bandages either impregnated with a therapeutic substance or applied over topical preparations), dietary manipulation, and habit reversal (Hoare 2000). For more severe atopic eczema, drugs such as cyclosporin A are used to suppress the immune system. Yet despite this range of treatments some patients remain unresponsive (Williams 1999) and some of them seek complementary medicine in the form of Chinese herbs. Chinese herbal medicine is part of Traditional Chinese Medicine (TCM), which uses acupuncture, herbs, dietary manipulation and Tai Qi exercise for both treatment and prevention of disease (Fulder 1996; Kirby 1997). This holistic approach focuses on maintaining a balance of body, mind and environment. Qi, or life energy, is said to be present in all vital organs, and it is this Qi which is believed to become unbalanced when illness or disease strikes (Fulder 1996; Kirby 1997). For diagnosis it is important to build up a picture of the individual. This is done by taking a careful history and by observing posture, and the appearance of the skin, hair and eyes. Special attention is paid to the quality of the pulse and the appearance of the tongue. Traditional Chinese Medicine identifies many different pulses believed to
  3. 3. correspond to the internal organs (Fulder 1996; Kirby 1997). Treatment depends on this individual, i.e. it is different from person to person, even if according to Western medicine each person appears to be suffering from the same illness.  Rationale for undertaking the review  Preliminary evidence suggests Chinese herbs may reduce inflammation and suppress the immune system (Xu 1997). However, there is concern regarding the potential of at least some of the herbs to poison the liver (Graham-Brown 1992; Perharic-Walton 1992; Rustin 1992). This concern is increased by the fact that there is no standardised treatment in that the individual practitioner determines the dose of each herb that is prescribed. Indeed, standardisation of herbal mixtures contradicts Chinese medical philosophy (Atherton 1992) but if we were to test the efficacy of Chinese herbs without standardisation, this lack of standardisation would introduce many confounding variables. O B J E C T I V E S To assess the effects of Chinese herbal mixtures in the treatment of atopic eczema. C R I T E R I A F O R C O N S I D E R I N G S T U D I E S F O R T H I S R E V I E W Types of studies Randomised controlled trials (RCTs) of Chinese herbal mixtures for atopic eczema, including cross-over designs. Types of participants  Anyone who was diagnosed with atopic eczema by a physician. Diagnostic criteria such as the Hanifin and Rajka definition (Hanifin 1980) or the UK modification (Williams 1994) was acceptable, when using the terms 'atopic eczema' or 'atopic dermatitis'.  The term 'eczema' was acceptable only when referring to children. All other terms such as 'Besnier's prurigo' or 'neurodermatitis' needed additional evidence of atopic eczema in the flexures, i.e. crooks of arms and backs of knees, before inclusion. Types of intervention Oral decoctions of Chinese herbs, either on their own or in combination with other drugs, compared with a control group. The control group could be placebo or no treatment. Types of outcome measures (1) Primary outcome measures  Self-rated clinical response  (i) Proportion of participants with clinically significant changes in self- rated symptoms (e.g. itch and sleep loss), as defined by each of the
  4. 4. studies and/or average score or change in self-rated symptoms.  (ii) Proportion of participants with clinically significant response in self- rated global (overall) changes, as defined by each of the studies and/or average score or change in self-rated overall well-being.  (iii) Proportion of participants with clinically significant changes in self- rated signs (e.g. dryness and cracking) as defined by each of the studies and/or average score or change in self-rated signs.  (iv) Participant preference Participant preference was not specified as an outcome in the protocol but was added to the review as very few of the specified outcomes were reported. It was reported in all three trials for Zemaphyte and placebo. (2) Secondary outcome measures  (a)Doctor-rated clinical response  (i) Proportion of participants with clinically significant response in doctor- rated global changes, as defined by each of the studies and/or average score or change in doctor-rated global state.  (ii) Proportion of participants with clinically significant changes in doctor- rated signs, as defined by each of the studies and/or average score or change in doctor-rated signs.  (iii) Proportion of participants with clinically significant changes in doctor- rated symptoms, as defined by each of the studies and/or average score or change in doctor-rated symptoms. In the absence of any indication in the studies of what was deemed clinically significant, the default procedure was to use the proportion of participants with good to excellent improvement as the main outcome. (b) Adverse events S E A R C H S T R A T E G Y F O R I D E N T I F I C A T I O N O F S T U D I E S See: Cochrane Skin Group search strategy  (1) Electronic databases  (a) The Cochrane Skin Group Specialised Register (January 2004)  See Table 05  (b) The Cochrane Central Register of Controlled Trials (CENTRAL) (January 2004)  See Table 06  (c) MEDLINE (from 1966 to January 2004)  See Table 07  (d) EMBASE (from 1980 to January 2004)  See Table 08  (e) CINAHL (from 1982 to January 2004)  See Table 09  (f) Allied and Complementary Medicine (AMED) (January 2004)  See Table 10
  5. 5.  (2) References from published studies  These were checked for further trials.  (3) Unpublished literature  Unpublished, on-going trials, and grey literature were obtained via correspondence with authors and pharmaceutical companies.  (4) Conference proceedings  One author (HW) handsearched dermatology conference proceedings for further RCTs as part of the Cochrane Skin Group's ongoing systematic handsearching project.  (5) Adverse events  A search for adverse events was carried out, using "traditional chinese medicine" and "adverse events" as key words with MEDLINE, EMBASE and CINHL.See Table 11.  Phytopharm Plc, the manufacturer of Zemaphyte, was asked to provide information relating to adverse events. We also contacted the Medical Toxicology Unit at Guy's and St Thomas' Hospital Trust. Data on adverse events is presented in Comparisons and data table 01.  (6) Other  No language restrictions were imposed. Six Chinese databases were searched for "atopic eczema" or "atopic dermatitis":  1. Chinese Medical Journal Index - National Chinese Medical Research Institute, P.R.China;  2. Journal and Thesis Index - Republic of China, Taiwan;  3. Traditional Chinese Medicine Database - P.R.China;  4. Chinese Postgraduate Thesis Index - P.R.China;  5. Chinese and Western Medical Journal Index - P.R.China;  6. CHINABASE-MED. M E T H O D S O F T H E R E V I E W  (1) Study selection  Titles and abstracts identified from the searches were checked by the principal reviewer (WZ). The full text of all studies of possible relevance was obtained for independent assessment by three reviewers (WZ, TL, CC). The reviewers decided which trials met the inclusion criteria, and recorded their methodological quality. Any disagreements were resolved by discussion between the reviewers. If any data were missing from the trial reports attempts were made to obtain that data by contacting the authors. Data extraction from the six Chinese databases was undertaken by two Chinese reviewers (WZ and CL) and the abstracts were translated for all relevant RCTs.  (2) Assessment of methodological quality  The quality assessment included an evaluation of the following components, for each included study, since there is some evidence that these are associated with biased estimates of treatment effect (Juni 2001):  (a) the method of generation of the randomization sequence;  (b) the method of allocation concealment - it was considered 'adequate' if the assignment could not be foreseen;
  6. 6.  (c) who was blinded or not blinded (participants, clinicians, outcome assessors);  (d) how many participants were lost to follow up in each arm (split into post-randomization exclusions and later losses, if possible), and whether participants were analysed in the groups to which they were originally randomised (intention to treat).  In addition the quality assessment also included:  (e) degree of certainty that the participants had atopic eczema;  (f) aims, interventions (including drug doses and duration of treatment) and outcome measures clearly defined;  (g) inclusion and exclusion criteria specified;  (h) main outcomes specified a priori;  (i) assessment of patient concordance with treatment. The information was recorded in a table of quality criteria (Table 04) and a description of the quality of the studies is given based on a summary of these components.  (3) Data extraction  This was performed independently by two reviewers (WZ, TL) and discrepancies resolved by discussion. Data were checked and entered onto the computer by one reviewer.  (4) Analysis  All four trials were of randomised controlled design but insufficient data were given in the papers for further analysis. Attempts are being made to obtain the raw data. The data from the original papers are presented in Table 02 and Table 03 and in the text.  (5) Other  Where there was uncertainty authors were contacted for clarification. A consumer was consulted, particularly for readability and understanding of the final review. D E S C R I P T I O N O F S T U D I E S From the searches we identified 14 published papers that possibly contained relevant RCTs. The full text of each paper was examined. Four trials eventually met the inclusion criteria, one undertaken in Hong Kong (Fung 1999) and three in England (Henderson 2000; Sheehan 1992a; Sheehan 1992b). The total number of participants randomised in the four trials was 159, and 131 were analysed. The participants' ages ranged from 1 to 60 years. Three included trials were randomised double-blind, placebo-controlled, cross-over trials with two treatment phases, each of eight weeks with a washout period of four weeks in between. The total length of these trials was 20 weeks. All investigated a commercial preparation called Zemaphyte, in sachet form, made by Phytopharm Plc, UK. Zemaphyte is a standardised mixture of 10 traditional Chinese herbs which are taken orally. Details of the constituents can be found in Table 01. The fourth trial was a head to head comparison of Zemaphyte in herbal form with Zemaphyte as a freeze dried preparation. Three studies in English were excluded on the grounds that they were non- randomised trials, or had no participant control groups or no clinical endpoints (Banerjee 1994; Latchman 1996; Liu 1993). One RCT was excluded because it was undertaken in dogs (Nagle 2001). Four papers in Chinese were excluded as they
  7. 7. were not RCTs (Li 1994, 2 papers); Zhou 1989, 2 papers). Two studies (Sheehan 1994; Sheehan 1995) were one-year observational follow-up studies of people that had been treated with Zemaphyte in RCTs. We therefore excluded them from our main analysis but qualitatively assessed the longer term efficacy and safety of Zemaphyte. M E T H O D O L O G I C A L Q U A L I T Y Three trials were randomised, placebo-controlled, cross-over designs. More information about their quality can be found in Table 04. The fourth trial was a randomised, open label, parallel design.  Randomisation and selection bias  No details were given for the method of allocation concealment in any of the trials. The method of generation of the randomisation sequence was described as 'using a pre-arranged code' for one trial (Henderson 2000) and not described in the other three.  Blinding of outcome assessment and detection bias  Three trials were described as "double-blind, placebo-controlled" but no details were given of who was blinded. The treatment was Zemaphyte, which is a mixture of ten active individual Chinese herbs. The placebo was a mixture of 10 inert plant materials having a similar appearance, taste and smell, but with no active herbs and no known benefit in atopic eczema (Table 01). Both active herbs and placebo were provided in the same type of sachet by Phytopharm Plc, UK. The fourth trial was open, as two different formulations were used - granules and herbs.  Handling of losses and attrition bias  Dropouts and the reason for dropouts were recorded. Dropout rates were 7.5%, 18.7%, 21.3%, and 22.5% for Fung 1999; Henderson 2000, Sheehan 1992a and Sheehan 1992b respectively. Intention to treat analysis was not used in any of the trials. Order and carry-over effects were reported in all three cross-over trials but no significant effects were found. R E S U L T S (1) Primary outcome measures Self-rated clinical response (i) Self-rated symptoms  Sleepimproved(2 studies, Table 03) Two trials (Sheehan 1992a; Sheehan 1992b) provided data on sleep improvement over eight weeks. The results showed more patients had improved sleep in the treatment phase than in the placebo phase.  Itch improved(1 study; Table 03) Only one trial reported this outcome (Sheehan 1992b), again over an eight week treatment period. Participants reported significantly less itching on Zemaphyte (p < 0.001).  (ii) Global changes and overall well being
  8. 8.  None of the trials reported this outcome.  (iii) Self-rated signs  None of the trials reported this outcome.  (iv) Participant preference (3 studies)  This outcome was not originally specified but was reported in all three trials for Zemaphyte and placebo. The proportion of participants preferring Zemaphyte was higher than placebo in two trials (Sheehan 1992a; Sheehan 1992b), but not in another (Fung 1999). It was significantly higher in one trial (p < 0.02) (Sheehan 1992b). (2) Secondary outcome measures (a) Doctor-rated clinical response  (i) Global changes  None of the trials reported this outcome.  (ii) Signs  Erythema and surface damage  All four studies reported erythema and surface damage as primary outcomes, but the results were presented differently and different statistical methods were used when analysing the data. For example, Wilcoxon signed rank test was used for two trials (Fung 1999; Sheehan 1992a), whereas a paired t-test was used for another (Sheehan 1992b). Fung 1999 did not report period estimates for their results and Sheehan et al reported their two studies differently, one as median percentage score change from baseline (Sheehan 1992a) and the other as geometric mean scores at the endpoint, irrespective of baseline differences (Sheehan 1992b). These factors made a reanalysis of the data impossible. The results are shown in Additional Table 02. Two trials showed the superiority of Zemaphyte over placebo (Sheehan 1992a; Sheehan 1992b) whilst one demonstrated similar effects for both (Fung 1999). The trial which compared two formulations of Zemaphyte showed a reduction, compared to baseline scores, at eight weeks for both erythema and surface damage. The mean fall in erythema score was 7.3 ( p> 0.05) for the tea-bag preparation and 10.5 (p<0.05) for the granules. The mean fall in surface damage score was 16.3 (p<0.01) for the tea-bag preparation and 11.1 (p<0.01) for the granules. Sheehan et al also undertook one-year follow-up observations after their randomised controlled trials. Seventeen adults who continued to take the herbal mixture were re-examined one year later, 12 had a greater than 90% reduction in the clinical score and the remaining 5 had greater than 60% reduction compared with baseline values (Sheehan 1995). This was significantly better than those 11 patients who chose not to take the medication (p = 0.005 and p = 0.002 for erythema and surface damage respectively). Similarly, the 23 children who opted to continue with the herbal mixture showed better results after one year follow-up than those who discontinued the herbal mixture (Sheehan 1995).  (iii) Symptoms  None of the trials reported this outcome. (b) Adverse events Blood picture, renal function and liver function were investigated in all three cross- over trials. No changes were observed for either treatment. A few minor adverse
  9. 9. events were reported with Zemaphyte. For example, in the Fung 1999 study, two patients complained of dizziness, four reported gastrointestinal upsets and one developed lichenoid eruption. Mild abdominal distension and headaches (two events) were reported in the Sheehan 1992b study in adults. However, two adverse events, one facial herpes and one loss of taste, were observed with placebo. Seventeen people developed mild nausea, abdominal discomfort, loose bowels or flatulence in the Henderson 2000 trial, this was intermittent in 13 people. One person developed nausea and dizziness and dropped out of the trial and one was admitted to hospital with a flare of eczema and associated bacterial infection. Both people were taking the herbal tea-bag preparation. Blood tests showed no significant alterations except for one person whose lymphocyte count fell transiently; intermittent lymphopaenia had been present for several years. Liver function abnormalities were observed in two children in the follow-up study but became normal after discontinuing the herbal therapy (Sheehan 1995). Gastrointestinal upsets were often reported after taking Zemaphyte and a mild laxative effect was noted in approximately one-third of participants who carried on with the treatment (Sheehan 1994; Sheehan 1995). Phytopharm Plc, the manufacturer of Zemaphyte, was asked to provide information relating to adverse events. Their medical director replied that they were not able to provide us with any further information other than that which was already published. The Medical Toxicology Unit at Guy's and St Thomas' Hospital was contacted and a conference poster was retrieved about the use of Zemaphyte (Allan 1994). This referred to an open follow up study based on 694 patients who had been given Zemaphyte by general practitioners (GPs), including 67 patients who had originally been involved in Sheehan's trials. The GPs were asked to record any side effects and also the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum creatinine. A total of 35 adverse events were reported in 694 patients (5.04%), most of which were gastrointestinal (2.58%) such as nausea, vomiting and mild diarrhoea. Other adverse events included urticaria, photosensitivity, an exacerbation of eczema, night diuresis, discolouration of teeth and bilirubin creatinine values outside normal limits. Liver function values were raised in seven patients but returned to normal after treatment was discontinued. D I S C U S S I O N This is the second systematic review of the best available evidence for the use of oral traditional Chinese herbs in the treatment of atopic eczema. The previous systematic review (Armstrong 1999) considered only two trials, we have included two more (Fung 1999; Henderson 2000). The four trials all examined the effects of a standardised mixture of herbs called Zemaphyte. The three cross-over trials all used a mixture of herbs which had to be simmered for 90 minutes and some people found the taste and smell unpalatable. The fourth trial compared this preparation with a freeze dried extract which had been developed to overcome these problems. Unfortunately none of these formulations are currently available as the manufacturer has been unable to obtain a license for Zemaphyte. All the trials used doctor-rated outcomes such as erythema and surface damage as the primary outcomes, and the three cross-over trials also used participant-related outcomes such as sleep, itch and participant-preference as the secondary outcomes. There are some discrepancies between the trials. For example, while Sheehan's two trials reported positive results in favour of Zemaphyte, Fung's trial did not find any differences between Zemaphyte and placebo. This may be due to:  (1) Lower doses of Zemaphyte in Fung's trial.
  10. 10.  The dosage of the herbal preparation was 33% less in the 7 to 13 year age group and 25% less in the 14 plus age group and the treatment was reduced from daily to twice weekly after crossover.  (2) Differences in drop-out rates.  In Sheehan's two trials there were much higher drop-out rates (21.3% and 22.5%) compared to Fung's trial (7.5%). More patients seemed to prefer Zemaphyte to placebo in Sheehan's trials. As none of the trials used intention to treat analysis, the positive results from Sheehan's trials have to be treated with caution, as they are more likely to be affected by withdrawal bias. Reasons for the drop outs were given as either having failed to take the treatment, or having been prescribed other drugs such as corticosteroids.  3) Different types of participants.  The participants in Fung's study were exclusively Chinese and racial variability in drug responsiveness has previously been documented (Johnson 1997). Participants whose eczema was infected or discharging (exudative) were excluded from the English studies but not from the Chinese study. The response to Zemaphyte may be different for exudative and non-exudative patients. We were unable to undertake a meta-analysis as different statistical methods were used and limited data were provided. However, based on the original analyses, Zemaphyte was statistically superior to placebo in the English studies but failed to demonstrate superiority over placebo in the Chinese trial. The two open follow-up studies (Sheehan 1994; Sheehan 1995) undertaken after the randomised controlled trials showed a sustained effect of Zemaphyte for erythema and surface damage over a period of one year. The trial which compared two different preparations of Zemaphyte (Henderson 2000), showed an improvement for both erythema and surface damage for both preparations. Side effects of Zemaphyte were reported, both in the randomised controlled period for 8 weeks, and in the follow-up period for one year. In the randomised controlled period, only a few minor adverse events such as gastrointestinal upsets were reported, whereas in the longer term follow up period, liver function abnormalities were observed in two cases, but these abnormalities disappeared after stopping the herbal therapy. The results were confirmed by a GP monitoring follow up study based on a larger sample size of 649 (Allan 1994), suggesting that Zemaphyte may be related to abnormal liver function. There have been reports of serious adverse effects of traditional Chinese herbs e.g. hepatitis (Kane 1995; Stickel 2000), skin eruption (Mather 2002) and nephritis (Uejima 2000). However, all of these are case reports, which are open to reporting bias. One of the herbs used in Zemaphyte, Clematis armandii, can be supplied interchangeably, in Chinese medicine, with Aristolochia manshuriensis, which is known to be nephro-toxic (Lord 1999). However there are no reports of nephrotoxicity with Zemaphyte. Information on the toxicity of each herb and possible interactions between the herbs is required. There are several caveats for this review. Firstly, we were unable to search the full literature of Chinese clinical studies. The six databases may only reflect part of the literature pool and they themselves have yet to be completed. This is important for a systematic review of this kind as Chinese herbal medicine has been largely practised in China, Japan and other Asian countries. Unfortunately we failed to identify a sound database to cover the evidence from this region. The review is therefore open to language bias. Secondly, the four trials included all have less than 50 participants. They are subject to 'small study effects' (Sterne 2000) i.e. small studies are more likely to provide
  11. 11. positive results. Thirdly, apart from the small study effects, the quality of each study is poor. There were no details of allocation concealment and no intention to treat analyses. Sheehan's studies, which both had drop-out rates of more than 20%, are likely to show positive results in favour of the treatment, as the people who drop-out may have done so either because of no effect of the treatment or because of side effects. A larger, well designed trial would have been necessary to demonstrate the efficacy of Zemaphyte. Finally, unlike Western medicine, Chinese herbal therapy uses mixtures of many herbs, which are individualised (by dose and choice of ingredients), according to the characteristics of the person being treated. A fixed preparation, such as Zemaphyte, which includes ten standard ingredients is therefore not used in practice, and may cause very different effects in different people, such as those seen in the different RCTs reported here. Although this systematic review shows some differences between Zemaphyte and placebo, it does not necessarily reflect real clinical practice, where the prescription (dose and ingredients) is based on the individual person, and therefore may not be generalisable to all types of atopic eczema. The true value of the 10 herbs in the mixture in different combinations and doses remains unknown. R E V I E W E R S ' C O N C L U S I O N S Implications for practice Zemaphyte, a mixture of traditional Chinese oral herbal medicines, may have some benefits for patients with atopic eczema. However, the fixed formulation and doses may not be effective for everyone and ideally adjustments should be made for type of disease and patient characteristics. At present people with eczema are being denied a potentially effective treatment as Zemaphyte has been withdrawn from the market by the manufacturer. Implications for research Only four small, poorly reported RCTs were available for assessment and the results were heterogeneous. The following suggestions are made for future work:  further RCTs with designs that allow adjustable formulations and doses of each herb in the mixture for individual patients;  well-designed epidemiological studies, such as cohort and case-control studies, to establish the association between potential toxic Chinese herbal mixtures and adverse events;  more experimental studies on the toxicity of each ingredient of an identified mixture;  different designs of RCTs such as 'n of 1' trials, where the participant undergoes pairs of treatment periods which are replicated until it is shown that the treatments are definitely different or not. A C K N O W L E D G E M E N T S We thank Dr Debbie Shaw from the Medical Toxicity Unit, Guy's and St Thomas' Hospital, for her advice on the adverse effects of Zemaphyte and help in identifying extra studies.  The editorial base would like to thank the following people who were the external referees for this review:
  12. 12.  David Atherton and Jane Ravenscroft (content experts) and David Potter (consumer). P O T E N T I A L C O N F L I C T O F I N T E R E S T None known. N O T E S Dr Clive Adams and the Schizophrenia Group provided advice and support in the development of the outcome measures T A B L E S Characteristics of included studies Study Fung 1999 Methods D: crossover8 wks - phase I4 wks - washout8 wks - phase IIAC: no infoRS: no infoB: 'double-blind' but unclear who was blinded Participants Incl: moderate to severe atopic dermatitis, resistant to topical tx, no overt bacterial skin infectionExcl: pregnant, concurrent illness, sensitivity to herbs, use of PUVA, systemic steroids, or other i/s tx (previous 8w)Set: 2 dermatology clinics in Hong KongAge: 8-52 years (mean 18)Duration: not givenRandomised: 40Evaluable: 37m/f: 19/18
  13. 13. Interventions a: Zemaphyteb: placeboidentical sealed porous sachets (2 types)8-13 years: 2 large + 2 small sachets14+ years: 3 large + 3 small sachetsFreq: daily for 4wks, then twice per wk for 4 wks Outcomes 1. erythema2. surface damage3. participant preference Notes Drop outs:2 - no further details givenExcluded:1 - additional tx prescribed Allocation concealment B Study Henderson 2000 Methods D: parallel8 weeksAC: no infoRS: pre-arranged codeB: open Participants Incl: persistent moderate to severe atopic eczemaExcl: pregnant, breast feeding, use of phototherapy, systemic steroids or i/s tx (previous 4w)Set: no infoAge: 17-60 (mean 29.8)Duration: 4-60 years (mean 23.5)Randomised: 32m/f: 18/14Evaluable: 26 Interventions a: Zemaphyte as herbs in tea bagb: Zemaphyte as granular freeze dried extract of herbs in sachetAll ages: 4 teabags or sachets Freq: daily Outcomes 1. erythema2. surface damage3. adverse events Notes Withdrawn:5 - adverse events1 - faied to attend Allocation concealment B Study Sheehan 1992a Methods D: crossover8 wks - phase I4 wks - washout8 wks - phase IIAC: no infoRS: no infoB: 'double-blind' but unclear who was blinded Participants Incl: extensive, non-exudative AE, resistant to topical tx, no overt bacterial skin infectionExcl: use of systemic and topical steroidsSet: tertiary referral centre in UKAge: 1.5-18.1 years (mean 8.7)Duration: not givenRandomised: 47m/f: 27/20Evaluable: 37m/f: 22/15 Interventions a: Zemaphyteb: placebosealed porous sachets (2 types)1-7 years: 2 large+2 small sachets8-13 years: 3 large+3 small sachets>14years: 4 large+4 small sachetsFreq: daily for 8 wks Outcomes 1. erythema2. surface damage3. adverse events4. parent preference5. ability to sleep
  14. 14. Notes Excluded:a: 4non-compliance because unpalatable (3), steroids (1)b: 6unpalatable (2), steroids (1), antibiotics (3)Compliance assessed with diary cards Allocation concealment B Study Sheehan 1992b Methods D: crossover8 wks - phase I4 wks - washout8 wks - phase IIAC: no infoRS: no infoB: 'double-blind' but unclear who was blinded Participants Incl: extensive, non-exudative, refractory atopic dermatitis, no overt bacterial skin infectionExcl: pregnant, breast feeding, concurrent illness, use of PUVA, systemic steroids or antibiotics, or other i/s tx ( previous 8w)Set: dermatology out-pt dept in UKAge: 19-57 years (mean 30)Duration: longstanding (mean 29 years)Randomised: 40m/f: 17/23Evaluable: 31 Interventions a: Zemaphyteb: placebo10g sealed porous sachets (2 types)all ages: 4 large and 4 small sachetsFreq: daily for 8 weeks Outcomes 1. erythema2. surface damage3. itched less4. slept better5. particpant preference Notes Excluded:a) 5b) 4non-compliance because unpalatable (8), pregnant (1) Allocation concealment B Abbreviations used METHODS D: design AC: method of allocation concealment RS: method of generating randomisation sequence B: blinding (participant, clinician, outcome assessment) PARTICIPANTS Incl: inclusion criteria Excl: exclusion criteria Set: setting Other definitions AE: atopic eczema dept - department freq: frequency g: gram GI: gastro-intestinal i/s: immunosuppressive m/f: male / female out-pt: out-patient tx: treatment wk(s): week(s)
  15. 15. Characteristics of excluded studies Study Reason for exclusion Banerjee 1994 no control group Latchman 1996 non-randomised controlled trial Li 1994 no control group Liu 1993 no control group Nagle 2001 RCT in dogs Sheehan 1994 one year observational follow-up study of RCT (children) Sheehan 1995 one year observational follow-up study of RCT (adults) Zhou 1989 no control group A D D I T I O N A L T A B L E S Table 01 Ingredients of Zemaphyte and placebo Zemaphyte placebo As used by Sheehan 1992a (sachets) Ledebouriella seseloides, Potentilla chinensis, Anebia clematidis, Rehmannia glutinosa, Paeonia lactiflora, Lophatherum gracile, Dictamnus dasycarpus, Tribulus terrestris, Glycyrrhiza uralensis and Schizonepeta tenuifolia As used by Sheehan 1992a (sachets) Humulus lupulus, Hordeum distichon, Hordeum distichon ustum, baker's bran (wheat), sucrose, Salvia spp, Thymus vulgaris, Rosmarinus officianalis, Mentha pipertia, Oleum caryophylli and Glycyrrhiza uralensis
  16. 16. Sheehan 1992b (sachets) Used Clematis armandii Fung 1999 (sachets) as Sheehan 1992b The herbs needed daily preparation by simmering the sachet in water for 90 minutes Henderson 2000 Compared PSE 101 (herbal teabag) and PSE222 (a freeze - dried extract of the herbal infusion, produced as lacquer coated granules, no simmering required) No further information given All formulations provided by Phytopharm, UK Sheehan 1992b (sachets) no Glycyrrhiza uralensis Fung 1999 (sachets) as Sheehan 1992b Table 02 Difference in erythema and surface damage between treatment and placebo Trial Statistic used No randomised No evaluable Diff in erythema 95% CI p value Diff in surf damage 95% CI p value Fung 1999 median change from baseline, at 4 weeks (Wilcoxon rank sum test) 40 37 0.10 no data 0.775 0.18 no data 0.822 Sheehan 1992(a) % median change from baseline (Wilcoxon- 47 37 44.9 13.4, 89.7 no data 56.9 19.2, 97.9 no data
  17. 17. based test) Sheehan 1992(b) % mean proportional change btwn end of placebo and active phases (paired t- test) 40 31 46.0 25.2, 67.0 no data 49.0 27.0, 71.0 no data Table 03 Slept better, itched less and preference for Zemaphyte and placebo Outcome Trial Statistic used No randomised No evaluable Zemaphyte Placebo P value Slept better Fung (n=37) None 40 37 no data no data no data Sheehan 1992a (n=37) None 47 37 19 3 no data Sheehan 1992b (n=31) Difference between proportions, Wilcoxon- based method 40 31 15 6 0.078 Itched less Fung (n=37) None 40 37 no data no data no data Sheehan 1992a (n=37) None 47 37 no data no data no data Sheehan 1992b (n=31) Difference between proportions, Wilcoxon- based method 40 31 14 1 <0.01 Participant preference Fung (n=37) None 40 37 14 12 no data Sheehan 1992a (n=37) None 47 37 27 2 no data Sheehan 1992b (n=31) Difference between proportions, Wilcoxon- based method 40 31 20 4 <0.02 Table 04 Quality Criteria Study ID Allocat'n Allocat'n Blindin Loss to Have Clear Inc & Outcome Concordance
  18. 18. generatio n concealed ? g follow up AE? def'n of aims ex criteria? s specified ? ? Fung 1999 not described not described 'double blind' 3/40 (7.5%) clear definitio n yes clearly describe d yes not stated Sheehan 1992(a) not described not described 'double blind' 10/47 (21.3% ) clear definitio n yes clearly describe d yes diary cards Sheehan 1992(b) not described not described 'double blind' 9/40 (22.5% ) clear definitio n yes clearly describe d yes daily diary Henderso n 2000 not described not described open 6/32 (18.7% ) unclear yes unclear yes not stated Table 05 Search strategy for Specialised Trials Register (January 04) Search strategy Skin Group Specialised Register 15jan04 ((chinese AND herb* AND medicin*) OR (traditional AND chinese AND medicin*) OR (drug* AND chinese AND herb*) OR (herb*) OR (Herb* AND medicin*) OR (medicin* AND herb*) OR (plant* AND medicin*) OR (drug* AND non AND prescript*) OR (alternative AND medicin*) OR (complementary AND medicin*) OR (tradition* AND medicin*) OR ( medicn* AND tradition* AND orient*)) AND ((atopic AND eczema) OR (atopic AND dermatitis) OR (besnier* AND prurigo) OR (neurodermatitis) OR (infant* AND eczema) OR (childhood AND eczema) OR ezcema) Table 06 Search strategy for CENTRAL (January 2004) search strategy Search strategy for CENTRAL (January 2004) #1. (atopic next dermatitis) #2. (atopic next eczema) #3. ECZEMA explode tree 1 (MeSH) #4. neurodermatitis #5. (besniers next prurigo) #6. eczema #7. (#1 or #2 or #3 or #4 or #5 or #6) #8. (chinese next herbal next medicine) #9. (traditional next chinese next medicine) #10. (drugs next chinese next herbal) #11. (#8 or #9 or #10) #12. MEDICINE HERBAL single term (MeSH) #13. ((plant* next medicin*) or (herb* next medicin*)) #14. (drug* near (non next prescription)) #15. ((complementary near medicin*) or (complementary near therap*)) #16. ((alternative near therap*) or (alternative near medicin*))
  19. 19. #17. ((traditional near therap*) or (traditional near medicin*)) #18. (chinese or china or oriental:ti) #19. (chinese or china or oriental:ab) #20. (#12 or #13 or #14 or #15 or #16 or #17) #21. (#18 or #19) #22. (#20 and #21) #23. (#11 or #22) #24. (#7 and #23) Table 07 Search strategy for MEDLINE (from 1966 to January 2004) Search strategy Database: Ovid MEDLINE(R) <1966 to February Week 3 2004> -------------------------------------------------------------------------------- 1 exp DERMATITIS, ATOPIC/ (7934) 2 dermatitis.mp. (23451) 3 atopic eczema.mp. or exp Eczema/ (6084) 4 infantile eczema.mp. (52) 5 childhood eczema.mp. (37) 6 exp NEURODERMATITIS/ or neurodermatitis.mp. (1064) 7 besnier's prurigo.mp. (17) 8 1 or 2 or 3 or 4 or 5 or 6 or 7 (31121) 9 exp Plants, Medicinal/ or exp Medicine, Oriental Traditional/ or exp Drugs, Chinese Herbal/ or chinese-herbal-medicine.mp. or exp Medicine, Chinese Traditional/ (48663) 10 herbs.mp. (1994) 11 herbs-medicinal.mp. (7) 12 medicinal-herbs.mp. (404) 13 drugs-non-prescription.mp. or exp Drugs, Non-Prescription/ (2781) 14 alternative-medicine.mp. or exp Complementary Therapies/ (90421) 15 complementary-medicine.mp. (733) 16 9 or 10 or 11 or 12 or 13 or 14 or 15 (131812) 17 exp Randomized Controlled Trials/ or randomised controlled trial.mp. or exp Clinical Trials/ or exp Random Allocation/ (186643) 18 exp Double-Blind Method/ or double blind.mp. or exp Placebos/ (103607) 19 single blind.mp. or exp Single-Blind Method/ (10511) 20 Comparative Study/ (1088049) 21 prospective studies.mp. or exp Prospective Studies/ (173544) 22 follow up studies.mp. or exp Follow-Up Studies/ (280848) 23 17 or 18 or 19 or 20 or 21 or 22 (1613465) 24 8 and 16 and 23 (77) 25 from 24 keep 1-77 (77) Table 08 Search strategy for EMBASE (from 1980 to January 2004 ) Search strategy Database: EMBASE <1980 to 2004 Week 10> Search Strategy: -------------------------------------------------------------------------------- 1 exp DERMATITIS, ATOPIC/ (7939) 2 dermatitis.mp. (21946)
  20. 20. 3 atopic eczema.mp. or exp Eczema/ (5677) 4 infantile eczema.mp. (26) 5 childhood eczema.mp. (32) 6 exp NEURODERMATITIS/ or neurodermatitis.mp. (550) 7 besnier's prurigo.mp. (2) 8 1 or 2 or 3 or 4 or 5 or 6 or 7 (27953) 9 exp Plants, Medicinal/ or exp Medicine, Oriental Traditional/ or exp Drugs, Chinese Herbal/ or chinese-herbal-medicine.mp. or exp Medicine, Chinese Traditional/ (35789) 10 herbs.mp. (1693) 11 herbs-medicinal.mp. (3) 12 medicinal-herbs.mp. (303) 13 drugs-non-prescription.mp. or exp Drugs, Non-Prescription/ (2146) 14 alternative-medicine.mp. or exp Complementary Therapies/ (6193) 15 complementary-medicine.mp. (648) 16 9 or 10 or 11 or 12 or 13 or 14 or 15 (38241) 17 exp Randomized Controlled Trials/ or randomised controlled trial.mp. or exp Clinical Trials/ or exp Random Allocation/ (305824) 18 exp Double-Blind Method/ or double blind.mp. or exp Placebos/ (119041) 19 single blind.mp. or exp Single-Blind Method/ (7694) 20 Comparative Study/ (49136) 21 prospective studies.mp. or exp Prospective Studies/ (42198) 22 follow up studies.mp. or exp Follow-Up Studies/ (129551) 23 17 or 18 or 19 or 20 or 21 or 22 (545124) 24 8 and 16 and 23 (105) Table 09 Search strategy for CINAHL (from 1982 to January 2004) Search strategy Database: CINAHL <1982 to March Week 1 2004> Search Strategy: -------------------------------------------------------------------------------- 1 exp DERMATITIS, ATOPIC/ (283) 2 dermatitis.mp. (650) 3 atopic eczema.mp. or exp Eczema/ (355) 4 infantile eczema.mp. (1) 5 childhood eczema.mp. (13) 6 exp NEURODERMATITIS/ or neurodermatitis.mp. (1) 7 besnier's prurigo.mp. (0) 8 1 or 2 or 3 or 4 or 5 or 6 or 7 (1076) 9 exp Plants, Medicinal/ or exp Medicine, Oriental Traditional/ or exp Drugs, Chinese Herbal/ or chinese-herbal-medicine.mp. or exp Medicine, Chinese Traditional/ (7190) 10 herbs.mp. (1941) 11 herbs-medicinal.mp. (1) 12 medicinal-herbs.mp. (46) 13 drugs-non-prescription.mp. or exp Drugs, Non-Prescription/ (776) 14 alternative-medicine.mp. or exp Complementary Therapies/ (29448) 15 complementary-medicine.mp. (495) 16 9 or 10 or 11 or 12 or 13 or 14 or 15 (33489) 17 exp Randomized Controlled Trials/ or randomised controlled trial.mp. or exp Clinical Trials/ or exp Random Allocation/ (24459) 18 exp Double-Blind Method/ or double blind.mp. or exp Placebos/ (4242)
  21. 21. 19 single blind.mp. or exp Single-Blind Method/ (275) 20 Comparative Study/ (22376) 21 prospective studies.mp. or exp Prospective Studies/ (29750) 22 follow up studies.mp. or exp Follow-Up Studies/ (29601) 23 17 or 18 or 19 or 20 or 21 or 22 (69790) 24 8 and 16 and 23 (9) Table 10 Search strategy for AMED (January 2004) Search strategy AMED search strategy 9jan04 1. randomized controlled trials/ 2. random allocation/ 3. double blind method/ 4. single-blind method/ 5. exp Clinical Trials/ 6. (clin$ adj25 trial$).tw. 7. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$ or dummy)).tw. 8. placebos/ 9. placebo$.tw. 10. random$.tw. 11. research design/ 12. Prospective studies/ 13. cross over studies/ 14. meta analysis/ 15. (meta?analys$ or systematic review$).tw. 16. control.tw. 17. (multicenter or multicentre).tw. 18. (multi-center or multi-centre).tw. 19. ((study or studies or design$) adj25 (factorial or prospective or intervention or crossover or cross-over or quasi-experiment$)).tw. 20. or/1-19 21. dermatitis/ or exp dermatitis atopic/ or exp eczema/ or exp neurodermatitis/ 22. besniers prurigo.mp. [mp=abstract, heading words, title] 23. prurigo.mp. 24. 21 or 23 25. exp drugs chinese herbal/ 26. exp traditional medicine chinese/ 27. exp plants medicinal/ 28. exp herbs/ 29. herbs/ or herbs.mp. 30. exp complementary medicine/ or exp complementary therapies/ 31. alternative medicine.mp. 32. traditional therapy.mp. 33. Traditional medicine/ or traditional medicine.mp. 34. alternative therapy.mp. 35. 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 36. 20 and 24 and 35 Table 11 Search strategy for side effects (MEDLINE, 1966 to February 2004)
  22. 22. Search strategy Database: Ovid MEDLINE(R) <1966 to February Week 3 2004> -------------------------------------------------------------------------------- 1 exp DERMATITIS, ATOPIC/ (7934) 2 dermatitis.mp. (23451) 3 atopic eczema.mp. or exp Eczema/ (6084) 4 infantile eczema.mp. (52) 5 childhood eczema.mp. (37) 6 exp NEURODERMATITIS/ or neurodermatitis.mp. (1064) 7 besnier's prurigo.mp. (17) 8 1 or 2 or 3 or 4 or 5 or 6 or 7 (31121) 9 exp Plants, Medicinal/ or exp Medicine, Oriental Traditional/ or exp Drugs, Chinese Herbal/ or chinese-herbal-medicine.mp. or exp Medicine, Chinese Traditional/ (48663) 10 herbs.mp. (1994) 11 herbs-medicinal.mp. (7) 12 medicinal-herbs.mp. (404) 13 drugs-non-prescription.mp. or exp Drugs, Non-Prescription/ (2781) 14 alternative-medicine.mp. or exp Complementary Therapies/ (90421) 15 complementary-medicine.mp. (733) 16 9 or 10 or 11 or 12 or 13 or 14 or 15 (131812) 17 adverse events.mp. (15145) 18 side effects.mp. (83811) 19 Product Surveillance, Postmarketing/ or Adverse Drug Reaction Reporting Systems/ or adverse drug reaction.mp. (5114) 20 17 or 18 or 19 (102048) 21 8 and 16 and 20 (24) 22 from 21 keep 1-24 (24) R E F E R E N C E S References to studies included in this review Fung 1999 {published data only} Fung AYP, Look PCN, Chong LY, But PPH, Wong E. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. International Journal of Dermatology 1999;38:387-92. Henderson 2000 {published data only} Henderson CA, Morries A, Wilson A, LLchyshyn A. An open study comparing the
  23. 23. efficacy of two different Chinese herbal therapy formulations in atopic eczema and their effects on circulating activated T-lymphocytes. Journal of Dermatological Treatment 2000;11:91-6. Sheehan 1992a {published data only} Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medical plants in widespread non-exudative atopic eczema. British Journal of Dermatology 1992;126:179-84. Sheehan 1992b {published data only} Sheehan MP, Rustin MHA, Atherton DJ, Buckley C, Harris DJ, Brostoff J, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13-7. * indicates the major publication for the study References to studies excluded from this review Banerjee 1994 Banerjee P. Efficacy of a new palatable formulation of Chinese herbal therapy as treatment of atopic eczema. British Journal of Dermatology 1994;131(Suppl 44):26. Latchman 1996 Latchman Y, Banerjee P, Poulter LW, Rustin M, Brostoff J. Association of immunological changes with clinical efficacy in atopic eczema patients treated with traditional Chinese herbal therapy (Zemaphyte). International Archives of Allergy and Immunology 1996;109:243-9. Li 1994 Li L. Clinical observation of traditional Chinese medicines in the treatment of 115 patients with atopic eczema. Journal of Traditional Chinese Medicine 1994;35(12):740-2. * Li L. Clincial observation of 115 malposition eczema treated by traditional Chinese medicines in Great Britain. Gangsu Journal of Traditional Chinese Medicine 1994;7(4):11-3. Liu 1993 Liu HN, Jaw SK, Wong CK. Chinese herbs and atopic dermatitis. Lancet 1993;342:1175-6. Nagle 2001 Nagle TM, Torres SM, Horne KL, Grover R, Stevens MT. A randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis. Veterinary Dermatology 2001;12:265-74. Sheehan 1994 Sheehan MP, Atherton DJ. One-year follow up of children treated with Chinese medical herbs for atopic eczema. British Journal of Dermatology 1994;130:488-493. Sheehan 1995 Sheehan MP, Stevens H, Ostlere LS, Atherton DJ, Brostoff J, Rustin MHA. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clinical Experimental Dermatology 1995;20:136-40. Zhou 1989 * Zhou S. Chinese herbs in the treatment of 31 patients with atopic eczema. Journal
  24. 24. of Traditional Chinese Medicine 1989;30(12):36-8. Zhou S. Traditional Chinese medicines in the treatment of atopic eczema - clinical analysis of 31 cases. Liaoling Journal of Traditional Chinese Medicine 1989;13 (10):26-8. Additional references Allan 1994 Allan JE, Atherton DJ, Guy GW, Rustin MHA, Sheehan MP, Whittle BA. Safety studies on a traditional Chinese phytotherapy (Zemaphyte) in general practice. In: European Scientific Cooperative on Phytotherapy Symposium, March 18th. 1994. Armstrong 1999 Armstrong NC, Ernst E. The treatment of eczema with Chinese herbs: a systematic review of randomised controlled trials. British Journal of Clinical Pharmacology 1999;48:262-4. Atherton 1992 Atherton DJ. Treatment of atopic eczema with traditional Chinese medicinal plants. Pediatric Dermatology 1992;9(4):373-5. Emerson 1997 Emerson RM, Williams HC, Allen BR. Severity distribution of atopic dermatitis in the community and its relationship to secondary referrals. British Journal of Dermatology 1997;137(Suppl 50):23. Fulder 1996 Fulder S. The Handbook of Alternative and Complementary Medicine. Oxford: Oxford University Press, 1996. Graham-Brown 1992 Graham-Brown R. Toxicity of Chinese herbal remedies (letter). BMJ 1992;340:673. Hanifin 1980 Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockholm) 1980;92:44-7. Herd 1996 Herd RM, Tidman MJ, Prescott RJ, Hunter JAA. Prevalence of atopic eczema in the community: the Lothian atopic dermatitis study. British Journal of Dermatology 1996;135:18-9. Hoare 2000 Hoare C, Li Wan Po A, Williams H. Systematic review of treatments for atopic eczema. Health Technology Assessment 2000;4(37). Johnson 1997 Johnson JA. Influence of race or ethnicity on pharmacokinetics of drugs. Journal of Pharmaceutical Sciences 1997;12:1328-33. Juni 2001 Juni P, Altman DG, Egger M. Assessing the quality of controlled clinical trials. BMJ 2001;323:42-6. Kane 1995 Kane JA, Kane SP, Jain S. Hepatitis induced by traditional Chinese herbs; possible toxic components. Gut 1995;36:146-7.
  25. 25. Kay 1994 Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The prevalence of childhood atopic eczema in a general population. Journal of the American Academy of Dermatology 1994;30:35-9. Kirby 1997 Kirby AJ, Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbs. Journal of Ethnopharmacology 1997;56(2):103-8. Lewis-Jones 1995 Lewis-Jones MS, Finlay AY. The children's dermatology life quality index (CDLQI): initial validation and practical use. British Journal of Dermatology 1995;132:942-9. Lord 1999 Lord G, Tagore R, Cook T, Gower P, Pusey C. Nephropathy caused by Chinese herbs in the UK. The Lancet 199;354:481-2. Mather 2002 Mather J, Knowles SR, Shapiro L, Binkley K. Skin eruption following the use of two Chinese herbal preparations: A case report. Canadian Journal of Clinical Pharmacology 2002;9:69-71. Neame 1995 Neame RL, Berth-Jones J, Kurinczuk JJ, Graham-Brown RAC. Prevalence of atopic dermatitis in Leicester: a study of methodology and examination of possible ethnic variations. British Journal of Dermatology 1995;132:772-7. Perharic-Walton 1992 Perharic-Walton L, Murray V. Toxicity of Chinese herbs (letter). BMJ 1992;340:674. Reid 1995 Reid P, Lewis-Jones MS. Sleep disturbances and their management in pre-schoolers with atopic eczema. Clinical Experimental Dermatology 1995;20:38-41. Rustin 1992 Rustin M, Atherton D. Toxicity of Chinese herbs (letter). BMJ 1992;340:673-4. Sterne 2000 Sterne JAC, Gavahan D, Egger M. Publication and related bias in meta-analysis: Power of statistical tests and prevalence in the literature. Journal of Clinical Epidemiology 2000;53:1119-29. Stickel 2000 Stickel F, Egerer G, Seitz HK. Hepatotoxicity of botanicals. Public Health Nutrition 2000;3:113-24. Uejima 2000 Uejima E, Takahashi K, Ohishi M et al. The risks of using personally imported traditional Chinese drugs (decoction). Japanese Journal of Clinical Pharmacology and Therapeutics 2000;31:693-9. Williams 1992a Williams HC. Is the prevalence of atopic dermatitis increasing?. Clinical Experimental Dermatology 1992;17:385-91. Williams 1992b Williams HC, Hay RH, Strachan D. Eczema and family size. Journal of Investigative
  26. 26. Dermatology 1992;98(4):601. Williams 1994 Williams HC, Burney PGJ, Pembroke AC, Hay RH. The UK Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. British Journal of Dermatology 1994;131(3):383-96. Williams 1995 Williams HC. Atopic eczema - why we should look to the environment. BMJ 1995;311:1241-2. Williams 1999 Williams HC. Epidemiology of atopic dermatitis: recent advances and future predictions. Current Problems in Dermatology 1999;28:9-17. Xu 1997 Xu X-J, Banerjee P, Rustin MHA, Poulter LW. Modulation by Chinese herbal therapy of immune mechanisms in the skin of patients with atopic eczema. British Journal of Dermatology 1997;136:54-9. G R A P H S Graphs and Tables To view a graph or table, click on the outcome title of the summary table below. 01 Adverse events Outcome title No. of studies No. of participants Statistical method Effect size 01 Adverse events Other data No numeric data
  27. 27. C O V E R S H E E T Chinese herbal medicine for atopic eczema Reviewer(s) Zhang W, Leonard T, Bath-Hextall F, Chambers CA, Lee C, Humphreys R, Williams HC Contribution of Reviewer(s) Link with editorial base and coordinate contributions from co-reviewers (WZ) Draft protocol (CC, TL, HW ) Run search (WZ, TL, FBH) Identify relevant titles and abstracts from searches i.e. broad screen (WZ, TL) Obtain copies of trials (CC) Select which trials to include ( WZ , TL, CC) Extract data from Chinese databases (WZ, CL) Extract data from trials (WZ, TL) Enter data into RevMan (WZ, TL) Carry out analysis (WZ, TL) Interpret analysis (WZ, HCW, TL) Draft final review (WZ with contribution from all) Update review (WZ, TL) Issue protocol first published 2000 issue 3 Issue review first published 2004 issue 4 Date of last minor amendment 04 May 2004 Date of last substantive amendment 25 August 2004 Most recent changes Information not supplied by reviewer Date new studies sought but none found Information not supplied by reviewer Date new studies found but not yet included/excluded Information not supplied by reviewer Date new studies found and included/excluded Information not supplied by reviewer Date reviewers' conclusions section amended Information not supplied by reviewer Contact address Dr Weiya Zhang Clinical Sciences Building City Hospital Nottingham England UK NG5 1PB Telephone: +44 115 8704 726 Facsimile: +44 115 8704 732 E-mail: Weiya.Zhang@nottingham.ac.uk Cochrane Library number CD002291 Editorial group Cochrane Skin Group Editorial group code SKIN S O U R C E S O F S U P P O R T
  28. 28. External sources of support  NHS Health Technology Assessment Programme UK  NHS Research and Development Programme UK  Dr Susil Kumar and Jamila Mitra Charitable Trust UK Internal sources of support  University of Nottingham UK S Y N O P S I S Some evidence shows that one type of traditional Chinese herbal medicine may be effective for atopic eczema Atopic eczema or dermatitis is one of the most common skin diseases. Chinese herbal mixtures, taken by mouth, have been used for this condition for many years. Recently, four randomised controlled trials have been undertaken to assess the efficacy and safety of this therapy. The review of these trials found that a Chinese herbal mixture, Zemaphyte, can improve erythema (redness), surface damage to the skin, sleep disturbance and itching. However, the trials are small and of poor quality and the side effects of Zemaphyte remain unclear. Well designed studies are needed but Zemaphyte is no longer being manufactured. K E Y W O R D S Humans; Dermatitis, Atopic[*drug therapy]; Drugs, Chinese Herbal[adverse effects] [*therapeutic use]; Phytotherapy[adverse effects][*methods]; Randomized Controlled Trials; Treatment Outcome

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